Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEA6_LEIMA

TriTrypDb:

LmjF.17.0840 , LMJLV39_170015500 , LMJSD75_170015100

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QEA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEA6

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.680
CLV_C14_Caspase3-7	8	12	PF00656	0.570
CLV_NRD_NRD_1	1	3	PF00675	0.726
CLV_NRD_NRD_1	106	108	PF00675	0.550
CLV_NRD_NRD_1	18	20	PF00675	0.626
CLV_NRD_NRD_1	190	192	PF00675	0.578
CLV_NRD_NRD_1	193	195	PF00675	0.621
CLV_NRD_NRD_1	197	199	PF00675	0.624
CLV_NRD_NRD_1	319	321	PF00675	0.426
CLV_NRD_NRD_1	342	344	PF00675	0.392

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD84	Leptomonas seymouri	62%	100%
A0A1X0NST3	Trypanosomatidae	45%	98%
A0A3S5IR66	Trypanosoma rangeli	48%	99%
A0A3S7WUG6	Leishmania donovani	93%	100%
A4H948	Leishmania braziliensis	79%	90%
A4HXG2	Leishmania infantum	93%	100%
C9ZP42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9AR57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AQX9	Trypanosoma cruzi	48%	99%

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