Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEC9_LEIMA

TriTrypDb:

LmjF.17.0770 , LMJLV39_170012500 , LMJSD75_170012200

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.372
CLV_NRD_NRD_1	193	195	PF00675	0.446
CLV_NRD_NRD_1	250	252	PF00675	0.575
CLV_NRD_NRD_1	300	302	PF00675	0.456
CLV_NRD_NRD_1	4	6	PF00675	0.636
CLV_NRD_NRD_1	93	95	PF00675	0.571
CLV_PCSK_KEX2_1	193	195	PF00082	0.366
CLV_PCSK_KEX2_1	250	252	PF00082	0.577
CLV_PCSK_KEX2_1	262	264	PF00082	0.562
CLV_PCSK_KEX2_1	300	302	PF00082	0.456
CLV_PCSK_KEX2_1	4	6	PF00082	0.628
CLV_PCSK_KEX2_1	92	94	PF00082	0.573
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.535
CLV_PCSK_SKI1_1	114	118	PF00082	0.515
CLV_PCSK_SKI1_1	286	290	PF00082	0.369
DEG_COP1_1	148	156	PF00400	0.438
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DEG_SCF_TRCP1_1	346	351	PF00400	0.334
DOC_CKS1_1	323	328	PF01111	0.432
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.615
DOC_MAPK_gen_1	112	121	PF00069	0.477
DOC_MAPK_gen_1	349	357	PF00069	0.376
DOC_MAPK_gen_1	424	433	PF00069	0.533
DOC_MAPK_gen_1	92	99	PF00069	0.603
DOC_MAPK_MEF2A_6	426	435	PF00069	0.532
DOC_PP2B_LxvP_1	431	434	PF13499	0.615
DOC_PP2B_LxvP_1	435	438	PF13499	0.579
DOC_PP4_FxxP_1	207	210	PF00568	0.500
DOC_SPAK_OSR1_1	280	284	PF12202	0.317
DOC_USP7_MATH_1	122	126	PF00917	0.617
DOC_USP7_MATH_1	163	167	PF00917	0.440
DOC_USP7_MATH_1	310	314	PF00917	0.435
DOC_USP7_MATH_1	391	395	PF00917	0.737
DOC_USP7_MATH_1	8	12	PF00917	0.620
DOC_USP7_MATH_2	143	149	PF00917	0.532
DOC_USP7_UBL2_3	420	424	PF12436	0.729
DOC_USP7_UBL2_3	60	64	PF12436	0.589
DOC_WW_Pin1_4	211	216	PF00397	0.559
DOC_WW_Pin1_4	256	261	PF00397	0.607
DOC_WW_Pin1_4	322	327	PF00397	0.451
DOC_WW_Pin1_4	72	77	PF00397	0.670
LIG_14-3-3_CanoR_1	10	17	PF00244	0.535
LIG_14-3-3_CanoR_1	114	121	PF00244	0.610
LIG_14-3-3_CanoR_1	127	135	PF00244	0.540
LIG_14-3-3_CanoR_1	173	178	PF00244	0.444
LIG_14-3-3_CanoR_1	193	197	PF00244	0.278
LIG_14-3-3_CanoR_1	241	245	PF00244	0.783
LIG_14-3-3_CanoR_1	34	40	PF00244	0.526
LIG_14-3-3_CanoR_1	380	386	PF00244	0.576
LIG_14-3-3_CanoR_1	69	76	PF00244	0.667
LIG_Actin_WH2_2	56	71	PF00022	0.597
LIG_BRCT_BRCA1_1	10	14	PF00533	0.532
LIG_BRCT_BRCA1_1	346	350	PF00533	0.343
LIG_FHA_1	217	223	PF00498	0.563
LIG_FHA_1	398	404	PF00498	0.548
LIG_FHA_1	414	420	PF00498	0.574
LIG_FHA_2	115	121	PF00498	0.598
LIG_FHA_2	341	347	PF00498	0.407
LIG_FHA_2	36	42	PF00498	0.617
LIG_GBD_Chelix_1	311	319	PF00786	0.473
LIG_LIR_Apic_2	204	210	PF02991	0.479
LIG_LIR_Apic_2	79	85	PF02991	0.628
LIG_LIR_Nem_3	11	17	PF02991	0.534
LIG_LIR_Nem_3	394	398	PF02991	0.510
LIG_PCNA_yPIPBox_3	40	52	PF02747	0.566
LIG_Pex14_2	277	281	PF04695	0.384
LIG_SH2_NCK_1	17	21	PF00017	0.617
LIG_SH2_NCK_1	27	31	PF00017	0.548
LIG_SH2_STAT3	305	308	PF00017	0.411
LIG_SH2_STAT5	168	171	PF00017	0.477
LIG_SH2_STAT5	305	308	PF00017	0.474
LIG_SH2_STAT5	328	331	PF00017	0.530
LIG_SH2_STAT5	62	65	PF00017	0.628
LIG_SH3_1	151	157	PF00018	0.438
LIG_SH3_3	132	138	PF00018	0.779
LIG_SH3_3	151	157	PF00018	0.363
LIG_SH3_3	314	320	PF00018	0.438
LIG_TRAF2_1	178	181	PF00917	0.362
MOD_CDC14_SPxK_1	259	262	PF00782	0.564
MOD_CDK_SPxK_1	256	262	PF00069	0.584
MOD_CDK_SPxK_1	72	78	PF00069	0.672
MOD_CDK_SPxxK_3	256	263	PF00069	0.573
MOD_CK1_1	214	220	PF00069	0.605
MOD_CK1_1	28	34	PF00069	0.618
MOD_CK1_1	394	400	PF00069	0.629
MOD_CK1_1	407	413	PF00069	0.512
MOD_CK1_1	72	78	PF00069	0.660
MOD_CK2_1	114	120	PF00069	0.599
MOD_CK2_1	35	41	PF00069	0.616
MOD_GlcNHglycan	124	127	PF01048	0.625
MOD_GlcNHglycan	147	150	PF01048	0.525
MOD_GlcNHglycan	16	20	PF01048	0.592
MOD_GlcNHglycan	346	349	PF01048	0.429
MOD_GlcNHglycan	367	370	PF01048	0.520
MOD_GlcNHglycan	389	392	PF01048	0.672
MOD_GlcNHglycan	71	74	PF01048	0.588
MOD_GSK3_1	129	136	PF00069	0.535
MOD_GSK3_1	163	170	PF00069	0.437
MOD_GSK3_1	25	32	PF00069	0.623
MOD_GSK3_1	340	347	PF00069	0.365
MOD_GSK3_1	361	368	PF00069	0.470
MOD_GSK3_1	387	394	PF00069	0.739
MOD_GSK3_1	404	411	PF00069	0.524
MOD_GSK3_1	43	50	PF00069	0.595
MOD_GSK3_1	95	102	PF00069	0.623
MOD_N-GLC_1	337	342	PF02516	0.395
MOD_NEK2_1	129	134	PF00069	0.783
MOD_NEK2_1	147	152	PF00069	0.379
MOD_NEK2_1	404	409	PF00069	0.614
MOD_NEK2_2	35	40	PF00069	0.617
MOD_PIKK_1	114	120	PF00454	0.515
MOD_PIKK_1	310	316	PF00454	0.399
MOD_PK_1	173	179	PF00069	0.479
MOD_PKA_2	192	198	PF00069	0.432
MOD_PKA_2	240	246	PF00069	0.794
MOD_PKA_2	299	305	PF00069	0.462
MOD_PKA_2	344	350	PF00069	0.361
MOD_PKA_2	9	15	PF00069	0.529
MOD_PKB_1	112	120	PF00069	0.524
MOD_PKB_1	171	179	PF00069	0.472
MOD_PKB_1	378	386	PF00069	0.518
MOD_Plk_1	95	101	PF00069	0.621
MOD_Plk_4	163	169	PF00069	0.436
MOD_Plk_4	361	367	PF00069	0.471
MOD_Plk_4	399	405	PF00069	0.525
MOD_Plk_4	43	49	PF00069	0.576
MOD_Plk_4	58	64	PF00069	0.567
MOD_Plk_4	86	92	PF00069	0.526
MOD_ProDKin_1	211	217	PF00069	0.559
MOD_ProDKin_1	256	262	PF00069	0.609
MOD_ProDKin_1	322	328	PF00069	0.443
MOD_ProDKin_1	72	78	PF00069	0.672
MOD_SUMO_rev_2	155	163	PF00179	0.455
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.619
TRG_ER_diArg_1	250	252	PF00400	0.577
TRG_ER_diArg_1	3	5	PF00400	0.642
TRG_ER_diArg_1	300	303	PF00400	0.464
TRG_ER_diArg_1	91	94	PF00400	0.579
TRG_NES_CRM1_1	272	284	PF08389	0.419
TRG_NES_CRM1_1	322	334	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3E0	Leptomonas seymouri	42%	91%
A0A3S5H708	Leishmania donovani	82%	99%
A4HXD9	Leishmania infantum	83%	99%
E9AR34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%