LeishMANIAdb
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Serine/threonine-protein kinase PLK

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase PLK
Gene product:
polo-like protein kinase, putative
Species:
Leishmania major
UniProt:
Q4QEC3_LEIMA
TriTrypDb:
LmjF.17.0790 , LMJLV39_170013800 * , LMJSD75_170013400 *
Length:
702

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 2
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0005813 centrosome 3 2
GO:0005815 microtubule organizing center 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QEC3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEC3

Function

Biological processes
Term Name Level Count
GO:0000278 mitotic cell cycle 3 2
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0007049 cell cycle 2 2
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0010564 regulation of cell cycle process 5 2
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0032465 regulation of cytokinesis 5 2
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051302 regulation of cell division 4 2
GO:0051726 regulation of cell cycle 4 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 10
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 478 482 PF00656 0.543
CLV_NRD_NRD_1 100 102 PF00675 0.315
CLV_NRD_NRD_1 139 141 PF00675 0.317
CLV_NRD_NRD_1 199 201 PF00675 0.237
CLV_NRD_NRD_1 346 348 PF00675 0.643
CLV_NRD_NRD_1 667 669 PF00675 0.259
CLV_PCSK_KEX2_1 100 102 PF00082 0.298
CLV_PCSK_KEX2_1 139 141 PF00082 0.319
CLV_PCSK_KEX2_1 201 203 PF00082 0.237
CLV_PCSK_KEX2_1 256 258 PF00082 0.255
CLV_PCSK_KEX2_1 346 348 PF00082 0.643
CLV_PCSK_KEX2_1 621 623 PF00082 0.308
CLV_PCSK_KEX2_1 666 668 PF00082 0.261
CLV_PCSK_PC1ET2_1 201 203 PF00082 0.237
CLV_PCSK_PC1ET2_1 256 258 PF00082 0.371
CLV_PCSK_PC1ET2_1 621 623 PF00082 0.308
CLV_PCSK_SKI1_1 100 104 PF00082 0.296
CLV_PCSK_SKI1_1 168 172 PF00082 0.237
CLV_PCSK_SKI1_1 363 367 PF00082 0.633
CLV_PCSK_SKI1_1 372 376 PF00082 0.538
CLV_PCSK_SKI1_1 556 560 PF00082 0.253
CLV_PCSK_SKI1_1 570 574 PF00082 0.179
CLV_PCSK_SKI1_1 576 580 PF00082 0.255
CLV_PCSK_SKI1_1 656 660 PF00082 0.204
CLV_PCSK_SKI1_1 690 694 PF00082 0.366
CLV_Separin_Metazoa 373 377 PF03568 0.647
DEG_APCC_DBOX_1 287 295 PF00400 0.255
DEG_APCC_DBOX_1 371 379 PF00400 0.587
DEG_Nend_UBRbox_2 1 3 PF02207 0.672
DEG_SCF_FBW7_1 306 313 PF00400 0.498
DEG_SPOP_SBC_1 20 24 PF00917 0.542
DEG_SPOP_SBC_1 327 331 PF00917 0.710
DEG_SPOP_SBC_1 611 615 PF00917 0.514
DOC_CKS1_1 307 312 PF01111 0.542
DOC_CKS1_1 660 665 PF01111 0.429
DOC_CYCLIN_yCln2_LP_2 308 314 PF00134 0.548
DOC_MAPK_gen_1 100 110 PF00069 0.298
DOC_MAPK_gen_1 115 124 PF00069 0.371
DOC_MAPK_gen_1 168 177 PF00069 0.315
DOC_MAPK_gen_1 621 632 PF00069 0.443
DOC_MAPK_gen_1 666 672 PF00069 0.499
