Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEA8_LEIMA

TriTrypDb:

LmjF.17.0820 , LMJLV39_170015300 , LMJSD75_170014900

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.704
CLV_NRD_NRD_1	135	137	PF00675	0.708
CLV_NRD_NRD_1	440	442	PF00675	0.731
CLV_PCSK_KEX2_1	135	137	PF00082	0.708
CLV_PCSK_KEX2_1	440	442	PF00082	0.731
CLV_PCSK_SKI1_1	3	7	PF00082	0.542
CLV_PCSK_SKI1_1	458	462	PF00082	0.737
DEG_SPOP_SBC_1	447	451	PF00917	0.752
DEG_SPOP_SBC_1	511	515	PF00917	0.724
DOC_MAPK_MEF2A_6	123	130	PF00069	0.728
DOC_USP7_MATH_1	16	20	PF00917	0.681
DOC_USP7_MATH_1	180	184	PF00917	0.683
DOC_USP7_MATH_1	212	216	PF00917	0.703
DOC_USP7_MATH_1	249	253	PF00917	0.846
DOC_USP7_MATH_1	255	259	PF00917	0.740
DOC_USP7_MATH_1	430	434	PF00917	0.789
DOC_USP7_MATH_1	442	446	PF00917	0.652
DOC_USP7_MATH_1	462	466	PF00917	0.509
DOC_USP7_MATH_1	61	65	PF00917	0.687
DOC_WW_Pin1_4	122	127	PF00397	0.706
DOC_WW_Pin1_4	186	191	PF00397	0.743
DOC_WW_Pin1_4	196	201	PF00397	0.748
DOC_WW_Pin1_4	263	268	PF00397	0.733
DOC_WW_Pin1_4	272	277	PF00397	0.738
DOC_WW_Pin1_4	314	319	PF00397	0.733
DOC_WW_Pin1_4	4	9	PF00397	0.799
DOC_WW_Pin1_4	73	78	PF00397	0.778
DOC_WW_Pin1_4	81	86	PF00397	0.699
LIG_14-3-3_CanoR_1	195	200	PF00244	0.748
LIG_14-3-3_CanoR_1	3	8	PF00244	0.735
LIG_14-3-3_CanoR_1	448	457	PF00244	0.746
LIG_14-3-3_CanoR_1	502	506	PF00244	0.717
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	126	130	PF00533	0.726
LIG_BRCT_BRCA1_1	525	529	PF00533	0.697
LIG_FHA_1	182	188	PF00498	0.823
LIG_FHA_1	228	234	PF00498	0.557
LIG_FHA_1	294	300	PF00498	0.650
LIG_FHA_1	87	93	PF00498	0.726
LIG_FHA_2	26	32	PF00498	0.791
LIG_Integrin_isoDGR_2	544	546	PF01839	0.849
LIG_LIR_Gen_1	51	61	PF02991	0.681
LIG_LIR_Gen_1	526	534	PF02991	0.720
LIG_LIR_LC3C_4	103	108	PF02991	0.799
LIG_LIR_Nem_3	368	373	PF02991	0.809
LIG_LIR_Nem_3	51	56	PF02991	0.679
LIG_LIR_Nem_3	526	532	PF02991	0.720
LIG_Pex14_1	244	248	PF04695	0.791
LIG_SH2_PTP2	264	267	PF00017	0.735
LIG_SH2_STAP1	176	180	PF00017	0.565
LIG_SH2_STAT5	264	267	PF00017	0.735
LIG_SH2_STAT5	331	334	PF00017	0.709
LIG_SH3_3	184	190	PF00018	0.739
LIG_SH3_3	21	27	PF00018	0.677
LIG_SH3_3	262	268	PF00018	0.718
LIG_SH3_3	378	384	PF00018	0.707
LIG_SH3_3	451	457	PF00018	0.742
LIG_SH3_3	5	11	PF00018	0.731
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.614
LIG_TRAF2_1	23	26	PF00917	0.829
LIG_TRAF2_1	44	47	PF00917	0.671
MOD_CDK_SPK_2	272	277	PF00069	0.738
MOD_CDK_SPK_2	4	9	PF00069	0.669
MOD_CK1_1	100	106	PF00069	0.695
MOD_CK1_1	147	153	PF00069	0.595
MOD_CK1_1	183	189	PF00069	0.825
MOD_CK1_1	206	212	PF00069	0.699
MOD_CK1_1	227	233	PF00069	0.654
MOD_CK1_1	257	263	PF00069	0.835
MOD_CK1_1	275	281	PF00069	0.737
MOD_CK1_1	285	291	PF00069	0.719
MOD_CK1_1	314	320	PF00069	0.810
MOD_CK1_1	392	398	PF00069	0.767
MOD_CK1_1	485	491	PF00069	0.727
MOD_CK1_1	500	506	PF00069	0.627
MOD_CK1_1	523	529	PF00069	0.691
MOD_CK1_1	86	92	PF00069	0.729
MOD_CK2_1	491	497	PF00069	0.657
MOD_GlcNHglycan	103	106	PF01048	0.696
MOD_GlcNHglycan	109	112	PF01048	0.770
MOD_GlcNHglycan	114	117	PF01048	0.632
MOD_GlcNHglycan	146	149	PF01048	0.699
MOD_GlcNHglycan	164	167	PF01048	0.434
MOD_GlcNHglycan	178	181	PF01048	0.590
MOD_GlcNHglycan	208	211	PF01048	0.737
MOD_GlcNHglycan	214	217	PF01048	0.646
MOD_GlcNHglycan	277	280	PF01048	0.737
MOD_GlcNHglycan	304	307	PF01048	0.689
MOD_GlcNHglycan	363	366	PF01048	0.638
MOD_GlcNHglycan	391	394	PF01048	0.732
MOD_GlcNHglycan	397	400	PF01048	0.710
MOD_GlcNHglycan	418	421	PF01048	0.711
MOD_GlcNHglycan	442	445	PF01048	0.739
MOD_GlcNHglycan	450	453	PF01048	0.716
MOD_GlcNHglycan	487	490	PF01048	0.727
MOD_GlcNHglycan	492	496	PF01048	0.713
MOD_GlcNHglycan	514	517	PF01048	0.730
MOD_GlcNHglycan	64	67	PF01048	0.728
MOD_GlcNHglycan	85	88	PF01048	0.734
MOD_GSK3_1	176	183	PF00069	0.650
MOD_GSK3_1	249	256	PF00069	0.609
MOD_GSK3_1	293	300	PF00069	0.692
MOD_GSK3_1	322	329	PF00069	0.719
MOD_GSK3_1	343	350	PF00069	0.626
MOD_GSK3_1	357	364	PF00069	0.691
MOD_GSK3_1	432	439	PF00069	0.728
MOD_GSK3_1	442	449	PF00069	0.746
MOD_GSK3_1	491	498	PF00069	0.670
MOD_GSK3_1	512	519	PF00069	0.711
MOD_GSK3_1	520	527	PF00069	0.680
MOD_GSK3_1	75	82	PF00069	0.745
MOD_GSK3_1	97	104	PF00069	0.803
MOD_N-GLC_1	485	490	PF02516	0.727
MOD_N-GLC_1	516	521	PF02516	0.722
MOD_N-GLC_1	73	78	PF02516	0.789
MOD_NEK2_1	106	111	PF00069	0.776
MOD_NEK2_1	302	307	PF00069	0.761
MOD_NEK2_1	416	421	PF00069	0.631
MOD_NEK2_1	512	517	PF00069	0.679
MOD_NEK2_1	524	529	PF00069	0.687
MOD_PIKK_1	147	153	PF00454	0.628
MOD_PIKK_1	400	406	PF00454	0.729
MOD_PK_1	136	142	PF00069	0.747
MOD_PKA_1	440	446	PF00069	0.843
MOD_PKA_2	194	200	PF00069	0.738
MOD_PKA_2	344	350	PF00069	0.672
MOD_PKA_2	357	363	PF00069	0.693
MOD_PKA_2	440	446	PF00069	0.772
MOD_PKA_2	447	453	PF00069	0.713
MOD_PKA_2	501	507	PF00069	0.717
MOD_PKB_1	73	81	PF00069	0.846
MOD_Plk_1	224	230	PF00069	0.612
MOD_Plk_1	485	491	PF00069	0.709
MOD_Plk_1	520	526	PF00069	0.719
MOD_Plk_2-3	25	31	PF00069	0.736
MOD_Plk_4	124	130	PF00069	0.702
MOD_Plk_4	224	230	PF00069	0.612
MOD_Plk_4	297	303	PF00069	0.800
MOD_Plk_4	524	530	PF00069	0.695
MOD_ProDKin_1	122	128	PF00069	0.704
MOD_ProDKin_1	186	192	PF00069	0.743
MOD_ProDKin_1	196	202	PF00069	0.747
MOD_ProDKin_1	263	269	PF00069	0.734
MOD_ProDKin_1	272	278	PF00069	0.738
MOD_ProDKin_1	314	320	PF00069	0.734
MOD_ProDKin_1	4	10	PF00069	0.792
MOD_ProDKin_1	73	79	PF00069	0.780
MOD_ProDKin_1	81	87	PF00069	0.698
MOD_SUMO_for_1	460	463	PF00179	0.776
TRG_DiLeu_BaEn_1	224	229	PF01217	0.615
TRG_DiLeu_BaEn_4	224	230	PF01217	0.612
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.612
TRG_ER_diArg_1	135	137	PF00400	0.762
TRG_ER_diArg_1	440	442	PF00400	0.833
TRG_ER_diArg_1	474	477	PF00400	0.691
TRG_ER_diArg_1	72	75	PF00400	0.849
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.767

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I516	Leptomonas seymouri	58%	98%
A0A3Q8IJG5	Leishmania donovani	96%	92%
A4H946	Leishmania braziliensis	85%	93%
A4HXG0	Leishmania infantum	96%	100%
E9AR55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%