Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEB7_LEIMA

TriTrypDb:

LmjF.17.0690 , LMJLV39_170014400 , LMJSD75_170014000

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.507
CLV_NRD_NRD_1	437	439	PF00675	0.591
CLV_NRD_NRD_1	85	87	PF00675	0.435
CLV_PCSK_KEX2_1	42	44	PF00082	0.510
CLV_PCSK_KEX2_1	437	439	PF00082	0.591
CLV_PCSK_SKI1_1	61	65	PF00082	0.524
CLV_PCSK_SKI1_1	93	97	PF00082	0.494
DEG_APCC_DBOX_1	42	50	PF00400	0.502
DEG_SCF_FBW7_1	344	351	PF00400	0.648
DEG_SPOP_SBC_1	310	314	PF00917	0.618
DEG_SPOP_SBC_1	462	466	PF00917	0.698
DOC_CDC14_PxL_1	337	345	PF14671	0.682
DOC_CKS1_1	220	225	PF01111	0.688
DOC_CKS1_1	255	260	PF01111	0.729
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.612
DOC_MAPK_gen_1	145	154	PF00069	0.496
DOC_MAPK_MEF2A_6	145	154	PF00069	0.496
DOC_PP1_RVXF_1	435	442	PF00149	0.541
DOC_PP2B_LxvP_1	416	419	PF13499	0.621
DOC_PP4_FxxP_1	20	23	PF00568	0.456
DOC_USP7_MATH_1	105	109	PF00917	0.603
DOC_USP7_MATH_1	128	132	PF00917	0.511
DOC_USP7_MATH_1	16	20	PF00917	0.504
DOC_USP7_MATH_1	205	209	PF00917	0.680
DOC_USP7_MATH_1	210	214	PF00917	0.821
DOC_USP7_MATH_1	276	280	PF00917	0.666
DOC_USP7_MATH_1	305	309	PF00917	0.664
DOC_USP7_MATH_1	310	314	PF00917	0.587
DOC_USP7_MATH_1	318	322	PF00917	0.646
DOC_USP7_MATH_1	331	335	PF00917	0.727
DOC_USP7_MATH_1	348	352	PF00917	0.534
DOC_USP7_MATH_1	359	363	PF00917	0.565
DOC_USP7_MATH_1	370	374	PF00917	0.773
DOC_USP7_MATH_1	375	379	PF00917	0.632
DOC_USP7_MATH_1	391	395	PF00917	0.676
DOC_USP7_MATH_1	485	489	PF00917	0.762
DOC_USP7_MATH_1	97	101	PF00917	0.595
DOC_USP7_UBL2_3	141	145	PF12436	0.478
DOC_WW_Pin1_4	103	108	PF00397	0.509
DOC_WW_Pin1_4	219	224	PF00397	0.629
DOC_WW_Pin1_4	254	259	PF00397	0.692
DOC_WW_Pin1_4	272	277	PF00397	0.511
DOC_WW_Pin1_4	314	319	PF00397	0.730
DOC_WW_Pin1_4	344	349	PF00397	0.615
DOC_WW_Pin1_4	355	360	PF00397	0.618
DOC_WW_Pin1_4	402	407	PF00397	0.684
DOC_WW_Pin1_4	464	469	PF00397	0.635
LIG_14-3-3_CanoR_1	162	168	PF00244	0.570
LIG_14-3-3_CanoR_1	173	180	PF00244	0.454
LIG_14-3-3_CanoR_1	240	248	PF00244	0.680
LIG_14-3-3_CanoR_1	409	416	PF00244	0.607
LIG_14-3-3_CanoR_1	93	102	PF00244	0.559
LIG_Actin_WH2_2	290	305	PF00022	0.443
LIG_BRCT_BRCA1_1	184	188	PF00533	0.661
LIG_BRCT_BRCA1_1	487	491	PF00533	0.638
LIG_EVH1_1	340	344	PF00568	0.594
LIG_FHA_1	133	139	PF00498	0.580
LIG_FHA_1	147	153	PF00498	0.370
LIG_FHA_1	255	261	PF00498	0.710
LIG_FHA_2	193	199	PF00498	0.711
LIG_LIR_Apic_2	18	23	PF02991	0.452
LIG_LIR_Gen_1	169	179	PF02991	0.503
LIG_LIR_Gen_1	488	496	PF02991	0.630
LIG_LIR_Nem_3	169	174	PF02991	0.529
LIG_LIR_Nem_3	488	494	PF02991	0.635
LIG_NRBOX	34	40	PF00104	0.434
LIG_NRBOX	454	460	PF00104	0.607
LIG_Pex14_2	20	24	PF04695	0.494
LIG_PTB_Apo_2	73	80	PF02174	0.437
LIG_PTB_Phospho_1	73	79	PF10480	0.437
LIG_SH2_STAP1	235	239	PF00017	0.631
LIG_SH2_STAT3	392	395	PF00017	0.716
LIG_SH3_3	225	231	PF00018	0.628
LIG_SH3_3	338	344	PF00018	0.783
LIG_SUMO_SIM_anti_2	282	287	PF11976	0.552
LIG_TRAF2_1	431	434	PF00917	0.563
LIG_UBA3_1	38	45	PF00899	0.420
LIG_WW_2	341	344	PF00397	0.593
MOD_CDK_SPxK_1	344	350	PF00069	0.618
