Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEA6_LEIMA

TriTrypDb:

LmjF.17.0840 , LMJLV39_170015500 , LMJSD75_170015100

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.680
CLV_C14_Caspase3-7	8	12	PF00656	0.570
CLV_NRD_NRD_1	1	3	PF00675	0.726
CLV_NRD_NRD_1	106	108	PF00675	0.550
CLV_NRD_NRD_1	18	20	PF00675	0.626
CLV_NRD_NRD_1	190	192	PF00675	0.578
CLV_NRD_NRD_1	193	195	PF00675	0.621
CLV_NRD_NRD_1	197	199	PF00675	0.624
CLV_NRD_NRD_1	319	321	PF00675	0.426
CLV_NRD_NRD_1	342	344	PF00675	0.392
CLV_PCSK_FUR_1	191	195	PF00082	0.721
CLV_PCSK_KEX2_1	106	108	PF00082	0.550
CLV_PCSK_KEX2_1	18	20	PF00082	0.584
CLV_PCSK_KEX2_1	192	194	PF00082	0.631
CLV_PCSK_KEX2_1	199	201	PF00082	0.664
CLV_PCSK_KEX2_1	3	5	PF00082	0.732
CLV_PCSK_KEX2_1	319	321	PF00082	0.426
CLV_PCSK_KEX2_1	342	344	PF00082	0.392
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.639
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.653
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.717
CLV_PCSK_SKI1_1	133	137	PF00082	0.595
CLV_PCSK_SKI1_1	138	142	PF00082	0.592
CLV_PCSK_SKI1_1	268	272	PF00082	0.584
CLV_PCSK_SKI1_1	427	431	PF00082	0.534
CLV_PCSK_SKI1_1	450	454	PF00082	0.530
CLV_PCSK_SKI1_1	504	508	PF00082	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.731
DEG_SPOP_SBC_1	263	267	PF00917	0.363
DEG_SPOP_SBC_1	395	399	PF00917	0.670
DOC_CYCLIN_RxL_1	115	126	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.558
DOC_MAPK_DCC_7	475	484	PF00069	0.521
DOC_MAPK_gen_1	115	124	PF00069	0.555
DOC_MAPK_gen_1	145	153	PF00069	0.537
DOC_MAPK_gen_1	319	326	PF00069	0.393
DOC_MAPK_gen_1	416	425	PF00069	0.444
DOC_MAPK_HePTP_8	472	484	PF00069	0.410
DOC_MAPK_MEF2A_6	475	484	PF00069	0.410
DOC_PP1_RVXF_1	118	125	PF00149	0.564
DOC_PP2B_LxvP_1	519	522	PF13499	0.621
DOC_PP4_FxxP_1	255	258	PF00568	0.556
DOC_PP4_FxxP_1	26	29	PF00568	0.726
DOC_PP4_FxxP_1	318	321	PF00568	0.419
DOC_USP7_MATH_1	116	120	PF00917	0.592
DOC_USP7_MATH_1	17	21	PF00917	0.669
DOC_USP7_MATH_1	209	213	PF00917	0.686
DOC_USP7_MATH_1	264	268	PF00917	0.587
DOC_USP7_MATH_1	281	285	PF00917	0.515
DOC_USP7_MATH_1	294	298	PF00917	0.688
DOC_USP7_MATH_1	304	308	PF00917	0.405
DOC_USP7_MATH_1	395	399	PF00917	0.707
DOC_USP7_UBL2_3	109	113	PF12436	0.581
DOC_USP7_UBL2_3	53	57	PF12436	0.773
DOC_WW_Pin1_4	254	259	PF00397	0.549
DOC_WW_Pin1_4	311	316	PF00397	0.480
DOC_WW_Pin1_4	356	361	PF00397	0.619
DOC_WW_Pin1_4	373	378	PF00397	0.542
LIG_14-3-3_CanoR_1	198	207	PF00244	0.729
LIG_14-3-3_CanoR_1	394	404	PF00244	0.659
LIG_14-3-3_CanoR_1	427	433	PF00244	0.442
LIG_APCC_ABBA_1	121	126	PF00400	0.577
LIG_APCC_ABBAyCdc20_2	120	126	PF00400	0.574
