Hydrolase, alpha/beta fold family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family-like protein

Species:

Leishmania major

UniProt:

Q4QE90_LEIMA

TriTrypDb:

LmjF.17.1010 , LMJLV39_170017300 , LMJSD75_170017000

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE90

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	32
GO:0016787	hydrolase activity	2	32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.352
CLV_NRD_NRD_1	146	148	PF00675	0.156
CLV_NRD_NRD_1	267	269	PF00675	0.454
CLV_NRD_NRD_1	279	281	PF00675	0.243
CLV_NRD_NRD_1	40	42	PF00675	0.458
CLV_PCSK_KEX2_1	146	148	PF00082	0.156
CLV_PCSK_KEX2_1	267	269	PF00082	0.454
CLV_PCSK_SKI1_1	30	34	PF00082	0.400
CLV_PCSK_SKI1_1	301	305	PF00082	0.316
DEG_APCC_DBOX_1	191	199	PF00400	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.451
DEG_SCF_TRCP1_1	94	99	PF00400	0.372
DOC_CKS1_1	104	109	PF01111	0.391
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.294
DOC_MAPK_gen_1	267	277	PF00069	0.365
DOC_MAPK_JIP1_4	200	206	PF00069	0.275
DOC_MAPK_MEF2A_6	268	277	PF00069	0.283
DOC_MAPK_MEF2A_6	314	322	PF00069	0.476
DOC_PP1_RVXF_1	299	306	PF00149	0.397
DOC_PP2B_LxvP_1	283	286	PF13499	0.307
DOC_USP7_MATH_2	73	79	PF00917	0.156
DOC_WW_Pin1_4	103	108	PF00397	0.344
DOC_WW_Pin1_4	115	120	PF00397	0.390
DOC_WW_Pin1_4	239	244	PF00397	0.536
LIG_14-3-3_CanoR_1	170	175	PF00244	0.283
LIG_14-3-3_CanoR_1	192	196	PF00244	0.355
LIG_Actin_WH2_2	191	209	PF00022	0.279
LIG_Actin_WH2_2	315	332	PF00022	0.253
LIG_BRCT_BRCA1_1	97	101	PF00533	0.339
LIG_Clathr_ClatBox_1	87	91	PF01394	0.191
LIG_FHA_1	104	110	PF00498	0.330
LIG_FHA_1	192	198	PF00498	0.404
LIG_FHA_2	126	132	PF00498	0.309
LIG_FHA_2	258	264	PF00498	0.223
LIG_FHA_2	38	44	PF00498	0.369
LIG_FHA_2	48	54	PF00498	0.359
LIG_FHA_2	97	103	PF00498	0.320
LIG_GBD_Chelix_1	61	69	PF00786	0.428
LIG_Integrin_RGD_1	221	223	PF01839	0.269
LIG_LIR_Apic_2	102	107	PF02991	0.387
LIG_LIR_Apic_2	182	188	PF02991	0.294
LIG_LIR_Gen_1	135	145	PF02991	0.411
LIG_LIR_Gen_1	29	38	PF02991	0.412
LIG_LIR_Nem_3	116	120	PF02991	0.317
LIG_LIR_Nem_3	135	140	PF02991	0.430
LIG_LIR_Nem_3	29	34	PF02991	0.382
LIG_LIR_Nem_3	98	104	PF02991	0.221
LIG_NRBOX	76	82	PF00104	0.250
LIG_NRP_CendR_1	334	337	PF00754	0.361
LIG_PCNA_yPIPBox_3	241	254	PF02747	0.473
LIG_Pex14_1	72	76	PF04695	0.249
LIG_PTB_Apo_2	80	87	PF02174	0.191
LIG_SH2_CRK	48	52	PF00017	0.443
LIG_SH2_GRB2like	287	290	PF00017	0.286
LIG_SH2_PTP2	185	188	PF00017	0.286
LIG_SH2_PTP2	317	320	PF00017	0.421
LIG_SH2_SRC	287	290	PF00017	0.286
LIG_SH2_SRC	317	320	PF00017	0.433
LIG_SH2_STAT5	127	130	PF00017	0.318
LIG_SH2_STAT5	185	188	PF00017	0.298
LIG_SH2_STAT5	212	215	PF00017	0.486
LIG_SH2_STAT5	224	227	PF00017	0.308
LIG_SH2_STAT5	317	320	PF00017	0.396
LIG_SH3_1	104	110	PF00018	0.183
LIG_SH3_3	104	110	PF00018	0.220
LIG_SH3_3	300	306	PF00018	0.381
LIG_SH3_3	51	57	PF00018	0.401
LIG_SH3_3	67	73	PF00018	0.173
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.531
LIG_SUMO_SIM_par_1	193	199	PF11976	0.335
LIG_SUMO_SIM_par_1	86	91	PF11976	0.156
LIG_TYR_ITIM	46	51	PF00017	0.429
MOD_CDK_SPxxK_3	239	246	PF00069	0.281
