Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEB4_LEIMA

TriTrypDb:

LmjF.17.0720 , LMJLV39_170014700 , LMJSD75_170014300

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.397
CLV_C14_Caspase3-7	533	537	PF00656	0.598
CLV_NRD_NRD_1	136	138	PF00675	0.382
CLV_NRD_NRD_1	547	549	PF00675	0.540
CLV_NRD_NRD_1	737	739	PF00675	0.446
CLV_NRD_NRD_1	96	98	PF00675	0.652
CLV_PCSK_KEX2_1	34	36	PF00082	0.378
CLV_PCSK_KEX2_1	547	549	PF00082	0.540
CLV_PCSK_KEX2_1	737	739	PF00082	0.451
CLV_PCSK_KEX2_1	96	98	PF00082	0.644
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.438
CLV_PCSK_SKI1_1	34	38	PF00082	0.345
CLV_PCSK_SKI1_1	410	414	PF00082	0.344
CLV_PCSK_SKI1_1	451	455	PF00082	0.775
CLV_PCSK_SKI1_1	547	551	PF00082	0.543
CLV_PCSK_SKI1_1	559	563	PF00082	0.536
CLV_PCSK_SKI1_1	763	767	PF00082	0.492
CLV_Separin_Metazoa	414	418	PF03568	0.425
DEG_APCC_DBOX_1	736	744	PF00400	0.387
DEG_SPOP_SBC_1	123	127	PF00917	0.722
DEG_SPOP_SBC_1	255	259	PF00917	0.519
DOC_CKS1_1	219	224	PF01111	0.621
DOC_CKS1_1	3	8	PF01111	0.590
DOC_CKS1_1	402	407	PF01111	0.592
DOC_CKS1_1	560	565	PF01111	0.546
DOC_CYCLIN_RxL_1	152	161	PF00134	0.444
DOC_MAPK_gen_1	137	144	PF00069	0.365
DOC_MAPK_gen_1	276	285	PF00069	0.448
DOC_MAPK_gen_1	547	553	PF00069	0.516
DOC_MAPK_MEF2A_6	137	144	PF00069	0.425
DOC_MAPK_MEF2A_6	19	26	PF00069	0.424
DOC_MAPK_MEF2A_6	291	298	PF00069	0.358
DOC_MAPK_NFAT4_5	19	27	PF00069	0.429
DOC_PP1_RVXF_1	153	160	PF00149	0.460
DOC_PP1_RVXF_1	388	395	PF00149	0.472
DOC_PP2B_LxvP_1	162	165	PF13499	0.408
DOC_PP2B_LxvP_1	781	784	PF13499	0.383
DOC_PP4_FxxP_1	298	301	PF00568	0.323
DOC_PP4_FxxP_1	413	416	PF00568	0.406
DOC_PP4_MxPP_1	1	4	PF00568	0.573
DOC_USP7_MATH_1	123	127	PF00917	0.558
DOC_USP7_MATH_1	256	260	PF00917	0.545
DOC_USP7_MATH_1	310	314	PF00917	0.527
DOC_USP7_MATH_1	348	352	PF00917	0.550
DOC_USP7_MATH_1	353	357	PF00917	0.491
DOC_USP7_MATH_1	461	465	PF00917	0.570
DOC_USP7_MATH_1	632	636	PF00917	0.441
DOC_USP7_MATH_1	643	647	PF00917	0.587
DOC_USP7_MATH_1	677	681	PF00917	0.367
DOC_USP7_MATH_2	67	73	PF00917	0.452
DOC_WW_Pin1_4	2	7	PF00397	0.623
DOC_WW_Pin1_4	218	223	PF00397	0.582
DOC_WW_Pin1_4	260	265	PF00397	0.485
DOC_WW_Pin1_4	344	349	PF00397	0.431
DOC_WW_Pin1_4	401	406	PF00397	0.588
DOC_WW_Pin1_4	44	49	PF00397	0.594
DOC_WW_Pin1_4	451	456	PF00397	0.575
DOC_WW_Pin1_4	480	485	PF00397	0.290
DOC_WW_Pin1_4	559	564	PF00397	0.546
DOC_WW_Pin1_4	648	653	PF00397	0.463
LIG_14-3-3_CanoR_1	108	116	PF00244	0.660
LIG_14-3-3_CanoR_1	155	160	PF00244	0.373
LIG_14-3-3_CanoR_1	361	366	PF00244	0.449
LIG_14-3-3_CanoR_1	390	395	PF00244	0.548
LIG_14-3-3_CanoR_1	417	421	PF00244	0.476
LIG_14-3-3_CanoR_1	645	650	PF00244	0.524
LIG_14-3-3_CanoR_1	692	700	PF00244	0.504
LIG_Actin_WH2_2	408	423	PF00022	0.434
LIG_Actin_WH2_2	554	569	PF00022	0.516
LIG_Actin_WH2_2	608	626	PF00022	0.510
LIG_BIR_III_4	443	447	PF00653	0.509
LIG_BIR_III_4	460	464	PF00653	0.449
LIG_BRCT_BRCA1_1	310	314	PF00533	0.534
LIG_BRCT_BRCA1_1	356	360	PF00533	0.510
LIG_DLG_GKlike_1	155	162	PF00625	0.341
LIG_DLG_GKlike_1	361	368	PF00625	0.445
LIG_EVH1_2	222	226	PF00568	0.524
LIG_FHA_1	144	150	PF00498	0.397
LIG_FHA_1	219	225	PF00498	0.778
LIG_FHA_1	255	261	PF00498	0.613
LIG_FHA_1	357	363	PF00498	0.368
LIG_FHA_1	54	60	PF00498	0.494
LIG_FHA_2	102	108	PF00498	0.505
LIG_FHA_2	11	17	PF00498	0.514
LIG_FHA_2	183	189	PF00498	0.642
LIG_FHA_2	402	408	PF00498	0.481
LIG_FHA_2	560	566	PF00498	0.548
LIG_FHA_2	620	626	PF00498	0.661
LIG_LIR_Apic_2	295	301	PF02991	0.318
LIG_LIR_Apic_2	399	405	PF02991	0.519
LIG_LIR_Apic_2	557	563	PF02991	0.540
LIG_LIR_Apic_2	663	667	PF02991	0.482
LIG_LIR_Gen_1	13	22	PF02991	0.484
LIG_LIR_Gen_1	158	165	PF02991	0.528
LIG_LIR_Gen_1	29	37	PF02991	0.440
LIG_LIR_Gen_1	321	331	PF02991	0.467
LIG_LIR_Gen_1	499	508	PF02991	0.432
LIG_LIR_Gen_1	607	617	PF02991	0.552
LIG_LIR_LC3C_4	475	480	PF02991	0.404
LIG_LIR_Nem_3	13	18	PF02991	0.482
LIG_LIR_Nem_3	158	162	PF02991	0.496
LIG_LIR_Nem_3	214	220	PF02991	0.544
LIG_LIR_Nem_3	29	33	PF02991	0.373
LIG_LIR_Nem_3	311	317	PF02991	0.481
LIG_LIR_Nem_3	321	326	PF02991	0.488
LIG_LIR_Nem_3	364	368	PF02991	0.432
LIG_LIR_Nem_3	387	392	PF02991	0.623
LIG_LIR_Nem_3	39	43	PF02991	0.364
LIG_LIR_Nem_3	499	503	PF02991	0.435
LIG_LIR_Nem_3	607	612	PF02991	0.550
LIG_LIR_Nem_3	707	711	PF02991	0.320
LIG_MYND_1	373	377	PF01753	0.525
LIG_Pex14_1	385	389	PF04695	0.504
LIG_Rb_LxCxE_1	651	668	PF01857	0.359
LIG_SH2_CRK	136	140	PF00017	0.429
LIG_SH2_CRK	15	19	PF00017	0.571
LIG_SH2_CRK	217	221	PF00017	0.659
LIG_SH2_CRK	30	34	PF00017	0.321
LIG_SH2_CRK	389	393	PF00017	0.476
LIG_SH2_NCK_1	402	406	PF00017	0.562
LIG_SH2_NCK_1	609	613	PF00017	0.488
LIG_SH2_PTP2	500	503	PF00017	0.314
LIG_SH2_SRC	15	18	PF00017	0.410
LIG_SH2_STAP1	511	515	PF00017	0.469
LIG_SH2_STAP1	711	715	PF00017	0.371
LIG_SH2_STAT5	134	137	PF00017	0.410
LIG_SH2_STAT5	411	414	PF00017	0.341
LIG_SH2_STAT5	500	503	PF00017	0.338
LIG_SH2_STAT5	664	667	PF00017	0.480
LIG_SH3_3	1	7	PF00018	0.798
LIG_SH3_3	126	132	PF00018	0.536
LIG_SH3_3	186	192	PF00018	0.635
LIG_SH3_3	193	199	PF00018	0.586
