Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4QE98_LEIMA

TriTrypDb:

LmjF.17.0920 , LMJLV39_170016400 , LMJSD75_170016000

Length:

2368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QE98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	11
GO:0010467	gene expression	4	5
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	3
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.538
CLV_C14_Caspase3-7	146	150	PF00656	0.582
CLV_C14_Caspase3-7	1473	1477	PF00656	0.591
CLV_C14_Caspase3-7	1682	1686	PF00656	0.444
CLV_C14_Caspase3-7	1691	1695	PF00656	0.433
CLV_C14_Caspase3-7	2101	2105	PF00656	0.434
CLV_C14_Caspase3-7	2328	2332	PF00656	0.456
CLV_MEL_PAP_1	2293	2299	PF00089	0.495
CLV_NRD_NRD_1	1168	1170	PF00675	0.238
CLV_NRD_NRD_1	1183	1185	PF00675	0.159

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE72	Leptomonas seymouri	74%	100%
A0A0S4JQT9	Bodo saltans	41%	100%
A0A1X0NT92	Trypanosomatidae	51%	100%
A0A3Q8I9S7	Leishmania donovani	96%	100%
A0A3Q8IBN2	Leishmania donovani	30%	100%
A0A3R7KB93	Trypanosoma rangeli	49%	100%
A4H739	Leishmania braziliensis	30%	100%
A4H938	Leishmania braziliensis	87%	100%
A4HVH9	Leishmania infantum	30%	100%
A4HXH0	Leishmania infantum	96%	100%

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