AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4QEC8_LEIMA

TriTrypDb:

LmjF.17.0760 , LMJLV39_170012600 , LMJSD75_170012300

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEC8

PDB structure(s): 7aih_Ak , 7ane_Ak

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.417
CLV_NRD_NRD_1	283	285	PF00675	0.488
CLV_NRD_NRD_1	318	320	PF00675	0.544
CLV_PCSK_KEX2_1	241	243	PF00082	0.417
CLV_PCSK_KEX2_1	282	284	PF00082	0.421
CLV_PCSK_KEX2_1	318	320	PF00082	0.597
CLV_PCSK_KEX2_1	43	45	PF00082	0.377
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.430
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.597
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.377
CLV_PCSK_SKI1_1	164	168	PF00082	0.513
CLV_PCSK_SKI1_1	235	239	PF00082	0.395
CLV_PCSK_SKI1_1	287	291	PF00082	0.479
DEG_SCF_FBW7_1	122	129	PF00400	0.330
DOC_CKS1_1	123	128	PF01111	0.323
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.286
DOC_MAPK_gen_1	144	151	PF00069	0.563
DOC_MAPK_gen_1	287	295	PF00069	0.337
DOC_MAPK_MEF2A_6	274	281	PF00069	0.456
DOC_PP2B_LxvP_1	220	223	PF13499	0.326
DOC_USP7_MATH_1	159	163	PF00917	0.420
DOC_USP7_UBL2_3	312	316	PF12436	0.591
DOC_WW_Pin1_4	122	127	PF00397	0.321
LIG_14-3-3_CanoR_1	106	114	PF00244	0.486
LIG_APCC_ABBA_1	231	236	PF00400	0.461
LIG_BRCT_BRCA1_1	298	302	PF00533	0.480
LIG_Clathr_ClatBox_1	120	124	PF01394	0.364
LIG_Clathr_ClatBox_1	17	21	PF01394	0.328
LIG_DLG_GKlike_1	116	123	PF00625	0.454
LIG_EH1_1	114	122	PF00400	0.419
LIG_FHA_1	1	7	PF00498	0.512
LIG_FHA_1	123	129	PF00498	0.317
LIG_FHA_1	30	36	PF00498	0.498
LIG_HCF-1_HBM_1	202	205	PF13415	0.513
LIG_HP1_1	16	20	PF01393	0.391
LIG_LIR_Gen_1	88	99	PF02991	0.362
LIG_LIR_Nem_3	202	208	PF02991	0.363
LIG_LIR_Nem_3	236	240	PF02991	0.387
LIG_LIR_Nem_3	88	94	PF02991	0.369
LIG_LIR_Nem_3	98	102	PF02991	0.348
LIG_Pex14_1	271	275	PF04695	0.351
LIG_REV1ctd_RIR_1	235	242	PF16727	0.407
LIG_SH2_CRK	99	103	PF00017	0.313
LIG_SH2_PTP2	205	208	PF00017	0.365
LIG_SH2_SRC	182	185	PF00017	0.428
LIG_SH2_SRC	205	208	PF00017	0.384
LIG_SH2_STAP1	182	186	PF00017	0.437
LIG_SH2_STAP1	45	49	PF00017	0.398
LIG_SH2_STAT5	205	208	PF00017	0.350
LIG_SH3_3	146	152	PF00018	0.441
LIG_SH3_3	211	217	PF00018	0.415
LIG_SH3_3	221	227	PF00018	0.384
LIG_SH3_3	56	62	PF00018	0.325
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.398
LIG_SUMO_SIM_par_1	119	125	PF11976	0.400
LIG_SUMO_SIM_par_1	15	21	PF11976	0.352
LIG_TRAF2_1	37	40	PF00917	0.457
MOD_CK1_1	162	168	PF00069	0.460
MOD_CK1_1	188	194	PF00069	0.570
MOD_CK1_1	298	304	PF00069	0.494
MOD_CK2_1	162	168	PF00069	0.352
MOD_CK2_1	177	183	PF00069	0.430
MOD_CK2_1	298	304	PF00069	0.623
MOD_CK2_1	63	69	PF00069	0.508
MOD_GlcNHglycan	164	167	PF01048	0.556
MOD_GlcNHglycan	188	191	PF01048	0.421
MOD_GlcNHglycan	256	259	PF01048	0.437
MOD_GlcNHglycan	28	32	PF01048	0.579
MOD_GlcNHglycan	298	301	PF01048	0.586
MOD_GSK3_1	122	129	PF00069	0.329
MOD_GSK3_1	162	169	PF00069	0.419
MOD_NEK2_1	107	112	PF00069	0.418
MOD_NEK2_1	167	172	PF00069	0.489
MOD_NEK2_1	186	191	PF00069	0.491
MOD_NEK2_1	20	25	PF00069	0.384
MOD_NEK2_1	27	32	PF00069	0.493
MOD_NEK2_1	295	300	PF00069	0.443
MOD_NEK2_1	48	53	PF00069	0.447
MOD_NEK2_1	63	68	PF00069	0.374
MOD_NEK2_1	73	78	PF00069	0.321
MOD_NEK2_1	95	100	PF00069	0.311
MOD_NEK2_2	159	164	PF00069	0.500
MOD_PKA_2	133	139	PF00069	0.517
MOD_Plk_1	154	160	PF00069	0.437
MOD_Plk_1	167	173	PF00069	0.459
MOD_Plk_1	177	183	PF00069	0.365
MOD_Plk_1	20	26	PF00069	0.490
MOD_Plk_4	1	7	PF00069	0.471
MOD_Plk_4	116	122	PF00069	0.328
MOD_Plk_4	177	183	PF00069	0.426
MOD_Plk_4	188	194	PF00069	0.387
MOD_ProDKin_1	122	128	PF00069	0.322
TRG_DiLeu_BaEn_1	291	296	PF01217	0.436
TRG_ENDOCYTIC_2	205	208	PF00928	0.350
TRG_ENDOCYTIC_2	45	48	PF00928	0.399
TRG_ENDOCYTIC_2	99	102	PF00928	0.336
TRG_ER_diArg_1	240	242	PF00400	0.412
TRG_ER_diArg_1	283	285	PF00400	0.490
TRG_ER_diLys_1	318	323	PF00400	0.629
TRG_NLS_MonoExtN_4	316	323	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBS7	Leptomonas seymouri	76%	78%
A0A0S4J8H7	Bodo saltans	40%	77%
A0A1X0NUK7	Trypanosomatidae	54%	81%
A0A3S7WUH0	Leishmania donovani	96%	100%
A0A422N4J3	Trypanosoma rangeli	55%	85%
A4H908	Leishmania braziliensis	87%	94%
A4HXE0	Leishmania infantum	95%	100%
C9ZU35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	85%
E9AR35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5API2	Trypanosoma cruzi	55%	86%