Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania major

UniProt:

Q4QE86_LEIMA

TriTrypDb:

LmjF.17.1050 , LMJLV39_170017800 , LMJSD75_170017500

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 35
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4QE86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE86

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016787	hydrolase activity	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	272	274	PF00675	0.296
CLV_NRD_NRD_1	45	47	PF00675	0.594
CLV_PCSK_KEX2_1	272	274	PF00082	0.317
CLV_PCSK_KEX2_1	45	47	PF00082	0.468
CLV_PCSK_SKI1_1	136	140	PF00082	0.246
CLV_PCSK_SKI1_1	166	170	PF00082	0.317
CLV_PCSK_SKI1_1	238	242	PF00082	0.302
CLV_PCSK_SKI1_1	45	49	PF00082	0.529
CLV_PCSK_SKI1_1	67	71	PF00082	0.428
DEG_APCC_DBOX_1	271	279	PF00400	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.440
DEG_SPOP_SBC_1	14	18	PF00917	0.478
DOC_MAPK_MEF2A_6	319	326	PF00069	0.411
DOC_PP1_RVXF_1	234	240	PF00149	0.398
DOC_PP1_RVXF_1	348	355	PF00149	0.362
DOC_PP4_FxxP_1	48	51	PF00568	0.299
DOC_PP4_FxxP_1	76	79	PF00568	0.353
DOC_USP7_MATH_1	141	145	PF00917	0.344
DOC_USP7_MATH_1	211	215	PF00917	0.354
DOC_USP7_MATH_1	300	304	PF00917	0.334
DOC_USP7_MATH_1	55	59	PF00917	0.415
DOC_WW_Pin1_4	128	133	PF00397	0.351
DOC_WW_Pin1_4	15	20	PF00397	0.655
LIG_14-3-3_CanoR_1	212	216	PF00244	0.187
LIG_14-3-3_CanoR_1	305	311	PF00244	0.454
LIG_14-3-3_CanoR_1	61	69	PF00244	0.423
LIG_BIR_III_4	160	164	PF00653	0.397
LIG_BRCT_BRCA1_1	122	126	PF00533	0.344
LIG_EVH1_1	48	52	PF00568	0.297
LIG_EVH1_2	37	41	PF00568	0.286
LIG_FHA_1	224	230	PF00498	0.218
LIG_FHA_1	380	386	PF00498	0.419
LIG_FHA_1	91	97	PF00498	0.278
LIG_FHA_2	122	128	PF00498	0.339
LIG_FHA_2	151	157	PF00498	0.306
LIG_FHA_2	246	252	PF00498	0.177
LIG_FHA_2	27	33	PF00498	0.468
LIG_FHA_2	63	69	PF00498	0.392
LIG_HP1_1	322	326	PF01393	0.398
LIG_HP1_1	332	336	PF01393	0.398
LIG_IRF3_LxIS_1	164	171	PF10401	0.287
LIG_LIR_Apic_2	127	132	PF02991	0.398
LIG_LIR_Apic_2	74	79	PF02991	0.370
LIG_LIR_Gen_1	53	63	PF02991	0.452
LIG_LIR_Gen_1	70	79	PF02991	0.252
LIG_LIR_LC3C_4	331	335	PF02991	0.187
LIG_LIR_Nem_3	123	129	PF02991	0.399
LIG_LIR_Nem_3	364	369	PF02991	0.374
LIG_LIR_Nem_3	53	59	PF02991	0.425
LIG_LIR_Nem_3	70	76	PF02991	0.274
LIG_LIR_Nem_3	98	104	PF02991	0.326
LIG_Pex14_1	97	101	PF04695	0.259
LIG_REV1ctd_RIR_1	237	245	PF16727	0.206
LIG_RPA_C_Fungi	373	385	PF08784	0.253
LIG_SH2_CRK	366	370	PF00017	0.227
LIG_SH2_GRB2like	115	118	PF00017	0.316
LIG_SH2_STAT5	104	107	PF00017	0.300
LIG_SH2_STAT5	111	114	PF00017	0.272
LIG_SH2_STAT5	152	155	PF00017	0.314
LIG_SH2_STAT5	360	363	PF00017	0.390
LIG_SH3_1	46	52	PF00018	0.295
LIG_SH3_3	205	211	PF00018	0.385
LIG_SH3_3	25	31	PF00018	0.651
LIG_SH3_3	349	355	PF00018	0.324
LIG_SH3_3	46	52	PF00018	0.516
LIG_SH3_3	76	82	PF00018	0.412
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.473
LIG_SUMO_SIM_par_1	331	337	PF11976	0.187
LIG_UBA3_1	164	169	PF00899	0.236
MOD_CK2_1	141	147	PF00069	0.336
MOD_CK2_1	245	251	PF00069	0.365
MOD_CK2_1	26	32	PF00069	0.481
MOD_CK2_1	298	304	PF00069	0.407
MOD_Cter_Amidation	270	273	PF01082	0.206
MOD_GlcNHglycan	204	207	PF01048	0.371
MOD_GlcNHglycan	283	287	PF01048	0.316
MOD_GlcNHglycan	300	303	PF01048	0.239
MOD_GlcNHglycan	312	315	PF01048	0.412
MOD_GlcNHglycan	73	76	PF01048	0.378
MOD_GSK3_1	146	153	PF00069	0.310
MOD_GSK3_1	22	29	PF00069	0.723
MOD_GSK3_1	278	285	PF00069	0.409
MOD_GSK3_1	294	301	PF00069	0.289
MOD_GSK3_1	306	313	PF00069	0.426
MOD_GSK3_1	67	74	PF00069	0.456
MOD_N-GLC_1	90	95	PF02516	0.206
MOD_NEK2_1	168	173	PF00069	0.309
MOD_NEK2_1	195	200	PF00069	0.287
MOD_NEK2_1	201	206	PF00069	0.283
MOD_NEK2_1	295	300	PF00069	0.222
MOD_NEK2_1	71	76	PF00069	0.503
MOD_NEK2_1	90	95	PF00069	0.380
MOD_NEK2_1	96	101	PF00069	0.382
MOD_NEK2_2	245	250	PF00069	0.361
MOD_PIKK_1	168	174	PF00454	0.206
MOD_PKA_2	211	217	PF00069	0.385
MOD_PKA_2	293	299	PF00069	0.412
MOD_PKA_2	304	310	PF00069	0.361
MOD_Plk_1	245	251	PF00069	0.428
MOD_Plk_1	379	385	PF00069	0.525
MOD_Plk_1	67	73	PF00069	0.350
MOD_Plk_1	90	96	PF00069	0.421
MOD_Plk_2-3	228	234	PF00069	0.398
MOD_Plk_4	211	217	PF00069	0.359
MOD_Plk_4	228	234	PF00069	0.371
MOD_Plk_4	91	97	PF00069	0.410
MOD_ProDKin_1	128	134	PF00069	0.351
MOD_ProDKin_1	15	21	PF00069	0.656
TRG_ENDOCYTIC_2	366	369	PF00928	0.453
TRG_ENDOCYTIC_2	73	76	PF00928	0.342
TRG_ER_diArg_1	235	238	PF00400	0.412
TRG_ER_diArg_1	44	46	PF00400	0.326
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	37%	90%
A0A0N0P3S4	Leptomonas seymouri	61%	100%
A0A0N1PA10	Leptomonas seymouri	39%	100%
A0A0N1PCQ2	Leptomonas seymouri	43%	100%
A0A0S4JQB3	Bodo saltans	36%	100%
A0A1X0NSR3	Trypanosomatidae	35%	87%
A0A1X0NSS6	Trypanosomatidae	40%	100%
A0A3Q8IAY1	Leishmania donovani	94%	100%
A0A3R7KKJ0	Trypanosoma rangeli	38%	100%
A0A3S5IRR1	Trypanosoma rangeli	33%	96%
A0A3S7WUJ3	Leishmania donovani	40%	100%
A0A3S7WUK0	Leishmania donovani	37%	90%
A0A3S7X1K2	Leishmania donovani	38%	100%
A0A422NS41	Trypanosoma rangeli	35%	91%
A4H956	Leishmania braziliensis	40%	100%
A4H959	Leishmania braziliensis	36%	91%
A4H960	Leishmania braziliensis	77%	100%
A4HGL0	Leishmania braziliensis	39%	100%
A4HXH8	Leishmania infantum	40%	100%
A4HXI1	Leishmania infantum	37%	90%
A4HXI2	Leishmania infantum	94%	100%
A4I3N6	Leishmania infantum	38%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	90%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4Q8A8	Leishmania major	38%	100%
Q4QE87	Leishmania major	38%	90%
Q4QE90	Leishmania major	40%	100%
Q54528	Streptomyces purpurascens	27%	100%
Q54809	Streptomyces peucetius	28%	100%
Q55217	Streptomyces sp. (strain C5)	28%	100%
V5AZB9	Trypanosoma cruzi	34%	91%
V5BER0	Trypanosoma cruzi	40%	100%
V5BNU9	Trypanosoma cruzi	30%	96%