Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

OSM3-like kinesin, putative

Species:

Leishmania major

UniProt:

Q4QEB1_LEIMA

TriTrypDb:

LmjF.17.0800 , LMJLV39_170015000 , LMJSD75_170014600

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	7
GO:0005875	microtubule associated complex	2	2
GO:0005929	cilium	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0099080	supramolecular complex	2	7

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Expansion

Sequence features

Q4QEB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB1

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	797	801	PF00656	0.626
CLV_NRD_NRD_1	203	205	PF00675	0.445
CLV_NRD_NRD_1	611	613	PF00675	0.682
CLV_NRD_NRD_1	860	862	PF00675	0.697
CLV_NRD_NRD_1	876	878	PF00675	0.566
CLV_NRD_NRD_1	906	908	PF00675	0.646
CLV_NRD_NRD_1	925	927	PF00675	0.528
CLV_PCSK_KEX2_1	202	204	PF00082	0.445
CLV_PCSK_KEX2_1	554	556	PF00082	0.728
CLV_PCSK_KEX2_1	611	613	PF00082	0.682

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L3	Leptomonas seymouri	68%	100%
A0A3Q8I9R7	Leishmania donovani	97%	100%
A4H925	Leishmania braziliensis	84%	100%
A4HXF7	Leishmania infantum	97%	100%
E9AR52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%

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