Putative ubiquitin hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania major

UniProt:

Q4QE82_LEIMA

TriTrypDb:

LmjF.17.1090 , LMJLV39_170018200 , LMJSD75_170017900

Length:

1310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0016579	protein deubiquitination	6	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044238	primary metabolic process	2	5
GO:0070646	protein modification by small protein removal	5	5

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004843	cysteine-type deubiquitinase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0008234	cysteine-type peptidase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0019783	ubiquitin-like protein peptidase activity	4	5
GO:0101005	deubiquitinase activity	5	5
GO:0140096	catalytic activity, acting on a protein	2	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	382	386	PF00656	0.619
CLV_NRD_NRD_1	1063	1065	PF00675	0.388
CLV_NRD_NRD_1	1088	1090	PF00675	0.384
CLV_NRD_NRD_1	1248	1250	PF00675	0.388
CLV_NRD_NRD_1	1251	1253	PF00675	0.359
CLV_NRD_NRD_1	1269	1271	PF00675	0.388
CLV_NRD_NRD_1	138	140	PF00675	0.584
CLV_NRD_NRD_1	170	172	PF00675	0.648
CLV_NRD_NRD_1	187	189	PF00675	0.537
CLV_NRD_NRD_1	5	7	PF00675	0.695

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE18	Leishmania donovani	90%	100%
A4H964	Leishmania braziliensis	71%	98%
E9AR81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%

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