LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QE91_LEIMA
TriTrypDb:
LmjF.17.1000 , LMJLV39_170017200 * , LMJSD75_170016900
Length:
729

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE91
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE91

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 552 556 PF00656 0.633
CLV_C14_Caspase3-7 578 582 PF00656 0.523
CLV_NRD_NRD_1 18 20 PF00675 0.364
CLV_NRD_NRD_1 370 372 PF00675 0.509
CLV_NRD_NRD_1 404 406 PF00675 0.536
CLV_PCSK_FUR_1 368 372 PF00082 0.536
CLV_PCSK_KEX2_1 18 20 PF00082 0.364
CLV_PCSK_KEX2_1 248 250 PF00082 0.526
CLV_PCSK_KEX2_1 370 372 PF00082 0.509
CLV_PCSK_KEX2_1 404 406 PF00082 0.536
CLV_PCSK_PC1ET2_1 248 250 PF00082 0.563
CLV_PCSK_PC7_1 14 20 PF00082 0.365
CLV_PCSK_SKI1_1 404 408 PF00082 0.536
CLV_PCSK_SKI1_1 508 512 PF00082 0.551
CLV_PCSK_SKI1_1 636 640 PF00082 0.384
CLV_PCSK_SKI1_1 74 78 PF00082 0.349
DEG_COP1_1 203 213 PF00400 0.498
DEG_SPOP_SBC_1 258 262 PF00917 0.615
DOC_CKS1_1 618 623 PF01111 0.361
DOC_CKS1_1 655 660 PF01111 0.419
DOC_CYCLIN_yClb3_PxF_3 397 405 PF00134 0.536
DOC_CYCLIN_yCln2_LP_2 108 114 PF00134 0.427
DOC_CYCLIN_yCln2_LP_2 496 502 PF00134 0.508
DOC_CYCLIN_yCln2_LP_2 538 544 PF00134 0.625
DOC_CYCLIN_yCln2_LP_2 637 643 PF00134 0.350
DOC_MAPK_DCC_7 462 470 PF00069 0.385
DOC_MAPK_gen_1 633 641 PF00069 0.401
DOC_MAPK_MEF2A_6 462 470 PF00069 0.400
DOC_MAPK_MEF2A_6 633 641 PF00069 0.401
DOC_PP2B_LxvP_1 108 111 PF13499 0.384
DOC_PP2B_LxvP_1 208 211 PF13499 0.452
DOC_PP2B_LxvP_1 496 499 PF13499 0.522
DOC_PP2B_LxvP_1 538 541 PF13499 0.634
DOC_PP2B_LxvP_1 637 640 PF13499 0.350
DOC_PP4_FxxP_1 618 621 PF00568 0.350
DOC_USP7_MATH_1 209 213 PF00917 0.424
DOC_USP7_MATH_1 275 279 PF00917 0.578
DOC_USP7_MATH_1 59 63 PF00917 0.563
DOC_USP7_MATH_1 626 630 PF00917 0.511
DOC_USP7_MATH_1 685 689 PF00917 0.586
DOC_USP7_UBL2_3 338 342 PF12436 0.630
DOC_WW_Pin1_4 139 144 PF00397 0.388
DOC_WW_Pin1_4 262 267 PF00397 0.666
DOC_WW_Pin1_4 320 325 PF00397 0.673
DOC_WW_Pin1_4 358 363 PF00397 0.655
DOC_WW_Pin1_4 530 535 PF00397 0.718
DOC_WW_Pin1_4 60 65 PF00397 0.482
DOC_WW_Pin1_4 617 622 PF00397 0.353
DOC_WW_Pin1_4 654 659 PF00397 0.429
DOC_WW_Pin1_4 683 688 PF00397 0.480
DOC_WW_Pin1_4 694 699 PF00397 0.602
LIG_14-3-3_CanoR_1 11 21 PF00244 0.413
LIG_14-3-3_CanoR_1 446 454 PF00244 0.418
LIG_14-3-3_CanoR_1 606 613 PF00244 0.410
LIG_APCC_ABBA_1 110 115 PF00400 0.405
LIG_BIR_II_1 1 5 PF00653 0.595
LIG_BIR_III_2 297 301 PF00653 0.608
LIG_BRCT_BRCA1_1 195 199 PF00533 0.516
LIG_BRCT_BRCA1_1 439 443 PF00533 0.473
LIG_BRCT_BRCA1_1 723 727 PF00533 0.531
LIG_FHA_1 212 218 PF00498 0.406
LIG_FHA_1 231 237 PF00498 0.436
LIG_FHA_1 289 295 PF00498 0.670
LIG_FHA_1 446 452 PF00498 0.410
LIG_FHA_1 618 624 PF00498 0.377
LIG_FHA_2 199 205 PF00498 0.491
LIG_FHA_2 279 285 PF00498 0.769
LIG_FHA_2 626 632 PF00498 0.570
LIG_LIR_Apic_2 412 416 PF02991 0.460
LIG_LIR_Apic_2 616 621 PF02991 0.353
LIG_LIR_Gen_1 125 134 PF02991 0.445
LIG_LIR_Gen_1 452 459 PF02991 0.420
LIG_LIR_Gen_1 609 619 PF02991 0.392
LIG_LIR_Gen_1 673 682 PF02991 0.377
LIG_LIR_Nem_3 120 124 PF02991 0.453
LIG_LIR_Nem_3 125 129 PF02991 0.516
LIG_LIR_Nem_3 196 202 PF02991 0.476
LIG_LIR_Nem_3 239 244 PF02991 0.461
LIG_LIR_Nem_3 378 384 PF02991 0.541
LIG_LIR_Nem_3 452 457 PF02991 0.422
LIG_LIR_Nem_3 609 615 PF02991 0.414
LIG_LIR_Nem_3 673 679 PF02991 0.378
LIG_LIR_Nem_3 688 693 PF02991 0.566
LIG_Pex14_1 428 432 PF04695 0.376
LIG_Pex14_2 202 206 PF04695 0.500
LIG_Pex14_2 402 406 PF04695 0.454
LIG_SH2_CRK 454 458 PF00017 0.418
LIG_SH2_GRB2like 352 355 PF00017 0.618
LIG_SH2_NCK_1 289 293 PF00017 0.619
LIG_SH2_NCK_1 352 356 PF00017 0.593
LIG_SH2_SRC 169 172 PF00017 0.335
LIG_SH2_STAP1 232 236 PF00017 0.416
LIG_SH2_STAP1 437 441 PF00017 0.411
LIG_SH2_STAT3 227 230 PF00017 0.372
LIG_SH2_STAT5 103 106 PF00017 0.481
LIG_SH2_STAT5 227 230 PF00017 0.372
LIG_SH2_STAT5 232 235 PF00017 0.431
LIG_SH2_STAT5 241 244 PF00017 0.537
LIG_SH2_STAT5 365 368 PF00017 0.642
LIG_SH2_STAT5 432 435 PF00017 0.417
LIG_SH2_STAT5 437 440 PF00017 0.409
LIG_SH2_STAT5 627 630 PF00017 0.584
LIG_SH3_3 148 154 PF00018 0.440
LIG_SH3_3 296 302 PF00018 0.609
LIG_SH3_3 340 346 PF00018 0.690
LIG_SH3_3 394 400 PF00018 0.573
LIG_SH3_3 419 425 PF00018 0.364
LIG_SH3_3 528 534 PF00018 0.697
LIG_SH3_3 538 544 PF00018 0.728
LIG_SH3_3 652 658 PF00018 0.427
LIG_SUMO_SIM_anti_2 479 485 PF11976 0.431
LIG_SUMO_SIM_par_1 547 552 PF11976 0.573
LIG_TRAF2_1 473 476 PF00917 0.365
LIG_TRAF2_1 607 610 PF00917 0.406
LIG_WRC_WIRS_1 199 204 PF05994 0.485
LIG_WW_2 299 302 PF00397 0.602
MOD_CDC14_SPxK_1 323 326 PF00782 0.496
MOD_CDC14_SPxK_1 533 536 PF00782 0.689
MOD_CDK_SPxK_1 320 326 PF00069 0.511
MOD_CDK_SPxK_1 530 536 PF00069 0.693
MOD_CK1_1 13 19 PF00069 0.451
MOD_CK1_1 252 258 PF00069 0.688
MOD_CK1_1 262 268 PF00069 0.583
MOD_CK1_1 273 279 PF00069 0.594
MOD_CK1_1 290 296 PF00069 0.558
MOD_CK1_1 333 339 PF00069 0.601
MOD_CK1_1 452 458 PF00069 0.493
MOD_CK1_1 529 535 PF00069 0.632
MOD_CK1_1 716 722 PF00069 0.612
MOD_CK2_1 198 204 PF00069 0.481
MOD_CK2_1 24 30 PF00069 0.397
MOD_CK2_1 278 284 PF00069 0.684
MOD_CK2_1 436 442 PF00069 0.411
MOD_CK2_1 470 476 PF00069 0.363
MOD_CK2_1 482 488 PF00069 0.360
MOD_CK2_1 604 610 PF00069 0.483
MOD_GlcNHglycan 217 220 PF01048 0.356
MOD_GlcNHglycan 261 264 PF01048 0.621
MOD_GlcNHglycan 267 270 PF01048 0.725
MOD_GlcNHglycan 272 275 PF01048 0.595
MOD_GlcNHglycan 277 280 PF01048 0.567
MOD_GlcNHglycan 335 338 PF01048 0.605
MOD_GlcNHglycan 439 442 PF01048 0.409
MOD_GlcNHglycan 45 48 PF01048 0.450
MOD_GlcNHglycan 454 457 PF01048 0.513
MOD_GlcNHglycan 511 514 PF01048 0.671
MOD_GlcNHglycan 517 521 PF01048 0.612
MOD_GlcNHglycan 52 55 PF01048 0.577
MOD_GlcNHglycan 551 554 PF01048 0.631
MOD_GlcNHglycan 555 559 PF01048 0.628
MOD_GlcNHglycan 568 571 PF01048 0.428
MOD_GlcNHglycan 6 9 PF01048 0.638
MOD_GlcNHglycan 628 631 PF01048 0.513
MOD_GlcNHglycan 633 636 PF01048 0.443
MOD_GlcNHglycan 86 89 PF01048 0.357
MOD_GSK3_1 211 218 PF00069 0.390
MOD_GSK3_1 249 256 PF00069 0.600
MOD_GSK3_1 257 264 PF00069 0.585
MOD_GSK3_1 283 290 PF00069 0.648
MOD_GSK3_1 329 336 PF00069 0.589
MOD_GSK3_1 405 412 PF00069 0.518
MOD_GSK3_1 43 50 PF00069 0.492
MOD_GSK3_1 431 438 PF00069 0.448
MOD_GSK3_1 445 452 PF00069 0.330
MOD_GSK3_1 526 533 PF00069 0.606
MOD_GSK3_1 575 582 PF00069 0.529
MOD_GSK3_1 6 13 PF00069 0.502
MOD_GSK3_1 721 728 PF00069 0.595
MOD_N-GLC_1 363 368 PF02516 0.602
MOD_N-GLC_1 527 532 PF02516 0.703
MOD_NEK2_1 1 6 PF00069 0.631
MOD_NEK2_1 10 15 PF00069 0.448
MOD_NEK2_1 102 107 PF00069 0.399
MOD_NEK2_1 192 197 PF00069 0.341
MOD_NEK2_1 24 29 PF00069 0.420
MOD_NEK2_1 242 247 PF00069 0.538
MOD_NEK2_1 270 275 PF00069 0.554
MOD_NEK2_1 304 309 PF00069 0.661
MOD_NEK2_1 330 335 PF00069 0.614
MOD_NEK2_1 579 584 PF00069 0.500
MOD_NEK2_1 721 726 PF00069 0.525
MOD_NEK2_2 363 368 PF00069 0.581
MOD_NEK2_2 6 11 PF00069 0.492
MOD_OFUCOSY 167 173 PF10250 0.337
MOD_PIKK_1 193 199 PF00454 0.493
MOD_PIKK_1 395 401 PF00454 0.534
MOD_PIKK_1 714 720 PF00454 0.598
MOD_PK_1 156 162 PF00069 0.438
MOD_PKA_2 10 16 PF00069 0.468
MOD_PKA_2 445 451 PF00069 0.404
MOD_PKA_2 47 53 PF00069 0.637
MOD_PKA_2 605 611 PF00069 0.400
MOD_Plk_1 363 369 PF00069 0.600
MOD_Plk_1 470 476 PF00069 0.384
MOD_Plk_1 526 532 PF00069 0.699
MOD_Plk_4 177 183 PF00069 0.375
MOD_Plk_4 24 30 PF00069 0.382
MOD_Plk_4 330 336 PF00069 0.566
MOD_Plk_4 449 455 PF00069 0.388
MOD_Plk_4 479 485 PF00069 0.380
MOD_Plk_4 575 581 PF00069 0.436
MOD_Plk_4 685 691 PF00069 0.559
MOD_Plk_4 76 82 PF00069 0.532
MOD_ProDKin_1 139 145 PF00069 0.387
MOD_ProDKin_1 262 268 PF00069 0.667
MOD_ProDKin_1 320 326 PF00069 0.672
MOD_ProDKin_1 358 364 PF00069 0.655
MOD_ProDKin_1 530 536 PF00069 0.720
MOD_ProDKin_1 60 66 PF00069 0.463
MOD_ProDKin_1 617 623 PF00069 0.359
MOD_ProDKin_1 654 660 PF00069 0.422
MOD_ProDKin_1 683 689 PF00069 0.489
MOD_ProDKin_1 694 700 PF00069 0.604
MOD_SUMO_for_1 341 344 PF00179 0.549
MOD_SUMO_for_1 416 419 PF00179 0.482
MOD_SUMO_rev_2 507 512 PF00179 0.680
TRG_AP2beta_CARGO_1 673 683 PF09066 0.381
TRG_DiLeu_BaLyEn_6 119 124 PF01217 0.399
TRG_DiLeu_BaLyEn_6 618 623 PF01217 0.361
TRG_ENDOCYTIC_2 241 244 PF00928 0.468
TRG_ENDOCYTIC_2 454 457 PF00928 0.426
TRG_ER_diArg_1 17 19 PF00400 0.362
TRG_ER_diArg_1 367 370 PF00400 0.616
TRG_ER_diArg_1 403 405 PF00400 0.535
TRG_ER_diArg_1 598 601 PF00400 0.411
TRG_NES_CRM1_1 464 476 PF08389 0.385
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4Y2 Leptomonas seymouri 60% 100%
A0A3Q8IJH6 Leishmania donovani 90% 100%
A4H955 Leishmania braziliensis 73% 100%
A4HXH7 Leishmania infantum 90% 100%
E9AR72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS