LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
RNA-binding protein, putative
Species:
Leishmania major
UniProt:
Q4QEB0_LEIMA
TriTrypDb:
LmjF.17.0810 * , LMJLV39_170015100 * , LMJSD75_170014700 *
Length:
378

Annotations

LeishMANIAdb annotations

A Kinetoplastid-specific protein. Unlikely to be a membrane protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEB0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEB0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 3
GO:0005488 binding 1 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.469
CLV_C14_Caspase3-7 187 191 PF00656 0.567
CLV_C14_Caspase3-7 261 265 PF00656 0.563
CLV_NRD_NRD_1 10 12 PF00675 0.427
CLV_NRD_NRD_1 181 183 PF00675 0.538
CLV_NRD_NRD_1 52 54 PF00675 0.588
CLV_PCSK_KEX2_1 10 12 PF00082 0.434
CLV_PCSK_KEX2_1 181 183 PF00082 0.622
CLV_PCSK_KEX2_1 52 54 PF00082 0.588
CLV_PCSK_SKI1_1 126 130 PF00082 0.335
CLV_PCSK_SKI1_1 182 186 PF00082 0.536
DEG_APCC_DBOX_1 125 133 PF00400 0.302
DEG_Nend_UBRbox_3 1 3 PF02207 0.501
DOC_CYCLIN_RxL_1 123 133 PF00134 0.304
DOC_MAPK_MEF2A_6 203 211 PF00069 0.480
DOC_USP7_MATH_1 111 115 PF00917 0.596
DOC_USP7_MATH_1 165 169 PF00917 0.599
DOC_USP7_MATH_1 352 356 PF00917 0.409
DOC_USP7_MATH_1 370 374 PF00917 0.473
DOC_USP7_MATH_1 85 89 PF00917 0.675
DOC_USP7_MATH_2 165 171 PF00917 0.460
DOC_USP7_UBL2_3 278 282 PF12436 0.593
DOC_WW_Pin1_4 262 267 PF00397 0.701
DOC_WW_Pin1_4 341 346 PF00397 0.466
DOC_WW_Pin1_4 83 88 PF00397 0.637
LIG_14-3-3_CanoR_1 172 176 PF00244 0.534
LIG_14-3-3_CanoR_1 196 204 PF00244 0.423
LIG_14-3-3_CanoR_1 240 248 PF00244 0.524
LIG_14-3-3_CanoR_1 41 47 PF00244 0.428
LIG_Actin_WH2_2 322 340 PF00022 0.475
LIG_BIR_III_4 190 194 PF00653 0.489
LIG_CtBP_PxDLS_1 208 212 PF00389 0.495
LIG_FHA_1 131 137 PF00498 0.447
LIG_FHA_1 240 246 PF00498 0.571
LIG_FHA_1 312 318 PF00498 0.404
LIG_FHA_1 41 47 PF00498 0.468
LIG_FHA_1 7 13 PF00498 0.458
LIG_FHA_1 75 81 PF00498 0.508
LIG_FHA_2 185 191 PF00498 0.424
LIG_FHA_2 338 344 PF00498 0.439
LIG_Integrin_isoDGR_2 67 69 PF01839 0.497
LIG_Integrin_RGD_1 301 303 PF01839 0.627
LIG_LIR_Gen_1 312 323 PF02991 0.254
LIG_LIR_Nem_3 312 318 PF02991 0.249
LIG_NRBOX 124 130 PF00104 0.307
LIG_Pex14_2 315 319 PF04695 0.253
LIG_PTB_Apo_2 330 337 PF02174 0.342
LIG_PTB_Phospho_1 330 336 PF10480 0.344
LIG_SH2_STAT5 274 277 PF00017 0.606
LIG_SH2_STAT5 336 339 PF00017 0.528
LIG_SH3_3 107 113 PF00018 0.555
LIG_SH3_3 346 352 PF00018 0.393
LIG_SUMO_SIM_anti_2 4 9 PF11976 0.461
LIG_SUMO_SIM_par_1 108 115 PF11976 0.406
LIG_SUMO_SIM_par_1 346 351 PF11976 0.374
LIG_SUMO_SIM_par_1 4 9 PF11976 0.486
LIG_TRAF2_1 258 261 PF00917 0.590
LIG_WRC_WIRS_1 185 190 PF05994 0.419
MOD_CDK_SPxxK_3 83 90 PF00069 0.487
MOD_CK1_1 168 174 PF00069 0.524
MOD_CK1_1 241 247 PF00069 0.502
MOD_CK1_1 277 283 PF00069 0.620
MOD_CK1_1 284 290 PF00069 0.574
MOD_CK2_1 337 343 PF00069 0.428
MOD_GlcNHglycan 114 117 PF01048 0.511
MOD_GlcNHglycan 151 154 PF01048 0.575
MOD_GlcNHglycan 283 286 PF01048 0.575
MOD_GlcNHglycan 289 292 PF01048 0.602
MOD_GlcNHglycan 320 323 PF01048 0.470
MOD_GlcNHglycan 354 357 PF01048 0.464
MOD_GlcNHglycan 87 90 PF01048 0.627
MOD_GSK3_1 159 166 PF00069 0.567
MOD_GSK3_1 167 174 PF00069 0.503
MOD_GSK3_1 192 199 PF00069 0.418
MOD_GSK3_1 273 280 PF00069 0.654
MOD_GSK3_1 283 290 PF00069 0.538
MOD_GSK3_1 337 344 PF00069 0.577
MOD_GSK3_1 370 377 PF00069 0.469
MOD_GSK3_1 58 65 PF00069 0.579
MOD_GSK3_1 98 105 PF00069 0.627
MOD_NEK2_1 149 154 PF00069 0.616
MOD_NEK2_1 6 11 PF00069 0.463
MOD_PIKK_1 196 202 PF00454 0.354
MOD_PIKK_1 370 376 PF00454 0.447
MOD_PKA_2 171 177 PF00069 0.474
MOD_PKA_2 195 201 PF00069 0.441
MOD_PKA_2 239 245 PF00069 0.594
MOD_PKA_2 337 343 PF00069 0.538
MOD_PKA_2 40 46 PF00069 0.520
MOD_Plk_4 159 165 PF00069 0.604
MOD_Plk_4 171 177 PF00069 0.457
MOD_ProDKin_1 262 268 PF00069 0.701
MOD_ProDKin_1 341 347 PF00069 0.454
MOD_ProDKin_1 83 89 PF00069 0.636
TRG_ER_diArg_1 10 12 PF00400 0.435
TRG_ER_diArg_1 181 183 PF00400 0.534
TRG_Pf-PMV_PEXEL_1 126 131 PF00026 0.302
TRG_Pf-PMV_PEXEL_1 217 222 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 31 35 PF00026 0.526

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKU0 Leptomonas seymouri 43% 73%
A0A1X0NT51 Trypanosomatidae 26% 76%
A0A3Q8ICU3 Leishmania donovani 93% 100%
A0A3R7JY32 Trypanosoma rangeli 26% 83%
A4H944 Leishmania braziliensis 76% 99%
C9ZP32 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 81%
E9AR53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5B6D3 Trypanosoma cruzi 29% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS