EOG090X0431

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

EOG090X0431

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE88_LEIMA

TriTrypDb:

LmjF.17.1030 , LMJLV39_170017600 , LMJSD75_170017300

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	393	397	PF00656	0.552
CLV_C14_Caspase3-7	535	539	PF00656	0.422
CLV_C14_Caspase3-7	641	645	PF00656	0.442
CLV_MEL_PAP_1	112	118	PF00089	0.652
CLV_NRD_NRD_1	146	148	PF00675	0.562
CLV_NRD_NRD_1	163	165	PF00675	0.494
CLV_NRD_NRD_1	296	298	PF00675	0.580
CLV_NRD_NRD_1	418	420	PF00675	0.647
CLV_NRD_NRD_1	427	429	PF00675	0.580
CLV_NRD_NRD_1	755	757	PF00675	0.426
CLV_PCSK_KEX2_1	146	148	PF00082	0.562
CLV_PCSK_KEX2_1	163	165	PF00082	0.494
CLV_PCSK_KEX2_1	433	435	PF00082	0.577
CLV_PCSK_KEX2_1	755	757	PF00082	0.426
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.577
CLV_PCSK_SKI1_1	671	675	PF00082	0.411
CLV_PCSK_SKI1_1	713	717	PF00082	0.383
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_MAPK_gen_1	146	154	PF00069	0.616
DOC_MAPK_gen_1	433	439	PF00069	0.578
DOC_MAPK_MEF2A_6	794	803	PF00069	0.383
DOC_PP2B_PxIxI_1	489	495	PF00149	0.505
DOC_PP4_FxxP_1	216	219	PF00568	0.632
DOC_USP7_MATH_1	189	193	PF00917	0.632
DOC_USP7_MATH_1	207	211	PF00917	0.535
DOC_USP7_MATH_1	235	239	PF00917	0.636
DOC_USP7_MATH_1	386	390	PF00917	0.587
DOC_USP7_MATH_1	457	461	PF00917	0.716
DOC_USP7_MATH_1	568	572	PF00917	0.382
DOC_USP7_UBL2_3	429	433	PF12436	0.580
DOC_USP7_UBL2_3	570	574	PF12436	0.370
DOC_WW_Pin1_4	255	260	PF00397	0.608
DOC_WW_Pin1_4	278	283	PF00397	0.590
DOC_WW_Pin1_4	486	491	PF00397	0.523
DOC_WW_Pin1_4	615	620	PF00397	0.352
DOC_WW_Pin1_4	652	657	PF00397	0.495
DOC_WW_Pin1_4	69	74	PF00397	0.788
DOC_WW_Pin1_4	809	814	PF00397	0.463
LIG_14-3-3_CanoR_1	170	175	PF00244	0.656
LIG_14-3-3_CanoR_1	203	211	PF00244	0.633
LIG_14-3-3_CanoR_1	330	336	PF00244	0.660
LIG_14-3-3_CanoR_1	419	424	PF00244	0.678
LIG_14-3-3_CanoR_1	428	437	PF00244	0.642
LIG_14-3-3_CanoR_1	50	59	PF00244	0.564
LIG_14-3-3_CanoR_1	522	528	PF00244	0.497
LIG_14-3-3_CanoR_1	722	730	PF00244	0.392
LIG_APCC_ABBA_1	83	88	PF00400	0.628
LIG_BIR_III_2	396	400	PF00653	0.683
LIG_BRCT_BRCA1_1	301	305	PF00533	0.489
LIG_BRCT_BRCA1_1	581	585	PF00533	0.481
LIG_BRCT_BRCA1_1	617	621	PF00533	0.346
LIG_BRCT_BRCA1_1	686	690	PF00533	0.330
LIG_Clathr_ClatBox_1	801	805	PF01394	0.371
LIG_deltaCOP1_diTrp_1	562	566	PF00928	0.393
LIG_EH1_1	511	519	PF00400	0.421
LIG_EVH1_2	606	610	PF00568	0.484
LIG_FHA_1	346	352	PF00498	0.635
LIG_FHA_1	353	359	PF00498	0.681
LIG_FHA_1	471	477	PF00498	0.504
LIG_FHA_1	586	592	PF00498	0.398
LIG_FHA_1	665	671	PF00498	0.408
LIG_FHA_1	768	774	PF00498	0.438
LIG_FHA_1	781	787	PF00498	0.504
LIG_FHA_2	391	397	PF00498	0.570
LIG_FHA_2	406	412	PF00498	0.614
LIG_FHA_2	581	587	PF00498	0.461
LIG_FHA_2	612	618	PF00498	0.438
LIG_LIR_Apic_2	215	219	PF02991	0.630
LIG_LIR_Gen_1	103	112	PF02991	0.656
LIG_LIR_Gen_1	134	142	PF02991	0.685
LIG_LIR_Gen_1	561	572	PF02991	0.343
LIG_LIR_Gen_1	638	647	PF02991	0.353
