Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEA2_LEIMA

TriTrypDb:

LmjF.17.0880 , LMJLV39_170015900 , LMJSD75_170015500

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QEA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.586
CLV_C14_Caspase3-7	253	257	PF00656	0.526
CLV_C14_Caspase3-7	287	291	PF00656	0.470
CLV_C14_Caspase3-7	294	298	PF00656	0.461
CLV_MEL_PAP_1	220	226	PF00089	0.662
CLV_NRD_NRD_1	155	157	PF00675	0.713
CLV_NRD_NRD_1	494	496	PF00675	0.744
CLV_NRD_NRD_1	509	511	PF00675	0.612
CLV_NRD_NRD_1	559	561	PF00675	0.553
CLV_NRD_NRD_1	89	91	PF00675	0.674
CLV_PCSK_KEX2_1	155	157	PF00082	0.761
CLV_PCSK_KEX2_1	222	224	PF00082	0.692
CLV_PCSK_KEX2_1	283	285	PF00082	0.720
CLV_PCSK_KEX2_1	494	496	PF00082	0.757
CLV_PCSK_KEX2_1	509	511	PF00082	0.651
CLV_PCSK_KEX2_1	559	561	PF00082	0.549
CLV_PCSK_KEX2_1	89	91	PF00082	0.674
CLV_PCSK_KEX2_1	95	97	PF00082	0.651
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.659
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.606
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.706
CLV_PCSK_SKI1_1	284	288	PF00082	0.607
CLV_PCSK_SKI1_1	32	36	PF00082	0.664
CLV_PCSK_SKI1_1	324	328	PF00082	0.634
CLV_PCSK_SKI1_1	416	420	PF00082	0.765
CLV_PCSK_SKI1_1	494	498	PF00082	0.714
DEG_COP1_1	528	536	PF00400	0.506
DEG_SPOP_SBC_1	234	238	PF00917	0.478
DOC_MAPK_gen_1	313	323	PF00069	0.481
DOC_MAPK_gen_1	509	521	PF00069	0.538
DOC_PIKK_1	212	220	PF02985	0.393
DOC_PP1_RVXF_1	30	37	PF00149	0.345
DOC_PP4_FxxP_1	311	314	PF00568	0.488
DOC_USP7_MATH_1	189	193	PF00917	0.485
DOC_USP7_MATH_1	2	6	PF00917	0.529
DOC_USP7_MATH_1	228	232	PF00917	0.579
DOC_USP7_MATH_1	234	238	PF00917	0.570
DOC_USP7_MATH_1	250	254	PF00917	0.495
DOC_USP7_MATH_1	461	465	PF00917	0.599
DOC_USP7_MATH_1	482	486	PF00917	0.500
DOC_USP7_MATH_1	527	531	PF00917	0.549
DOC_WW_Pin1_4	134	139	PF00397	0.546
DOC_WW_Pin1_4	235	240	PF00397	0.545
DOC_WW_Pin1_4	423	428	PF00397	0.479
DOC_WW_Pin1_4	9	14	PF00397	0.425
LIG_14-3-3_CanoR_1	155	164	PF00244	0.505
LIG_14-3-3_CanoR_1	367	376	PF00244	0.502
LIG_14-3-3_CanoR_1	465	474	PF00244	0.585
LIG_14-3-3_CanoR_1	67	71	PF00244	0.491
LIG_14-3-3_CterR_2	559	561	PF00244	0.725
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_BIR_III_1	1	5	PF00653	0.589
LIG_BIR_III_3	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	231	235	PF00533	0.520
LIG_BRCT_BRCA1_1	472	476	PF00533	0.536
LIG_BRCT_BRCA1_1	98	102	PF00533	0.496
