HTH myb-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Myb-like DNA-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEB5_LEIMA

TriTrypDb:

LmjF.17.0710 , LMJLV39_170014600 , LMJSD75_170014200

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	2
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QEB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB5

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.708
CLV_C14_Caspase3-7	313	317	PF00656	0.587
CLV_C14_Caspase3-7	450	454	PF00656	0.686
CLV_C14_Caspase3-7	618	622	PF00656	0.608
CLV_NRD_NRD_1	151	153	PF00675	0.502
CLV_NRD_NRD_1	154	156	PF00675	0.527
CLV_NRD_NRD_1	194	196	PF00675	0.473
CLV_NRD_NRD_1	228	230	PF00675	0.524
CLV_NRD_NRD_1	231	233	PF00675	0.498
CLV_NRD_NRD_1	503	505	PF00675	0.616
CLV_NRD_NRD_1	778	780	PF00675	0.542
CLV_NRD_NRD_1	92	94	PF00675	0.269
CLV_PCSK_FUR_1	148	152	PF00082	0.440
CLV_PCSK_KEX2_1	148	150	PF00082	0.480
CLV_PCSK_KEX2_1	151	153	PF00082	0.506
CLV_PCSK_KEX2_1	435	437	PF00082	0.625
CLV_PCSK_KEX2_1	778	780	PF00082	0.542
CLV_PCSK_KEX2_1	92	94	PF00082	0.269
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.625
CLV_PCSK_SKI1_1	20	24	PF00082	0.269
CLV_PCSK_SKI1_1	232	236	PF00082	0.497
CLV_PCSK_SKI1_1	297	301	PF00082	0.493
CLV_PCSK_SKI1_1	334	338	PF00082	0.620
CLV_PCSK_SKI1_1	346	350	PF00082	0.495
CLV_PCSK_SKI1_1	368	372	PF00082	0.713
CLV_PCSK_SKI1_1	375	379	PF00082	0.599
CLV_PCSK_SKI1_1	41	45	PF00082	0.269
CLV_PCSK_SKI1_1	438	442	PF00082	0.639
CLV_PCSK_SKI1_1	617	621	PF00082	0.608
CLV_PCSK_SKI1_1	632	636	PF00082	0.558
CLV_PCSK_SKI1_1	708	712	PF00082	0.617
CLV_PCSK_SKI1_1	760	764	PF00082	0.513
CLV_PCSK_SKI1_1	772	776	PF00082	0.554
DEG_APCC_DBOX_1	333	341	PF00400	0.537
DEG_APCC_DBOX_1	437	445	PF00400	0.625
DEG_APCC_DBOX_1	777	785	PF00400	0.493
DEG_SPOP_SBC_1	417	421	PF00917	0.561
DEG_SPOP_SBC_1	473	477	PF00917	0.685
DEG_SPOP_SBC_1	544	548	PF00917	0.682
DOC_CKS1_1	595	600	PF01111	0.605
DOC_MAPK_DCC_7	436	446	PF00069	0.691
DOC_MAPK_gen_1	758	765	PF00069	0.537
DOC_MAPK_MEF2A_6	758	765	PF00069	0.433
DOC_MAPK_NFAT4_5	758	766	PF00069	0.433
DOC_PP1_RVXF_1	1	7	PF00149	0.529
DOC_PP2B_LxvP_1	426	429	PF13499	0.609
DOC_PP2B_LxvP_1	498	501	PF13499	0.593
DOC_PP2B_LxvP_1	739	742	PF13499	0.643
DOC_PP4_MxPP_1	425	428	PF00568	0.625
DOC_USP7_MATH_1	261	265	PF00917	0.679
DOC_USP7_MATH_1	323	327	PF00917	0.745
DOC_USP7_MATH_1	351	355	PF00917	0.524
DOC_USP7_MATH_1	417	421	PF00917	0.654
DOC_USP7_MATH_1	430	434	PF00917	0.552
DOC_USP7_MATH_1	472	476	PF00917	0.652
DOC_USP7_MATH_1	523	527	PF00917	0.692
DOC_USP7_MATH_1	585	589	PF00917	0.671
DOC_USP7_MATH_1	603	607	PF00917	0.599
DOC_USP7_MATH_1	649	653	PF00917	0.593
DOC_USP7_UBL2_3	192	196	PF12436	0.473
DOC_USP7_UBL2_3	392	396	PF12436	0.727
DOC_WW_Pin1_4	353	358	PF00397	0.766
DOC_WW_Pin1_4	587	592	PF00397	0.665
DOC_WW_Pin1_4	594	599	PF00397	0.614
DOC_WW_Pin1_4	701	706	PF00397	0.584
DOC_WW_Pin1_4	91	96	PF00397	0.469
LIG_14-3-3_CanoR_1	33	38	PF00244	0.478
LIG_14-3-3_CanoR_1	368	377	PF00244	0.620
