Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

OSM3-like kinesin, putative

Species:

Leishmania major

UniProt:

Q4QEB1_LEIMA

TriTrypDb:

LmjF.17.0800 , LMJLV39_170015000 , LMJSD75_170014600

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	7
GO:0005875	microtubule associated complex	2	2
GO:0005929	cilium	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QEB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	797	801	PF00656	0.626
CLV_NRD_NRD_1	203	205	PF00675	0.445
CLV_NRD_NRD_1	611	613	PF00675	0.682
CLV_NRD_NRD_1	860	862	PF00675	0.697
CLV_NRD_NRD_1	876	878	PF00675	0.566
CLV_NRD_NRD_1	906	908	PF00675	0.646
CLV_NRD_NRD_1	925	927	PF00675	0.528
CLV_PCSK_KEX2_1	202	204	PF00082	0.445
CLV_PCSK_KEX2_1	554	556	PF00082	0.728
CLV_PCSK_KEX2_1	611	613	PF00082	0.682
CLV_PCSK_KEX2_1	809	811	PF00082	0.642
CLV_PCSK_KEX2_1	876	878	PF00082	0.646
CLV_PCSK_KEX2_1	905	907	PF00082	0.643
CLV_PCSK_KEX2_1	925	927	PF00082	0.512
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.728
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.642
CLV_PCSK_SKI1_1	120	124	PF00082	0.485
CLV_PCSK_SKI1_1	156	160	PF00082	0.445
CLV_PCSK_SKI1_1	339	343	PF00082	0.398
CLV_PCSK_SKI1_1	369	373	PF00082	0.605
CLV_PCSK_SKI1_1	495	499	PF00082	0.655
CLV_PCSK_SKI1_1	530	534	PF00082	0.701
CLV_PCSK_SKI1_1	640	644	PF00082	0.640
CLV_PCSK_SKI1_1	754	758	PF00082	0.615
CLV_PCSK_SKI1_1	830	834	PF00082	0.619
CLV_PCSK_SKI1_1	861	865	PF00082	0.610
CLV_PCSK_SKI1_1	918	922	PF00082	0.712
CLV_Separin_Metazoa	492	496	PF03568	0.761
DEG_APCC_KENBOX_2	24	28	PF00400	0.430
DEG_SPOP_SBC_1	136	140	PF00917	0.430
DOC_CKS1_1	470	475	PF01111	0.743
DOC_CYCLIN_RxL_1	751	758	PF00134	0.620
DOC_MAPK_gen_1	779	788	PF00069	0.701
DOC_MAPK_gen_1	867	874	PF00069	0.646
DOC_MAPK_MEF2A_6	161	168	PF00069	0.445
DOC_MAPK_MEF2A_6	265	274	PF00069	0.445
DOC_MAPK_MEF2A_6	32	39	PF00069	0.445
DOC_MAPK_MEF2A_6	342	349	PF00069	0.563
DOC_MAPK_MEF2A_6	391	399	PF00069	0.682
DOC_PP1_RVXF_1	309	316	PF00149	0.445
DOC_PP4_FxxP_1	470	473	PF00568	0.739
DOC_PP4_FxxP_1	75	78	PF00568	0.441
DOC_USP7_MATH_1	212	216	PF00917	0.423
DOC_USP7_MATH_1	238	242	PF00917	0.445
DOC_USP7_MATH_1	292	296	PF00917	0.445
DOC_USP7_MATH_1	402	406	PF00917	0.584
DOC_USP7_MATH_1	454	458	PF00917	0.624
DOC_USP7_MATH_1	560	564	PF00917	0.752
DOC_USP7_MATH_1	616	620	PF00917	0.754
DOC_USP7_MATH_1	665	669	PF00917	0.709
DOC_USP7_MATH_1	729	733	PF00917	0.649
DOC_USP7_MATH_2	649	655	PF00917	0.716
DOC_USP7_UBL2_3	529	533	PF12436	0.785
DOC_USP7_UBL2_3	766	770	PF12436	0.601
DOC_USP7_UBL2_3	830	834	PF12436	0.619
DOC_WW_Pin1_4	293	298	PF00397	0.445
DOC_WW_Pin1_4	469	474	PF00397	0.740
LIG_14-3-3_CanoR_1	20	29	PF00244	0.547
LIG_14-3-3_CanoR_1	216	221	PF00244	0.547
LIG_14-3-3_CanoR_1	237	246	PF00244	0.445
LIG_14-3-3_CanoR_1	323	332	PF00244	0.445