LIG_SH3_3	216	222	PF00018	0.556
LIG_SH3_3	261	267	PF00018	0.444
LIG_SH3_3	298	304	PF00018	0.385
LIG_SH3_3	367	373	PF00018	0.494
LIG_SH3_3	395	401	PF00018	0.496
LIG_SH3_3	755	761	PF00018	0.554
LIG_SH3_5	704	708	PF00018	0.364
LIG_SH3_CIN85_PxpxPR_1	7	12	PF14604	0.498
LIG_SUMO_SIM_anti_2	475	480	PF11976	0.391
LIG_SUMO_SIM_anti_2	499	506	PF11976	0.438
LIG_SUMO_SIM_anti_2	611	616	PF11976	0.517
LIG_SUMO_SIM_anti_2	680	686	PF11976	0.351
LIG_SUMO_SIM_anti_2	785	792	PF11976	0.478
LIG_SUMO_SIM_par_1	58	64	PF11976	0.449
LIG_SUMO_SIM_par_1	680	686	PF11976	0.351
LIG_SUMO_SIM_par_1	785	792	PF11976	0.454
LIG_SxIP_EBH_1	190	201	PF03271	0.552
LIG_TRAF2_1	211	214	PF00917	0.629
LIG_TRAF2_1	341	344	PF00917	0.381
LIG_TRAF2_1	404	407	PF00917	0.597
LIG_TRAF2_1	434	437	PF00917	0.520
LIG_TRAF2_1	48	51	PF00917	0.413
LIG_TRAF2_1	562	565	PF00917	0.555
LIG_TRAF2_1	588	591	PF00917	0.558
LIG_TRAF2_1	597	600	PF00917	0.502
LIG_TYR_ITIM	498	503	PF00017	0.431
LIG_TYR_ITSM	11	18	PF00017	0.437
LIG_TYR_ITSM	605	612	PF00017	0.493
LIG_WRC_WIRS_1	362	367	PF05994	0.489
MOD_CDK_SPK_2	7	12	PF00069	0.564
MOD_CDK_SPxxK_3	480	487	PF00069	0.284
MOD_CDK_SPxxK_3	648	655	PF00069	0.556
MOD_CK1_1	10	16	PF00069	0.506
MOD_CK1_1	176	182	PF00069	0.671
MOD_CK1_1	258	264	PF00069	0.513
MOD_CK1_1	347	353	PF00069	0.640
MOD_CK1_1	354	360	PF00069	0.515
MOD_CK1_1	44	50	PF00069	0.468
MOD_CK1_1	648	654	PF00069	0.487
MOD_CK2_1	401	407	PF00069	0.552
MOD_CK2_1	499	505	PF00069	0.435
MOD_CK2_1	551	557	PF00069	0.580
MOD_CK2_1	559	565	PF00069	0.549
MOD_CK2_1	567	573	PF00069	0.606
MOD_CK2_1	594	600	PF00069	0.746
MOD_CK2_1	786	792	PF00069	0.412
MOD_CMANNOS	99	102	PF00535	0.640
MOD_Cter_Amidation	545	548	PF01082	0.565
MOD_Cter_Amidation	94	97	PF01082	0.531
MOD_GlcNHglycan	109	112	PF01048	0.576
MOD_GlcNHglycan	126	129	PF01048	0.689
MOD_GlcNHglycan	230	233	PF01048	0.610
MOD_GlcNHglycan	286	289	PF01048	0.392
MOD_GlcNHglycan	309	313	PF01048	0.530
MOD_GlcNHglycan	350	353	PF01048	0.626
MOD_GlcNHglycan	356	359	PF01048	0.538
MOD_GlcNHglycan	432	435	PF01048	0.461
MOD_GlcNHglycan	544	547	PF01048	0.693
MOD_GlcNHglycan	628	631	PF01048	0.579
MOD_GlcNHglycan	634	637	PF01048	0.502
MOD_GlcNHglycan	641	644	PF01048	0.560
MOD_GlcNHglycan	685	688	PF01048	0.391
MOD_GlcNHglycan	81	84	PF01048	0.612
MOD_GlcNHglycan	90	93	PF01048	0.534
MOD_GSK3_1	175	182	PF00069	0.642
MOD_GSK3_1	254	261	PF00069	0.522
MOD_GSK3_1	270	277	PF00069	0.423
MOD_GSK3_1	299	306	PF00069	0.415
MOD_GSK3_1	344	351	PF00069	0.435
MOD_GSK3_1	371	378	PF00069	0.462