LIG_BIR_III_2	11	15	PF00653	0.555
LIG_BRCT_BRCA1_1	240	244	PF00533	0.476
LIG_BRCT_BRCA1_1	278	282	PF00533	0.606
LIG_BRCT_BRCA1_1	306	310	PF00533	0.589
LIG_BRCT_BRCA1_1	455	459	PF00533	0.377
LIG_BRCT_BRCA1_1	76	80	PF00533	0.613
LIG_EH_1	77	81	PF12763	0.636
LIG_FHA_1	169	175	PF00498	0.706
LIG_FHA_1	226	232	PF00498	0.696
LIG_FHA_1	264	270	PF00498	0.514
LIG_FHA_1	44	50	PF00498	0.690
LIG_FHA_1	469	475	PF00498	0.550
LIG_FHA_2	288	294	PF00498	0.724
LIG_FHA_2	384	390	PF00498	0.708
LIG_FHA_2	434	440	PF00498	0.584
LIG_FHA_2	54	60	PF00498	0.747
LIG_LIR_Apic_2	23	29	PF02991	0.724
LIG_LIR_Apic_2	316	321	PF02991	0.452
LIG_LIR_Gen_1	139	149	PF02991	0.518
LIG_LIR_Gen_1	307	318	PF02991	0.530
LIG_LIR_Gen_1	466	477	PF02991	0.577
LIG_LIR_Nem_3	139	144	PF02991	0.517
LIG_LIR_Nem_3	241	247	PF02991	0.450
LIG_LIR_Nem_3	279	285	PF02991	0.643
LIG_LIR_Nem_3	338	344	PF02991	0.390
LIG_LIR_Nem_3	466	472	PF02991	0.570
LIG_LIR_Nem_3	505	510	PF02991	0.343
LIG_LIR_Nem_3	95	99	PF02991	0.653
LIG_MYND_1	351	355	PF01753	0.542
LIG_NRBOX	268	274	PF00104	0.587
LIG_Pex14_2	282	286	PF04695	0.657
LIG_SH2_CRK	346	350	PF00017	0.302
LIG_SH2_CRK	469	473	PF00017	0.434
LIG_SH2_GRB2like	165	168	PF00017	0.557
LIG_SH2_NCK_1	99	103	PF00017	0.658
LIG_SH2_STAT5	146	149	PF00017	0.518
LIG_SH2_STAT5	165	168	PF00017	0.557
LIG_SH2_STAT5	285	288	PF00017	0.682
LIG_SH2_STAT5	356	359	PF00017	0.490
LIG_SH2_STAT5	424	427	PF00017	0.418
LIG_SH2_STAT5	477	480	PF00017	0.437
LIG_SH2_STAT5	518	521	PF00017	0.595
LIG_SH3_2	14	19	PF14604	0.724
LIG_SH3_3	11	17	PF00018	0.721
LIG_SH3_3	91	97	PF00018	0.700
LIG_SH3_CIN85_PxpxPR_1	13	18	PF14604	0.718
LIG_SUMO_SIM_par_1	271	276	PF11976	0.577
LIG_SUMO_SIM_par_1	402	408	PF11976	0.402
LIG_TRAF2_1	102	105	PF00917	0.590
LIG_TRAF2_1	290	293	PF00917	0.645
LIG_TRAF2_1	360	363	PF00917	0.676
LIG_TYR_ITIM	344	349	PF00017	0.335
LIG_UBA3_1	325	332	PF00899	0.554
MOD_CK1_1	20	26	PF00069	0.668
MOD_CK1_1	201	207	PF00069	0.727
MOD_CK1_1	262	268	PF00069	0.554
MOD_CK1_1	276	282	PF00069	0.673
MOD_CK1_1	33	39	PF00069	0.689
MOD_CK1_1	369	375	PF00069	0.783
MOD_CK1_1	383	389	PF00069	0.685
MOD_CK1_1	408	414	PF00069	0.364
MOD_CK1_1	433	439	PF00069	0.569
MOD_CK1_1	95	101	PF00069	0.634
MOD_CK2_1	287	293	PF00069	0.709
MOD_CK2_1	433	439	PF00069	0.555
MOD_CK2_1	442	448	PF00069	0.475
MOD_CK2_1	82	88	PF00069	0.511
MOD_Cter_Amidation	50	53	PF01082	0.690
MOD_GlcNHglycan	19	22	PF01048	0.655
MOD_GlcNHglycan	194	197	PF01048	0.683
MOD_GlcNHglycan	215	218	PF01048	0.773
MOD_GlcNHglycan	261	264	PF01048	0.551
MOD_GlcNHglycan	296	299	PF01048	0.729
MOD_GlcNHglycan	368	371	PF01048	0.746
MOD_GlcNHglycan	382	385	PF01048	0.741