MOD_CK1_1	179	185	PF00069	0.374
MOD_CK1_1	95	101	PF00069	0.350
MOD_CK2_1	257	263	PF00069	0.285
MOD_CK2_1	37	43	PF00069	0.317
MOD_Cter_Amidation	278	281	PF01082	0.463
MOD_GlcNHglycan	181	184	PF01048	0.490
MOD_GlcNHglycan	94	97	PF01048	0.363
MOD_GSK3_1	172	179	PF00069	0.260
MOD_GSK3_1	92	99	PF00069	0.356
MOD_N-GLC_1	237	242	PF02516	0.264
MOD_NEK2_1	150	155	PF00069	0.333
MOD_NEK2_1	308	313	PF00069	0.351
MOD_NEK2_1	65	70	PF00069	0.379
MOD_NEK2_2	202	207	PF00069	0.286
MOD_PKA_2	191	197	PF00069	0.533
MOD_PKA_2	257	263	PF00069	0.431
MOD_PKA_2	92	98	PF00069	0.399
MOD_Plk_4	125	131	PF00069	0.321
MOD_Plk_4	138	144	PF00069	0.269
MOD_Plk_4	65	71	PF00069	0.422
MOD_ProDKin_1	103	109	PF00069	0.344
MOD_ProDKin_1	115	121	PF00069	0.390
MOD_ProDKin_1	239	245	PF00069	0.533
MOD_SUMO_rev_2	223	231	PF00179	0.305
TRG_ENDOCYTIC_2	317	320	PF00928	0.447
TRG_ENDOCYTIC_2	48	51	PF00928	0.342
TRG_ER_diArg_1	145	147	PF00400	0.204
TRG_ER_diArg_1	266	268	PF00400	0.415
TRG_NES_CRM1_1	75	91	PF08389	0.359
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	31%	78%
A0A0N0P3S4	Leptomonas seymouri	36%	93%
A0A0N1PA10	Leptomonas seymouri	40%	99%
A0A0N1PCQ2	Leptomonas seymouri	55%	100%
A0A0S4JQB3	Bodo saltans	37%	99%
A0A1X0NSR3	Trypanosomatidae	38%	75%
A0A1X0NSS6	Trypanosomatidae	41%	100%
A0A3Q8IAY1	Leishmania donovani	40%	86%
A0A3R7KKJ0	Trypanosoma rangeli	45%	100%
A0A3S5IRR1	Trypanosoma rangeli	29%	83%
A0A3S7WUJ3	Leishmania donovani	88%	100%
A0A3S7WUK0	Leishmania donovani	37%	78%
A0A3S7X1K2	Leishmania donovani	42%	97%
A0A422NS41	Trypanosoma rangeli	39%	78%
A1JMX1	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	25%	100%
A4H956	Leishmania braziliensis	55%	94%
A4H959	Leishmania braziliensis	31%	79%
A4H960	Leishmania braziliensis	36%	86%
A4HGL0	Leishmania braziliensis	42%	100%
A4HXH8	Leishmania infantum	88%	100%
A4HXI1	Leishmania infantum	31%	78%
A4HXI2	Leishmania infantum	40%	86%
A4I3N6	Leishmania infantum	42%	97%
A4VQH7	Pseudomonas stutzeri (strain A1501)	28%	100%
A8GCT3	Serratia proteamaculans (strain 568)	26%	100%
A9W3H8	Methylorubrum extorquens (strain PA1)	28%	100%
B0SW62	Caulobacter sp. (strain K31)	25%	100%
B1ZB18	Methylorubrum populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)	28%	100%
C5CN82	Variovorax paradoxus (strain S110)	26%	100%
C7CM33	Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)	28%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D5VGV3	Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059)	27%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	78%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	86%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
P9WNH0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WNH1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q48MQ7	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	29%	100%
Q4Q8A8	Leishmania major	42%	100%
Q4QE86	Leishmania major	40%	100%
Q54528	Streptomyces purpurascens	28%	100%
Q54809	Streptomyces peucetius	26%	100%
Q55217	Streptomyces sp. (strain C5)	25%	100%
V5AZB9	Trypanosoma cruzi	39%	79%
V5BER0	Trypanosoma cruzi	46%	100%
V5BNU9	Trypanosoma cruzi	26%	83%