MOD_GSK3_1	619	626	PF00069	0.597
MOD_GSK3_1	639	646	PF00069	0.542
MOD_GSK3_1	782	789	PF00069	0.432
MOD_N-GLC_1	166	171	PF02516	0.494
MOD_N-GLC_1	480	485	PF02516	0.421
MOD_N-GLC_1	582	587	PF02516	0.580
MOD_NEK2_1	168	173	PF00069	0.575
MOD_NEK2_1	392	397	PF00069	0.503
MOD_NEK2_1	41	46	PF00069	0.558
MOD_NEK2_1	428	433	PF00069	0.434
MOD_NEK2_1	59	64	PF00069	0.249
MOD_NEK2_1	623	628	PF00069	0.646
MOD_NEK2_1	678	683	PF00069	0.538
MOD_NEK2_2	310	315	PF00069	0.522
MOD_NEK2_2	416	421	PF00069	0.439
MOD_NEK2_2	619	624	PF00069	0.546
MOD_PIKK_1	602	608	PF00454	0.632
MOD_PKA_2	107	113	PF00069	0.641
MOD_PKA_2	275	281	PF00069	0.462
MOD_PKA_2	416	422	PF00069	0.391
MOD_PKA_2	623	629	PF00069	0.581
MOD_Plk_1	472	478	PF00069	0.407
MOD_Plk_1	582	588	PF00069	0.723
MOD_Plk_1	619	625	PF00069	0.590
MOD_Plk_1	777	783	PF00069	0.478
MOD_Plk_2-3	472	478	PF00069	0.421
MOD_Plk_2-3	499	505	PF00069	0.432
MOD_Plk_2-3	786	792	PF00069	0.469
MOD_Plk_4	499	505	PF00069	0.420
MOD_Plk_4	660	666	PF00069	0.463
MOD_Plk_4	678	684	PF00069	0.396
MOD_Plk_4	720	726	PF00069	0.417
MOD_Plk_4	786	792	PF00069	0.469
MOD_ProDKin_1	2	8	PF00069	0.620
MOD_ProDKin_1	218	224	PF00069	0.584
MOD_ProDKin_1	260	266	PF00069	0.476
MOD_ProDKin_1	344	350	PF00069	0.436
MOD_ProDKin_1	401	407	PF00069	0.580
MOD_ProDKin_1	44	50	PF00069	0.596
MOD_ProDKin_1	451	457	PF00069	0.573
MOD_ProDKin_1	480	486	PF00069	0.283
MOD_ProDKin_1	559	565	PF00069	0.546
MOD_ProDKin_1	648	654	PF00069	0.459
MOD_SUMO_rev_2	564	569	PF00179	0.517
TRG_DiLeu_BaEn_1	321	326	PF01217	0.366
TRG_DiLeu_BaEn_1	499	504	PF01217	0.429
TRG_DiLeu_BaEn_4	387	393	PF01217	0.378
TRG_ENDOCYTIC_2	136	139	PF00928	0.458
TRG_ENDOCYTIC_2	15	18	PF00928	0.563
TRG_ENDOCYTIC_2	217	220	PF00928	0.656
TRG_ENDOCYTIC_2	30	33	PF00928	0.325
TRG_ENDOCYTIC_2	389	392	PF00928	0.487
TRG_ENDOCYTIC_2	500	503	PF00928	0.430
TRG_ENDOCYTIC_2	511	514	PF00928	0.468
TRG_ENDOCYTIC_2	609	612	PF00928	0.488
TRG_ER_diArg_1	547	549	PF00400	0.696
TRG_ER_diArg_1	736	738	PF00400	0.449
TRG_ER_diArg_1	96	98	PF00400	0.638
TRG_NES_CRM1_1	709	722	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	513	518	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L1	Leptomonas seymouri	51%	100%
A0A1X0NSU7	Trypanosomatidae	28%	100%
A0A3R7RDK2	Trypanosoma rangeli	31%	100%
A0A3S7WUG5	Leishmania donovani	89%	100%
A4H922	Leishmania braziliensis	73%	97%
A4HXF4	Leishmania infantum	89%	100%
C9ZP26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AR49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%