Methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methyltransferase

Gene product:

Putative methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QEB6_LEIMA

TriTrypDb:

LmjF.17.0700 , LMJLV39_170014500 , LMJSD75_170014100

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB6

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.769
CLV_NRD_NRD_1	182	184	PF00675	0.443
CLV_NRD_NRD_1	368	370	PF00675	0.460
CLV_NRD_NRD_1	438	440	PF00675	0.806
CLV_PCSK_FUR_1	436	440	PF00082	0.811
CLV_PCSK_KEX2_1	137	139	PF00082	0.373
CLV_PCSK_KEX2_1	182	184	PF00082	0.597
CLV_PCSK_KEX2_1	368	370	PF00082	0.477
CLV_PCSK_KEX2_1	436	438	PF00082	0.776
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.369
CLV_PCSK_PC7_1	133	139	PF00082	0.369
CLV_PCSK_SKI1_1	122	126	PF00082	0.441
CLV_PCSK_SKI1_1	196	200	PF00082	0.620
CLV_Separin_Metazoa	433	437	PF03568	0.680
DEG_Nend_Nbox_1	1	3	PF02207	0.467
DEG_SPOP_SBC_1	233	237	PF00917	0.685
DEG_SPOP_SBC_1	422	426	PF00917	0.588
DEG_SPOP_SBC_1	73	77	PF00917	0.468
DOC_ANK_TNKS_1	440	447	PF00023	0.768
DOC_CKS1_1	247	252	PF01111	0.584
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.408
DOC_PP1_RVXF_1	394	400	PF00149	0.426
DOC_PP2B_LxvP_1	214	217	PF13499	0.502
DOC_PP2B_LxvP_1	83	86	PF13499	0.408
DOC_PP4_FxxP_1	429	432	PF00568	0.718
DOC_USP7_MATH_1	158	162	PF00917	0.585
DOC_USP7_MATH_1	217	221	PF00917	0.447
DOC_USP7_MATH_1	227	231	PF00917	0.543
DOC_USP7_MATH_1	232	236	PF00917	0.624
DOC_USP7_MATH_1	356	360	PF00917	0.549
DOC_USP7_MATH_1	459	463	PF00917	0.790
DOC_USP7_MATH_1	73	77	PF00917	0.462
DOC_USP7_UBL2_3	166	170	PF12436	0.478
DOC_WW_Pin1_4	183	188	PF00397	0.695
DOC_WW_Pin1_4	246	251	PF00397	0.597
DOC_WW_Pin1_4	8	13	PF00397	0.471
LIG_14-3-3_CanoR_1	115	125	PF00244	0.344
LIG_14-3-3_CanoR_1	148	156	PF00244	0.323
LIG_14-3-3_CanoR_1	188	194	PF00244	0.679
LIG_14-3-3_CanoR_1	205	211	PF00244	0.427
LIG_14-3-3_CanoR_1	396	405	PF00244	0.447
LIG_14-3-3_CanoR_1	421	431	PF00244	0.744
LIG_14-3-3_CanoR_1	64	74	PF00244	0.487
LIG_BRCT_BRCA1_1	193	197	PF00533	0.689
LIG_BRCT_BRCA1_1	425	429	PF00533	0.792
LIG_eIF4E_1	272	278	PF01652	0.481
LIG_FHA_1	188	194	PF00498	0.627
LIG_FHA_1	236	242	PF00498	0.648
LIG_FHA_1	327	333	PF00498	0.557
LIG_FHA_1	376	382	PF00498	0.459
LIG_FHA_2	174	180	PF00498	0.397
LIG_FHA_2	271	277	PF00498	0.383
LIG_FHA_2	278	284	PF00498	0.411
LIG_FHA_2	398	404	PF00498	0.524
LIG_FHA_2	450	456	PF00498	0.767
LIG_LIR_Apic_2	18	24	PF02991	0.490
LIG_LIR_Apic_2	258	264	PF02991	0.442
LIG_LIR_Apic_2	426	432	PF02991	0.714
LIG_LIR_Gen_1	249	259	PF02991	0.416
LIG_LIR_Gen_1	299	308	PF02991	0.430
LIG_LIR_Gen_1	325	335	PF02991	0.496
LIG_LIR_Gen_1	362	371	PF02991	0.447
LIG_LIR_Nem_3	10	16	PF02991	0.413
LIG_LIR_Nem_3	249	254	PF02991	0.424
LIG_LIR_Nem_3	266	270	PF02991	0.401
LIG_LIR_Nem_3	299	305	PF02991	0.427
LIG_LIR_Nem_3	325	331	PF02991	0.503
LIG_LIR_Nem_3	362	366	PF02991	0.442
LIG_LIR_Nem_3	68	74	PF02991	0.369
LIG_Pex14_2	152	156	PF04695	0.482
LIG_SH2_CRK	261	265	PF00017	0.452
LIG_SH2_PTP2	253	256	PF00017	0.467
