ACB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QED2_LEIMA

TriTrypDb:

LmjF.17.0620 , LMJLV39_170012100 , LMJSD75_170011800

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	3
GO:0005737	cytoplasm	2	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QED2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QED2

PDB structure(s): 5ijm_A , 7des_A , 7fc7_A , 7wfs_A , 7wfs_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	16
GO:0000166	nucleotide binding	3	16
GO:0005488	binding	1	16
GO:0008289	lipid binding	2	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0033218	amide binding	2	16
GO:0036094	small molecule binding	2	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0120227	acyl-CoA binding	3	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:1901567	fatty acid derivative binding	3	16
GO:1901681	sulfur compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	80	82	PF00675	0.405
CLV_PCSK_KEX2_1	80	82	PF00082	0.368
CLV_PCSK_SKI1_1	37	41	PF00082	0.284
CLV_PCSK_SKI1_1	67	71	PF00082	0.448
CLV_PCSK_SKI1_1	80	84	PF00082	0.447
DEG_APCC_DBOX_1	79	87	PF00400	0.260
DOC_CYCLIN_RxL_1	75	88	PF00134	0.262
DOC_PP1_RVXF_1	27	33	PF00149	0.307
DOC_USP7_MATH_1	62	66	PF00917	0.435
LIG_14-3-3_CanoR_1	80	86	PF00244	0.309
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_FHA_2	38	44	PF00498	0.400
LIG_NRBOX	81	87	PF00104	0.299
LIG_PDZ_Class_1	98	103	PF00595	0.637
LIG_SH2_STAT5	12	15	PF00017	0.328
LIG_SH2_STAT5	78	81	PF00017	0.315
MOD_CMANNOS	60	63	PF00535	0.350
MOD_GlcNHglycan	1	4	PF01048	0.436
MOD_GSK3_1	81	88	PF00069	0.347
MOD_N-GLC_2	64	66	PF02516	0.289
MOD_NEK2_1	85	90	PF00069	0.333
MOD_NEK2_2	62	67	PF00069	0.289
MOD_PIKK_1	44	50	PF00454	0.308
MOD_PIKK_1	85	91	PF00454	0.421
MOD_Plk_4	31	37	PF00069	0.350
MOD_Plk_4	81	87	PF00069	0.340
MOD_SUMO_for_1	69	72	PF00179	0.333
MOD_SUMO_rev_2	71	77	PF00179	0.402
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.390
TRG_ER_diArg_1	79	81	PF00400	0.221
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.325
TRG_PTS1	100	103	PF00515	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F5	Leptomonas seymouri	74%	100%
A0A0N1PC41	Leptomonas seymouri	65%	100%
A0A0S4J1D0	Bodo saltans	76%	100%
A0A3Q8I9Q9	Leishmania donovani	92%	100%
A0A3S7WUM4	Leishmania donovani	84%	100%
A4H905	Leishmania braziliensis	79%	100%
A4H907	Leishmania braziliensis	75%	100%
A4HXD6	Leishmania infantum	92%	100%
A4HXD8	Leishmania infantum	84%	100%
C9ZU33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AR31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AR33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O01805	Caenorhabditis elegans	38%	100%
O04066	Ricinus communis	39%	100%
O09035	Mus musculus	40%	100%
O22643	Fritillaria agrestis	35%	100%
P07107	Bos taurus	41%	100%
P07108	Homo sapiens	42%	100%
P0C8L7	Hypsibius exemplaris	39%	100%
P11030	Rattus norvegicus	38%	100%
P12026	Sus scrofa	40%	100%
P31786	Mus musculus	37%	100%
P31824	Manduca sexta	35%	100%
P42281	Drosophila melanogaster	38%	100%
P45882	Anas platyrhynchos	35%	100%
P45883	Pelophylax ridibundus	37%	100%
P56702	Rattus norvegicus	42%	100%
P82934	Chaetophractus villosus	38%	100%
Q20507	Caenorhabditis elegans	44%	89%
Q39315	Brassica napus	36%	100%
Q39779	Gossypium hirsutum	34%	100%
Q3SZF0	Bos taurus	39%	100%
Q4QED0	Leishmania major	88%	100%
Q5FXM5	Dictyostelium discoideum	51%	100%
Q75G87	Oryza sativa subsp. japonica	41%	66%
Q84SC3	Oryza sativa subsp. japonica	38%	100%
Q8N6N7	Homo sapiens	38%	100%
Q8WN94	Oryctolagus cuniculus	44%	100%
Q9D258	Mus musculus	36%	100%
Q9MZG3	Bos taurus	40%	100%
Q9PRL8	Gallus gallus	42%	100%
Q9TQX6	Canis lupus familiaris	39%	100%
Q9Y7Z3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5BE16	Trypanosoma cruzi	63%	100%