LIG_LIR_Gen_1	737	746	PF02991	0.414
LIG_LIR_Gen_1	81	86	PF02991	0.610
LIG_LIR_Nem_3	134	138	PF02991	0.809
LIG_LIR_Nem_3	210	216	PF02991	0.639
LIG_LIR_Nem_3	302	308	PF02991	0.560
LIG_LIR_Nem_3	561	567	PF02991	0.350
LIG_LIR_Nem_3	576	580	PF02991	0.376
LIG_LIR_Nem_3	618	624	PF02991	0.349
LIG_LIR_Nem_3	638	642	PF02991	0.222
LIG_LIR_Nem_3	737	743	PF02991	0.420
LIG_PALB2_WD40_1	559	567	PF16756	0.402
LIG_PDZ_Class_1	817	822	PF00595	0.433
LIG_PTB_Apo_2	76	83	PF02174	0.659
LIG_RPA_C_Fungi	283	295	PF08784	0.511
LIG_SH2_CRK	701	705	PF00017	0.361
LIG_SH2_GRB2like	519	522	PF00017	0.457
LIG_SH2_PTP2	630	633	PF00017	0.359
LIG_SH2_STAT5	438	441	PF00017	0.584
LIG_SH2_STAT5	519	522	PF00017	0.457
LIG_SH2_STAT5	6	9	PF00017	0.641
LIG_SH2_STAT5	630	633	PF00017	0.383
LIG_SH2_STAT5	742	745	PF00017	0.395
LIG_SH3_3	35	41	PF00018	0.727
LIG_SH3_3	58	64	PF00018	0.588
LIG_SH3_3	706	712	PF00018	0.384
LIG_SUMO_SIM_anti_2	797	803	PF11976	0.448
LIG_SxIP_EBH_1	766	777	PF03271	0.422
LIG_TRAF2_1	532	535	PF00917	0.453
LIG_TYR_ITIM	699	704	PF00017	0.362
LIG_WRC_WIRS_1	101	106	PF05994	0.662
LIG_WRC_WIRS_1	116	121	PF05994	0.587
LIG_WRC_WIRS_1	213	218	PF05994	0.628
MOD_CK1_1	103	109	PF00069	0.640
MOD_CK1_1	134	140	PF00069	0.737
MOD_CK1_1	141	147	PF00069	0.651
MOD_CK1_1	157	163	PF00069	0.562
MOD_CK1_1	173	179	PF00069	0.781
MOD_CK1_1	212	218	PF00069	0.632
MOD_CK1_1	238	244	PF00069	0.599
MOD_CK1_1	251	257	PF00069	0.579
MOD_CK1_1	258	264	PF00069	0.452
MOD_CK1_1	390	396	PF00069	0.654
MOD_CK1_1	400	406	PF00069	0.712
MOD_CK1_1	460	466	PF00069	0.619
MOD_CK1_1	529	535	PF00069	0.450
MOD_CK1_1	676	682	PF00069	0.420
MOD_CK1_1	723	729	PF00069	0.387
MOD_CK2_1	405	411	PF00069	0.664
MOD_CK2_1	529	535	PF00069	0.453
MOD_CK2_1	580	586	PF00069	0.424
MOD_CK2_1	611	617	PF00069	0.438
MOD_CK2_1	676	682	PF00069	0.482
MOD_CK2_1	747	753	PF00069	0.437
MOD_CMANNOS	563	566	PF00535	0.324
MOD_Cter_Amidation	417	420	PF01082	0.685
MOD_GlcNHglycan	119	122	PF01048	0.625
MOD_GlcNHglycan	140	143	PF01048	0.653
MOD_GlcNHglycan	149	152	PF01048	0.678
MOD_GlcNHglycan	187	190	PF01048	0.619
MOD_GlcNHglycan	191	194	PF01048	0.598
MOD_GlcNHglycan	205	208	PF01048	0.561
MOD_GlcNHglycan	250	253	PF01048	0.664
MOD_GlcNHglycan	290	293	PF01048	0.664
MOD_GlcNHglycan	301	304	PF01048	0.421
MOD_GlcNHglycan	388	392	PF01048	0.800
MOD_GlcNHglycan	459	462	PF01048	0.684
MOD_GlcNHglycan	464	467	PF01048	0.644
MOD_GlcNHglycan	483	487	PF01048	0.382
MOD_GlcNHglycan	53	56	PF01048	0.745
MOD_GlcNHglycan	555	558	PF01048	0.404
MOD_GlcNHglycan	64	67	PF01048	0.612
MOD_GlcNHglycan	678	681	PF01048	0.452
MOD_GlcNHglycan	691	694	PF01048	0.399
MOD_GlcNHglycan	760	763	PF01048	0.437
MOD_GlcNHglycan	9	12	PF01048	0.592
MOD_GSK3_1	133	140	PF00069	0.780
MOD_GSK3_1	185	192	PF00069	0.636
MOD_GSK3_1	199	206	PF00069	0.608
MOD_GSK3_1	251	258	PF00069	0.640
MOD_GSK3_1	278	285	PF00069	0.538
MOD_GSK3_1	386	393	PF00069	0.753
MOD_GSK3_1	397	404	PF00069	0.679
MOD_GSK3_1	424	431	PF00069	0.656
MOD_GSK3_1	456	463	PF00069	0.621
MOD_GSK3_1	468	475	PF00069	0.470
MOD_GSK3_1	482	489	PF00069	0.441
MOD_GSK3_1	495	502	PF00069	0.498
MOD_GSK3_1	558	565	PF00069	0.362
MOD_GSK3_1	611	618	PF00069	0.373
MOD_GSK3_1	672	679	PF00069	0.392
MOD_GSK3_1	685	692	PF00069	0.321
MOD_GSK3_1	720	727	PF00069	0.401
MOD_GSK3_1	747	754	PF00069	0.389
MOD_N-GLC_1	405	410	PF02516	0.673
MOD_N-GLC_1	424	429	PF02516	0.562
MOD_N-GLC_1	611	616	PF02516	0.407
MOD_NEK2_1	154	159	PF00069	0.672
MOD_NEK2_1	168	173	PF00069	0.541
MOD_NEK2_1	185	190	PF00069	0.653
MOD_NEK2_1	248	253	PF00069	0.736
MOD_NEK2_1	354	359	PF00069	0.654
MOD_NEK2_1	472	477	PF00069	0.445
MOD_NEK2_1	481	486	PF00069	0.387
MOD_NEK2_1	51	56	PF00069	0.668
MOD_NEK2_1	580	585	PF00069	0.423
MOD_NEK2_1	587	592	PF00069	0.250
MOD_NEK2_1	611	616	PF00069	0.494
MOD_NEK2_1	643	648	PF00069	0.400
MOD_NEK2_1	715	720	PF00069	0.417
MOD_NEK2_2	180	185	PF00069	0.679
MOD_PIKK_1	124	130	PF00454	0.604
MOD_PIKK_1	157	163	PF00454	0.687
MOD_PIKK_1	219	225	PF00454	0.613
MOD_PIKK_1	329	335	PF00454	0.752
MOD_PIKK_1	365	371	PF00454	0.597
MOD_PIKK_1	580	586	PF00454	0.453
MOD_PIKK_1	673	679	PF00454	0.475
MOD_PK_1	297	303	PF00069	0.489
MOD_PK_1	419	425	PF00069	0.674
MOD_PKA_1	297	303	PF00069	0.538
MOD_PKA_1	419	425	PF00069	0.643
MOD_PKA_1	428	434	PF00069	0.559
MOD_PKA_2	329	335	PF00069	0.758
MOD_PKA_2	427	433	PF00069	0.519
MOD_PKA_2	499	505	PF00069	0.461
MOD_PKA_2	51	57	PF00069	0.668
MOD_PKA_2	521	527	PF00069	0.481
MOD_PKA_2	558	564	PF00069	0.406
MOD_PKA_2	747	753	PF00069	0.536
MOD_Plk_1	404	410	PF00069	0.662
MOD_Plk_1	585	591	PF00069	0.323
MOD_Plk_1	611	617	PF00069	0.406
MOD_Plk_1	643	649	PF00069	0.398
MOD_Plk_2-3	405	411	PF00069	0.664
MOD_Plk_4	180	186	PF00069	0.646
MOD_Plk_4	476	482	PF00069	0.391
MOD_Plk_4	568	574	PF00069	0.339
MOD_Plk_4	685	691	PF00069	0.330
MOD_Plk_4	715	721	PF00069	0.420
MOD_Plk_4	78	84	PF00069	0.678
MOD_ProDKin_1	255	261	PF00069	0.608
MOD_ProDKin_1	278	284	PF00069	0.592
MOD_ProDKin_1	486	492	PF00069	0.514
MOD_ProDKin_1	615	621	PF00069	0.347
MOD_ProDKin_1	652	658	PF00069	0.493
MOD_ProDKin_1	69	75	PF00069	0.786
MOD_ProDKin_1	809	815	PF00069	0.470
MOD_SUMO_rev_2	778	786	PF00179	0.460
TRG_DiLeu_BaEn_1	797	802	PF01217	0.435
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.497
TRG_ENDOCYTIC_2	174	177	PF00928	0.632
TRG_ENDOCYTIC_2	213	216	PF00928	0.569
TRG_ENDOCYTIC_2	374	377	PF00928	0.455
TRG_ENDOCYTIC_2	5	8	PF00928	0.636
TRG_ENDOCYTIC_2	630	633	PF00928	0.359
TRG_ENDOCYTIC_2	701	704	PF00928	0.359
TRG_ENDOCYTIC_2	717	720	PF00928	0.364
TRG_ER_diArg_1	145	147	PF00400	0.616
TRG_ER_diArg_1	162	164	PF00400	0.490
TRG_ER_diArg_1	755	757	PF00400	0.407
TRG_ER_diArg_1	774	777	PF00400	0.409
TRG_ER_diArg_1	786	789	PF00400	0.531
TRG_NES_CRM1_1	795	808	PF08389	0.379
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHP8	Leptomonas seymouri	59%	100%
A0A1X0NU85	Trypanosomatidae	38%	100%
A0A3S7WUI6	Leishmania donovani	93%	100%
A4H958	Leishmania braziliensis	78%	99%
A4HXI0	Leishmania infantum	94%	100%
E9AR75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%