MOD_GlcNHglycan	410	413	PF01048	0.494
MOD_GlcNHglycan	439	442	PF01048	0.676
MOD_GlcNHglycan	494	497	PF01048	0.467
MOD_GlcNHglycan	59	63	PF01048	0.557
MOD_GSK3_1	194	201	PF00069	0.695
MOD_GSK3_1	209	216	PF00069	0.759
MOD_GSK3_1	259	266	PF00069	0.526
MOD_GSK3_1	271	278	PF00069	0.527
MOD_GSK3_1	281	288	PF00069	0.533
MOD_GSK3_1	294	301	PF00069	0.623
MOD_GSK3_1	304	311	PF00069	0.409
MOD_GSK3_1	365	372	PF00069	0.753
MOD_GSK3_1	428	435	PF00069	0.450
MOD_GSK3_1	455	462	PF00069	0.408
MOD_GSK3_1	82	89	PF00069	0.558
MOD_N-GLC_1	33	38	PF02516	0.705
MOD_NEK2_1	238	243	PF00069	0.616
MOD_NEK2_1	273	278	PF00069	0.633
MOD_NEK2_1	309	314	PF00069	0.543
MOD_NEK2_1	423	428	PF00069	0.420
MOD_NEK2_1	432	437	PF00069	0.470
MOD_NEK2_1	453	458	PF00069	0.432
MOD_NEK2_1	459	464	PF00069	0.431
MOD_NEK2_1	468	473	PF00069	0.473
MOD_NEK2_1	58	63	PF00069	0.678
MOD_PIKK_1	324	330	PF00454	0.460
MOD_PIKK_1	332	338	PF00454	0.422
MOD_PIKK_1	430	436	PF00454	0.546
MOD_PIKK_1	459	465	PF00454	0.497
MOD_PKA_1	192	198	PF00069	0.720
MOD_PKA_1	199	205	PF00069	0.746
MOD_PKA_2	17	23	PF00069	0.664
MOD_PKA_2	192	198	PF00069	0.685
MOD_PKA_2	199	205	PF00069	0.645
MOD_PKA_2	294	300	PF00069	0.714
MOD_PKB_1	198	206	PF00069	0.708
MOD_Plk_2-3	442	448	PF00069	0.595
MOD_Plk_4	268	274	PF00069	0.531
MOD_Plk_4	281	287	PF00069	0.575
MOD_Plk_4	313	319	PF00069	0.543
MOD_Plk_4	455	461	PF00069	0.374
MOD_Plk_4	506	512	PF00069	0.486
MOD_ProDKin_1	254	260	PF00069	0.546
MOD_ProDKin_1	311	317	PF00069	0.480
MOD_ProDKin_1	356	362	PF00069	0.636
MOD_ProDKin_1	373	379	PF00069	0.543
MOD_SUMO_for_1	114	117	PF00179	0.621
MOD_SUMO_rev_2	105	114	PF00179	0.540
MOD_SUMO_rev_2	168	177	PF00179	0.560
MOD_SUMO_rev_2	442	452	PF00179	0.602
MOD_SUMO_rev_2	500	506	PF00179	0.582
MOD_SUMO_rev_2	67	74	PF00179	0.661
TRG_AP2beta_CARGO_1	139	148	PF09066	0.519
TRG_ENDOCYTIC_2	346	349	PF00928	0.341
TRG_ENDOCYTIC_2	417	420	PF00928	0.445
TRG_ENDOCYTIC_2	469	472	PF00928	0.434
TRG_ER_diArg_1	1	4	PF00400	0.730
TRG_ER_diArg_1	17	19	PF00400	0.662
TRG_ER_diArg_1	191	194	PF00400	0.693
TRG_ER_diArg_1	318	320	PF00400	0.451
TRG_ER_diArg_1	341	343	PF00400	0.386
TRG_NLS_MonoCore_2	190	195	PF00514	0.711
TRG_NLS_MonoExtN_4	191	196	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD84	Leptomonas seymouri	62%	100%
A0A1X0NST3	Trypanosomatidae	45%	98%
A0A3S5IR66	Trypanosoma rangeli	48%	99%
A0A3S7WUG6	Leishmania donovani	93%	100%
A4H948	Leishmania braziliensis	79%	90%
A4HXG2	Leishmania infantum	93%	100%
C9ZP42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9AR57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AQX9	Trypanosoma cruzi	48%	99%