Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE84_LEIMA

TriTrypDb:

LmjF.17.1070 , LMJLV39_170018000 , LMJSD75_170017700

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QE84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.780
CLV_NRD_NRD_1	203	205	PF00675	0.491
CLV_NRD_NRD_1	339	341	PF00675	0.474
CLV_PCSK_KEX2_1	203	205	PF00082	0.491
CLV_PCSK_KEX2_1	339	341	PF00082	0.474
CLV_PCSK_SKI1_1	196	200	PF00082	0.484
CLV_PCSK_SKI1_1	206	210	PF00082	0.399
CLV_PCSK_SKI1_1	32	36	PF00082	0.529
CLV_PCSK_SKI1_1	372	376	PF00082	0.514
CLV_PCSK_SKI1_1	420	424	PF00082	0.674
CLV_PCSK_SKI1_1	477	481	PF00082	0.442
CLV_PCSK_SKI1_1	91	95	PF00082	0.560
DEG_SCF_FBW7_1	252	259	PF00400	0.577
DEG_SCF_FBW7_1	514	521	PF00400	0.465
DEG_SPOP_SBC_1	52	56	PF00917	0.661
DOC_CDC14_PxL_1	497	505	PF14671	0.348
DOC_CKS1_1	2	7	PF01111	0.708
DOC_CKS1_1	253	258	PF01111	0.585
DOC_CKS1_1	33	38	PF01111	0.728
DOC_CKS1_1	379	384	PF01111	0.577
DOC_CKS1_1	67	72	PF01111	0.724
DOC_CYCLIN_RxL_1	203	211	PF00134	0.694
DOC_CYCLIN_yCln2_LP_2	352	358	PF00134	0.618
DOC_MAPK_gen_1	203	209	PF00069	0.691
DOC_MAPK_gen_1	339	347	PF00069	0.654
DOC_PP1_RVXF_1	204	210	PF00149	0.673
DOC_PP2B_LxvP_1	22	25	PF13499	0.662
DOC_PP2B_LxvP_1	243	246	PF13499	0.670
DOC_PP2B_LxvP_1	307	310	PF13499	0.700
DOC_PP2B_LxvP_1	352	355	PF13499	0.614
DOC_PP2B_LxvP_1	455	458	PF13499	0.388
DOC_USP7_MATH_1	273	277	PF00917	0.719
DOC_USP7_MATH_1	332	336	PF00917	0.762
DOC_USP7_MATH_1	367	371	PF00917	0.662
DOC_USP7_MATH_1	405	409	PF00917	0.388
DOC_USP7_MATH_1	436	440	PF00917	0.372
DOC_USP7_MATH_1	488	492	PF00917	0.388
DOC_WW_Pin1_4	1	6	PF00397	0.710
DOC_WW_Pin1_4	126	131	PF00397	0.686
DOC_WW_Pin1_4	17	22	PF00397	0.788
DOC_WW_Pin1_4	180	185	PF00397	0.640
DOC_WW_Pin1_4	252	257	PF00397	0.575
DOC_WW_Pin1_4	32	37	PF00397	0.730
DOC_WW_Pin1_4	378	383	PF00397	0.579
DOC_WW_Pin1_4	514	519	PF00397	0.544
DOC_WW_Pin1_4	66	71	PF00397	0.800
LIG_14-3-3_CanoR_1	105	112	PF00244	0.738
LIG_14-3-3_CanoR_1	196	205	PF00244	0.686
LIG_14-3-3_CanoR_1	262	270	PF00244	0.642
LIG_14-3-3_CanoR_1	73	81	PF00244	0.745
LIG_BRCT_BRCA1_1	112	116	PF00533	0.641
LIG_BRCT_BRCA1_1	275	279	PF00533	0.724
LIG_FHA_1	18	24	PF00498	0.779
LIG_FHA_1	282	288	PF00498	0.712
LIG_FHA_1	439	445	PF00498	0.397
