DUF106-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEB8_LEIMA

TriTrypDb:

LmjF.17.0680 , LMJLV39_170014300 , LMJSD75_170013900

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QEB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.578
CLV_MEL_PAP_1	198	204	PF00089	0.388
CLV_NRD_NRD_1	358	360	PF00675	0.415
CLV_NRD_NRD_1	367	369	PF00675	0.373
CLV_NRD_NRD_1	388	390	PF00675	0.534
CLV_NRD_NRD_1	432	434	PF00675	0.395
CLV_NRD_NRD_1	90	92	PF00675	0.297
CLV_PCSK_FUR_1	365	369	PF00082	0.405
CLV_PCSK_KEX2_1	323	325	PF00082	0.415
CLV_PCSK_KEX2_1	358	360	PF00082	0.399
CLV_PCSK_KEX2_1	367	369	PF00082	0.381
CLV_PCSK_KEX2_1	387	389	PF00082	0.547
CLV_PCSK_KEX2_1	432	434	PF00082	0.388
CLV_PCSK_KEX2_1	90	92	PF00082	0.440
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.457
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.411
CLV_PCSK_SKI1_1	266	270	PF00082	0.310
CLV_PCSK_SKI1_1	304	308	PF00082	0.423
CLV_PCSK_SKI1_1	323	327	PF00082	0.338
CLV_PCSK_SKI1_1	336	340	PF00082	0.339
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DOC_CKS1_1	30	35	PF01111	0.387
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.401
DOC_MAPK_gen_1	213	223	PF00069	0.536
DOC_MAPK_gen_1	333	343	PF00069	0.609
DOC_MAPK_MEF2A_6	214	223	PF00069	0.494
DOC_MAPK_MEF2A_6	411	418	PF00069	0.594
DOC_PP1_RVXF_1	199	205	PF00149	0.593
DOC_PP1_RVXF_1	302	308	PF00149	0.607
DOC_PP1_RVXF_1	82	89	PF00149	0.547
DOC_PP2B_LxvP_1	130	133	PF13499	0.362
DOC_PP2B_LxvP_1	240	243	PF13499	0.421
DOC_PP2B_LxvP_1	47	50	PF13499	0.357
DOC_PP4_FxxP_1	247	250	PF00568	0.350
DOC_PP4_FxxP_1	280	283	PF00568	0.623
DOC_USP7_MATH_1	120	124	PF00917	0.413
DOC_USP7_MATH_1	169	173	PF00917	0.454
DOC_USP7_MATH_1	227	231	PF00917	0.428
DOC_USP7_UBL2_3	356	360	PF12436	0.666
DOC_WW_Pin1_4	148	153	PF00397	0.399
DOC_WW_Pin1_4	2	7	PF00397	0.614
DOC_WW_Pin1_4	29	34	PF00397	0.400
LIG_14-3-3_CanoR_1	106	115	PF00244	0.536
LIG_14-3-3_CanoR_1	196	204	PF00244	0.565
LIG_14-3-3_CanoR_1	368	374	PF00244	0.713
LIG_Actin_WH2_2	252	268	PF00022	0.402
LIG_APCC_ABBA_1	341	346	PF00400	0.628
LIG_APCC_ABBA_1	51	56	PF00400	0.399
LIG_Clathr_ClatBox_1	176	180	PF01394	0.410
LIG_FHA_1	108	114	PF00498	0.555
LIG_FHA_1	137	143	PF00498	0.383
LIG_FHA_1	180	186	PF00498	0.366
LIG_FHA_1	2	8	PF00498	0.641
LIG_FHA_1	235	241	PF00498	0.397
LIG_FHA_1	260	266	PF00498	0.467
LIG_FHA_1	313	319	PF00498	0.664
LIG_FHA_2	306	312	PF00498	0.614
LIG_FHA_2	370	376	PF00498	0.609
LIG_LIR_Gen_1	190	198	PF02991	0.546
LIG_LIR_Gen_1	75	83	PF02991	0.607
LIG_LIR_Nem_3	102	108	PF02991	0.615
LIG_LIR_Nem_3	190	195	PF02991	0.463
LIG_LIR_Nem_3	75	79	PF02991	0.531
LIG_MYND_1	250	254	PF01753	0.322
LIG_PCNA_yPIPBox_3	201	212	PF02747	0.544
