VID27 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VID27 cytoplasmic protein, putative

Species:

Leishmania major

UniProt:

Q4QEC2_LEIMA

TriTrypDb:

LmjF.17.0640 , LMJLV39_170013900 , LMJSD75_170013500

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	339	341	PF00675	0.461
CLV_NRD_NRD_1	372	374	PF00675	0.339
CLV_NRD_NRD_1	438	440	PF00675	0.466
CLV_PCSK_SKI1_1	341	345	PF00082	0.354
CLV_PCSK_SKI1_1	382	386	PF00082	0.350
CLV_PCSK_SKI1_1	515	519	PF00082	0.466
DEG_SPOP_SBC_1	407	411	PF00917	0.480
DEG_SPOP_SBC_1	517	521	PF00917	0.531
DOC_CYCLIN_RxL_1	382	390	PF00134	0.382
DOC_MAPK_gen_1	439	446	PF00069	0.359
DOC_MAPK_JIP1_4	279	285	PF00069	0.480
DOC_MAPK_MEF2A_6	391	399	PF00069	0.335
DOC_PP1_RVXF_1	305	312	PF00149	0.408
DOC_PP4_FxxP_1	108	111	PF00568	0.513
DOC_PP4_FxxP_1	72	75	PF00568	0.572
DOC_USP7_MATH_1	181	185	PF00917	0.467
DOC_USP7_MATH_1	192	196	PF00917	0.432
DOC_USP7_MATH_1	284	288	PF00917	0.490
DOC_USP7_MATH_1	295	299	PF00917	0.424
DOC_USP7_MATH_1	335	339	PF00917	0.414
DOC_USP7_MATH_1	495	499	PF00917	0.449
DOC_USP7_MATH_1	87	91	PF00917	0.506
DOC_WW_Pin1_4	446	451	PF00397	0.386
LIG_14-3-3_CanoR_1	133	139	PF00244	0.381
LIG_14-3-3_CanoR_1	524	531	PF00244	0.569
LIG_14-3-3_CanoR_1	550	555	PF00244	0.578
LIG_APCC_ABBA_1	413	418	PF00400	0.480
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BRCT_BRCA1_1	194	198	PF00533	0.430
LIG_BRCT_BRCA1_1	409	413	PF00533	0.449
LIG_BRCT_BRCA1_1	428	432	PF00533	0.408
LIG_BRCT_BRCA1_1	465	469	PF00533	0.344
LIG_CaM_NSCaTE_8	151	158	PF13499	0.542
LIG_Clathr_ClatBox_1	414	418	PF01394	0.480
LIG_FHA_1	117	123	PF00498	0.498
LIG_FHA_1	133	139	PF00498	0.411
LIG_FHA_1	158	164	PF00498	0.551
LIG_FHA_1	167	173	PF00498	0.586
LIG_FHA_1	241	247	PF00498	0.511
LIG_FHA_1	251	257	PF00498	0.447
LIG_FHA_1	3	9	PF00498	0.536
LIG_FHA_1	36	42	PF00498	0.396
LIG_FHA_1	409	415	PF00498	0.461
LIG_FHA_1	417	423	PF00498	0.390
LIG_FHA_1	473	479	PF00498	0.438
LIG_FHA_1	488	494	PF00498	0.408
LIG_FHA_1	86	92	PF00498	0.546
LIG_FHA_2	138	144	PF00498	0.448
LIG_FHA_2	157	163	PF00498	0.569
LIG_FHA_2	243	249	PF00498	0.424
LIG_FHA_2	384	390	PF00498	0.334
LIG_FHA_2	530	536	PF00498	0.398
LIG_GBD_Chelix_1	309	317	PF00786	0.447
LIG_HCF-1_HBM_1	24	27	PF13415	0.623
LIG_LIR_Apic_2	24	30	PF02991	0.605
LIG_LIR_Apic_2	332	337	PF02991	0.402
LIG_LIR_Apic_2	69	75	PF02991	0.585
LIG_LIR_Apic_2	83	87	PF02991	0.325
LIG_LIR_Gen_1	135	142	PF02991	0.406