LIG_SH2_PTP2	363	366	PF00017	0.472
LIG_SH2_STAT5	253	256	PF00017	0.422
LIG_SH2_STAT5	272	275	PF00017	0.401
LIG_SH2_STAT5	363	366	PF00017	0.447
LIG_SH3_2	432	437	PF14604	0.717
LIG_SH3_3	428	434	PF00018	0.810
LIG_SH3_3	6	12	PF00018	0.411
LIG_SH3_3	67	73	PF00018	0.299
LIG_SH3_3	83	89	PF00018	0.408
LIG_TYR_ITIM	361	366	PF00017	0.484
LIG_WW_3	433	437	PF00397	0.719
MOD_CDK_SPK_2	183	188	PF00069	0.660
MOD_CK1_1	209	215	PF00069	0.468
MOD_CK1_1	235	241	PF00069	0.689
MOD_CK1_1	341	347	PF00069	0.575
MOD_CK1_1	359	365	PF00069	0.474
MOD_CK1_1	75	81	PF00069	0.445
MOD_CK2_1	270	276	PF00069	0.369
MOD_CK2_1	342	348	PF00069	0.573
MOD_CK2_1	397	403	PF00069	0.502
MOD_Cter_Amidation	310	313	PF01082	0.385
MOD_GlcNHglycan	217	220	PF01048	0.507
MOD_GlcNHglycan	344	347	PF01048	0.622
MOD_GlcNHglycan	414	417	PF01048	0.706
MOD_GlcNHglycan	425	428	PF01048	0.688
MOD_GlcNHglycan	449	452	PF01048	0.612
MOD_GlcNHglycan	45	48	PF01048	0.408
MOD_GlcNHglycan	59	62	PF01048	0.428
MOD_GlcNHglycan	78	81	PF01048	0.242
MOD_GSK3_1	183	190	PF00069	0.589
MOD_GSK3_1	205	212	PF00069	0.482
MOD_GSK3_1	232	239	PF00069	0.654
MOD_GSK3_1	242	249	PF00069	0.664
MOD_GSK3_1	338	345	PF00069	0.558
MOD_GSK3_1	355	362	PF00069	0.489
MOD_GSK3_1	447	454	PF00069	0.656
MOD_GSK3_1	72	79	PF00069	0.453
MOD_N-GLC_1	35	40	PF02516	0.645
MOD_N-GLC_1	447	452	PF02516	0.613
MOD_N-GLC_2	289	291	PF02516	0.387
MOD_NEK2_1	197	202	PF00069	0.548
MOD_NEK2_1	210	215	PF00069	0.384
MOD_NEK2_1	270	275	PF00069	0.383
MOD_NEK2_1	277	282	PF00069	0.388
MOD_NEK2_1	35	40	PF00069	0.606
MOD_NEK2_1	412	417	PF00069	0.633
MOD_NEK2_1	55	60	PF00069	0.155
MOD_NEK2_1	74	79	PF00069	0.344
MOD_PKA_1	437	443	PF00069	0.736
MOD_PKA_2	147	153	PF00069	0.320
MOD_PKA_2	187	193	PF00069	0.492
MOD_PKA_2	392	398	PF00069	0.406
MOD_PKA_2	412	418	PF00069	0.426
MOD_PKA_2	420	426	PF00069	0.708
MOD_PKA_2	437	443	PF00069	0.783
MOD_Plk_1	35	41	PF00069	0.602
MOD_Plk_4	159	165	PF00069	0.573
MOD_Plk_4	206	212	PF00069	0.506
MOD_Plk_4	356	362	PF00069	0.552
MOD_ProDKin_1	183	189	PF00069	0.699
MOD_ProDKin_1	246	252	PF00069	0.583
MOD_ProDKin_1	8	14	PF00069	0.469
MOD_SUMO_for_1	222	225	PF00179	0.477
MOD_SUMO_for_1	405	408	PF00179	0.616
TRG_ENDOCYTIC_2	13	16	PF00928	0.429
TRG_ENDOCYTIC_2	253	256	PF00928	0.395
TRG_ENDOCYTIC_2	363	366	PF00928	0.472
TRG_ENDOCYTIC_2	372	375	PF00928	0.502
TRG_ER_diArg_1	396	399	PF00400	0.467
TRG_ER_diArg_1	435	438	PF00400	0.802
TRG_NES_CRM1_1	123	136	PF08389	0.444
TRG_NES_CRM1_1	167	179	PF08389	0.531
TRG_NLS_MonoCore_2	468	473	PF00514	0.615
TRG_NLS_MonoExtC_3	469	474	PF00514	0.773
TRG_NLS_MonoExtN_4	469	475	PF00514	0.811

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWR5	Leptomonas seymouri	59%	100%
A0A1X0NSU1	Trypanosomatidae	41%	100%
A0A3S7WUF8	Leishmania donovani	93%	100%
A0A422N4P6	Trypanosoma rangeli	41%	100%
A4H920	Leishmania braziliensis	77%	100%
A4HXF2	Leishmania infantum	93%	100%
C9ZP24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AR47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%