Major royal jelly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QED1_LEIMA

TriTrypDb:

LmjF.17.0630 , LMJLV39_170012200 , LMJSD75_170011900

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QED1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QED1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	234	236	PF00675	0.587
CLV_PCSK_KEX2_1	234	236	PF00082	0.584
CLV_PCSK_SKI1_1	138	142	PF00082	0.411
CLV_PCSK_SKI1_1	235	239	PF00082	0.448
CLV_PCSK_SKI1_1	28	32	PF00082	0.478
CLV_PCSK_SKI1_1	313	317	PF00082	0.427
CLV_PCSK_SKI1_1	342	346	PF00082	0.351
CLV_PCSK_SKI1_1	376	380	PF00082	0.433
CLV_Separin_Metazoa	343	347	PF03568	0.334
CLV_Separin_Metazoa	383	387	PF03568	0.379
DEG_APCC_DBOX_1	233	241	PF00400	0.624
DEG_APCC_DBOX_1	375	383	PF00400	0.387
DEG_SPOP_SBC_1	243	247	PF00917	0.588
DOC_CYCLIN_RxL_1	25	33	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.443
DOC_MAPK_gen_1	194	203	PF00069	0.453
DOC_MAPK_MEF2A_6	194	203	PF00069	0.453
DOC_PP1_RVXF_1	136	143	PF00149	0.415
DOC_PP2B_LxvP_1	226	229	PF13499	0.452
DOC_PP4_FxxP_1	116	119	PF00568	0.658
DOC_SPAK_OSR1_1	196	200	PF12202	0.453
DOC_USP7_MATH_1	181	185	PF00917	0.547
DOC_USP7_MATH_1	243	247	PF00917	0.658
DOC_USP7_MATH_1	71	75	PF00917	0.425
DOC_USP7_UBL2_3	215	219	PF12436	0.483
DOC_USP7_UBL2_3	363	367	PF12436	0.491
LIG_14-3-3_CanoR_1	296	302	PF00244	0.495
LIG_APCC_ABBA_1	6	11	PF00400	0.424
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BIR_III_4	287	291	PF00653	0.473
LIG_BIR_III_4	81	85	PF00653	0.504
LIG_deltaCOP1_diTrp_1	78	85	PF00928	0.515
LIG_FHA_1	14	20	PF00498	0.302
LIG_FHA_1	155	161	PF00498	0.495
LIG_FHA_1	31	37	PF00498	0.415
LIG_FHA_1	364	370	PF00498	0.479
LIG_FHA_2	175	181	PF00498	0.502
LIG_FHA_2	200	206	PF00498	0.407
LIG_FHA_2	257	263	PF00498	0.490
LIG_FHA_2	378	384	PF00498	0.358
LIG_Integrin_isoDGR_2	136	138	PF01839	0.445
LIG_Integrin_RGD_1	21	23	PF01839	0.499
LIG_Integrin_RGD_1	284	286	PF01839	0.502
LIG_LIR_Apic_2	113	119	PF02991	0.653
LIG_LIR_Nem_3	208	214	PF02991	0.281
LIG_REV1ctd_RIR_1	139	149	PF16727	0.449
LIG_REV1ctd_RIR_1	209	216	PF16727	0.454
LIG_SH2_CRK	348	352	PF00017	0.406
LIG_SH2_STAT3	230	233	PF00017	0.460
LIG_SH2_STAT5	231	234	PF00017	0.471
LIG_SH2_STAT5	278	281	PF00017	0.459
LIG_SH2_STAT5	350	353	PF00017	0.449
LIG_SH3_3	116	122	PF00018	0.585
LIG_SH3_3	248	254	PF00018	0.550
LIG_SH3_3	84	90	PF00018	0.454
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.490
LIG_SUMO_SIM_anti_2	266	276	PF11976	0.342
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.360
LIG_SUMO_SIM_par_1	256	263	PF11976	0.490
LIG_TRAF2_1	177	180	PF00917	0.564
LIG_UBA3_1	124	129	PF00899	0.379
LIG_UBA3_1	210	219	PF00899	0.421
MOD_CK2_1	174	180	PF00069	0.553
MOD_CK2_1	181	187	PF00069	0.501
MOD_CK2_1	199	205	PF00069	0.234
MOD_CK2_1	243	249	PF00069	0.644
MOD_CK2_1	377	383	PF00069	0.361
MOD_GlcNHglycan	133	136	PF01048	0.308
MOD_GlcNHglycan	23	27	PF01048	0.483
MOD_GlcNHglycan	304	307	PF01048	0.500
MOD_GlcNHglycan	44	48	PF01048	0.480
MOD_GSK3_1	101	108	PF00069	0.496
MOD_GSK3_1	22	29	PF00069	0.499
MOD_GSK3_1	238	245	PF00069	0.625
MOD_N-GLC_1	235	240	PF02516	0.532
MOD_N-GLC_1	243	248	PF02516	0.579
MOD_NEK2_1	110	115	PF00069	0.565
MOD_NEK2_1	124	129	PF00069	0.408
MOD_NEK2_1	13	18	PF00069	0.420
MOD_NEK2_1	30	35	PF00069	0.304
MOD_NEK2_1	43	48	PF00069	0.324
MOD_NEK2_2	26	31	PF00069	0.460
MOD_PKA_2	110	116	PF00069	0.607
MOD_Plk_1	13	19	PF00069	0.458
MOD_Plk_1	235	241	PF00069	0.460
MOD_Plk_1	43	49	PF00069	0.482
MOD_Plk_2-3	174	180	PF00069	0.522
MOD_Plk_2-3	187	193	PF00069	0.394
MOD_Plk_4	105	111	PF00069	0.449
MOD_Plk_4	181	187	PF00069	0.536
MOD_Plk_4	253	259	PF00069	0.473
MOD_Plk_4	26	32	PF00069	0.487
MOD_SUMO_rev_2	248	257	PF00179	0.494
MOD_SUMO_rev_2	334	344	PF00179	0.505
TRG_DiLeu_BaEn_1	266	271	PF01217	0.441
TRG_DiLeu_BaEn_1	312	317	PF01217	0.438
TRG_DiLeu_BaEn_2	382	388	PF01217	0.287
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.474
TRG_DiLeu_LyEn_5	159	164	PF01217	0.466
TRG_ENDOCYTIC_2	348	351	PF00928	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICT3	Leishmania donovani	94%	100%
A0A3Q8IJF2	Leishmania donovani	94%	100%
A4H906	Leishmania braziliensis	75%	93%
A4HXD7	Leishmania infantum	94%	100%
E9AR32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
N4WEA4	Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T)	29%	82%