LIG_FHA_1	519	525	PF00498	0.528
LIG_FHA_2	13	19	PF00498	0.713
LIG_FHA_2	141	147	PF00498	0.719
LIG_FHA_2	197	203	PF00498	0.682
LIG_FHA_2	488	494	PF00498	0.402
LIG_FHA_2	53	59	PF00498	0.725
LIG_Integrin_isoDGR_2	30	32	PF01839	0.536
LIG_LIR_Apic_2	251	256	PF02991	0.647
LIG_LIR_Gen_1	113	124	PF02991	0.740
LIG_LIR_Gen_1	163	171	PF02991	0.649
LIG_LIR_Gen_1	451	459	PF02991	0.240
LIG_LIR_Nem_3	163	168	PF02991	0.714
LIG_LIR_Nem_3	172	178	PF02991	0.692
LIG_LIR_Nem_3	237	243	PF02991	0.556
LIG_LIR_Nem_3	451	455	PF02991	0.240
LIG_LYPXL_yS_3	240	243	PF13949	0.643
LIG_LYPXL_yS_3	80	83	PF13949	0.722
LIG_MYND_1	354	358	PF01753	0.675
LIG_PDZ_Class_2	523	528	PF00595	0.506
LIG_Pex14_1	384	388	PF04695	0.561
LIG_Pex14_1	474	478	PF04695	0.573
LIG_PTAP_UEV_1	315	320	PF05743	0.690
LIG_PTB_Apo_2	247	254	PF02174	0.651
LIG_PTB_Phospho_1	247	253	PF10480	0.647
LIG_RPA_C_Fungi	335	347	PF08784	0.596
LIG_SH2_CRK	253	257	PF00017	0.606
LIG_SH2_CRK	322	326	PF00017	0.645
LIG_SH2_CRK	464	468	PF00017	0.388
LIG_SH2_STAT3	148	151	PF00017	0.568
LIG_SH3_2	382	387	PF14604	0.426
LIG_SH3_3	124	130	PF00018	0.681
LIG_SH3_3	221	227	PF00018	0.602
LIG_SH3_3	30	36	PF00018	0.618
LIG_SH3_3	313	319	PF00018	0.610
LIG_SH3_3	348	354	PF00018	0.596
LIG_SH3_3	379	385	PF00018	0.444
LIG_SH3_3	64	70	PF00018	0.739
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.382
LIG_TRAF2_1	199	202	PF00917	0.731
LIG_TYR_ITIM	238	243	PF00017	0.534
MOD_CDC14_SPxK_1	129	132	PF00782	0.575
MOD_CDK_SPxK_1	126	132	PF00069	0.576
MOD_CDK_SPxxK_3	66	73	PF00069	0.575
MOD_CK1_1	131	137	PF00069	0.691
MOD_CK1_1	264	270	PF00069	0.511
MOD_CK1_1	282	288	PF00069	0.582
MOD_CK1_1	378	384	PF00069	0.559
MOD_CK2_1	12	18	PF00069	0.644
MOD_CK2_1	140	146	PF00069	0.657
MOD_CK2_1	196	202	PF00069	0.578
MOD_CK2_1	367	373	PF00069	0.617
MOD_CK2_1	374	380	PF00069	0.553
MOD_CK2_1	436	442	PF00069	0.512
MOD_DYRK1A_RPxSP_1	32	36	PF00069	0.661
MOD_GlcNHglycan	112	115	PF01048	0.653
MOD_GlcNHglycan	116	119	PF01048	0.687
MOD_GlcNHglycan	162	165	PF01048	0.545
MOD_GlcNHglycan	271	274	PF01048	0.610
MOD_GlcNHglycan	295	299	PF01048	0.685
MOD_GlcNHglycan	334	337	PF01048	0.622
MOD_GlcNHglycan	359	362	PF01048	0.588
MOD_GlcNHglycan	468	471	PF01048	0.420
MOD_GSK3_1	110	117	PF00069	0.503
MOD_GSK3_1	156	163	PF00069	0.611
