G-patch domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEA9_LEIMA

TriTrypDb:

LmjF.17.0815 , LMJLV39_170015200 , LMJSD75_170014800

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QEA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEA9

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0090069	regulation of ribosome biogenesis	5	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.797
CLV_C14_Caspase3-7	149	153	PF00656	0.706
CLV_C14_Caspase3-7	155	159	PF00656	0.641
CLV_C14_Caspase3-7	95	99	PF00656	0.731
CLV_NRD_NRD_1	139	141	PF00675	0.682
CLV_NRD_NRD_1	35	37	PF00675	0.369
CLV_NRD_NRD_1	75	77	PF00675	0.663
CLV_PCSK_FUR_1	137	141	PF00082	0.676
CLV_PCSK_KEX2_1	136	138	PF00082	0.750
CLV_PCSK_KEX2_1	139	141	PF00082	0.748
CLV_PCSK_KEX2_1	160	162	PF00082	0.738
CLV_PCSK_KEX2_1	201	203	PF00082	0.588
CLV_PCSK_KEX2_1	35	37	PF00082	0.344
CLV_PCSK_KEX2_1	77	79	PF00082	0.611
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.750
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.738
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.663
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.611
CLV_PCSK_PC7_1	132	138	PF00082	0.788
CLV_PCSK_PC7_1	156	162	PF00082	0.694
CLV_PCSK_SKI1_1	176	180	PF00082	0.559
DEG_SPOP_SBC_1	113	117	PF00917	0.672
DEG_SPOP_SBC_1	141	145	PF00917	0.711
DOC_USP7_MATH_1	113	117	PF00917	0.760
DOC_USP7_MATH_1	146	150	PF00917	0.744
DOC_USP7_UBL2_3	122	126	PF12436	0.741
DOC_USP7_UBL2_3	28	32	PF12436	0.414
DOC_USP7_UBL2_3	7	11	PF12436	0.444
DOC_USP7_UBL2_3	73	77	PF12436	0.571
DOC_WW_Pin1_4	142	147	PF00397	0.714
LIG_14-3-3_CanoR_1	140	146	PF00244	0.639
LIG_14-3-3_CanoR_1	172	179	PF00244	0.606
LIG_14-3-3_CanoR_1	78	87	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_FHA_1	57	63	PF00498	0.628
LIG_FHA_2	32	38	PF00498	0.369
LIG_FHA_2	90	96	PF00498	0.677
LIG_LIR_Gen_1	29	38	PF02991	0.344
LIG_LIR_Nem_3	29	33	PF02991	0.344
LIG_LIR_Nem_3	65	71	PF02991	0.560
LIG_SH2_CRK	68	72	PF00017	0.592
LIG_SH2_PTP2	30	33	PF00017	0.348
LIG_SH2_STAT5	30	33	PF00017	0.348
MOD_CK1_1	104	110	PF00069	0.727
MOD_CK1_1	111	117	PF00069	0.645
MOD_CK1_1	118	124	PF00069	0.585
MOD_CK1_1	144	150	PF00069	0.686
MOD_CK1_1	159	165	PF00069	0.544
MOD_CK1_1	55	61	PF00069	0.602
MOD_CK2_1	118	124	PF00069	0.600
MOD_CK2_1	159	165	PF00069	0.656
MOD_CK2_1	171	177	PF00069	0.682
MOD_CK2_1	90	96	PF00069	0.721
MOD_GlcNHglycan	1	4	PF01048	0.560
MOD_GlcNHglycan	110	113	PF01048	0.687
MOD_GlcNHglycan	117	120	PF01048	0.636
MOD_GlcNHglycan	148	151	PF01048	0.784
MOD_GlcNHglycan	23	27	PF01048	0.432
MOD_GSK3_1	101	108	PF00069	0.712
MOD_GSK3_1	111	118	PF00069	0.628
MOD_GSK3_1	140	147	PF00069	0.667
MOD_GSK3_1	22	29	PF00069	0.401
MOD_GSK3_1	52	59	PF00069	0.665
MOD_NEK2_1	56	61	PF00069	0.608
MOD_PKA_2	171	177	PF00069	0.627
MOD_PKA_2	79	85	PF00069	0.644
MOD_PKB_1	78	86	PF00069	0.629
MOD_Plk_1	168	174	PF00069	0.579
MOD_Plk_4	26	32	PF00069	0.369
MOD_ProDKin_1	142	148	PF00069	0.715
MOD_SUMO_rev_2	114	123	PF00179	0.765
MOD_SUMO_rev_2	152	162	PF00179	0.764
TRG_ENDOCYTIC_2	30	33	PF00928	0.369
TRG_ENDOCYTIC_2	68	71	PF00928	0.557
TRG_ER_diArg_1	137	140	PF00400	0.677
TRG_ER_diArg_1	192	195	PF00400	0.589
TRG_NLS_MonoExtC_3	135	140	PF00514	0.723
TRG_NLS_MonoExtC_3	159	165	PF00514	0.730
TRG_NLS_MonoExtC_3	75	80	PF00514	0.659
TRG_NLS_MonoExtN_4	73	80	PF00514	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6K7	Leptomonas seymouri	53%	99%
A0A0S4J7Y3	Bodo saltans	35%	100%
A0A3S5H710	Leishmania donovani	96%	100%
A4H945	Leishmania braziliensis	75%	98%
A4HXF9	Leishmania infantum	95%	100%
C9ZP33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AR54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AQX6	Trypanosoma cruzi	41%	78%