Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

esterase-like protein

Species:

Leishmania major

UniProt:

Q4QE85_LEIMA

TriTrypDb:

LmjF.17.1060 , LMJLV39_170017900 , LMJSD75_170017600

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.266
CLV_C14_Caspase3-7	319	323	PF00656	0.740
CLV_C14_Caspase3-7	449	453	PF00656	0.732
CLV_C14_Caspase3-7	458	462	PF00656	0.635
CLV_NRD_NRD_1	209	211	PF00675	0.508
CLV_NRD_NRD_1	216	218	PF00675	0.390
CLV_NRD_NRD_1	232	234	PF00675	0.339
CLV_NRD_NRD_1	463	465	PF00675	0.691
CLV_NRD_NRD_1	508	510	PF00675	0.630
CLV_NRD_NRD_1	692	694	PF00675	0.628
CLV_PCSK_KEX2_1	208	210	PF00082	0.490
CLV_PCSK_KEX2_1	216	218	PF00082	0.334
CLV_PCSK_KEX2_1	232	234	PF00082	0.339
CLV_PCSK_KEX2_1	309	311	PF00082	0.597
CLV_PCSK_KEX2_1	429	431	PF00082	0.717
CLV_PCSK_KEX2_1	463	465	PF00082	0.654
CLV_PCSK_KEX2_1	508	510	PF00082	0.669
CLV_PCSK_KEX2_1	692	694	PF00082	0.628
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.343
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.623
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.717
CLV_PCSK_SKI1_1	193	197	PF00082	0.339
CLV_PCSK_SKI1_1	209	213	PF00082	0.339
CLV_PCSK_SKI1_1	237	241	PF00082	0.341
CLV_PCSK_SKI1_1	266	270	PF00082	0.332
CLV_PCSK_SKI1_1	313	317	PF00082	0.727
CLV_PCSK_SKI1_1	472	476	PF00082	0.700
CLV_PCSK_SKI1_1	533	537	PF00082	0.750
CLV_PCSK_SKI1_1	90	94	PF00082	0.433
DEG_APCC_DBOX_1	208	216	PF00400	0.399
DEG_SCF_FBW7_1	554	560	PF00400	0.651
DEG_SPOP_SBC_1	151	155	PF00917	0.339
DEG_SPOP_SBC_1	432	436	PF00917	0.680
DOC_CKS1_1	422	427	PF01111	0.660
DOC_CKS1_1	554	559	PF01111	0.651
DOC_CYCLIN_RxL_1	272	281	PF00134	0.339
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.339
DOC_MAPK_gen_1	208	215	PF00069	0.339
DOC_MAPK_gen_1	309	318	PF00069	0.546
DOC_MAPK_gen_1	79	87	PF00069	0.348
DOC_MAPK_MEF2A_6	309	318	PF00069	0.546
DOC_MAPK_MEF2A_6	79	87	PF00069	0.466
DOC_PP2B_LxvP_1	117	120	PF13499	0.339
DOC_PP2B_LxvP_1	139	142	PF13499	0.339
DOC_PP2B_LxvP_1	244	247	PF13499	0.348
DOC_PP2B_LxvP_1	85	88	PF13499	0.339
DOC_PP4_FxxP_1	22	25	PF00568	0.404
DOC_USP7_MATH_1	317	321	PF00917	0.658
DOC_USP7_MATH_1	418	422	PF00917	0.674
DOC_USP7_MATH_1	431	435	PF00917	0.667
DOC_USP7_MATH_1	446	450	PF00917	0.546
DOC_USP7_MATH_1	490	494	PF00917	0.736
DOC_USP7_MATH_1	545	549	PF00917	0.733
DOC_USP7_MATH_1	557	561	PF00917	0.531
DOC_USP7_MATH_1	599	603	PF00917	0.667
DOC_USP7_MATH_1	609	613	PF00917	0.717
DOC_WW_Pin1_4	376	381	PF00397	0.550
DOC_WW_Pin1_4	421	426	PF00397	0.658
DOC_WW_Pin1_4	433	438	PF00397	0.569
DOC_WW_Pin1_4	476	481	PF00397	0.702
DOC_WW_Pin1_4	492	497	PF00397	0.515
DOC_WW_Pin1_4	553	558	PF00397	0.678
DOC_WW_Pin1_4	652	657	PF00397	0.683
DOC_WW_Pin1_4	675	680	PF00397	0.681
LIG_14-3-3_CanoR_1	144	149	PF00244	0.339
LIG_14-3-3_CanoR_1	177	182	PF00244	0.408
LIG_14-3-3_CanoR_1	188	193	PF00244	0.285
LIG_14-3-3_CanoR_1	210	216	PF00244	0.514
LIG_14-3-3_CanoR_1	217	221	PF00244	0.340
LIG_14-3-3_CanoR_1	266	271	PF00244	0.317
LIG_14-3-3_CanoR_1	361	367	PF00244	0.631
LIG_14-3-3_CanoR_1	468	476	PF00244	0.676
LIG_14-3-3_CanoR_1	620	628	PF00244	0.704
LIG_Actin_WH2_2	182	199	PF00022	0.339
LIG_APCC_ABBA_1	295	300	PF00400	0.337
LIG_deltaCOP1_diTrp_1	164	170	PF00928	0.399
LIG_DLG_GKlike_1	188	195	PF00625	0.339
LIG_DLG_GKlike_1	216	224	PF00625	0.433
LIG_FHA_1	143	149	PF00498	0.341
LIG_FHA_1	422	428	PF00498	0.619
LIG_FHA_1	633	639	PF00498	0.716
LIG_FHA_1	658	664	PF00498	0.553
LIG_FHA_2	178	184	PF00498	0.461
LIG_FHA_2	317	323	PF00498	0.739
LIG_FHA_2	41	47	PF00498	0.399
LIG_FHA_2	585	591	PF00498	0.668
LIG_FHA_2	70	76	PF00498	0.339
LIG_LIR_Apic_2	368	372	PF02991	0.704
LIG_LIR_Gen_1	109	119	PF02991	0.338
LIG_LIR_Gen_1	16	25	PF02991	0.359
LIG_LIR_Gen_1	164	172	PF02991	0.399
LIG_LIR_Gen_1	415	425	PF02991	0.723
LIG_LIR_Gen_1	497	506	PF02991	0.626
LIG_LIR_Gen_1	711	716	PF02991	0.754
LIG_LIR_Nem_3	109	114	PF02991	0.343
LIG_LIR_Nem_3	16	22	PF02991	0.346
LIG_LIR_Nem_3	164	169	PF02991	0.399
LIG_LIR_Nem_3	415	420	PF02991	0.697
LIG_LIR_Nem_3	497	502	PF02991	0.600
LIG_LIR_Nem_3	52	58	PF02991	0.266
LIG_LIR_Nem_3	711	716	PF02991	0.687
LIG_MYND_1	679	683	PF01753	0.581
LIG_NRBOX	191	197	PF00104	0.339
LIG_PCNA_yPIPBox_3	173	185	PF02747	0.339
LIG_PDZ_Class_1	711	716	PF00595	0.687
LIG_Pex14_1	45	49	PF04695	0.353
LIG_Pex14_2	286	290	PF04695	0.390
LIG_Pex14_2	538	542	PF04695	0.565
LIG_PTAP_UEV_1	595	600	PF05743	0.556
LIG_SH2_CRK	198	202	PF00017	0.466
LIG_SH2_CRK	273	277	PF00017	0.471
LIG_SH2_CRK	417	421	PF00017	0.720
LIG_SH2_GRB2like	63	66	PF00017	0.339
LIG_SH2_NCK_1	198	202	PF00017	0.466
LIG_SH2_NCK_1	417	421	PF00017	0.653
LIG_SH2_PTP2	369	372	PF00017	0.634
LIG_SH2_SRC	220	223	PF00017	0.266
LIG_SH2_STAP1	273	277	PF00017	0.339
LIG_SH2_STAP1	70	74	PF00017	0.366
LIG_SH2_STAT5	206	209	PF00017	0.339
LIG_SH2_STAT5	285	288	PF00017	0.384
LIG_SH2_STAT5	369	372	PF00017	0.634
LIG_SH2_STAT5	59	62	PF00017	0.339
LIG_SH2_STAT5	591	594	PF00017	0.609
LIG_SH3_1	593	599	PF00018	0.546
LIG_SH3_3	155	161	PF00018	0.339
LIG_SH3_3	254	260	PF00018	0.339
LIG_SH3_3	311	317	PF00018	0.659
LIG_SH3_3	388	394	PF00018	0.593
LIG_SH3_3	397	403	PF00018	0.576
LIG_SH3_3	417	423	PF00018	0.446
LIG_SH3_3	551	557	PF00018	0.663
LIG_SH3_3	593	599	PF00018	0.617
LIG_SH3_3	653	659	PF00018	0.595
LIG_SUMO_SIM_par_1	275	281	PF11976	0.339
LIG_SUMO_SIM_par_1	632	639	PF11976	0.689
LIG_SUMO_SIM_par_1	659	664	PF11976	0.553
LIG_TRAF2_1	335	338	PF00917	0.660
LIG_TRAF2_1	587	590	PF00917	0.602
LIG_TRAF2_1	688	691	PF00917	0.697
LIG_TRAF2_2	100	105	PF00917	0.466
LIG_TRFH_1	198	202	PF08558	0.466
LIG_TYR_ITIM	271	276	PF00017	0.466
LIG_UBA3_1	276	280	PF00899	0.339
LIG_WW_3	174	178	PF00397	0.466
MOD_CDC14_SPxK_1	495	498	PF00782	0.580
MOD_CDK_SPxK_1	492	498	PF00069	0.584
MOD_CDK_SPxxK_3	376	383	PF00069	0.671
MOD_CDK_SPxxK_3	679	686	PF00069	0.587
MOD_CK1_1	147	153	PF00069	0.339
MOD_CK1_1	320	326	PF00069	0.626
MOD_CK1_1	421	427	PF00069	0.738
MOD_CK1_1	436	442	PF00069	0.573
MOD_CK1_1	521	527	PF00069	0.641
MOD_CK1_1	541	547	PF00069	0.666