LIG_deltaCOP1_diTrp_1	159	164	PF00928	0.544
LIG_deltaCOP1_diTrp_1	304	311	PF00928	0.519
LIG_FHA_1	111	117	PF00498	0.549
LIG_FHA_1	202	208	PF00498	0.470
LIG_FHA_1	261	267	PF00498	0.480
LIG_FHA_1	400	406	PF00498	0.548
LIG_FHA_1	521	527	PF00498	0.591
LIG_FHA_1	535	541	PF00498	0.316
LIG_FHA_1	553	559	PF00498	0.649
LIG_FHA_2	171	177	PF00498	0.489
LIG_FHA_2	267	273	PF00498	0.506
LIG_FHA_2	285	291	PF00498	0.356
LIG_FHA_2	292	298	PF00498	0.556
LIG_FHA_2	434	440	PF00498	0.461
LIG_FHA_2	513	519	PF00498	0.571
LIG_LIR_Apic_2	308	314	PF02991	0.498
LIG_LIR_Apic_2	528	534	PF02991	0.537
LIG_LIR_Gen_1	172	183	PF02991	0.516
LIG_LIR_Gen_1	195	205	PF02991	0.465
LIG_LIR_Gen_1	256	267	PF02991	0.471
LIG_LIR_Gen_1	304	314	PF02991	0.474
LIG_LIR_Gen_1	436	443	PF02991	0.514
LIG_LIR_Nem_3	195	200	PF02991	0.457
LIG_LIR_Nem_3	256	262	PF02991	0.476
LIG_LIR_Nem_3	304	309	PF02991	0.482
LIG_LIR_Nem_3	374	380	PF02991	0.482
LIG_LIR_Nem_3	436	440	PF02991	0.477
LIG_LIR_Nem_3	80	86	PF02991	0.491
LIG_PCNA_yPIPBox_3	18	32	PF02747	0.381
LIG_REV1ctd_RIR_1	324	333	PF16727	0.548
LIG_SH2_CRK	489	493	PF00017	0.476
LIG_SH2_CRK	531	535	PF00017	0.534
LIG_SH2_GRB2like	16	19	PF00017	0.386
LIG_SH2_NCK_1	183	187	PF00017	0.435
LIG_SH2_NCK_1	249	253	PF00017	0.533
LIG_SH2_NCK_1	489	493	PF00017	0.516
LIG_SH2_NCK_1	531	535	PF00017	0.529
LIG_SH2_STAP1	16	20	PF00017	0.410
LIG_SH2_STAP1	171	175	PF00017	0.541
LIG_SH2_STAT5	16	19	PF00017	0.386
LIG_SH2_STAT5	197	200	PF00017	0.419
LIG_SH2_STAT5	258	261	PF00017	0.480
LIG_SH2_STAT5	86	89	PF00017	0.431
LIG_SH3_3	402	408	PF00018	0.571
LIG_SH3_3	421	427	PF00018	0.347
LIG_SH3_3	516	522	PF00018	0.603
LIG_SUMO_SIM_anti_2	211	219	PF11976	0.474
LIG_SUMO_SIM_anti_2	341	346	PF11976	0.508
LIG_TRAF2_1	468	471	PF00917	0.583
LIG_WRC_WIRS_1	49	54	PF05994	0.707
MOD_CDK_SPxxK_3	134	141	PF00069	0.661
MOD_CK1_1	100	106	PF00069	0.664
MOD_CK1_1	110	116	PF00069	0.586
MOD_CK1_1	192	198	PF00069	0.591
MOD_CK1_1	291	297	PF00069	0.630
MOD_CK1_1	464	470	PF00069	0.759
MOD_CK1_1	532	538	PF00069	0.735
MOD_CK2_1	16	22	PF00069	0.618
MOD_CK2_1	266	272	PF00069	0.577
MOD_CK2_1	330	336	PF00069	0.624
MOD_CK2_1	353	359	PF00069	0.600
MOD_CK2_1	464	470	PF00069	0.781
MOD_CMANNOS	161	164	PF00535	0.650
MOD_GlcNHglycan	121	124	PF01048	0.630
MOD_GlcNHglycan	167	170	PF01048	0.632
MOD_GlcNHglycan	18	21	PF01048	0.683
MOD_GlcNHglycan	191	194	PF01048	0.618
MOD_GlcNHglycan	263	266	PF01048	0.576
MOD_GlcNHglycan	99	102	PF01048	0.635
MOD_GSK3_1	12	19	PF00069	0.671
MOD_GSK3_1	229	236	PF00069	0.658
MOD_GSK3_1	250	257	PF00069	0.635
MOD_GSK3_1	284	291	PF00069	0.672
MOD_GSK3_1	295	302	PF00069	0.693
MOD_GSK3_1	367	374	PF00069	0.665
MOD_GSK3_1	423	430	PF00069	0.673
MOD_GSK3_1	461	468	PF00069	0.708
MOD_GSK3_1	66	73	PF00069	0.730
MOD_GSK3_1	96	103	PF00069	0.596
MOD_LATS_1	274	280	PF00433	0.608
MOD_LATS_1	351	357	PF00433	0.610
MOD_N-GLC_1	110	115	PF02516	0.627
MOD_N-GLC_1	119	124	PF02516	0.632
MOD_N-GLC_1	201	206	PF02516	0.507
MOD_N-GLC_1	70	75	PF02516	0.707
MOD_NEK2_1	14	19	PF00069	0.712
MOD_NEK2_1	369	374	PF00069	0.707
MOD_NEK2_1	390	395	PF00069	0.661
MOD_NEK2_1	476	481	PF00069	0.626
MOD_NEK2_1	552	557	PF00069	0.620
MOD_NEK2_1	66	71	PF00069	0.707
MOD_PIKK_1	222	228	PF00454	0.591
MOD_PIKK_1	367	373	PF00454	0.709
MOD_PIKK_1	451	457	PF00454	0.744
MOD_PKA_1	155	161	PF00069	0.647
MOD_PKA_1	222	228	PF00069	0.591
MOD_PKA_2	155	161	PF00069	0.647
MOD_PKA_2	222	228	PF00069	0.669
MOD_PKA_2	299	305	PF00069	0.612
MOD_PKA_2	464	470	PF00069	0.734
MOD_PKA_2	476	482	PF00069	0.645
MOD_PKA_2	66	72	PF00069	0.668
MOD_Plk_1	105	111	PF00069	0.717
MOD_Plk_1	47	53	PF00069	0.619
MOD_Plk_1	470	476	PF00069	0.691
MOD_Plk_1	512	518	PF00069	0.543
MOD_Plk_1	527	533	PF00069	0.500
MOD_Plk_2-3	74	80	PF00069	0.688
MOD_Plk_4	250	256	PF00069	0.615
MOD_Plk_4	276	282	PF00069	0.628
MOD_Plk_4	330	336	PF00069	0.657
MOD_Plk_4	372	378	PF00069	0.701
MOD_Plk_4	385	391	PF00069	0.475
MOD_Plk_4	433	439	PF00069	0.625
MOD_Plk_4	470	476	PF00069	0.745
MOD_Plk_4	48	54	PF00069	0.710
MOD_ProDKin_1	134	140	PF00069	0.698
MOD_ProDKin_1	235	241	PF00069	0.699
MOD_ProDKin_1	423	429	PF00069	0.607
MOD_ProDKin_1	9	15	PF00069	0.528
MOD_SUMO_for_1	132	135	PF00179	0.626
MOD_SUMO_for_1	45	48	PF00179	0.454
MOD_SUMO_rev_2	91	97	PF00179	0.701
TRG_DiLeu_BaEn_2	47	53	PF01217	0.585
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.657
TRG_ENDOCYTIC_2	197	200	PF00928	0.615
TRG_ENDOCYTIC_2	377	380	PF00928	0.648
TRG_ENDOCYTIC_2	489	492	PF00928	0.631
TRG_ER_diArg_1	154	156	PF00400	0.643
TRG_ER_diArg_1	494	496	PF00400	0.712
TRG_ER_diArg_1	558	560	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P605	Leptomonas seymouri	36%	100%
A0A1X0NTG4	Trypanosomatidae	24%	100%
A0A3S7WUI7	Leishmania donovani	91%	100%
A4H941	Leishmania braziliensis	71%	100%
A4HXG6	Leishmania infantum	92%	100%
C9ZP51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AR61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%