Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QE83_LEIMA

TriTrypDb:

LmjF.17.1080 , LMJLV39_170018100 , LMJSD75_170017800

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.563
CLV_C14_Caspase3-7	490	494	PF00656	0.427
CLV_C14_Caspase3-7	636	640	PF00656	0.508
CLV_NRD_NRD_1	261	263	PF00675	0.572
CLV_NRD_NRD_1	629	631	PF00675	0.460
CLV_PCSK_KEX2_1	629	631	PF00082	0.460
CLV_PCSK_SKI1_1	211	215	PF00082	0.506
CLV_PCSK_SKI1_1	457	461	PF00082	0.701
CLV_PCSK_SKI1_1	48	52	PF00082	0.532
CLV_PCSK_SKI1_1	500	504	PF00082	0.419
CLV_PCSK_SKI1_1	520	524	PF00082	0.429
CLV_PCSK_SKI1_1	650	654	PF00082	0.453
DEG_APCC_DBOX_1	499	507	PF00400	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DEG_SCF_FBW7_1	244	251	PF00400	0.548
DEG_SCF_FBW7_1	444	451	PF00400	0.570
DEG_SCF_FBW7_2	131	138	PF00400	0.620
DEG_SPOP_SBC_1	109	113	PF00917	0.705
DOC_ANK_TNKS_1	308	315	PF00023	0.549
DOC_CKS1_1	132	137	PF01111	0.764
DOC_CKS1_1	404	409	PF01111	0.654
DOC_CKS1_1	445	450	PF01111	0.578
DOC_CYCLIN_RxL_1	273	284	PF00134	0.536
DOC_CYCLIN_RxL_1	497	507	PF00134	0.416
DOC_CYCLIN_RxL_1	517	525	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.501
DOC_MAPK_gen_1	497	505	PF00069	0.423
DOC_MAPK_gen_1	524	532	PF00069	0.520
DOC_MAPK_gen_1	98	107	PF00069	0.565
DOC_MAPK_MEF2A_6	344	352	PF00069	0.702
DOC_PP2B_LxvP_1	106	109	PF13499	0.588
DOC_USP7_MATH_1	110	114	PF00917	0.636
DOC_USP7_MATH_1	248	252	PF00917	0.653
DOC_USP7_MATH_1	285	289	PF00917	0.553
DOC_USP7_MATH_1	322	326	PF00917	0.639
DOC_USP7_MATH_1	354	358	PF00917	0.728
DOC_USP7_MATH_1	364	368	PF00917	0.620
DOC_USP7_MATH_1	428	432	PF00917	0.572
DOC_USP7_MATH_1	448	452	PF00917	0.608
DOC_USP7_MATH_1	459	463	PF00917	0.769
DOC_USP7_MATH_1	478	482	PF00917	0.517
DOC_USP7_MATH_1	723	727	PF00917	0.626
DOC_WW_Pin1_4	131	136	PF00397	0.690
DOC_WW_Pin1_4	196	201	PF00397	0.696
DOC_WW_Pin1_4	244	249	PF00397	0.562
DOC_WW_Pin1_4	250	255	PF00397	0.532
DOC_WW_Pin1_4	403	408	PF00397	0.656
DOC_WW_Pin1_4	418	423	PF00397	0.524
DOC_WW_Pin1_4	444	449	PF00397	0.557
DOC_WW_Pin1_4	536	541	PF00397	0.524
DOC_WW_Pin1_4	559	564	PF00397	0.581
DOC_WW_Pin1_4	583	588	PF00397	0.616
DOC_WW_Pin1_4	695	700	PF00397	0.669
DOC_WW_Pin1_4	726	731	PF00397	0.612
LIG_14-3-3_CanoR_1	265	273	PF00244	0.478
LIG_14-3-3_CanoR_1	399	403	PF00244	0.706
LIG_14-3-3_CanoR_1	504	513	PF00244	0.419
LIG_14-3-3_CanoR_1	607	615	PF00244	0.419
LIG_14-3-3_CanoR_1	629	638	PF00244	0.557
LIG_14-3-3_CanoR_1	710	715	PF00244	0.547
LIG_14-3-3_CanoR_1	73	79	PF00244	0.454
LIG_14-3-3_CanoR_1	98	107	PF00244	0.648
LIG_Actin_WH2_2	425	442	PF00022	0.534
LIG_Actin_WH2_2	509	526	PF00022	0.453
LIG_BIR_III_4	493	497	PF00653	0.455
LIG_BRCT_BRCA1_1	679	683	PF00533	0.658
LIG_BRCT_BRCA1_1	711	715	PF00533	0.442
LIG_CaM_NSCaTE_8	334	341	PF13499	0.527
LIG_Clathr_ClatBox_1	486	490	PF01394	0.426
LIG_deltaCOP1_diTrp_1	639	645	PF00928	0.443
LIG_EVH1_1	696	700	PF00568	0.583
LIG_FHA_1	139	145	PF00498	0.550
LIG_FHA_1	17	23	PF00498	0.438
LIG_FHA_1	201	207	PF00498	0.579
LIG_FHA_1	237	243	PF00498	0.640
LIG_FHA_1	244	250	PF00498	0.595
LIG_FHA_1	288	294	PF00498	0.440
LIG_FHA_1	333	339	PF00498	0.720
LIG_FHA_1	367	373	PF00498	0.650
LIG_FHA_1	4	10	PF00498	0.628
LIG_FHA_1	419	425	PF00498	0.593
LIG_FHA_1	448	454	PF00498	0.744
LIG_FHA_1	466	472	PF00498	0.766
LIG_FHA_1	493	499	PF00498	0.561
LIG_FHA_1	540	546	PF00498	0.422
LIG_FHA_1	56	62	PF00498	0.427
LIG_FHA_1	74	80	PF00498	0.616
LIG_FHA_2	73	79	PF00498	0.519
LIG_FXI_DFP_1	62	66	PF00024	0.492
LIG_LIR_Gen_1	127	135	PF02991	0.664
LIG_LIR_Gen_1	141	147	PF02991	0.473
LIG_LIR_Gen_1	643	653	PF02991	0.517
LIG_LIR_Gen_1	712	723	PF02991	0.472
LIG_LIR_Nem_3	127	132	PF02991	0.659
LIG_LIR_Nem_3	141	145	PF02991	0.484
LIG_LIR_Nem_3	541	546	PF02991	0.389
LIG_LIR_Nem_3	643	648	PF02991	0.527
LIG_LIR_Nem_3	712	718	PF02991	0.516
LIG_NRBOX	276	282	PF00104	0.456
LIG_PDZ_Class_2	735	740	PF00595	0.563
LIG_SH2_CRK	129	133	PF00017	0.579
LIG_SH2_CRK	219	223	PF00017	0.384
LIG_SH2_NCK_1	142	146	PF00017	0.485
LIG_SH2_NCK_1	37	41	PF00017	0.504
LIG_SH2_STAP1	35	39	PF00017	0.403
LIG_SH2_STAT5	219	222	PF00017	0.400
LIG_SH3_3	194	200	PF00018	0.782
LIG_SH3_3	529	535	PF00018	0.616
LIG_SH3_3	560	566	PF00018	0.602
LIG_SH3_3	694	700	PF00018	0.676
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.579
LIG_SUMO_SIM_anti_2	480	487	PF11976	0.528
LIG_SUMO_SIM_par_1	143	149	PF11976	0.579
LIG_TRAF2_1	356	359	PF00917	0.690
LIG_ULM_U2AF65_1	262	267	PF00076	0.499
LIG_WW_3	119	123	PF00397	0.647
MOD_CK1_1	112	118	PF00069	0.784
MOD_CK1_1	149	155	PF00069	0.567
MOD_CK1_1	198	204	PF00069	0.585
MOD_CK1_1	367	373	PF00069	0.696
MOD_CK1_1	379	385	PF00069	0.587
MOD_CK1_1	405	411	PF00069	0.650
MOD_CK1_1	463	469	PF00069	0.741
MOD_CK1_1	539	545	PF00069	0.505
MOD_CK1_1	633	639	PF00069	0.493
MOD_CK1_1	674	680	PF00069	0.656
MOD_CK1_1	686	692	PF00069	0.683
MOD_CK1_1	726	732	PF00069	0.607
MOD_CK1_1	88	94	PF00069	0.560
MOD_CK2_1	166	172	PF00069	0.778
MOD_CMANNOS	642	645	PF00535	0.428
MOD_GlcNHglycan	101	104	PF01048	0.606
MOD_GlcNHglycan	117	120	PF01048	0.785
MOD_GlcNHglycan	151	154	PF01048	0.538
MOD_GlcNHglycan	225	228	PF01048	0.525
MOD_GlcNHglycan	287	290	PF01048	0.555
MOD_GlcNHglycan	3	6	PF01048	0.553
MOD_GlcNHglycan	320	323	PF01048	0.637
MOD_GlcNHglycan	339	342	PF01048	0.500
MOD_GlcNHglycan	378	381	PF01048	0.690
MOD_GlcNHglycan	407	410	PF01048	0.620
MOD_GlcNHglycan	524	527	PF01048	0.672
MOD_GlcNHglycan	575	578	PF01048	0.567
MOD_GlcNHglycan	665	668	PF01048	0.509
MOD_GlcNHglycan	688	691	PF01048	0.784
MOD_GSK3_1	108	115	PF00069	0.635
MOD_GSK3_1	127	134	PF00069	0.748
MOD_GSK3_1	145	152	PF00069	0.522
MOD_GSK3_1	162	169	PF00069	0.602
MOD_GSK3_1	196	203	PF00069	0.703
MOD_GSK3_1	217	224	PF00069	0.402
MOD_GSK3_1	243	250	PF00069	0.658
MOD_GSK3_1	287	294	PF00069	0.401
MOD_GSK3_1	314	321	PF00069	0.801
MOD_GSK3_1	360	367	PF00069	0.739
MOD_GSK3_1	375	382	PF00069	0.559
MOD_GSK3_1	398	405	PF00069	0.573
MOD_GSK3_1	416	423	PF00069	0.764
MOD_GSK3_1	443	450	PF00069	0.545
MOD_GSK3_1	459	466	PF00069	0.774
MOD_GSK3_1	473	480	PF00069	0.533
MOD_GSK3_1	488	495	PF00069	0.510
MOD_GSK3_1	579	586	PF00069	0.637
MOD_GSK3_1	684	691	PF00069	0.563
MOD_GSK3_1	73	80	PF00069	0.581
MOD_GSK3_1	81	88	PF00069	0.511
MOD_N-GLC_1	236	241	PF02516	0.774
MOD_N-GLC_1	73	78	PF02516	0.439
MOD_NEK2_1	1	6	PF00069	0.558
MOD_NEK2_1	114	119	PF00069	0.618
MOD_NEK2_1	221	226	PF00069	0.434
MOD_NEK2_1	293	298	PF00069	0.618
MOD_NEK2_1	337	342	PF00069	0.551
MOD_NEK2_1	375	380	PF00069	0.648
MOD_NEK2_1	402	407	PF00069	0.591
MOD_NEK2_1	460	465	PF00069	0.721
MOD_NEK2_1	498	503	PF00069	0.548
MOD_NEK2_1	522	527	PF00069	0.571
MOD_NEK2_1	545	550	PF00069	0.491
MOD_NEK2_1	662	667	PF00069	0.573
MOD_NEK2_1	709	714	PF00069	0.521
MOD_NEK2_1	72	77	PF00069	0.516
MOD_NEK2_1	79	84	PF00069	0.453
MOD_PIKK_1	112	118	PF00454	0.633
MOD_PIKK_1	354	360	PF00454	0.680
MOD_PIKK_1	488	494	PF00454	0.406
MOD_PIKK_1	633	639	PF00454	0.461
MOD_PIKK_1	79	85	PF00454	0.430
MOD_PK_1	291	297	PF00069	0.434
MOD_PKA_2	264	270	PF00069	0.538
MOD_PKA_2	375	381	PF00069	0.646
MOD_PKA_2	398	404	PF00069	0.678
MOD_PKA_2	460	466	PF00069	0.613
MOD_PKA_2	606	612	PF00069	0.417
MOD_PKA_2	674	680	PF00069	0.607
MOD_PKA_2	709	715	PF00069	0.448
MOD_PKA_2	72	78	PF00069	0.455
MOD_Plk_1	360	366	PF00069	0.688
MOD_Plk_2-3	138	144	PF00069	0.524
MOD_Plk_2-3	166	172	PF00069	0.592
MOD_Plk_4	127	133	PF00069	0.578
MOD_Plk_4	201	207	PF00069	0.483
MOD_Plk_4	217	223	PF00069	0.413
MOD_Plk_4	384	390	PF00069	0.779
MOD_Plk_4	398	404	PF00069	0.621
MOD_Plk_4	478	484	PF00069	0.634
MOD_Plk_4	570	576	PF00069	0.538
MOD_Plk_4	710	716	PF00069	0.394
MOD_ProDKin_1	131	137	PF00069	0.688
MOD_ProDKin_1	196	202	PF00069	0.683
MOD_ProDKin_1	244	250	PF00069	0.560
MOD_ProDKin_1	403	409	PF00069	0.654
MOD_ProDKin_1	418	424	PF00069	0.516
MOD_ProDKin_1	444	450	PF00069	0.565
MOD_ProDKin_1	536	542	PF00069	0.515
MOD_ProDKin_1	559	565	PF00069	0.583
MOD_ProDKin_1	583	589	PF00069	0.613
MOD_ProDKin_1	695	701	PF00069	0.666
MOD_ProDKin_1	726	732	PF00069	0.607
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.497
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.590
TRG_ENDOCYTIC_2	129	132	PF00928	0.577
TRG_ENDOCYTIC_2	142	145	PF00928	0.479
TRG_ENDOCYTIC_2	219	222	PF00928	0.429
TRG_NLS_MonoExtN_4	261	266	PF00514	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIE2	Leptomonas seymouri	34%	100%
A0A3S5H715	Leishmania donovani	87%	100%
A4H963	Leishmania braziliensis	68%	99%
A4HXI5	Leishmania infantum	87%	100%
E9AR80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%