LIG_LIR_Gen_1	149	158	PF02991	0.435
LIG_LIR_Gen_1	195	204	PF02991	0.496
LIG_LIR_Gen_1	300	310	PF02991	0.401
LIG_LIR_Gen_1	410	421	PF02991	0.359
LIG_LIR_Gen_1	466	473	PF02991	0.408
LIG_LIR_LC3C_4	231	235	PF02991	0.585
LIG_LIR_Nem_3	135	139	PF02991	0.400
LIG_LIR_Nem_3	140	145	PF02991	0.444
LIG_LIR_Nem_3	148	154	PF02991	0.404
LIG_LIR_Nem_3	195	201	PF02991	0.517
LIG_LIR_Nem_3	300	305	PF02991	0.401
LIG_LIR_Nem_3	410	416	PF02991	0.359
LIG_LIR_Nem_3	466	472	PF02991	0.335
LIG_LIR_Nem_3	90	96	PF02991	0.401
LIG_PCNA_yPIPBox_3	121	133	PF02747	0.507
LIG_SH2_CRK	136	140	PF00017	0.424
LIG_SH2_CRK	152	156	PF00017	0.442
LIG_SH2_CRK	28	32	PF00017	0.540
LIG_SH2_CRK	302	306	PF00017	0.355
LIG_SH2_CRK	334	338	PF00017	0.480
LIG_SH2_CRK	366	370	PF00017	0.335
LIG_SH2_CRK	84	88	PF00017	0.526
LIG_SH2_GRB2like	290	293	PF00017	0.447
LIG_SH2_NCK_1	142	146	PF00017	0.597
LIG_SH2_NCK_1	334	338	PF00017	0.402
LIG_SH2_NCK_1	84	88	PF00017	0.488
LIG_SH2_SRC	142	145	PF00017	0.573
LIG_SH2_SRC	16	19	PF00017	0.582
LIG_SH2_SRC	290	293	PF00017	0.447
LIG_SH2_SRC	421	424	PF00017	0.480
LIG_SH2_SRC	60	63	PF00017	0.494
LIG_SH2_STAT5	154	157	PF00017	0.443
LIG_SH2_STAT5	302	305	PF00017	0.335
LIG_SH2_STAT5	353	356	PF00017	0.386
LIG_SH2_STAT5	366	369	PF00017	0.298
LIG_SH2_STAT5	379	382	PF00017	0.355
LIG_SH2_STAT5	405	408	PF00017	0.335
LIG_SH2_STAT5	421	424	PF00017	0.335
LIG_SH2_STAT5	487	490	PF00017	0.378
LIG_SH2_STAT5	60	63	PF00017	0.483
LIG_SH3_3	88	94	PF00018	0.445
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.529
LIG_SUMO_SIM_par_1	393	398	PF11976	0.342
LIG_SUMO_SIM_par_1	59	67	PF11976	0.518
LIG_TRAF2_1	19	22	PF00917	0.600
LIG_TRAF2_1	207	210	PF00917	0.603
LIG_TYR_ITSM	138	145	PF00017	0.588
LIG_UBA3_1	414	420	PF00899	0.480
LIG_WRC_WIRS_1	34	39	PF05994	0.456
MOD_CK1_1	137	143	PF00069	0.460
MOD_CK1_1	2	8	PF00069	0.532
MOD_CK1_1	242	248	PF00069	0.440
MOD_CK1_1	300	306	PF00069	0.432
MOD_CK1_1	499	505	PF00069	0.480
MOD_CK1_1	53	59	PF00069	0.638
MOD_CK1_1	85	91	PF00069	0.412
MOD_CK2_1	1	7	PF00069	0.612
MOD_CK2_1	156	162	PF00069	0.567
MOD_CK2_1	204	210	PF00069	0.519
MOD_CK2_1	242	248	PF00069	0.381
MOD_CK2_1	53	59	PF00069	0.652
MOD_GlcNHglycan	1	4	PF01048	0.657
MOD_GlcNHglycan	260	263	PF01048	0.407
MOD_GlcNHglycan	297	300	PF01048	0.377
MOD_GlcNHglycan	358	362	PF01048	0.380
MOD_GlcNHglycan	459	462	PF01048	0.368
MOD_GlcNHglycan	465	468	PF01048	0.328
MOD_GlcNHglycan	501	504	PF01048	0.658
MOD_GlcNHglycan	508	511	PF01048	0.477
