HMA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEC4_LEIMA

TriTrypDb:

LmjF.17.0733 , LMJLV39_170013300 , LMJSD75_170012900

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.794
CLV_C14_Caspase3-7	62	66	PF00656	0.667
CLV_NRD_NRD_1	164	166	PF00675	0.736
CLV_NRD_NRD_1	303	305	PF00675	0.698
CLV_PCSK_KEX2_1	432	434	PF00082	0.567
CLV_PCSK_KEX2_1	5	7	PF00082	0.567
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.602
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.507
CLV_PCSK_SKI1_1	169	173	PF00082	0.716
CLV_PCSK_SKI1_1	20	24	PF00082	0.524
CLV_PCSK_SKI1_1	320	324	PF00082	0.522
DEG_APCC_DBOX_1	335	343	PF00400	0.542
DEG_Nend_UBRbox_1	1	4	PF02207	0.520
DOC_CKS1_1	161	166	PF01111	0.835
DOC_CKS1_1	295	300	PF01111	0.532
DOC_CKS1_1	414	419	PF01111	0.556
DOC_CYCLIN_yClb5_NLxxxL_5	396	405	PF00134	0.514
DOC_MAPK_gen_1	320	329	PF00069	0.487
DOC_MAPK_gen_1	376	384	PF00069	0.500
DOC_MAPK_MEF2A_6	320	329	PF00069	0.487
DOC_USP7_MATH_1	119	123	PF00917	0.837
DOC_USP7_MATH_1	142	146	PF00917	0.717
DOC_USP7_MATH_1	303	307	PF00917	0.611
DOC_USP7_UBL2_3	20	24	PF12436	0.524
DOC_WW_Pin1_4	150	155	PF00397	0.846
DOC_WW_Pin1_4	157	162	PF00397	0.594
DOC_WW_Pin1_4	177	182	PF00397	0.448
DOC_WW_Pin1_4	216	221	PF00397	0.659
DOC_WW_Pin1_4	230	235	PF00397	0.686
DOC_WW_Pin1_4	258	263	PF00397	0.658
DOC_WW_Pin1_4	266	271	PF00397	0.657
DOC_WW_Pin1_4	294	299	PF00397	0.519
DOC_WW_Pin1_4	413	418	PF00397	0.549
LIG_14-3-3_CanoR_1	304	311	PF00244	0.690
LIG_14-3-3_CanoR_1	336	340	PF00244	0.593
LIG_14-3-3_CanoR_1	345	353	PF00244	0.496
LIG_14-3-3_CanoR_1	356	361	PF00244	0.279
LIG_BIR_III_2	175	179	PF00653	0.688
LIG_CSL_BTD_1	259	262	PF09270	0.657
LIG_CtBP_PxDLS_1	181	185	PF00389	0.769
LIG_EVH1_1	236	240	PF00568	0.664
LIG_FHA_1	132	138	PF00498	0.694
LIG_FHA_1	219	225	PF00498	0.659
LIG_FHA_1	267	273	PF00498	0.758
LIG_FHA_1	322	328	PF00498	0.427
LIG_FHA_1	401	407	PF00498	0.579
LIG_FHA_1	49	55	PF00498	0.814
LIG_FHA_1	5	11	PF00498	0.606
LIG_FHA_1	66	72	PF00498	0.725
LIG_FHA_2	246	252	PF00498	0.693
LIG_FHA_2	53	59	PF00498	0.682
LIG_FHA_2	62	68	PF00498	0.649
LIG_GBD_Chelix_1	405	413	PF00786	0.541
LIG_LIR_Apic_2	254	259	PF02991	0.677
LIG_LIR_Apic_2	412	417	PF02991	0.464
LIG_LIR_Gen_1	284	290	PF02991	0.452
LIG_LIR_Nem_3	341	346	PF02991	0.647
LIG_MYND_1	234	238	PF01753	0.663
LIG_PAM2_1	170	182	PF00658	0.690
LIG_PAM2_1	251	263	PF00658	0.673
LIG_Pex14_2	311	315	PF04695	0.619
LIG_PTAP_UEV_1	219	224	PF05743	0.661
LIG_SH2_CRK	343	347	PF00017	0.600
LIG_SH2_GRB2like	383	386	PF00017	0.387
LIG_SH2_PTP2	231	234	PF00017	0.717
LIG_SH2_STAP1	392	396	PF00017	0.469
LIG_SH2_STAP1	453	457	PF00017	0.512
LIG_SH2_STAT5	231	234	PF00017	0.717
LIG_SH2_STAT5	383	386	PF00017	0.387
LIG_SH2_STAT5	434	437	PF00017	0.504
LIG_SH2_STAT5	438	441	PF00017	0.513
LIG_SH2_STAT5	9	12	PF00017	0.643
LIG_SH3_1	231	237	PF00018	0.709
LIG_SH3_1	256	262	PF00018	0.690
LIG_SH3_2	161	166	PF14604	0.835
LIG_SH3_2	300	305	PF14604	0.577
LIG_SH3_3	158	164	PF00018	0.748
LIG_SH3_3	175	181	PF00018	0.530
LIG_SH3_3	208	214	PF00018	0.684
LIG_SH3_3	217	223	PF00018	0.686
LIG_SH3_3	231	237	PF00018	0.685
LIG_SH3_3	256	262	PF00018	0.666
LIG_SH3_3	292	298	PF00018	0.551
LIG_SH3_3	357	363	PF00018	0.601
LIG_SH3_3	444	450	PF00018	0.566
LIG_SUMO_SIM_anti_2	454	459	PF11976	0.484
LIG_SUMO_SIM_par_1	180	186	PF11976	0.766
LIG_SUMO_SIM_par_1	323	328	PF11976	0.423
LIG_SUMO_SIM_par_1	456	462	PF11976	0.490
LIG_TRAF2_1	79	82	PF00917	0.797
LIG_TRAF2_1	89	92	PF00917	0.756
LIG_TRAF2_1	98	101	PF00917	0.571
LIG_UBA3_1	370	378	PF00899	0.476
MOD_CDK_SPK_2	150	155	PF00069	0.761
MOD_CDK_SPK_2	160	165	PF00069	0.586
MOD_CDK_SPxK_1	160	166	PF00069	0.837
MOD_CK1_1	153	159	PF00069	0.742
MOD_CK1_1	160	166	PF00069	0.569
MOD_CK1_1	180	186	PF00069	0.436
MOD_CK1_1	286	292	PF00069	0.601
MOD_CK1_1	48	54	PF00069	0.640
MOD_CK1_1	80	86	PF00069	0.686
MOD_CK2_1	61	67	PF00069	0.798
MOD_Cter_Amidation	17	20	PF01082	0.518
MOD_Cter_Amidation	430	433	PF01082	0.495
MOD_GlcNHglycan	120	124	PF01048	0.704
MOD_GlcNHglycan	144	147	PF01048	0.835
MOD_GlcNHglycan	20	23	PF01048	0.618
MOD_GlcNHglycan	253	256	PF01048	0.740
MOD_GlcNHglycan	28	31	PF01048	0.698
MOD_GlcNHglycan	285	288	PF01048	0.592
MOD_GlcNHglycan	409	412	PF01048	0.477
MOD_GlcNHglycan	42	45	PF01048	0.808
MOD_GlcNHglycan	47	50	PF01048	0.705
MOD_GSK3_1	153	160	PF00069	0.755
MOD_GSK3_1	245	252	PF00069	0.724
MOD_GSK3_1	4	11	PF00069	0.559
MOD_GSK3_1	409	416	PF00069	0.481
MOD_GSK3_1	48	55	PF00069	0.694
MOD_GSK3_1	61	68	PF00069	0.655
MOD_N-GLC_1	356	361	PF02516	0.610
MOD_N-GLC_1	384	389	PF02516	0.632
MOD_N-GLC_1	399	404	PF02516	0.342
MOD_NEK2_1	189	194	PF00069	0.776
MOD_NEK2_1	26	31	PF00069	0.773
MOD_NEK2_1	311	316	PF00069	0.549
MOD_NEK2_1	442	447	PF00069	0.519
MOD_NEK2_2	335	340	PF00069	0.559
MOD_NEK2_2	351	356	PF00069	0.439
MOD_PIKK_1	400	406	PF00454	0.578
MOD_PK_1	356	362	PF00069	0.602
MOD_PKA_1	24	30	PF00069	0.537
MOD_PKA_1	243	249	PF00069	0.729
MOD_PKA_1	304	310	PF00069	0.694
MOD_PKA_2	303	309	PF00069	0.692
MOD_PKA_2	335	341	PF00069	0.595
MOD_PKA_2	344	350	PF00069	0.529
MOD_PKA_2	442	448	PF00069	0.628
MOD_Plk_1	264	270	PF00069	0.654
MOD_Plk_1	351	357	PF00069	0.491
MOD_Plk_1	80	86	PF00069	0.840
MOD_Plk_2-3	61	67	PF00069	0.637
MOD_Plk_4	189	195	PF00069	0.676
MOD_Plk_4	409	415	PF00069	0.483
MOD_Plk_4	71	77	PF00069	0.656
MOD_ProDKin_1	150	156	PF00069	0.847
MOD_ProDKin_1	157	163	PF00069	0.592
MOD_ProDKin_1	177	183	PF00069	0.446
MOD_ProDKin_1	216	222	PF00069	0.654
MOD_ProDKin_1	230	236	PF00069	0.686
MOD_ProDKin_1	258	264	PF00069	0.657
MOD_ProDKin_1	266	272	PF00069	0.657
MOD_ProDKin_1	294	300	PF00069	0.522
MOD_ProDKin_1	413	419	PF00069	0.553
MOD_SUMO_for_1	102	105	PF00179	0.827
MOD_SUMO_for_1	154	157	PF00179	0.767
MOD_SUMO_for_1	242	245	PF00179	0.815
MOD_SUMO_for_1	44	47	PF00179	0.784
MOD_SUMO_for_1	59	62	PF00179	0.581
MOD_SUMO_rev_2	286	295	PF00179	0.616
MOD_SUMO_rev_2	440	448	PF00179	0.632
TRG_DiLeu_BaEn_3	104	110	PF01217	0.745
TRG_ENDOCYTIC_2	343	346	PF00928	0.607
TRG_ENDOCYTIC_2	422	425	PF00928	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C3	Leptomonas seymouri	67%	100%
A0A3S7WUF4	Leishmania donovani	90%	100%
A4H912	Leishmania braziliensis	71%	100%
A4HXE4	Leishmania infantum	90%	100%
E9AR39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%