MOD_CK1_1	682	688	PF00069	0.666
MOD_CK2_1	177	183	PF00069	0.503
MOD_CK2_1	332	338	PF00069	0.637
MOD_CK2_1	362	368	PF00069	0.725
MOD_CK2_1	45	51	PF00069	0.422
MOD_CK2_1	480	486	PF00069	0.708
MOD_CK2_1	584	590	PF00069	0.669
MOD_CK2_1	685	691	PF00069	0.595
MOD_CK2_1	69	75	PF00069	0.345
MOD_GlcNHglycan	319	322	PF01048	0.647
MOD_GlcNHglycan	332	335	PF01048	0.721
MOD_GlcNHglycan	345	351	PF01048	0.630
MOD_GlcNHglycan	438	441	PF01048	0.606
MOD_GlcNHglycan	529	532	PF01048	0.604
MOD_GlcNHglycan	543	546	PF01048	0.642
MOD_GlcNHglycan	559	562	PF01048	0.548
MOD_GlcNHglycan	601	604	PF01048	0.679
MOD_GlcNHglycan	638	641	PF01048	0.608
MOD_GSK3_1	142	149	PF00069	0.351
MOD_GSK3_1	211	218	PF00069	0.339
MOD_GSK3_1	316	323	PF00069	0.652
MOD_GSK3_1	432	439	PF00069	0.664
MOD_GSK3_1	45	52	PF00069	0.399
MOD_GSK3_1	476	483	PF00069	0.668
MOD_GSK3_1	490	497	PF00069	0.531
MOD_GSK3_1	527	534	PF00069	0.672
MOD_GSK3_1	540	547	PF00069	0.608
MOD_GSK3_1	553	560	PF00069	0.613
MOD_GSK3_1	605	612	PF00069	0.727
MOD_GSK3_1	632	639	PF00069	0.663
MOD_GSK3_1	657	664	PF00069	0.555
MOD_GSK3_1	675	682	PF00069	0.678
MOD_GSK3_1	708	715	PF00069	0.616
MOD_N-GLC_1	177	182	PF02516	0.343
MOD_NEK2_1	125	130	PF00069	0.347
MOD_NEK2_1	146	151	PF00069	0.361
MOD_NEK2_1	152	157	PF00069	0.321
MOD_NEK2_1	211	216	PF00069	0.512
MOD_NEK2_1	290	295	PF00069	0.396
MOD_NEK2_1	362	367	PF00069	0.600
MOD_NEK2_1	40	45	PF00069	0.391
MOD_NEK2_1	455	460	PF00069	0.688
MOD_NEK2_1	49	54	PF00069	0.291
MOD_NEK2_1	636	641	PF00069	0.618
MOD_NEK2_2	667	672	PF00069	0.656
MOD_PIKK_1	8	14	PF00454	0.358
MOD_PK_1	332	338	PF00069	0.664
MOD_PKA_1	216	222	PF00069	0.328
MOD_PKA_2	215	221	PF00069	0.345
MOD_PKA_2	467	473	PF00069	0.650
MOD_PKA_2	527	533	PF00069	0.743
MOD_PKA_2	619	625	PF00069	0.703
MOD_PKA_2	685	691	PF00069	0.579
MOD_Plk_1	142	148	PF00069	0.339
MOD_Plk_1	177	183	PF00069	0.339
MOD_Plk_1	45	51	PF00069	0.399
MOD_Plk_1	632	638	PF00069	0.694
MOD_Plk_4	147	153	PF00069	0.339
MOD_Plk_4	266	272	PF00069	0.317
MOD_Plk_4	290	296	PF00069	0.399
MOD_Plk_4	49	55	PF00069	0.340
MOD_ProDKin_1	376	382	PF00069	0.543
MOD_ProDKin_1	421	427	PF00069	0.659
MOD_ProDKin_1	433	439	PF00069	0.569
MOD_ProDKin_1	476	482	PF00069	0.700
MOD_ProDKin_1	492	498	PF00069	0.516
MOD_ProDKin_1	553	559	PF00069	0.678
MOD_ProDKin_1	652	658	PF00069	0.683
MOD_ProDKin_1	675	681	PF00069	0.684
MOD_SUMO_rev_2	351	360	PF00179	0.644
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.466
TRG_ENDOCYTIC_2	19	22	PF00928	0.390
TRG_ENDOCYTIC_2	273	276	PF00928	0.341
TRG_ENDOCYTIC_2	417	420	PF00928	0.712
TRG_ENDOCYTIC_2	55	58	PF00928	0.266
TRG_ER_diArg_1	209	211	PF00400	0.413
TRG_ER_diArg_1	215	217	PF00400	0.448
TRG_ER_diArg_1	231	233	PF00400	0.250
TRG_ER_diArg_1	3	6	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI2	Leptomonas seymouri	48%	89%
A0A3Q8IAT8	Leishmania donovani	92%	99%
A4H961	Leishmania braziliensis	69%	99%
A4HXI3	Leishmania infantum	92%	90%
E9AR78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%