MOD_GSK3_1	248	255	PF00069	0.602
MOD_GSK3_1	269	276	PF00069	0.521
MOD_GSK3_1	310	317	PF00069	0.752
MOD_GSK3_1	374	381	PF00069	0.593
MOD_GSK3_1	434	441	PF00069	0.446
MOD_GSK3_1	514	521	PF00069	0.601
MOD_GSK3_1	92	99	PF00069	0.779
MOD_LATS_1	338	344	PF00433	0.515
MOD_N-GLC_1	390	395	PF02516	0.515
MOD_N-GLC_1	514	519	PF02516	0.566
MOD_NEK2_1	208	213	PF00069	0.679
MOD_NEK2_1	248	253	PF00069	0.503
MOD_NEK2_1	269	274	PF00069	0.621
MOD_NEK2_1	331	336	PF00069	0.658
MOD_NEK2_1	374	379	PF00069	0.663
MOD_NEK2_1	487	492	PF00069	0.451
MOD_NEK2_1	6	11	PF00069	0.709
MOD_NEK2_1	92	97	PF00069	0.703
MOD_NEK2_2	422	427	PF00069	0.491
MOD_PIKK_1	405	411	PF00454	0.400
MOD_PIKK_1	53	59	PF00454	0.575
MOD_PIKK_1	73	79	PF00454	0.650
MOD_PKA_2	104	110	PF00069	0.703
MOD_PKA_2	131	137	PF00069	0.704
MOD_PKA_2	248	254	PF00069	0.594
MOD_PKA_2	261	267	PF00069	0.552
MOD_PKB_1	10	18	PF00069	0.567
MOD_Plk_1	107	113	PF00069	0.589
MOD_Plk_1	114	120	PF00069	0.599
MOD_Plk_1	282	288	PF00069	0.610
MOD_Plk_1	390	396	PF00069	0.494
MOD_Plk_1	518	524	PF00069	0.595
MOD_Plk_1	99	105	PF00069	0.587
MOD_Plk_4	107	113	PF00069	0.563
MOD_Plk_4	170	176	PF00069	0.518
MOD_Plk_4	182	188	PF00069	0.488
MOD_Plk_4	248	254	PF00069	0.526
MOD_Plk_4	256	262	PF00069	0.529
MOD_Plk_4	282	288	PF00069	0.636
MOD_Plk_4	422	428	PF00069	0.493
MOD_ProDKin_1	1	7	PF00069	0.635
MOD_ProDKin_1	126	132	PF00069	0.603
MOD_ProDKin_1	17	23	PF00069	0.747
MOD_ProDKin_1	180	186	PF00069	0.538
MOD_ProDKin_1	252	258	PF00069	0.447
MOD_ProDKin_1	32	38	PF00069	0.662
MOD_ProDKin_1	378	384	PF00069	0.451
MOD_ProDKin_1	514	520	PF00069	0.684
MOD_ProDKin_1	66	72	PF00069	0.763
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.589
TRG_DiLeu_LyEn_5	18	23	PF01217	0.559
TRG_ENDOCYTIC_2	240	243	PF00928	0.541
TRG_ENDOCYTIC_2	397	400	PF00928	0.388
TRG_ENDOCYTIC_2	464	467	PF00928	0.388
TRG_ENDOCYTIC_2	484	487	PF00928	0.388
TRG_ENDOCYTIC_2	80	83	PF00928	0.786
TRG_ER_diArg_1	203	206	PF00400	0.605
TRG_ER_diArg_1	212	215	PF00400	0.559
TRG_ER_diArg_1	220	223	PF00400	0.514
TRG_ER_diArg_1	480	483	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAR6	Leishmania donovani	87%	100%
A4H962	Leishmania braziliensis	61%	100%
A4HXI4	Leishmania infantum	87%	100%
E9AR79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%