LIG_SH2_SRC	76	79	PF00017	0.538
LIG_SH2_STAP1	238	242	PF00017	0.503
LIG_SH2_STAP1	328	332	PF00017	0.582
LIG_SH2_STAT3	285	288	PF00017	0.598
LIG_SH2_STAT3	54	57	PF00017	0.565
LIG_SH2_STAT5	128	131	PF00017	0.317
LIG_SH2_STAT5	251	254	PF00017	0.282
LIG_SH2_STAT5	76	79	PF00017	0.618
LIG_SH3_3	27	33	PF00018	0.294
LIG_SH3_3	280	286	PF00018	0.625
LIG_SH3_3	77	83	PF00018	0.558
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.605
LIG_SUMO_SIM_par_1	151	156	PF11976	0.383
LIG_TRAF2_1	398	401	PF00917	0.707
LIG_WRC_WIRS_1	137	142	PF05994	0.367
MOD_CDK_SPxxK_3	2	9	PF00069	0.607
MOD_CK1_1	123	129	PF00069	0.244
MOD_CK1_1	164	170	PF00069	0.481
MOD_CK1_1	172	178	PF00069	0.306
MOD_CK1_1	260	266	PF00069	0.336
MOD_CK1_1	29	35	PF00069	0.435
MOD_CK1_1	379	385	PF00069	0.742
MOD_CK1_1	406	412	PF00069	0.702
MOD_CK2_1	391	397	PF00069	0.792
MOD_CK2_1	406	412	PF00069	0.612
MOD_GlcNHglycan	122	125	PF01048	0.355
MOD_GlcNHglycan	171	174	PF01048	0.682
MOD_GlcNHglycan	259	262	PF01048	0.421
MOD_GlcNHglycan	39	42	PF01048	0.407
MOD_GlcNHglycan	393	397	PF01048	0.584
MOD_GSK3_1	161	168	PF00069	0.460
MOD_GSK3_1	175	182	PF00069	0.355
MOD_GSK3_1	260	267	PF00069	0.310
MOD_GSK3_1	314	321	PF00069	0.679
MOD_N-GLC_1	270	275	PF02516	0.344
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	108	113	PF00069	0.630
MOD_NEK2_1	12	17	PF00069	0.421
MOD_NEK2_1	153	158	PF00069	0.383
MOD_NEK2_1	165	170	PF00069	0.455
MOD_NEK2_1	257	262	PF00069	0.297
MOD_NEK2_1	305	310	PF00069	0.598
MOD_NEK2_1	369	374	PF00069	0.718
MOD_NEK2_1	37	42	PF00069	0.368
MOD_NEK2_1	391	396	PF00069	0.721
MOD_NEK2_2	187	192	PF00069	0.357
MOD_PIKK_1	196	202	PF00454	0.528
MOD_PIKK_1	318	324	PF00454	0.599
MOD_PIKK_1	379	385	PF00454	0.731
MOD_PKA_2	108	114	PF00069	0.500
MOD_Plk_4	12	18	PF00069	0.357
MOD_Plk_4	123	129	PF00069	0.315
MOD_Plk_4	136	142	PF00069	0.302
MOD_Plk_4	172	178	PF00069	0.252
MOD_Plk_4	227	233	PF00069	0.309
MOD_Plk_4	264	270	PF00069	0.390
MOD_ProDKin_1	148	154	PF00069	0.395
MOD_ProDKin_1	2	8	PF00069	0.609
MOD_ProDKin_1	29	35	PF00069	0.396
TRG_ENDOCYTIC_2	76	79	PF00928	0.526
TRG_ER_diArg_1	367	369	PF00400	0.639
TRG_ER_diArg_1	386	389	PF00400	0.742
TRG_ER_diArg_1	426	429	PF00400	0.643
TRG_ER_diArg_1	90	92	PF00400	0.551
TRG_NLS_MonoCore_2	357	362	PF00514	0.629
TRG_NLS_MonoExtN_4	356	363	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N4	Leptomonas seymouri	60%	94%
A0A0S4KHH7	Bodo saltans	37%	90%
A0A1X0NTB3	Trypanosomatidae	48%	100%
A0A3S7WUI4	Leishmania donovani	98%	100%
A4H918	Leishmania braziliensis	83%	100%
A4HXF0	Leishmania infantum	98%	100%
C9ZP21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AR45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BFE7	Trypanosoma cruzi	46%	100%