LIG_14-3-3_CanoR_1	424	428	PF00244	0.645
LIG_14-3-3_CanoR_1	430	435	PF00244	0.632
LIG_14-3-3_CanoR_1	55	59	PF00244	0.445
LIG_14-3-3_CanoR_1	555	559	PF00244	0.821
LIG_14-3-3_CanoR_1	918	924	PF00244	0.770
LIG_14-3-3_CanoR_1	925	931	PF00244	0.747
LIG_Actin_WH2_2	504	521	PF00022	0.638
LIG_Actin_WH2_2	847	863	PF00022	0.605
LIG_APCC_ABBAyCdc20_2	687	693	PF00400	0.743
LIG_Clathr_ClatBox_1	431	435	PF01394	0.732
LIG_Clathr_ClatBox_1	785	789	PF01394	0.630
LIG_deltaCOP1_diTrp_1	461	470	PF00928	0.733
LIG_deltaCOP1_diTrp_1	54	58	PF00928	0.547
LIG_FHA_1	173	179	PF00498	0.547
LIG_FHA_1	226	232	PF00498	0.471
LIG_FHA_1	234	240	PF00498	0.493
LIG_FHA_1	297	303	PF00498	0.445
LIG_FHA_1	358	364	PF00498	0.525
LIG_FHA_1	376	382	PF00498	0.614
LIG_FHA_1	41	47	PF00498	0.547
LIG_FHA_1	427	433	PF00498	0.634
LIG_FHA_1	485	491	PF00498	0.670
LIG_FHA_1	513	519	PF00498	0.709
LIG_FHA_1	623	629	PF00498	0.772
LIG_FHA_1	71	77	PF00498	0.386
LIG_FHA_1	78	84	PF00498	0.386
LIG_FHA_1	780	786	PF00498	0.623
LIG_FHA_2	228	234	PF00498	0.445
LIG_FHA_2	261	267	PF00498	0.445
LIG_FHA_2	277	283	PF00498	0.445
LIG_FHA_2	470	476	PF00498	0.644
LIG_FHA_2	487	493	PF00498	0.652
LIG_FHA_2	526	532	PF00498	0.687
LIG_FHA_2	578	584	PF00498	0.707
LIG_FHA_2	728	734	PF00498	0.754
LIG_FHA_2	735	741	PF00498	0.641
LIG_FHA_2	753	759	PF00498	0.457
LIG_GBD_Chelix_1	362	370	PF00786	0.546
LIG_IRF3_LxIS_1	441	448	PF10401	0.743
LIG_LIR_Apic_2	73	78	PF02991	0.445
LIG_LIR_Gen_1	142	151	PF02991	0.440
LIG_LIR_Gen_1	219	225	PF02991	0.445
LIG_LIR_Gen_1	312	320	PF02991	0.445
LIG_LIR_Gen_1	464	473	PF02991	0.733
LIG_LIR_Gen_1	57	66	PF02991	0.445
LIG_LIR_Gen_1	688	696	PF02991	0.641
LIG_LIR_Gen_1	69	79	PF02991	0.445
LIG_LIR_Nem_3	142	147	PF02991	0.440
LIG_LIR_Nem_3	219	224	PF02991	0.445
LIG_LIR_Nem_3	312	318	PF02991	0.445
LIG_LIR_Nem_3	464	470	PF02991	0.735
LIG_LIR_Nem_3	57	61	PF02991	0.445
LIG_LIR_Nem_3	688	694	PF02991	0.744
LIG_LIR_Nem_3	69	75	PF02991	0.445
LIG_LIR_Nem_3	772	776	PF02991	0.716
LIG_PCNA_yPIPBox_3	111	123	PF02747	0.469
LIG_PCNA_yPIPBox_3	152	161	PF02747	0.445
LIG_Pex14_1	463	467	PF04695	0.731
LIG_Pex14_1	846	850	PF04695	0.603
LIG_PTB_Apo_2	60	67	PF02174	0.445
LIG_Rb_LxCxE_1	222	240	PF01857	0.445
LIG_REV1ctd_RIR_1	174	183	PF16727	0.469
LIG_SH2_STAP1	722	726	PF00017	0.650
LIG_SH2_STAT3	579	582	PF00017	0.658
LIG_SH2_STAT5	144	147	PF00017	0.445
LIG_SH2_STAT5	469	472	PF00017	0.634
LIG_SH2_STAT5	579	582	PF00017	0.704
LIG_SH2_STAT5	773	776	PF00017	0.616
LIG_SH3_3	183	189	PF00018	0.423
LIG_SH3_3	625	631	PF00018	0.811
LIG_SUMO_SIM_par_1	42	48	PF11976	0.547
LIG_SUMO_SIM_par_1	648	657	PF11976	0.754
LIG_SUMO_SIM_par_1	782	789	PF11976	0.626
LIG_TRAF2_1	489	492	PF00917	0.684
LIG_TRAF2_1	506	509	PF00917	0.450
LIG_TRAF2_1	580	583	PF00917	0.658
LIG_TRAF2_1	863	866	PF00917	0.610
LIG_TRAF2_1	901	904	PF00917	0.730