LIG_14-3-3_CanoR_1	572	577	PF00244	0.468
LIG_14-3-3_CanoR_1	602	608	PF00244	0.494
LIG_14-3-3_CanoR_1	617	625	PF00244	0.571
LIG_14-3-3_CanoR_1	648	654	PF00244	0.637
LIG_Actin_WH2_2	749	766	PF00022	0.492
LIG_APCC_ABBA_1	277	282	PF00400	0.549
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BIR_III_4	129	133	PF00653	0.573
LIG_BIR_III_4	316	320	PF00653	0.606
LIG_BRCT_BRCA1_1	361	365	PF00533	0.607
LIG_EVH1_1	426	430	PF00568	0.611
LIG_FHA_1	180	186	PF00498	0.459
LIG_FHA_1	220	226	PF00498	0.530
LIG_FHA_1	365	371	PF00498	0.750
LIG_FHA_1	495	501	PF00498	0.641
LIG_FHA_1	512	518	PF00498	0.683
LIG_FHA_1	698	704	PF00498	0.558
LIG_FHA_1	764	770	PF00498	0.492
LIG_FHA_2	10	16	PF00498	0.472
LIG_FHA_2	155	161	PF00498	0.458
LIG_FHA_2	445	451	PF00498	0.726
LIG_FHA_2	555	561	PF00498	0.590
LIG_FHA_2	588	594	PF00498	0.674
LIG_FHA_2	595	601	PF00498	0.603
LIG_FHA_2	616	622	PF00498	0.753
LIG_FHA_2	795	801	PF00498	0.446
LIG_LIR_Apic_2	51	56	PF02991	0.478
LIG_LIR_Gen_1	106	115	PF02991	0.371
LIG_LIR_Gen_1	271	280	PF02991	0.598
LIG_LIR_Gen_1	30	38	PF02991	0.469
LIG_LIR_Gen_1	493	503	PF02991	0.568
LIG_LIR_Gen_1	693	702	PF02991	0.522
LIG_LIR_Nem_3	106	112	PF02991	0.368
LIG_LIR_Nem_3	271	277	PF02991	0.612
LIG_LIR_Nem_3	30	34	PF02991	0.469
LIG_LIR_Nem_3	48	53	PF02991	0.583
LIG_LIR_Nem_3	493	498	PF02991	0.582
LIG_LIR_Nem_3	693	697	PF02991	0.517
LIG_Pex14_2	79	83	PF04695	0.467
LIG_SH2_CRK	712	716	PF00017	0.527
LIG_SH2_PTP2	98	101	PF00017	0.401
LIG_SH2_SRC	53	56	PF00017	0.532
LIG_SH2_STAT3	119	122	PF00017	0.422
LIG_SH2_STAT3	280	283	PF00017	0.539
LIG_SH2_STAT3	802	805	PF00017	0.565
LIG_SH2_STAT5	109	112	PF00017	0.359
LIG_SH2_STAT5	119	122	PF00017	0.442
LIG_SH2_STAT5	53	56	PF00017	0.532
LIG_SH2_STAT5	714	717	PF00017	0.534
LIG_SH2_STAT5	747	750	PF00017	0.562
LIG_SH2_STAT5	98	101	PF00017	0.401
LIG_SH3_3	424	430	PF00018	0.611
LIG_SH3_3	463	469	PF00018	0.753
LIG_SH3_3	650	656	PF00018	0.497
LIG_SUMO_SIM_par_1	442	447	PF11976	0.690
LIG_TRAF2_1	157	160	PF00917	0.450
LIG_TRAF2_1	234	237	PF00917	0.497
LIG_TRAF2_1	391	394	PF00917	0.592
LIG_TRAF2_1	447	450	PF00917	0.723
LIG_TRAF2_1	65	68	PF00917	0.469
LIG_WRC_WIRS_1	141	146	PF05994	0.488
LIG_WW_2	429	432	PF00397	0.668
MOD_CDK_SPxxK_3	701	708	PF00069	0.537
MOD_CK1_1	140	146	PF00069	0.494
MOD_CK1_1	327	333	PF00069	0.607
MOD_CK1_1	350	356	PF00069	0.740
MOD_CK1_1	36	42	PF00069	0.304
MOD_CK1_1	416	422	PF00069	0.595
MOD_CK1_1	475	481	PF00069	0.641
MOD_CK1_1	624	630	PF00069	0.565
MOD_CK2_1	154	160	PF00069	0.462
MOD_CK2_1	210	216	PF00069	0.455
MOD_CK2_1	355	361	PF00069	0.708
MOD_CK2_1	444	450	PF00069	0.727
MOD_CK2_1	476	482	PF00069	0.650
MOD_CK2_1	554	560	PF00069	0.599
MOD_CK2_1	594	600	PF00069	0.608
MOD_CK2_1	603	609	PF00069	0.531
MOD_CK2_1	62	68	PF00069	0.333
MOD_CK2_1	9	15	PF00069	0.352
MOD_GlcNHglycan	168	171	PF01048	0.506
MOD_GlcNHglycan	219	222	PF01048	0.521
MOD_GlcNHglycan	263	266	PF01048	0.577
MOD_GlcNHglycan	312	315	PF01048	0.710
MOD_GlcNHglycan	349	352	PF01048	0.611
MOD_GlcNHglycan	353	356	PF01048	0.605
