HTH myb-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Myb-like DNA-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEB5_LEIMA

TriTrypDb:

LmjF.17.0710 , LMJLV39_170014600 , LMJSD75_170014200

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	2
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

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Expansion

Sequence features

Q4QEB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB5

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.708
CLV_C14_Caspase3-7	313	317	PF00656	0.587
CLV_C14_Caspase3-7	450	454	PF00656	0.686
CLV_C14_Caspase3-7	618	622	PF00656	0.608
CLV_NRD_NRD_1	151	153	PF00675	0.502
CLV_NRD_NRD_1	154	156	PF00675	0.527
CLV_NRD_NRD_1	194	196	PF00675	0.473
CLV_NRD_NRD_1	228	230	PF00675	0.524
CLV_NRD_NRD_1	231	233	PF00675	0.498
CLV_NRD_NRD_1	503	505	PF00675	0.616

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC2	Leptomonas seymouri	54%	100%
A0A3S7WUG8	Leishmania donovani	92%	100%
A4H921	Leishmania braziliensis	81%	100%
A4HXF3	Leishmania infantum	92%	100%
E9AR48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%

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