LIG_TRFH_1	469	473	PF08558	0.737
LIG_UBA3_1	586	591	PF00899	0.772
LIG_WRC_WIRS_1	144	149	PF05994	0.445
MOD_CDK_SPxxK_3	469	476	PF00069	0.744
MOD_CK1_1	214	220	PF00069	0.445
MOD_CK1_1	260	266	PF00069	0.445
MOD_CK1_1	296	302	PF00069	0.445
MOD_CK1_1	375	381	PF00069	0.511
MOD_CK1_1	448	454	PF00069	0.643
MOD_CK1_1	654	660	PF00069	0.735
MOD_CK1_1	686	692	PF00069	0.663
MOD_CK1_1	704	710	PF00069	0.452
MOD_CK1_1	919	925	PF00069	0.806
MOD_CK1_1	99	105	PF00069	0.413
MOD_CK2_1	109	115	PF00069	0.469
MOD_CK2_1	143	149	PF00069	0.445
MOD_CK2_1	20	26	PF00069	0.445
MOD_CK2_1	260	266	PF00069	0.445
MOD_CK2_1	469	475	PF00069	0.639
MOD_CK2_1	486	492	PF00069	0.651
MOD_CK2_1	503	509	PF00069	0.450
MOD_CK2_1	518	524	PF00069	0.703
MOD_CK2_1	525	531	PF00069	0.584
MOD_CK2_1	577	583	PF00069	0.711
MOD_CK2_1	727	733	PF00069	0.660
MOD_CK2_1	734	740	PF00069	0.645
MOD_CK2_1	752	758	PF00069	0.459
MOD_CK2_1	774	780	PF00069	0.584
MOD_CK2_1	878	884	PF00069	0.749
MOD_Cter_Amidation	1	4	PF01082	0.732
MOD_GlcNHglycan	259	262	PF01048	0.445
MOD_GlcNHglycan	274	277	PF01048	0.445
MOD_GlcNHglycan	449	453	PF01048	0.736
MOD_GlcNHglycan	618	621	PF01048	0.736
MOD_GlcNHglycan	634	637	PF01048	0.719
MOD_GlcNHglycan	645	648	PF01048	0.814
MOD_GlcNHglycan	656	659	PF01048	0.687
MOD_GlcNHglycan	818	821	PF01048	0.654
MOD_GlcNHglycan	918	921	PF01048	0.791
MOD_GlcNHglycan	96	99	PF01048	0.364
MOD_GSK3_1	135	142	PF00069	0.422
MOD_GSK3_1	212	219	PF00069	0.438
MOD_GSK3_1	233	240	PF00069	0.445
MOD_GSK3_1	272	279	PF00069	0.445
MOD_GSK3_1	292	299	PF00069	0.216
MOD_GSK3_1	323	330	PF00069	0.445
MOD_GSK3_1	412	419	PF00069	0.597
MOD_GSK3_1	426	433	PF00069	0.523
MOD_GSK3_1	632	639	PF00069	0.837
MOD_GSK3_1	734	741	PF00069	0.717
MOD_GSK3_1	812	819	PF00069	0.608
MOD_GSK3_1	925	932	PF00069	0.712
MOD_GSK3_1	99	106	PF00069	0.445
MOD_N-GLC_1	110	115	PF02516	0.469
MOD_N-GLC_1	270	275	PF02516	0.445
MOD_N-GLC_1	323	328	PF02516	0.445
MOD_N-GLC_1	400	405	PF02516	0.595
MOD_N-GLC_1	606	611	PF02516	0.544
MOD_N-GLC_1	62	67	PF02516	0.443
MOD_N-GLC_1	640	645	PF02516	0.717
MOD_N-GLC_1	87	92	PF02516	0.445
MOD_NEK2_1	109	114	PF00069	0.514
MOD_NEK2_1	143	148	PF00069	0.434
MOD_NEK2_1	272	277	PF00069	0.445
MOD_NEK2_1	302	307	PF00069	0.445
MOD_NEK2_1	484	489	PF00069	0.766
MOD_NEK2_1	518	523	PF00069	0.763
MOD_NEK2_1	532	537	PF00069	0.699
MOD_NEK2_1	652	657	PF00069	0.745
MOD_NEK2_1	774	779	PF00069	0.609
MOD_NEK2_1	79	84	PF00069	0.430
MOD_NEK2_1	87	92	PF00069	0.386
MOD_PIKK_1	436	442	PF00454	0.695
MOD_PIKK_1	454	460	PF00454	0.579
MOD_PIKK_1	461	467	PF00454	0.640
MOD_PIKK_1	518	524	PF00454	0.766
MOD_PIKK_1	64	70	PF00454	0.445
MOD_PK_1	216	222	PF00069	0.445
MOD_PK_1	554	560	PF00069	0.715
MOD_PKA_1	554	560	PF00069	0.735
MOD_PKA_1	925	931	PF00069	0.758
MOD_PKA_2	423	429	PF00069	0.642
MOD_PKA_2	525	531	PF00069	0.594
MOD_PKA_2	54	60	PF00069	0.445
MOD_PKA_2	554	560	PF00069	0.735
MOD_PKA_2	686	692	PF00069	0.663
MOD_PKA_2	924	930	PF00069	0.837
MOD_PKB_1	18	26	PF00069	0.445
MOD_PKB_1	202	210	PF00069	0.445
MOD_Plk_1	110	116	PF00069	0.469
MOD_Plk_1	172	178	PF00069	0.547
MOD_Plk_1	270	276	PF00069	0.445
MOD_Plk_1	436	442	PF00069	0.627
MOD_Plk_1	502	508	PF00069	0.685
MOD_Plk_1	577	583	PF00069	0.711
MOD_Plk_1	606	612	PF00069	0.546
MOD_Plk_1	62	68	PF00069	0.423
MOD_Plk_1	704	710	PF00069	0.633
MOD_Plk_1	734	740	PF00069	0.719
MOD_Plk_1	823	829	PF00069	0.645
MOD_Plk_1	87	93	PF00069	0.445
MOD_Plk_2-3	503	509	PF00069	0.535
MOD_Plk_2-3	54	60	PF00069	0.445
MOD_Plk_4	139	145	PF00069	0.451
MOD_Plk_4	172	178	PF00069	0.445
MOD_Plk_4	216	222	PF00069	0.445
MOD_Plk_4	276	282	PF00069	0.445
MOD_Plk_4	296	302	PF00069	0.216
MOD_Plk_4	309	315	PF00069	0.445
MOD_Plk_4	45	51	PF00069	0.547
MOD_Plk_4	686	692	PF00069	0.663
MOD_Plk_4	79	85	PF00069	0.430
MOD_Plk_4	87	93	PF00069	0.445
MOD_Plk_4	919	925	PF00069	0.728
MOD_ProDKin_1	293	299	PF00069	0.445
MOD_ProDKin_1	469	475	PF00069	0.741
MOD_SUMO_for_1	371	374	PF00179	0.627
MOD_SUMO_for_1	546	549	PF00179	0.708
MOD_SUMO_for_1	678	681	PF00179	0.717
MOD_SUMO_for_1	702	705	PF00179	0.700
MOD_SUMO_for_1	901	904	PF00179	0.730
MOD_SUMO_rev_2	350	357	PF00179	0.587
MOD_SUMO_rev_2	513	521	PF00179	0.727
MOD_SUMO_rev_2	548	556	PF00179	0.718
MOD_SUMO_rev_2	578	587	PF00179	0.667
MOD_SUMO_rev_2	672	678	PF00179	0.643
MOD_SUMO_rev_2	721	727	PF00179	0.621
MOD_SUMO_rev_2	794	801	PF00179	0.624
MOD_SUMO_rev_2	847	854	PF00179	0.627
MOD_SUMO_rev_2	859	869	PF00179	0.692
TRG_DiLeu_BaEn_1	870	875	PF01217	0.655
TRG_DiLeu_BaEn_4	383	389	PF01217	0.575
TRG_DiLeu_BaEn_4	605	611	PF01217	0.673
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.738
TRG_DiLeu_LyEn_5	870	875	PF01217	0.655
TRG_ENDOCYTIC_2	144	147	PF00928	0.445
TRG_ENDOCYTIC_2	467	470	PF00928	0.742
TRG_ENDOCYTIC_2	691	694	PF00928	0.643
TRG_ENDOCYTIC_2	773	776	PF00928	0.718
TRG_ER_diArg_1	17	20	PF00400	0.400
TRG_ER_diArg_1	202	204	PF00400	0.445
TRG_ER_diArg_1	610	612	PF00400	0.676
TRG_ER_diArg_1	875	877	PF00400	0.643
TRG_ER_diArg_1	905	907	PF00400	0.741
TRG_ER_diArg_1	924	926	PF00400	0.521
TRG_NES_CRM1_1	387	400	PF08389	0.588
TRG_NES_CRM1_1	436	449	PF08389	0.656
TRG_NLS_MonoExtC_3	829	834	PF00514	0.621
TRG_NLS_MonoExtN_4	828	834	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.733
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.772
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.776
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	862	866	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L3	Leptomonas seymouri	68%	100%
A0A3Q8I9R7	Leishmania donovani	97%	100%
A4H925	Leishmania braziliensis	84%	100%
A4HXF7	Leishmania infantum	97%	100%
E9AR52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%