Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEA0_LEIMA

TriTrypDb:

LmjF.17.0900 , LMJLV39_170016200 , LMJSD75_170015800

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	9
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4QEA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.367
CLV_C14_Caspase3-7	528	532	PF00656	0.656
CLV_NRD_NRD_1	574	576	PF00675	0.802
CLV_NRD_NRD_1	656	658	PF00675	0.664
CLV_PCSK_FUR_1	7	11	PF00082	0.667
CLV_PCSK_KEX2_1	147	149	PF00082	0.429
CLV_PCSK_KEX2_1	637	639	PF00082	0.472
CLV_PCSK_KEX2_1	656	658	PF00082	0.685
CLV_PCSK_KEX2_1	9	11	PF00082	0.630
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.429
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.452
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.630
CLV_PCSK_PC7_1	633	639	PF00082	0.388
CLV_PCSK_SKI1_1	147	151	PF00082	0.403
CLV_PCSK_SKI1_1	194	198	PF00082	0.551
CLV_PCSK_SKI1_1	497	501	PF00082	0.521
CLV_PCSK_SKI1_1	656	660	PF00082	0.687
CLV_Separin_Metazoa	630	634	PF03568	0.447
DEG_APCC_DBOX_1	123	131	PF00400	0.427
DEG_APCC_DBOX_1	147	155	PF00400	0.407
DEG_APCC_DBOX_1	309	317	PF00400	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SCF_FBW7_2	623	628	PF00400	0.480
DEG_SPOP_SBC_1	329	333	PF00917	0.343
DOC_CYCLIN_RxL_1	332	343	PF00134	0.385
DOC_CYCLIN_RxL_1	447	458	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	175	178	PF00134	0.533
DOC_MAPK_gen_1	387	397	PF00069	0.300
DOC_MIT_MIM_1	615	623	PF04212	0.472
DOC_PP1_RVXF_1	266	272	PF00149	0.412
DOC_PP1_RVXF_1	333	340	PF00149	0.392
DOC_PP2B_LxvP_1	175	178	PF13499	0.533
DOC_PP2B_LxvP_1	309	312	PF13499	0.326
DOC_SPAK_OSR1_1	546	550	PF12202	0.536
DOC_USP7_MATH_1	161	165	PF00917	0.566
DOC_USP7_MATH_1	20	24	PF00917	0.587
DOC_USP7_MATH_1	211	215	PF00917	0.604
DOC_USP7_MATH_1	305	309	PF00917	0.430
DOC_USP7_MATH_1	469	473	PF00917	0.744
DOC_USP7_MATH_1	483	487	PF00917	0.756
DOC_USP7_MATH_1	503	507	PF00917	0.615
DOC_USP7_MATH_1	530	534	PF00917	0.714
DOC_USP7_MATH_1	551	555	PF00917	0.721
DOC_USP7_MATH_1	571	575	PF00917	0.654
DOC_USP7_MATH_1	609	613	PF00917	0.486
DOC_USP7_UBL2_3	138	142	PF12436	0.417
DOC_WW_Pin1_4	204	209	PF00397	0.556
DOC_WW_Pin1_4	47	52	PF00397	0.476
DOC_WW_Pin1_4	586	591	PF00397	0.596
DOC_WW_Pin1_4	621	626	PF00397	0.502
LIG_14-3-3_CanoR_1	268	272	PF00244	0.461
LIG_14-3-3_CanoR_1	279	288	PF00244	0.567
LIG_14-3-3_CanoR_1	301	309	PF00244	0.371
LIG_14-3-3_CanoR_1	387	393	PF00244	0.385
LIG_14-3-3_CanoR_1	430	439	PF00244	0.408
LIG_14-3-3_CanoR_1	497	502	PF00244	0.585
LIG_14-3-3_CanoR_1	546	555	PF00244	0.666
LIG_BIR_III_4	404	408	PF00653	0.385
LIG_BRCT_BRCA1_1	466	470	PF00533	0.606
LIG_BRCT_BRCA1_1	543	547	PF00533	0.598
LIG_Clathr_ClatBox_1	613	617	PF01394	0.471
LIG_deltaCOP1_diTrp_1	143	150	PF00928	0.451
LIG_eIF4E_1	144	150	PF01652	0.415
LIG_FHA_1	239	245	PF00498	0.395
LIG_FHA_1	268	274	PF00498	0.397
LIG_FHA_1	281	287	PF00498	0.468
LIG_FHA_1	331	337	PF00498	0.389
LIG_FHA_1	389	395	PF00498	0.352
LIG_FHA_1	485	491	PF00498	0.730
LIG_FHA_1	494	500	PF00498	0.763
LIG_FHA_1	578	584	PF00498	0.648
LIG_FHA_2	205	211	PF00498	0.639
LIG_FHA_2	302	308	PF00498	0.376
LIG_FHA_2	622	628	PF00498	0.503
LIG_FHA_2	94	100	PF00498	0.430
LIG_FXI_DFP_1	39	43	PF00024	0.495
LIG_LIR_Gen_1	22	30	PF02991	0.484
LIG_LIR_Gen_1	255	265	PF02991	0.505
LIG_LIR_Gen_1	85	95	PF02991	0.403
LIG_LIR_Nem_3	143	149	PF02991	0.515
LIG_LIR_Nem_3	255	261	PF02991	0.418
LIG_LIR_Nem_3	617	623	PF02991	0.501
LIG_LIR_Nem_3	85	90	PF02991	0.415
LIG_PCNA_yPIPBox_3	80	90	PF02747	0.498
LIG_Pex14_1	146	150	PF04695	0.330
LIG_Pex14_2	267	271	PF04695	0.403
LIG_SH2_CRK	87	91	PF00017	0.475
LIG_SH2_STAP1	254	258	PF00017	0.397
LIG_SH2_STAP1	494	498	PF00017	0.613
LIG_SH2_STAP1	87	91	PF00017	0.381
LIG_SH2_STAT3	640	643	PF00017	0.506
LIG_SH2_STAT5	238	241	PF00017	0.352
LIG_SH2_STAT5	303	306	PF00017	0.318
LIG_SH2_STAT5	368	371	PF00017	0.339
LIG_SH2_STAT5	53	56	PF00017	0.485
LIG_SH3_3	12	18	PF00018	0.660
LIG_SH3_3	239	245	PF00018	0.426
LIG_SH3_3	357	363	PF00018	0.444
LIG_SH3_3	587	593	PF00018	0.738
LIG_SH3_3	92	98	PF00018	0.458
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.406
LIG_SUMO_SIM_par_1	495	502	PF11976	0.746
LIG_SUMO_SIM_par_1	612	617	PF11976	0.470
LIG_TRAF2_1	363	366	PF00917	0.331
LIG_TRAF2_1	521	524	PF00917	0.773
LIG_TRAF2_1	57	60	PF00917	0.491
LIG_TRAF2_1	625	628	PF00917	0.505
LIG_WRC_WIRS_1	264	269	PF05994	0.445
LIG_WRPW_2	251	254	PF00400	0.447
MOD_CDK_SPK_2	204	209	PF00069	0.556
MOD_CK1_1	131	137	PF00069	0.447
MOD_CK1_1	198	204	PF00069	0.625
MOD_CK1_1	330	336	PF00069	0.343
MOD_CK1_1	340	346	PF00069	0.289
MOD_CK1_1	455	461	PF00069	0.462
MOD_CK1_1	486	492	PF00069	0.629
MOD_CK1_1	554	560	PF00069	0.648
MOD_CK2_1	301	307	PF00069	0.406
MOD_CK2_1	431	437	PF00069	0.550
MOD_CK2_1	499	505	PF00069	0.705
MOD_CK2_1	54	60	PF00069	0.504
MOD_CK2_1	609	615	PF00069	0.490
MOD_CK2_1	621	627	PF00069	0.497
MOD_CK2_1	66	72	PF00069	0.418
MOD_GlcNHglycan	200	203	PF01048	0.653
MOD_GlcNHglycan	454	457	PF01048	0.426
MOD_GlcNHglycan	501	504	PF01048	0.687
MOD_GSK3_1	194	201	PF00069	0.601
MOD_GSK3_1	263	270	PF00069	0.379
MOD_GSK3_1	301	308	PF00069	0.399
MOD_GSK3_1	477	484	PF00069	0.790
MOD_GSK3_1	485	492	PF00069	0.632
MOD_GSK3_1	493	500	PF00069	0.531
MOD_GSK3_1	541	548	PF00069	0.621
MOD_GSK3_1	93	100	PF00069	0.473
MOD_N-GLC_1	171	176	PF02516	0.569
MOD_N-GLC_1	388	393	PF02516	0.325
MOD_N-GLC_1	609	614	PF02516	0.485
MOD_NEK2_1	162	167	PF00069	0.570
MOD_NEK2_1	189	194	PF00069	0.624
MOD_NEK2_1	267	272	PF00069	0.424
MOD_NEK2_1	328	333	PF00069	0.352
MOD_NEK2_1	337	342	PF00069	0.316
MOD_NEK2_1	388	393	PF00069	0.304
MOD_NEK2_1	411	416	PF00069	0.464
MOD_NEK2_1	431	436	PF00069	0.292
MOD_NEK2_1	452	457	PF00069	0.483
MOD_NEK2_1	499	504	PF00069	0.656
MOD_NEK2_1	54	59	PF00069	0.486
MOD_NEK2_1	547	552	PF00069	0.768
MOD_NEK2_1	594	599	PF00069	0.525
MOD_NEK2_1	644	649	PF00069	0.567
MOD_NEK2_1	66	71	PF00069	0.384
MOD_NEK2_2	263	268	PF00069	0.409
MOD_NEK2_2	305	310	PF00069	0.431
MOD_PIKK_1	189	195	PF00454	0.623
MOD_PIKK_1	337	343	PF00454	0.385
MOD_PIKK_1	444	450	PF00454	0.490
MOD_PIKK_1	455	461	PF00454	0.493
MOD_PIKK_1	515	521	PF00454	0.634
MOD_PIKK_1	578	584	PF00454	0.697
MOD_PIKK_1	93	99	PF00454	0.426
MOD_PKA_2	131	137	PF00069	0.524
MOD_PKA_2	267	273	PF00069	0.385
MOD_PKA_2	278	284	PF00069	0.531
MOD_PKA_2	545	551	PF00069	0.668
MOD_PKA_2	571	577	PF00069	0.655
MOD_PKA_2	668	674	PF00069	0.604
MOD_Plk_1	211	217	PF00069	0.601
MOD_Plk_1	388	394	PF00069	0.325
MOD_Plk_1	463	469	PF00069	0.604
MOD_Plk_1	530	536	PF00069	0.698
MOD_Plk_1	561	567	PF00069	0.652
MOD_Plk_1	578	584	PF00069	0.626
MOD_Plk_1	609	615	PF00069	0.490
MOD_Plk_1	644	650	PF00069	0.683
MOD_Plk_4	171	177	PF00069	0.668
MOD_Plk_4	179	185	PF00069	0.572
MOD_Plk_4	351	357	PF00069	0.390
MOD_Plk_4	489	495	PF00069	0.608
MOD_Plk_4	49	55	PF00069	0.449
MOD_Plk_4	609	615	PF00069	0.510
MOD_Plk_4	97	103	PF00069	0.501
MOD_ProDKin_1	204	210	PF00069	0.555
MOD_ProDKin_1	47	53	PF00069	0.478
MOD_ProDKin_1	586	592	PF00069	0.594
MOD_ProDKin_1	621	627	PF00069	0.497
TRG_DiLeu_BaEn_1	291	296	PF01217	0.459
TRG_DiLeu_BaEn_1	351	356	PF01217	0.412
TRG_DiLeu_BaEn_4	463	469	PF01217	0.562
TRG_DiLeu_BaEn_4	81	87	PF01217	0.504
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.710
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.443
TRG_ENDOCYTIC_2	254	257	PF00928	0.374
TRG_ENDOCYTIC_2	303	306	PF00928	0.352
TRG_ENDOCYTIC_2	87	90	PF00928	0.390
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS3	Leptomonas seymouri	62%	100%
A0A3R7LWJ9	Trypanosoma rangeli	40%	100%
A0A3S7WUQ4	Leishmania donovani	94%	100%
A4H936	Leishmania braziliensis	78%	100%
A4HXG8	Leishmania infantum	94%	100%
C9ZP54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AR63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%