MOD_CDK_SPxxK_3	402	409	PF00069	0.685
MOD_CDK_SPxxK_3	464	471	PF00069	0.542
MOD_CK1_1	106	112	PF00069	0.570
MOD_CK1_1	308	314	PF00069	0.573
MOD_CK1_1	317	323	PF00069	0.646
MOD_CK1_1	360	366	PF00069	0.688
MOD_CK1_1	461	467	PF00069	0.644
MOD_CK1_1	475	481	PF00069	0.714
MOD_CK1_1	492	498	PF00069	0.495
MOD_CK2_1	192	198	PF00069	0.681
MOD_CK2_1	276	282	PF00069	0.561
MOD_CK2_1	322	328	PF00069	0.642
MOD_GlcNHglycan	111	114	PF01048	0.592
MOD_GlcNHglycan	163	166	PF01048	0.548
MOD_GlcNHglycan	184	187	PF01048	0.624
MOD_GlcNHglycan	207	210	PF01048	0.698
MOD_GlcNHglycan	212	215	PF01048	0.670
MOD_GlcNHglycan	260	263	PF01048	0.716
MOD_GlcNHglycan	324	327	PF01048	0.741
MOD_GlcNHglycan	337	340	PF01048	0.781
MOD_GlcNHglycan	359	362	PF01048	0.679
MOD_GlcNHglycan	363	366	PF01048	0.628
MOD_GlcNHglycan	383	386	PF01048	0.578
MOD_GlcNHglycan	395	398	PF01048	0.662
MOD_GlcNHglycan	477	480	PF01048	0.732
MOD_GlcNHglycan	487	490	PF01048	0.637
MOD_GlcNHglycan	494	497	PF01048	0.534
MOD_GSK3_1	103	110	PF00069	0.606
MOD_GSK3_1	124	131	PF00069	0.569
MOD_GSK3_1	182	189	PF00069	0.657
MOD_GSK3_1	254	261	PF00069	0.813
MOD_GSK3_1	272	279	PF00069	0.508
MOD_GSK3_1	305	312	PF00069	0.550
MOD_GSK3_1	314	321	PF00069	0.642
MOD_GSK3_1	331	338	PF00069	0.774
MOD_GSK3_1	344	351	PF00069	0.630
MOD_GSK3_1	355	362	PF00069	0.608
MOD_GSK3_1	458	465	PF00069	0.558
MOD_GSK3_1	485	492	PF00069	0.758
MOD_GSK3_1	93	100	PF00069	0.453
MOD_N-GLC_1	182	187	PF02516	0.599
MOD_NEK2_1	132	137	PF00069	0.502
MOD_NEK2_1	309	314	PF00069	0.588
MOD_NEK2_1	41	46	PF00069	0.395
MOD_NEK2_1	451	456	PF00069	0.545
MOD_NEK2_1	458	463	PF00069	0.515
MOD_NEK2_2	97	102	PF00069	0.454
MOD_PIKK_1	119	125	PF00454	0.597
MOD_PIKK_1	132	138	PF00454	0.434
MOD_PIKK_1	199	205	PF00454	0.698
MOD_PIKK_1	391	397	PF00454	0.667
MOD_PKA_2	146	152	PF00069	0.459
MOD_PKA_2	161	167	PF00069	0.402
MOD_PKA_2	205	211	PF00069	0.717
MOD_PKA_2	239	245	PF00069	0.626
MOD_PKA_2	408	414	PF00069	0.609
MOD_PKA_2	41	47	PF00069	0.395
MOD_PKA_2	472	478	PF00069	0.719
MOD_Plk_1	31	37	PF00069	0.517
MOD_Plk_1	411	417	PF00069	0.691
MOD_Plk_2-3	472	478	PF00069	0.669
MOD_Plk_4	31	37	PF00069	0.574
MOD_ProDKin_1	103	109	PF00069	0.515
MOD_ProDKin_1	219	225	PF00069	0.629
MOD_ProDKin_1	254	260	PF00069	0.694
MOD_ProDKin_1	272	278	PF00069	0.505
MOD_ProDKin_1	314	320	PF00069	0.733
MOD_ProDKin_1	344	350	PF00069	0.618
MOD_ProDKin_1	355	361	PF00069	0.618
MOD_ProDKin_1	402	408	PF00069	0.683
MOD_ProDKin_1	464	470	PF00069	0.637
MOD_SUMO_rev_2	11	19	PF00179	0.368
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.468
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.508
TRG_ENDOCYTIC_2	235	238	PF00928	0.634
TRG_ENDOCYTIC_2	85	88	PF00928	0.356
TRG_ER_diArg_1	297	300	PF00400	0.541
TRG_ER_diArg_1	41	43	PF00400	0.501
TRG_ER_diArg_1	437	439	PF00400	0.515
TRG_NES_CRM1_1	142	156	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW8	Leptomonas seymouri	40%	96%
A0A3S5H709	Leishmania donovani	93%	100%
A4H919	Leishmania braziliensis	70%	96%
A4HXF1	Leishmania infantum	93%	100%
E9AR46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%