MOD_GlcNHglycan	407	410	PF01048	0.710
MOD_GlcNHglycan	415	418	PF01048	0.612
MOD_GlcNHglycan	421	424	PF01048	0.567
MOD_GlcNHglycan	478	481	PF01048	0.655
MOD_GlcNHglycan	538	542	PF01048	0.696
MOD_GlcNHglycan	547	550	PF01048	0.660
MOD_GlcNHglycan	613	616	PF01048	0.679
MOD_GlcNHglycan	626	629	PF01048	0.575
MOD_GSK3_1	160	167	PF00069	0.658
MOD_GSK3_1	217	224	PF00069	0.506
MOD_GSK3_1	323	330	PF00069	0.651
MOD_GSK3_1	346	353	PF00069	0.751
MOD_GSK3_1	355	362	PF00069	0.613
MOD_GSK3_1	364	371	PF00069	0.487
MOD_GSK3_1	375	382	PF00069	0.520
MOD_GSK3_1	413	420	PF00069	0.605
MOD_GSK3_1	472	479	PF00069	0.628
MOD_GSK3_1	517	524	PF00069	0.713
MOD_GSK3_1	545	552	PF00069	0.615
MOD_GSK3_1	611	618	PF00069	0.638
MOD_GSK3_1	624	631	PF00069	0.691
MOD_GSK3_1	697	704	PF00069	0.640
MOD_GSK3_1	790	797	PF00069	0.494
MOD_GSK3_1	84	91	PF00069	0.325
MOD_N-GLC_1	544	549	PF02516	0.618
MOD_NEK2_1	180	185	PF00069	0.436
MOD_NEK2_1	225	230	PF00069	0.548
MOD_NEK2_1	359	364	PF00069	0.721
MOD_NEK2_1	395	400	PF00069	0.525
MOD_NEK2_1	402	407	PF00069	0.618
MOD_NEK2_1	418	423	PF00069	0.587
MOD_NEK2_1	637	642	PF00069	0.605
MOD_NEK2_1	721	726	PF00069	0.506
MOD_NEK2_2	221	226	PF00069	0.510
MOD_PIKK_1	41	47	PF00454	0.324
MOD_PIKK_1	549	555	PF00454	0.532
MOD_PIKK_1	632	638	PF00454	0.682
MOD_PIKK_1	670	676	PF00454	0.578
MOD_PK_1	442	448	PF00069	0.664
MOD_PK_1	572	578	PF00069	0.469
MOD_PKA_2	154	160	PF00069	0.462
MOD_PKA_2	225	231	PF00069	0.515
MOD_PKA_2	261	267	PF00069	0.679
MOD_PKA_2	579	585	PF00069	0.608
MOD_PKA_2	763	769	PF00069	0.520
MOD_Plk_1	255	261	PF00069	0.538
MOD_Plk_1	452	458	PF00069	0.648
MOD_Plk_1	632	638	PF00069	0.622
MOD_Plk_1	794	800	PF00069	0.466
MOD_Plk_2-3	137	143	PF00069	0.544
MOD_Plk_2-3	255	261	PF00069	0.526
MOD_Plk_2-3	62	68	PF00069	0.304
MOD_Plk_4	140	146	PF00069	0.494
MOD_Plk_4	33	39	PF00069	0.340
MOD_Plk_4	355	361	PF00069	0.616
MOD_Plk_4	603	609	PF00069	0.522
MOD_ProDKin_1	353	359	PF00069	0.767
MOD_ProDKin_1	587	593	PF00069	0.668
MOD_ProDKin_1	594	600	PF00069	0.612
MOD_ProDKin_1	701	707	PF00069	0.583
MOD_ProDKin_1	91	97	PF00069	0.304
MOD_SUMO_for_1	112	115	PF00179	0.373
MOD_SUMO_for_1	209	212	PF00179	0.451
MOD_SUMO_for_1	391	394	PF00179	0.603
MOD_SUMO_rev_2	278	286	PF00179	0.556
MOD_SUMO_rev_2	390	398	PF00179	0.545
MOD_SUMO_rev_2	65	73	PF00179	0.304
TRG_DiLeu_BaEn_1	68	73	PF01217	0.304
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.304
TRG_ENDOCYTIC_2	109	112	PF00928	0.359
TRG_ENDOCYTIC_2	712	715	PF00928	0.530
TRG_ER_diArg_1	148	151	PF00400	0.488
TRG_ER_diArg_1	758	761	PF00400	0.694
TRG_ER_diArg_1	777	779	PF00400	0.487
TRG_NLS_MonoExtC_3	228	233	PF00514	0.510
TRG_NLS_MonoExtN_4	226	233	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	779	783	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC2	Leptomonas seymouri	54%	100%
A0A3S7WUG8	Leishmania donovani	92%	100%
A4H921	Leishmania braziliensis	81%	100%
A4HXF3	Leishmania infantum	92%	100%
E9AR48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%