DOC_PP1_RVXF_1 519 525 PF00149 0.499
DOC_PP2B_LxvP_1 308 311 PF13499 0.473
DOC_PP2B_LxvP_1 319 322 PF13499 0.501
DOC_PP2B_LxvP_1 366 369 PF13499 0.569
DOC_PP4_FxxP_1 317 320 PF00568 0.601
DOC_SPAK_OSR1_1 140 144 PF12202 0.255
DOC_USP7_MATH_1 21 25 PF00917 0.621
DOC_USP7_MATH_1 33 37 PF00917 0.572
DOC_USP7_MATH_1 611 615 PF00917 0.582
DOC_USP7_MATH_1 671 675 PF00917 0.389
DOC_USP7_UBL2_3 87 91 PF12436 0.287
DOC_WW_Pin1_4 204 209 PF00397 0.287
DOC_WW_Pin1_4 281 286 PF00397 0.371
DOC_WW_Pin1_4 300 305 PF00397 0.483
DOC_WW_Pin1_4 306 311 PF00397 0.470
DOC_WW_Pin1_4 388 393 PF00397 0.666
DOC_WW_Pin1_4 418 423 PF00397 0.620
DOC_WW_Pin1_4 438 443 PF00397 0.605
DOC_WW_Pin1_4 585 590 PF00397 0.524
DOC_WW_Pin1_4 595 600 PF00397 0.292
DOC_WW_Pin1_4 659 664 PF00397 0.429
LIG_14-3-3_CanoR_1 139 144 PF00244 0.323
LIG_14-3-3_CanoR_1 295 300 PF00244 0.343
LIG_14-3-3_CanoR_1 346 355 PF00244 0.724
LIG_14-3-3_CanoR_1 436 442 PF00244 0.648
LIG_14-3-3_CanoR_1 465 471 PF00244 0.548
LIG_14-3-3_CanoR_1 556 562 PF00244 0.530
LIG_14-3-3_CanoR_1 584 589 PF00244 0.503
LIG_14-3-3_CanoR_1 607 611 PF00244 0.621
LIG_14-3-3_CanoR_1 656 661 PF00244 0.404
LIG_14-3-3_CanoR_1 666 671 PF00244 0.404
LIG_14-3-3_CanoR_1 687 693 PF00244 0.402
LIG_14-3-3_CanoR_1 80 84 PF00244 0.315
LIG_BRCT_BRCA1_1 613 617 PF00533 0.622
LIG_eIF4E_1 118 124 PF01652 0.371
LIG_EVH1_2 310 314 PF00568 0.533
LIG_FHA_1 144 150 PF00498 0.272
LIG_FHA_1 21 27 PF00498 0.574
LIG_FHA_1 227 233 PF00498 0.293
LIG_FHA_1 236 242 PF00498 0.254
LIG_FHA_1 276 282 PF00498 0.401
LIG_FHA_1 426 432 PF00498 0.759
LIG_FHA_1 518 524 PF00498 0.404
LIG_FHA_1 526 532 PF00498 0.404
LIG_FHA_1 636 642 PF00498 0.417
LIG_FHA_1 667 673 PF00498 0.409
LIG_FHA_1 687 693 PF00498 0.232
LIG_FHA_1 70 76 PF00498 0.339
LIG_FHA_2 111 117 PF00498 0.255
LIG_FHA_2 129 135 PF00498 0.255
LIG_FHA_2 288 294 PF00498 0.241
LIG_FHA_2 611 617 PF00498 0.557
LIG_FHA_2 675 681 PF00498 0.568
LIG_LIR_Apic_2 207 213 PF02991 0.242
LIG_LIR_Apic_2 316 320 PF02991 0.619
LIG_LIR_Apic_2 352 358 PF02991 0.488
LIG_LIR_Apic_2 659 663 PF02991 0.425
LIG_LIR_Gen_1 116 124 PF02991 0.336
LIG_LIR_Gen_1 145 156 PF02991 0.280
LIG_LIR_Gen_1 313 322 PF02991 0.576
LIG_LIR_Gen_1 614 624 PF02991 0.469
LIG_LIR_Gen_1 691 702 PF02991 0.428
LIG_LIR_Nem_3 116 121 PF02991 0.276
LIG_LIR_Nem_3 145 151 PF02991 0.280
LIG_LIR_Nem_3 252 258 PF02991 0.243
LIG_LIR_Nem_3 313 317 PF02991 0.572
LIG_LIR_Nem_3 575 581 PF02991 0.453
LIG_LIR_Nem_3 614 620 PF02991 0.468
LIG_LIR_Nem_3 652 658 PF02991 0.499
LIG_LIR_Nem_3 691 697 PF02991 0.404
LIG_MYND_1 306 310 PF01753 0.457
LIG_NRBOX 131 137 PF00104 0.371
LIG_NRBOX 235 241 PF00104 0.237
LIG_Pex14_2 110 114 PF04695 0.277
LIG_SH2_CRK 237 241 PF00017 0.253
LIG_SH2_CRK 255 259 PF00017 0.174
LIG_SH2_CRK 263 267 PF00017 0.237
