Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania major

UniProt:

Q4QE87_LEIMA

TriTrypDb:

LmjF.17.1040 , LMJLV39_170017700 , LMJSD75_170017400

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QE87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE87

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016787	hydrolase activity	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	404	406	PF00675	0.520
CLV_PCSK_KEX2_1	237	239	PF00082	0.305
CLV_PCSK_KEX2_1	276	278	PF00082	0.257
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.409
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.294
CLV_PCSK_SKI1_1	234	238	PF00082	0.309
CLV_PCSK_SKI1_1	269	273	PF00082	0.309
CLV_PCSK_SKI1_1	286	290	PF00082	0.237
CLV_PCSK_SKI1_1	325	329	PF00082	0.193
DEG_APCC_DBOX_1	21	29	PF00400	0.264
DEG_APCC_DBOX_1	285	293	PF00400	0.403
DEG_SPOP_SBC_1	207	211	PF00917	0.334
DOC_CKS1_1	331	336	PF01111	0.342
DOC_CYCLIN_RxL_1	172	183	PF00134	0.261
DOC_MAPK_DCC_7	332	342	PF00069	0.325
DOC_MAPK_gen_1	273	281	PF00069	0.372
DOC_MAPK_MEF2A_6	49	57	PF00069	0.289
DOC_MIT_MIM_1	146	155	PF04212	0.193
DOC_PP1_RVXF_1	147	153	PF00149	0.193
DOC_PP2B_LxvP_1	10	13	PF13499	0.716
DOC_PP2B_LxvP_1	292	295	PF13499	0.361
DOC_PP2B_PxIxI_1	337	343	PF00149	0.214
DOC_PP4_FxxP_1	335	338	PF00568	0.193
DOC_USP7_MATH_1	241	245	PF00917	0.298
DOC_USP7_MATH_1	399	403	PF00917	0.430
DOC_USP7_MATH_1	5	9	PF00917	0.773
DOC_USP7_UBL2_3	423	427	PF12436	0.702
DOC_WW_Pin1_4	185	190	PF00397	0.334
DOC_WW_Pin1_4	330	335	PF00397	0.256
DOC_WW_Pin1_4	58	63	PF00397	0.292
DOC_WW_Pin1_4	8	13	PF00397	0.615
LIG_14-3-3_CanoR_1	175	180	PF00244	0.294
LIG_14-3-3_CanoR_1	238	246	PF00244	0.335
LIG_14-3-3_CanoR_1	30	38	PF00244	0.434
LIG_14-3-3_CanoR_1	302	311	PF00244	0.344
LIG_14-3-3_CanoR_1	325	335	PF00244	0.460
LIG_14-3-3_CanoR_1	356	362	PF00244	0.332
LIG_14-3-3_CanoR_1	69	74	PF00244	0.416
LIG_Actin_WH2_1	366	384	PF00022	0.394
LIG_BIR_III_4	140	144	PF00653	0.406
LIG_FHA_1	109	115	PF00498	0.469
LIG_FHA_1	14	20	PF00498	0.480
LIG_FHA_1	326	332	PF00498	0.297
LIG_FHA_1	337	343	PF00498	0.250
LIG_FHA_1	35	41	PF00498	0.379
LIG_FHA_2	131	137	PF00498	0.303
LIG_FHA_2	220	226	PF00498	0.193
LIG_FHA_2	92	98	PF00498	0.337
LIG_LIR_Apic_2	333	338	PF02991	0.191
LIG_LIR_Gen_1	201	207	PF02991	0.392
LIG_LIR_Gen_1	244	253	PF02991	0.411
LIG_LIR_Gen_1	383	393	PF02991	0.368
LIG_LIR_Gen_1	77	85	PF02991	0.423
LIG_LIR_Nem_3	111	116	PF02991	0.333
LIG_LIR_Nem_3	140	145	PF02991	0.397
LIG_LIR_Nem_3	201	205	PF02991	0.345
LIG_LIR_Nem_3	244	249	PF02991	0.378
LIG_LIR_Nem_3	383	388	PF02991	0.392
LIG_LIR_Nem_3	77	83	PF02991	0.313
LIG_NRBOX	69	75	PF00104	0.262
LIG_PDZ_Class_1	427	432	PF00595	0.682
LIG_SH2_CRK	80	84	PF00017	0.472
LIG_SH2_GRB2like	116	119	PF00017	0.152
LIG_SH2_NCK_1	116	120	PF00017	0.152
LIG_SH2_PTP2	385	388	PF00017	0.451
LIG_SH2_SRC	116	119	PF00017	0.214
LIG_SH2_STAP1	116	120	PF00017	0.415
LIG_SH2_STAP1	214	218	PF00017	0.408
LIG_SH2_STAP1	242	246	PF00017	0.410
LIG_SH2_STAT5	113	116	PF00017	0.410
LIG_SH2_STAT5	132	135	PF00017	0.313
LIG_SH2_STAT5	336	339	PF00017	0.390
LIG_SH2_STAT5	368	371	PF00017	0.336
LIG_SH2_STAT5	385	388	PF00017	0.396
LIG_SH3_3	1	7	PF00018	0.734
LIG_SH3_3	104	110	PF00018	0.439
LIG_SH3_3	15	21	PF00018	0.631
LIG_SH3_3	345	351	PF00018	0.288
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.235
LIG_SUMO_SIM_par_1	174	180	PF11976	0.278
LIG_TRAF2_1	223	226	PF00917	0.410
LIG_UBA3_1	199	208	PF00899	0.366
LIG_WRC_WIRS_1	199	204	PF05994	0.285
LIG_WRC_WIRS_1	42	47	PF05994	0.320
MOD_CDK_SPxxK_3	8	15	PF00069	0.682
MOD_CK1_1	183	189	PF00069	0.289
MOD_CK1_1	201	207	PF00069	0.219
MOD_CK1_1	407	413	PF00069	0.676
MOD_CK1_1	8	14	PF00069	0.712
MOD_CK2_1	124	130	PF00069	0.344
MOD_CK2_1	219	225	PF00069	0.314
MOD_Cter_Amidation	403	406	PF01082	0.414
MOD_GlcNHglycan	210	213	PF01048	0.390
MOD_GlcNHglycan	222	225	PF01048	0.409
MOD_GlcNHglycan	253	256	PF01048	0.364
MOD_GlcNHglycan	328	331	PF01048	0.414
MOD_GlcNHglycan	76	79	PF01048	0.455
MOD_GSK3_1	177	184	PF00069	0.269
MOD_GSK3_1	237	244	PF00069	0.327
MOD_GSK3_1	251	258	PF00069	0.329
MOD_GSK3_1	275	282	PF00069	0.227
MOD_GSK3_1	30	37	PF00069	0.507
MOD_GSK3_1	321	328	PF00069	0.423
MOD_GSK3_1	404	411	PF00069	0.590
MOD_N-GLC_1	321	326	PF02516	0.218
MOD_NEK2_1	155	160	PF00069	0.343
MOD_NEK2_1	177	182	PF00069	0.293
MOD_NEK2_1	275	280	PF00069	0.284
MOD_NEK2_1	311	316	PF00069	0.228
MOD_NEK2_1	373	378	PF00069	0.361
MOD_NEK2_1	381	386	PF00069	0.393
MOD_NEK2_1	74	79	PF00069	0.410
MOD_NEK2_2	124	129	PF00069	0.214
MOD_PIKK_1	309	315	PF00454	0.450
MOD_PIKK_1	404	410	PF00454	0.359
MOD_PK_1	304	310	PF00069	0.415
MOD_PKA_1	237	243	PF00069	0.152
MOD_PKA_2	219	225	PF00069	0.193
MOD_PKA_2	237	243	PF00069	0.428
MOD_PKA_2	251	257	PF00069	0.224
MOD_PKA_2	303	309	PF00069	0.405
MOD_PKA_2	381	387	PF00069	0.473
MOD_PKA_2	404	410	PF00069	0.519
MOD_PKB_1	302	310	PF00069	0.214
MOD_Plk_2-3	130	136	PF00069	0.286
MOD_Plk_4	109	115	PF00069	0.355
MOD_Plk_4	177	183	PF00069	0.253
MOD_Plk_4	198	204	PF00069	0.359
MOD_Plk_4	336	342	PF00069	0.269
MOD_Plk_4	357	363	PF00069	0.297
MOD_Plk_4	373	379	PF00069	0.278
MOD_Plk_4	381	387	PF00069	0.426
MOD_Plk_4	69	75	PF00069	0.412
MOD_ProDKin_1	185	191	PF00069	0.334
MOD_ProDKin_1	330	336	PF00069	0.256
MOD_ProDKin_1	58	64	PF00069	0.292
MOD_ProDKin_1	8	14	PF00069	0.614
MOD_SUMO_rev_2	233	239	PF00179	0.277
TRG_AP2beta_CARGO_1	140	149	PF09066	0.193
TRG_DiLeu_BaEn_4	225	231	PF01217	0.410
TRG_ENDOCYTIC_2	385	388	PF00928	0.463
TRG_ENDOCYTIC_2	42	45	PF00928	0.332
TRG_ENDOCYTIC_2	80	83	PF00928	0.331
TRG_ER_diArg_1	148	151	PF00400	0.414
TRG_ER_diArg_1	19	22	PF00400	0.582
TRG_ER_diArg_1	227	230	PF00400	0.383
TRG_ER_diArg_1	301	304	PF00400	0.375
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.345
TRG_PTS1	429	432	PF00515	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	65%	100%
A0A0N0P3S4	Leptomonas seymouri	36%	100%
A0A0N1PA10	Leptomonas seymouri	30%	100%
A0A0N1PCQ2	Leptomonas seymouri	33%	100%
A0A0S4JQB3	Bodo saltans	30%	100%
A0A0S4KKL9	Bodo saltans	28%	82%
A0A1X0NSR3	Trypanosomatidae	29%	97%
A0A1X0NSS6	Trypanosomatidae	33%	100%
A0A1X0NT85	Trypanosomatidae	34%	88%
A0A3Q8IAY1	Leishmania donovani	37%	100%
A0A3R7KKJ0	Trypanosoma rangeli	33%	100%
A0A3S5IRR1	Trypanosoma rangeli	37%	100%
A0A3S7WUJ3	Leishmania donovani	30%	100%
A0A3S7WUK0	Leishmania donovani	93%	100%
A0A3S7X1K2	Leishmania donovani	31%	100%
A0A422NS41	Trypanosoma rangeli	30%	100%
A4H956	Leishmania braziliensis	33%	100%
A4H959	Leishmania braziliensis	77%	100%
A4H960	Leishmania braziliensis	35%	100%
A4HGL0	Leishmania braziliensis	31%	100%
A4HXH8	Leishmania infantum	31%	100%
A4HXI1	Leishmania infantum	92%	100%
A4HXI2	Leishmania infantum	37%	100%
A4I3N6	Leishmania infantum	32%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q8A8	Leishmania major	32%	97%
Q4QE86	Leishmania major	38%	100%
Q54809	Streptomyces peucetius	26%	100%
Q55217	Streptomyces sp. (strain C5)	26%	100%
V5AZB9	Trypanosoma cruzi	30%	100%
V5BER0	Trypanosoma cruzi	33%	100%
V5BNU9	Trypanosoma cruzi	33%	100%