PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QE99_LEIMA

TriTrypDb:

LmjF.17.0910 , LMJLV39_170016300 , LMJSD75_170015900

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QE99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE99

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0036149	phosphatidylinositol acyl-chain remodeling	7	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046488	phosphatidylinositol metabolic process	6	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.532
CLV_NRD_NRD_1	194	196	PF00675	0.251
CLV_NRD_NRD_1	387	389	PF00675	0.313
CLV_NRD_NRD_1	462	464	PF00675	0.369
CLV_NRD_NRD_1	470	472	PF00675	0.431
CLV_PCSK_FUR_1	460	464	PF00082	0.372
CLV_PCSK_KEX2_1	194	196	PF00082	0.220
CLV_PCSK_KEX2_1	387	389	PF00082	0.362
CLV_PCSK_KEX2_1	462	464	PF00082	0.372
CLV_PCSK_PC7_1	383	389	PF00082	0.328
CLV_PCSK_SKI1_1	157	161	PF00082	0.185
CLV_PCSK_SKI1_1	178	182	PF00082	0.205
CLV_PCSK_SKI1_1	239	243	PF00082	0.323
CLV_PCSK_SKI1_1	338	342	PF00082	0.255
CLV_PCSK_SKI1_1	359	363	PF00082	0.275
CLV_PCSK_SKI1_1	37	41	PF00082	0.557
CLV_PCSK_SKI1_1	434	438	PF00082	0.413
CLV_PCSK_SKI1_1	462	466	PF00082	0.452
DEG_APCC_DBOX_1	416	424	PF00400	0.308
DEG_APCC_DBOX_1	60	68	PF00400	0.271
DEG_MDM2_SWIB_1	415	423	PF02201	0.311
DEG_Nend_UBRbox_1	1	4	PF02207	0.632
DEG_SCF_FBW7_1	450	456	PF00400	0.488
DOC_CDC14_PxL_1	164	172	PF14671	0.451
DOC_CKS1_1	450	455	PF01111	0.496
DOC_CYCLIN_RxL_1	106	114	PF00134	0.531
DOC_CYCLIN_RxL_1	175	183	PF00134	0.455
DOC_CYCLIN_RxL_1	332	343	PF00134	0.532
DOC_MAPK_gen_1	293	299	PF00069	0.546
DOC_MAPK_gen_1	387	395	PF00069	0.518
DOC_MAPK_JIP1_4	280	286	PF00069	0.587
DOC_MAPK_MEF2A_6	261	270	PF00069	0.435
DOC_PP1_RVXF_1	134	140	PF00149	0.449
DOC_PP1_RVXF_1	193	200	PF00149	0.508
DOC_PP2B_LxvP_1	117	120	PF13499	0.576
DOC_PP2B_PxIxI_1	206	212	PF00149	0.435
DOC_SPAK_OSR1_1	344	348	PF12202	0.417
DOC_USP7_UBL2_3	161	165	PF12436	0.470
DOC_WW_Pin1_4	203	208	PF00397	0.508
DOC_WW_Pin1_4	216	221	PF00397	0.508
DOC_WW_Pin1_4	449	454	PF00397	0.499
LIG_14-3-3_CanoR_1	150	160	PF00244	0.550
LIG_14-3-3_CanoR_1	417	427	PF00244	0.302
LIG_APCC_ABBA_1	209	214	PF00400	0.429
LIG_CaM_IQ_9	455	471	PF13499	0.537
LIG_deltaCOP1_diTrp_1	138	146	PF00928	0.432
LIG_EH1_1	403	411	PF00400	0.173
LIG_eIF4E_1	404	410	PF01652	0.173
LIG_FHA_1	147	153	PF00498	0.430
LIG_FHA_1	204	210	PF00498	0.460
LIG_FHA_1	244	250	PF00498	0.447
LIG_FHA_1	326	332	PF00498	0.489
LIG_FHA_1	346	352	PF00498	0.536
LIG_FHA_1	420	426	PF00498	0.366
LIG_FHA_2	80	86	PF00498	0.531
LIG_LIR_Apic_2	273	277	PF02991	0.585
LIG_LIR_Gen_1	108	117	PF02991	0.491
LIG_LIR_Gen_1	138	147	PF02991	0.405
LIG_LIR_Gen_1	421	432	PF02991	0.275
LIG_LIR_Gen_1	445	455	PF02991	0.548
LIG_LIR_Gen_1	78	87	PF02991	0.428
LIG_LIR_Nem_3	108	113	PF02991	0.512
LIG_LIR_Nem_3	142	146	PF02991	0.458
LIG_LIR_Nem_3	175	180	PF02991	0.424
LIG_LIR_Nem_3	408	414	PF02991	0.401
LIG_LIR_Nem_3	421	427	PF02991	0.182
LIG_LIR_Nem_3	445	450	PF02991	0.541
LIG_LIR_Nem_3	78	84	PF02991	0.424
LIG_MAD2	115	123	PF02301	0.510
LIG_PCNA_PIPBox_1	193	202	PF02747	0.455
LIG_Pex14_1	139	143	PF04695	0.464
LIG_Pex14_1	385	389	PF04695	0.527
LIG_Pex14_2	177	181	PF04695	0.398
LIG_Pex14_2	414	418	PF04695	0.379
LIG_REV1ctd_RIR_1	412	421	PF16727	0.304
LIG_SH2_CRK	274	278	PF00017	0.627
LIG_SH2_CRK	390	394	PF00017	0.514
LIG_SH2_GRB2like	447	450	PF00017	0.435
LIG_SH2_NCK_1	81	85	PF00017	0.469
LIG_SH2_SRC	447	450	PF00017	0.523
LIG_SH2_STAP1	141	145	PF00017	0.451
LIG_SH2_STAP1	229	233	PF00017	0.508
LIG_SH2_STAP1	272	276	PF00017	0.477
LIG_SH2_STAT3	389	392	PF00017	0.513
LIG_SH2_STAT5	110	113	PF00017	0.475
LIG_SH2_STAT5	141	144	PF00017	0.466
LIG_SH2_STAT5	145	148	PF00017	0.424
LIG_SH2_STAT5	158	161	PF00017	0.338
LIG_SH2_STAT5	179	182	PF00017	0.415
LIG_SH2_STAT5	272	275	PF00017	0.479
LIG_SH2_STAT5	34	37	PF00017	0.502
LIG_SH2_STAT5	38	41	PF00017	0.399
LIG_SH2_STAT5	412	415	PF00017	0.497
LIG_SH2_STAT5	447	450	PF00017	0.569
LIG_SH2_STAT5	63	66	PF00017	0.337
LIG_SH2_STAT5	81	84	PF00017	0.467
LIG_SH3_2	120	125	PF14604	0.512
LIG_SH3_3	113	119	PF00018	0.473
LIG_SH3_3	230	236	PF00018	0.429
LIG_SH3_3	238	244	PF00018	0.385
LIG_SH3_3	378	384	PF00018	0.580
LIG_SH3_3	396	402	PF00018	0.390
LIG_SH3_3	447	453	PF00018	0.596
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.435
LIG_SUMO_SIM_par_1	246	254	PF11976	0.515
LIG_TRAF2_1	321	324	PF00917	0.522
LIG_TYR_ITIM	79	84	PF00017	0.449
LIG_UBA3_1	152	161	PF00899	0.540
LIG_WRC_WIRS_1	140	145	PF05994	0.451
MOD_CK2_1	20	26	PF00069	0.304
MOD_GSK3_1	266	273	PF00069	0.432
MOD_GSK3_1	449	456	PF00069	0.623
MOD_GSK3_1	75	82	PF00069	0.346
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	146	151	PF00069	0.520
MOD_NEK2_1	180	185	PF00069	0.467
MOD_NEK2_1	298	303	PF00069	0.549
MOD_NEK2_1	340	345	PF00069	0.455
MOD_NEK2_1	59	64	PF00069	0.356
MOD_NEK2_1	75	80	PF00069	0.330
MOD_NEK2_2	20	25	PF00069	0.238
MOD_NEK2_2	96	101	PF00069	0.538
MOD_PIKK_1	118	124	PF00454	0.577
MOD_PIKK_1	223	229	PF00454	0.483
MOD_PKA_2	244	250	PF00069	0.415
MOD_Plk_1	282	288	PF00069	0.532
MOD_Plk_1	453	459	PF00069	0.582
MOD_Plk_4	139	145	PF00069	0.451
MOD_Plk_4	405	411	PF00069	0.288
MOD_Plk_4	419	425	PF00069	0.205
MOD_Plk_4	442	448	PF00069	0.559
MOD_Plk_4	453	459	PF00069	0.542
MOD_Plk_4	79	85	PF00069	0.457
MOD_ProDKin_1	203	209	PF00069	0.508
MOD_ProDKin_1	216	222	PF00069	0.508
MOD_ProDKin_1	449	455	PF00069	0.495
MOD_SUMO_rev_2	162	167	PF00179	0.486
MOD_SUMO_rev_2	467	476	PF00179	0.618
TRG_AP2beta_CARGO_1	175	184	PF09066	0.435
TRG_DiLeu_BaEn_1	337	342	PF01217	0.530
TRG_ENDOCYTIC_2	110	113	PF00928	0.503
TRG_ENDOCYTIC_2	141	144	PF00928	0.508
TRG_ENDOCYTIC_2	179	182	PF00928	0.415
TRG_ENDOCYTIC_2	390	393	PF00928	0.598
TRG_ENDOCYTIC_2	411	414	PF00928	0.249
TRG_ENDOCYTIC_2	447	450	PF00928	0.581
TRG_ENDOCYTIC_2	81	84	PF00928	0.449
TRG_ER_diArg_1	193	195	PF00400	0.404
TRG_ER_diArg_1	386	388	PF00400	0.529
TRG_ER_diArg_1	460	463	PF00400	0.609
TRG_ER_diLys_1	472	477	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC7	Leptomonas seymouri	58%	100%
A0A0S4J7G6	Bodo saltans	31%	100%
A0A1X0NU94	Trypanosomatidae	38%	100%
A0A3Q8IE09	Leishmania donovani	96%	100%
A0A422NH08	Trypanosoma rangeli	42%	100%
A4H937	Leishmania braziliensis	75%	100%
A4HXG9	Leishmania infantum	96%	100%
C9ZP55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AR64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q20800	Caenorhabditis elegans	27%	100%
Q5F3X0	Gallus gallus	28%	100%
V5BF39	Trypanosoma cruzi	40%	100%