LIG_SH2_CRK 660 664 PF00017 0.429
LIG_SH2_CRK 694 698 PF00017 0.487
LIG_SH2_NCK_1 660 664 PF00017 0.425
LIG_SH2_PTP2 148 151 PF00017 0.315
LIG_SH2_PTP2 210 213 PF00017 0.237
LIG_SH2_STAP1 237 241 PF00017 0.299
LIG_SH2_STAP1 73 77 PF00017 0.280
LIG_SH2_STAT5 119 122 PF00017 0.309
LIG_SH2_STAT5 148 151 PF00017 0.358
LIG_SH2_STAT5 210 213 PF00017 0.237
LIG_SH2_STAT5 237 240 PF00017 0.255
LIG_SH2_STAT5 577 580 PF00017 0.319
LIG_SH2_STAT5 581 584 PF00017 0.349
LIG_SH2_STAT5 619 622 PF00017 0.336
LIG_SH2_STAT5 660 663 PF00017 0.404
LIG_SH3_2 602 607 PF14604 0.607
LIG_SH3_3 238 244 PF00018 0.237
LIG_SH3_3 301 307 PF00018 0.424
LIG_SH3_3 318 324 PF00018 0.558
LIG_SH3_3 354 360 PF00018 0.651
LIG_SH3_3 371 377 PF00018 0.597
LIG_SH3_3 379 385 PF00018 0.568
LIG_SH3_3 386 392 PF00018 0.531
LIG_SH3_3 405 411 PF00018 0.701
LIG_SH3_3 482 488 PF00018 0.548
LIG_SH3_3 520 526 PF00018 0.417
LIG_SH3_3 596 602 PF00018 0.517
LIG_SH3_4 28 35 PF00018 0.501
LIG_SH3_CIN85_PxpxPR_1 602 607 PF14604 0.532
LIG_TRAF2_2 245 250 PF00917 0.237
LIG_TYR_ITIM 235 240 PF00017 0.255
LIG_TYR_ITIM 692 697 PF00017 0.472
LIG_UBA3_1 132 137 PF00899 0.280
LIG_WRC_WIRS_1 111 116 PF05994 0.255
LIG_WRC_WIRS_1 314 319 PF05994 0.594
LIG_WW_3 604 608 PF00397 0.539
MOD_CDC14_SPxK_1 588 591 PF00782 0.483
MOD_CDK_SPK_2 388 393 PF00069 0.706
MOD_CDK_SPK_2 418 423 PF00069 0.631
MOD_CDK_SPxK_1 585 591 PF00069 0.561
MOD_CDK_SPxxK_3 281 288 PF00069 0.364
MOD_CDK_SPxxK_3 659 666 PF00069 0.429
MOD_CK1_1 298 304 PF00069 0.563
MOD_CK1_1 313 319 PF00069 0.666
MOD_CK1_1 635 641 PF00069 0.414
MOD_CK1_1 67 73 PF00069 0.405
MOD_CK1_1 674 680 PF00069 0.422
MOD_CK1_1 94 100 PF00069 0.315
MOD_CK2_1 139 145 PF00069 0.301
MOD_CK2_1 19 25 PF00069 0.637
MOD_CK2_1 33 39 PF00069 0.291
MOD_CK2_1 674 680 PF00069 0.610
MOD_Cter_Amidation 664 667 PF01082 0.299
MOD_GlcNHglycan 154 157 PF01048 0.296
MOD_GlcNHglycan 333 336 PF01048 0.722
MOD_GlcNHglycan 343 346 PF01048 0.574
MOD_GlcNHglycan 348 351 PF01048 0.502
MOD_GlcNHglycan 41 45 PF01048 0.517
MOD_GlcNHglycan 423 426 PF01048 0.716
MOD_GlcNHglycan 433 436 PF01048 0.636
MOD_GlcNHglycan 663 666 PF01048 0.259
MOD_GSK3_1 139 146 PF00069 0.295
MOD_GSK3_1 200 207 PF00069 0.237
MOD_GSK3_1 217 224 PF00069 0.357
MOD_GSK3_1 295 302 PF00069 0.360
MOD_GSK3_1 306 313 PF00069 0.461
MOD_GSK3_1 327 334 PF00069 0.602
MOD_GSK3_1 421 428 PF00069 0.710
MOD_GSK3_1 505 512 PF00069 0.418
MOD_GSK3_1 606 613 PF00069 0.601
MOD_N-GLC_1 418 423 PF02516 0.502
MOD_N-GLC_1 516 521 PF02516 0.209
MOD_N-GLC_1 635 640 PF02516 0.217
MOD_NEK2_1 110 115 PF00069 0.286
MOD_NEK2_1 299 304 PF00069 0.609
MOD_NEK2_1 40 45 PF00069 0.556
MOD_NEK2_1 466 471 PF00069 0.394
MOD_NEK2_1 516 521 PF00069 0.409
MOD_NEK2_1 632 637 PF00069 0.404
MOD_NEK2_1 686 691 PF00069 0.458