MOD_GlcNHglycan	520	523	PF01048	0.261
MOD_GlcNHglycan	84	87	PF01048	0.496
MOD_GSK3_1	238	245	PF00069	0.472
MOD_GSK3_1	291	298	PF00069	0.394
MOD_GSK3_1	3	10	PF00069	0.476
MOD_GSK3_1	33	40	PF00069	0.354
MOD_GSK3_1	341	348	PF00069	0.328
MOD_GSK3_1	383	390	PF00069	0.355
MOD_GSK3_1	427	434	PF00069	0.406
MOD_GSK3_1	446	453	PF00069	0.221
MOD_GSK3_1	495	502	PF00069	0.480
MOD_GSK3_1	513	520	PF00069	0.392
MOD_GSK3_1	546	553	PF00069	0.572
MOD_N-GLC_1	291	296	PF02516	0.447
MOD_N-GLC_1	53	58	PF02516	0.650
MOD_N-GLC_2	132	134	PF02516	0.365
MOD_N-GLC_2	189	191	PF02516	0.407
MOD_N-GLC_2	55	57	PF02516	0.408
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	37	42	PF00069	0.522
MOD_NEK2_1	387	392	PF00069	0.355
MOD_NEK2_1	416	421	PF00069	0.355
MOD_NEK2_1	478	483	PF00069	0.447
MOD_NEK2_1	489	494	PF00069	0.437
MOD_NEK2_1	518	523	PF00069	0.484
MOD_NEK2_1	80	85	PF00069	0.438
MOD_NEK2_2	450	455	PF00069	0.480
MOD_NEK2_2	87	92	PF00069	0.516
MOD_OFUCOSY	479	484	PF10250	0.480
MOD_PIKK_1	175	181	PF00454	0.561
MOD_PIKK_1	346	352	PF00454	0.480
MOD_PIKK_1	496	502	PF00454	0.468
MOD_PKA_2	132	138	PF00069	0.385
MOD_PKA_2	270	276	PF00069	0.486
MOD_PKA_2	523	529	PF00069	0.580
MOD_Plk_1	209	215	PF00069	0.556
MOD_Plk_1	250	256	PF00069	0.436
MOD_Plk_1	450	456	PF00069	0.482
MOD_Plk_1	53	59	PF00069	0.669
MOD_Plk_2-3	209	215	PF00069	0.577
MOD_Plk_4	11	17	PF00069	0.428
MOD_Plk_4	134	140	PF00069	0.480
MOD_Plk_4	242	248	PF00069	0.447
MOD_Plk_4	250	256	PF00069	0.447
MOD_Plk_4	270	276	PF00069	0.150
MOD_Plk_4	297	303	PF00069	0.407
MOD_Plk_4	383	389	PF00069	0.335
MOD_Plk_4	409	415	PF00069	0.466
MOD_Plk_4	513	519	PF00069	0.574
MOD_ProDKin_1	446	452	PF00069	0.386
MOD_SUMO_for_1	544	547	PF00179	0.573
MOD_SUMO_rev_2	321	331	PF00179	0.427
MOD_SUMO_rev_2	412	422	PF00179	0.487
TRG_ENDOCYTIC_2	136	139	PF00928	0.401
TRG_ENDOCYTIC_2	142	145	PF00928	0.452
TRG_ENDOCYTIC_2	152	155	PF00928	0.427
TRG_ENDOCYTIC_2	28	31	PF00928	0.477
TRG_ENDOCYTIC_2	302	305	PF00928	0.335
TRG_ENDOCYTIC_2	353	356	PF00928	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK8	Leptomonas seymouri	64%	100%
A0A1X0NPH3	Trypanosomatidae	41%	100%
A0A3R7NJV3	Trypanosoma rangeli	42%	100%
A0A3S7WUG9	Leishmania donovani	98%	100%
A4H914	Leishmania braziliensis	89%	100%
A4HXE6	Leishmania infantum	98%	100%
C9ZUK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AR41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BNW8	Trypanosoma cruzi	44%	100%