META domain containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

META domain containing protein

Species:

Leishmania major

UniProt:

Q4QEA3_LEIMA

TriTrypDb:

LmjF.17.0870 , LMJLV39_170015800 , LMJSD75_170015400

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QEA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEA3

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	2
GO:0006979	response to oxidative stress	3	2
GO:0009266	response to temperature stimulus	3	2
GO:0009408	response to heat	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034599	cellular response to oxidative stress	4	2
GO:0034605	cellular response to heat	4	2
GO:0042221	response to chemical	2	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0062197	cellular response to chemical stress	4	2
GO:0070887	cellular response to chemical stimulus	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.514
CLV_PCSK_SKI1_1	328	332	PF00082	0.557
CLV_PCSK_SKI1_1	353	357	PF00082	0.467
CLV_PCSK_SKI1_1	373	377	PF00082	0.411
DOC_CKS1_1	137	142	PF01111	0.501
DOC_MAPK_MEF2A_6	243	250	PF00069	0.541
DOC_MAPK_MEF2A_6	412	419	PF00069	0.510
DOC_USP7_MATH_1	178	182	PF00917	0.526
DOC_USP7_MATH_1	284	288	PF00917	0.501
DOC_USP7_MATH_1	71	75	PF00917	0.544
DOC_WW_Pin1_4	136	141	PF00397	0.538
DOC_WW_Pin1_4	66	71	PF00397	0.518
LIG_14-3-3_CanoR_1	219	226	PF00244	0.604
LIG_14-3-3_CanoR_1	386	392	PF00244	0.477
LIG_Actin_WH2_2	33	49	PF00022	0.429
LIG_Actin_WH2_2	83	101	PF00022	0.510
LIG_AP2alpha_1	83	87	PF02296	0.510
LIG_BIR_III_2	440	444	PF00653	0.572
LIG_BRCT_BRCA1_1	189	193	PF00533	0.552
LIG_BRCT_BRCA1_1	246	250	PF00533	0.436
LIG_BRCT_BRCA1_1	79	83	PF00533	0.552
LIG_Clathr_ClatBox_1	182	186	PF01394	0.513
LIG_deltaCOP1_diTrp_1	371	376	PF00928	0.393
LIG_FHA_1	24	30	PF00498	0.467
LIG_FHA_1	253	259	PF00498	0.468
LIG_FHA_1	269	275	PF00498	0.414
LIG_FHA_1	35	41	PF00498	0.467
LIG_FHA_1	378	384	PF00498	0.529
LIG_FHA_2	1	7	PF00498	0.615
LIG_FHA_2	172	178	PF00498	0.400
LIG_FHA_2	291	297	PF00498	0.547
LIG_FHA_2	62	68	PF00498	0.541
LIG_GBD_Chelix_1	148	156	PF00786	0.425
LIG_Integrin_RGD_1	168	170	PF01839	0.474
LIG_LIR_Gen_1	326	337	PF02991	0.587
LIG_LIR_Gen_1	85	93	PF02991	0.510
LIG_LIR_Nem_3	247	253	PF02991	0.561
LIG_LIR_Nem_3	326	332	PF02991	0.569
LIG_LIR_Nem_3	371	377	PF02991	0.436
LIG_LIR_Nem_3	85	90	PF02991	0.510
LIG_LRP6_Inhibitor_1	263	269	PF00058	0.474
LIG_Pex14_2	193	197	PF04695	0.552
LIG_Pex14_2	303	307	PF04695	0.425
LIG_Pex14_2	83	87	PF04695	0.436
LIG_PTB_Apo_2	349	356	PF02174	0.436
LIG_SH2_GRB2like	52	55	PF00017	0.552
LIG_SH2_STAT3	439	442	PF00017	0.496
LIG_SH2_STAT5	11	14	PF00017	0.510
LIG_SH2_STAT5	230	233	PF00017	0.466
LIG_SH2_STAT5	350	353	PF00017	0.488
LIG_SH2_STAT5	413	416	PF00017	0.513
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.567
LIG_SUMO_SIM_par_1	121	127	PF11976	0.652
LIG_SUMO_SIM_par_1	413	418	PF11976	0.504
LIG_TRAF2_1	130	133	PF00917	0.544
LIG_TRAF2_1	280	283	PF00917	0.552
LIG_TRAF2_1	293	296	PF00917	0.337
LIG_TRAF2_1	70	73	PF00917	0.552
LIG_WRC_WIRS_1	232	237	PF05994	0.510
MOD_CK1_1	111	117	PF00069	0.587
MOD_CK1_1	252	258	PF00069	0.319
MOD_CK1_1	60	66	PF00069	0.564
MOD_CK2_1	171	177	PF00069	0.425
MOD_CK2_1	221	227	PF00069	0.513
MOD_CK2_1	277	283	PF00069	0.479
MOD_CK2_1	290	296	PF00069	0.366
MOD_CK2_1	392	398	PF00069	0.430
MOD_CK2_1	61	67	PF00069	0.529
MOD_GlcNHglycan	102	105	PF01048	0.507
MOD_GlcNHglycan	203	206	PF01048	0.510
MOD_GSK3_1	132	139	PF00069	0.490
MOD_GSK3_1	290	297	PF00069	0.430
MOD_GSK3_1	34	41	PF00069	0.513
MOD_GSK3_1	342	349	PF00069	0.503
MOD_GSK3_1	57	64	PF00069	0.466
MOD_N-GLC_1	201	206	PF02516	0.510
MOD_N-GLC_1	377	382	PF02516	0.411
MOD_N-GLC_2	352	354	PF02516	0.474
MOD_NEK2_1	171	176	PF00069	0.506
MOD_NEK2_1	201	206	PF00069	0.429
MOD_NEK2_1	285	290	PF00069	0.441
MOD_NEK2_1	46	51	PF00069	0.492
MOD_NEK2_1	61	66	PF00069	0.342
MOD_NEK2_2	25	30	PF00069	0.510
MOD_PIKK_1	171	177	PF00454	0.552
MOD_PIKK_1	294	300	PF00454	0.512
MOD_PKA_2	108	114	PF00069	0.527
MOD_PKA_2	268	274	PF00069	0.481
MOD_PKA_2	387	393	PF00069	0.472
MOD_PKA_2	46	52	PF00069	0.485
MOD_Plk_1	132	138	PF00069	0.481
MOD_Plk_1	178	184	PF00069	0.552
MOD_Plk_1	258	264	PF00069	0.508
MOD_Plk_1	294	300	PF00069	0.496
MOD_Plk_1	318	324	PF00069	0.423
MOD_Plk_1	415	421	PF00069	0.433
MOD_Plk_4	132	138	PF00069	0.388
MOD_Plk_4	143	149	PF00069	0.390
MOD_Plk_4	178	184	PF00069	0.479
MOD_Plk_4	244	250	PF00069	0.436
MOD_Plk_4	38	44	PF00069	0.504
MOD_ProDKin_1	136	142	PF00069	0.538
MOD_ProDKin_1	66	72	PF00069	0.518
MOD_SUMO_for_1	355	358	PF00179	0.510
MOD_SUMO_rev_2	14	21	PF00179	0.427
MOD_SUMO_rev_2	369	375	PF00179	0.469
TRG_DiLeu_BaEn_1	203	208	PF01217	0.504
TRG_DiLeu_BaEn_1	358	363	PF01217	0.510
TRG_DiLeu_BaEn_4	294	300	PF01217	0.552
TRG_ER_diArg_1	383	386	PF00400	0.529
TRG_NES_CRM1_1	77	92	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L4	Leptomonas seymouri	62%	100%
A0A1X0NSU0	Trypanosomatidae	37%	100%
A0A3Q8IAQ3	Leishmania donovani	96%	100%
A0A422NH16	Trypanosoma rangeli	34%	100%
A4H951	Leishmania braziliensis	82%	100%
A4HXG5	Leishmania infantum	96%	100%
C9ZP52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AR60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%