MOD_NEK2_2 33 38 PF00069 0.485
MOD_PIKK_1 143 149 PF00454 0.255
MOD_PIKK_1 275 281 PF00454 0.402
MOD_PIKK_1 489 495 PF00454 0.461
MOD_PK_1 139 145 PF00069 0.226
MOD_PKA_1 139 145 PF00069 0.371
MOD_PKA_1 200 206 PF00069 0.237
MOD_PKA_1 346 352 PF00069 0.601
MOD_PKA_1 570 576 PF00069 0.462
MOD_PKA_1 666 672 PF00069 0.499
MOD_PKA_2 139 145 PF00069 0.299
MOD_PKA_2 287 293 PF00069 0.237
MOD_PKA_2 346 352 PF00069 0.601
MOD_PKA_2 505 511 PF00069 0.428
MOD_PKA_2 606 612 PF00069 0.615
MOD_PKA_2 632 638 PF00069 0.404
MOD_PKA_2 666 672 PF00069 0.404
MOD_PKA_2 686 692 PF00069 0.231
MOD_PKA_2 79 85 PF00069 0.315
MOD_Plk_1 251 257 PF00069 0.373
MOD_Plk_1 635 641 PF00069 0.417
MOD_Plk_1 94 100 PF00069 0.315
MOD_Plk_2-3 128 134 PF00069 0.371
MOD_Plk_4 128 134 PF00069 0.298
MOD_Plk_4 235 241 PF00069 0.286
MOD_Plk_4 287 293 PF00069 0.254
MOD_Plk_4 295 301 PF00069 0.241
MOD_Plk_4 33 39 PF00069 0.436
MOD_Plk_4 577 583 PF00069 0.352
MOD_Plk_4 688 694 PF00069 0.366
MOD_ProDKin_1 204 210 PF00069 0.287
MOD_ProDKin_1 281 287 PF00069 0.371
MOD_ProDKin_1 300 306 PF00069 0.484
MOD_ProDKin_1 388 394 PF00069 0.668
MOD_ProDKin_1 418 424 PF00069 0.621
MOD_ProDKin_1 438 444 PF00069 0.603
MOD_ProDKin_1 585 591 PF00069 0.517
MOD_ProDKin_1 595 601 PF00069 0.304
MOD_ProDKin_1 659 665 PF00069 0.429
MOD_SUMO_for_1 537 540 PF00179 0.499
MOD_SUMO_for_1 552 555 PF00179 0.499
MOD_SUMO_rev_2 163 172 PF00179 0.393
MOD_SUMO_rev_2 193 203 PF00179 0.237
MOD_SUMO_rev_2 214 220 PF00179 0.371
MOD_SUMO_rev_2 567 573 PF00179 0.503
TRG_ENDOCYTIC_2 119 122 PF00928 0.316
TRG_ENDOCYTIC_2 148 151 PF00928 0.315
TRG_ENDOCYTIC_2 237 240 PF00928 0.253
TRG_ENDOCYTIC_2 255 258 PF00928 0.174
TRG_ENDOCYTIC_2 694 697 PF00928 0.480
TRG_ER_diArg_1 100 102 PF00400 0.343
TRG_ER_diArg_1 138 140 PF00400 0.257
TRG_ER_diArg_1 666 668 PF00400 0.492
TRG_NES_CRM1_1 134 145 PF08389 0.371
TRG_NES_CRM1_1 180 193 PF08389 0.281
TRG_Pf-PMV_PEXEL_1 274 279 PF00026 0.371
TRG_Pf-PMV_PEXEL_1 622 627 PF00026 0.461

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I191 Leptomonas seymouri 72% 95%
A0A0S4JMY6 Bodo saltans 48% 91%
A0A1X0NTN5 Trypanosomatidae 50% 93%
A0A3Q8IAR8 Leishmania donovani 97% 100%
A0A422N3U8 Trypanosoma rangeli 48% 97%
A4H913 Leishmania braziliensis 91% 100%
A4HXE5 Leishmania infantum 97% 100%
C9ZTW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AR40 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 99%
P0C8M8 Zea mays 38% 100%
P32562 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P50528 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
P53351 Mus musculus 30% 100%
Q07832 Mus musculus 32% 100%
Q4FZD7 Mus musculus 29% 100%
Q62673 Rattus norvegicus 32% 100%
Q9R012 Rattus norvegicus 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS