UDP-sugar pyrophosphorylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-sugar pyrophosphorylase

Species:

Leishmania major

UniProt:

Q4QE75_LEIMA

TriTrypDb:

LmjF.17.1160 , LMJLV39_170018900 , LMJSD75_170018700

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE75

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	2
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	2
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009225	nucleotide-sugar metabolic process	4	2
GO:0009226	nucleotide-sugar biosynthetic process	5	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046349	amino sugar biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0002134	UTP binding	4	2
GO:0003824	catalytic activity	1	11
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	6	2
GO:0005488	binding	1	2
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016779	nucleotidyltransferase activity	4	11
GO:0017103	UTP:galactose-1-phosphate uridylyltransferase activity	7	2
GO:0019103	pyrimidine nucleotide binding	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0032553	ribonucleotide binding	3	2
GO:0032557	pyrimidine ribonucleotide binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0043763	UTP:glucose-1-phosphate uridylyltransferase regulator activity	3	2
GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	6	5
GO:0070569	uridylyltransferase activity	5	11
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0098772	molecular function regulator activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.678
CLV_MEL_PAP_1	424	430	PF00089	0.432
CLV_NRD_NRD_1	218	220	PF00675	0.230
CLV_NRD_NRD_1	393	395	PF00675	0.537
CLV_NRD_NRD_1	466	468	PF00675	0.419
CLV_NRD_NRD_1	96	98	PF00675	0.473
CLV_PCSK_KEX2_1	237	239	PF00082	0.625
CLV_PCSK_KEX2_1	393	395	PF00082	0.537
CLV_PCSK_KEX2_1	465	467	PF00082	0.423
CLV_PCSK_KEX2_1	96	98	PF00082	0.473
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.621
CLV_PCSK_SKI1_1	101	105	PF00082	0.394
CLV_PCSK_SKI1_1	114	118	PF00082	0.227
CLV_PCSK_SKI1_1	394	398	PF00082	0.485
CLV_PCSK_SKI1_1	466	470	PF00082	0.432
CLV_PCSK_SKI1_1	487	491	PF00082	0.316
DEG_APCC_DBOX_1	464	472	PF00400	0.368
DEG_COP1_1	375	383	PF00400	0.376
DEG_SCF_TRCP1_1	243	248	PF00400	0.452
DOC_AGCK_PIF_1	425	430	PF00069	0.349
DOC_ANK_TNKS_1	466	473	PF00023	0.375
DOC_CDC14_PxL_1	88	96	PF14671	0.474
DOC_CKS1_1	16	21	PF01111	0.520
DOC_CKS1_1	517	522	PF01111	0.443
DOC_CYCLIN_RxL_1	176	187	PF00134	0.407
DOC_MAPK_gen_1	301	309	PF00069	0.313
DOC_MAPK_gen_1	465	475	PF00069	0.322
DOC_MAPK_gen_1	601	607	PF00069	0.265
DOC_MAPK_HePTP_8	463	475	PF00069	0.372
DOC_MAPK_MEF2A_6	161	168	PF00069	0.488
DOC_MAPK_MEF2A_6	466	475	PF00069	0.337
DOC_MAPK_MEF2A_6	493	500	PF00069	0.374
DOC_PP2B_LxvP_1	186	189	PF13499	0.455
DOC_PP2B_LxvP_1	82	85	PF13499	0.411
DOC_PP4_FxxP_1	383	386	PF00568	0.356
DOC_PP4_FxxP_1	396	399	PF00568	0.378
DOC_PP4_FxxP_1	517	520	PF00568	0.397
DOC_PP4_FxxP_1	89	92	PF00568	0.461
DOC_USP7_MATH_1	288	292	PF00917	0.402
DOC_USP7_MATH_1	332	336	PF00917	0.544
DOC_USP7_MATH_1	4	8	PF00917	0.516
DOC_USP7_MATH_1	553	557	PF00917	0.295
DOC_USP7_MATH_1	71	75	PF00917	0.439
DOC_USP7_UBL2_3	216	220	PF12436	0.419
DOC_WW_Pin1_4	15	20	PF00397	0.391
DOC_WW_Pin1_4	350	355	PF00397	0.411
DOC_WW_Pin1_4	516	521	PF00397	0.433
LIG_14-3-3_CanoR_1	127	137	PF00244	0.490
LIG_14-3-3_CanoR_1	393	397	PF00244	0.463
LIG_14-3-3_CanoR_1	427	431	PF00244	0.330
LIG_14-3-3_CanoR_1	588	595	PF00244	0.468
LIG_14-3-3_CanoR_1	96	104	PF00244	0.450
LIG_Actin_WH2_2	181	197	PF00022	0.474
LIG_Actin_WH2_2	359	376	PF00022	0.403
LIG_Actin_WH2_2	456	471	PF00022	0.360
LIG_AP2alpha_2	319	321	PF02296	0.392
LIG_BIR_III_4	488	492	PF00653	0.237
LIG_BRCT_BRCA1_1	264	268	PF00533	0.368
LIG_CtBP_PxDLS_1	281	285	PF00389	0.282
LIG_EVH1_2	85	89	PF00568	0.448
LIG_FHA_1	107	113	PF00498	0.525
LIG_FHA_1	143	149	PF00498	0.482
LIG_FHA_1	16	22	PF00498	0.457
LIG_FHA_1	175	181	PF00498	0.414
LIG_FHA_1	212	218	PF00498	0.516
LIG_FHA_1	275	281	PF00498	0.284
LIG_FHA_1	528	534	PF00498	0.402
LIG_FHA_2	100	106	PF00498	0.379
LIG_FHA_2	167	173	PF00498	0.426
LIG_FHA_2	31	37	PF00498	0.485
LIG_FHA_2	421	427	PF00498	0.433
LIG_FHA_2	610	616	PF00498	0.517
LIG_GBD_Chelix_1	120	128	PF00786	0.213
LIG_LIR_Apic_2	382	386	PF02991	0.355
LIG_LIR_Apic_2	395	399	PF02991	0.383
LIG_LIR_Gen_1	115	124	PF02991	0.426
LIG_LIR_Gen_1	162	172	PF02991	0.469
LIG_LIR_Gen_1	293	303	PF02991	0.341
LIG_LIR_Gen_1	327	334	PF02991	0.352
LIG_LIR_Gen_1	423	433	PF02991	0.340
LIG_LIR_Gen_1	76	87	PF02991	0.377
LIG_LIR_Nem_3	115	120	PF02991	0.426
LIG_LIR_Nem_3	145	150	PF02991	0.482
LIG_LIR_Nem_3	293	299	PF02991	0.332
LIG_LIR_Nem_3	327	331	PF02991	0.344
LIG_LIR_Nem_3	350	355	PF02991	0.401
LIG_LIR_Nem_3	423	428	PF02991	0.352
LIG_LIR_Nem_3	429	433	PF02991	0.341
LIG_LIR_Nem_3	457	463	PF02991	0.300
LIG_LIR_Nem_3	543	548	PF02991	0.319
LIG_LIR_Nem_3	76	82	PF02991	0.391
LIG_PTB_Apo_2	322	329	PF02174	0.409
LIG_PTB_Apo_2	382	389	PF02174	0.348
LIG_PTB_Phospho_1	322	328	PF10480	0.403
LIG_PTB_Phospho_1	382	388	PF10480	0.387
LIG_SH2_CRK	130	134	PF00017	0.469
LIG_SH2_CRK	430	434	PF00017	0.292
LIG_SH2_CRK	545	549	PF00017	0.407
LIG_SH2_SRC	430	433	PF00017	0.340
LIG_SH2_STAP1	263	267	PF00017	0.306
LIG_SH2_STAT3	461	464	PF00017	0.408
LIG_SH2_STAT3	477	480	PF00017	0.458
LIG_SH2_STAT5	147	150	PF00017	0.426
LIG_SH2_STAT5	151	154	PF00017	0.426
LIG_SH2_STAT5	369	372	PF00017	0.335
LIG_SH2_STAT5	451	454	PF00017	0.307
LIG_SH2_STAT5	62	65	PF00017	0.319
LIG_SH3_3	132	138	PF00018	0.469
LIG_SH3_3	297	303	PF00018	0.336
LIG_SH3_3	343	349	PF00018	0.460
LIG_SUMO_SIM_anti_2	408	417	PF11976	0.302
LIG_SUMO_SIM_par_1	495	502	PF11976	0.289
LIG_SUMO_SIM_par_1	529	534	PF11976	0.328
LIG_TRAF2_1	436	439	PF00917	0.366
LIG_TYR_ITIM	128	133	PF00017	0.444
LIG_Vh1_VBS_1	166	184	PF01044	0.398
MOD_CDK_SPxK_1	516	522	PF00069	0.359
MOD_CK1_1	170	176	PF00069	0.413
MOD_CK1_1	347	353	PF00069	0.456
MOD_CK1_1	358	364	PF00069	0.268
MOD_CK1_1	389	395	PF00069	0.491
MOD_CK1_1	506	512	PF00069	0.431
MOD_CK1_1	587	593	PF00069	0.495
MOD_CK2_1	30	36	PF00069	0.520
MOD_CK2_1	420	426	PF00069	0.412
MOD_CK2_1	433	439	PF00069	0.446
MOD_CK2_1	476	482	PF00069	0.459
MOD_CK2_1	609	615	PF00069	0.599
MOD_CK2_1	99	105	PF00069	0.379
MOD_GlcNHglycan	204	207	PF01048	0.341
MOD_GlcNHglycan	243	246	PF01048	0.678
MOD_GlcNHglycan	286	289	PF01048	0.351
MOD_GlcNHglycan	316	319	PF01048	0.501
MOD_GlcNHglycan	506	509	PF01048	0.415
MOD_GlcNHglycan	621	624	PF01048	0.668
MOD_GSK3_1	129	136	PF00069	0.458
MOD_GSK3_1	138	145	PF00069	0.458
MOD_GSK3_1	166	173	PF00069	0.413
MOD_GSK3_1	241	248	PF00069	0.606
MOD_GSK3_1	276	283	PF00069	0.344
MOD_GSK3_1	284	291	PF00069	0.333
MOD_GSK3_1	310	317	PF00069	0.391
MOD_GSK3_1	499	506	PF00069	0.364
MOD_GSK3_1	609	616	PF00069	0.638
MOD_GSK3_1	95	102	PF00069	0.517
MOD_N-GLC_1	143	148	PF02516	0.255
MOD_N-GLC_1	232	237	PF02516	0.274
MOD_N-GLC_1	294	299	PF02516	0.306
MOD_NEK2_1	112	117	PF00069	0.444
MOD_NEK2_1	128	133	PF00069	0.365
MOD_NEK2_1	202	207	PF00069	0.478
MOD_NEK2_1	211	216	PF00069	0.477
MOD_NEK2_1	294	299	PF00069	0.332
MOD_NEK2_1	310	315	PF00069	0.491
MOD_NEK2_1	364	369	PF00069	0.388
MOD_NEK2_1	373	378	PF00069	0.309
MOD_NEK2_1	475	480	PF00069	0.495
MOD_NEK2_1	503	508	PF00069	0.420
MOD_NEK2_1	600	605	PF00069	0.502
MOD_NEK2_2	129	134	PF00069	0.455
MOD_NEK2_2	232	237	PF00069	0.437
MOD_NEK2_2	546	551	PF00069	0.339
MOD_NEK2_2	571	576	PF00069	0.387
MOD_PIKK_1	476	482	PF00454	0.336
MOD_PKA_1	314	320	PF00069	0.395
MOD_PKA_2	373	379	PF00069	0.418
MOD_PKA_2	392	398	PF00069	0.391
MOD_PKA_2	426	432	PF00069	0.327
MOD_PKA_2	584	590	PF00069	0.530
MOD_PKA_2	71	77	PF00069	0.473
MOD_PKA_2	95	101	PF00069	0.460
MOD_Plk_1	143	149	PF00069	0.455
MOD_Plk_1	174	180	PF00069	0.474
MOD_Plk_1	232	238	PF00069	0.455
MOD_Plk_1	288	294	PF00069	0.358
MOD_Plk_1	481	487	PF00069	0.405
MOD_Plk_1	99	105	PF00069	0.370
MOD_Plk_4	112	118	PF00069	0.426
MOD_Plk_4	143	149	PF00069	0.444
MOD_Plk_4	226	232	PF00069	0.444
MOD_Plk_4	262	268	PF00069	0.345
MOD_Plk_4	358	364	PF00069	0.302
MOD_Plk_4	365	371	PF00069	0.294
MOD_Plk_4	401	407	PF00069	0.285
MOD_Plk_4	420	426	PF00069	0.446
MOD_Plk_4	527	533	PF00069	0.309
MOD_ProDKin_1	15	21	PF00069	0.383
MOD_ProDKin_1	350	356	PF00069	0.400
MOD_ProDKin_1	516	522	PF00069	0.437
TRG_AP2beta_CARGO_1	457	467	PF09066	0.364
TRG_DiLeu_BaEn_1	213	218	PF01217	0.378
TRG_DiLeu_BaEn_1	305	310	PF01217	0.323
TRG_DiLeu_BaEn_1	439	444	PF01217	0.305
TRG_DiLeu_BaEn_2	263	269	PF01217	0.361
TRG_DiLeu_LyEn_5	83	88	PF01217	0.462
TRG_ENDOCYTIC_2	130	133	PF00928	0.444
TRG_ENDOCYTIC_2	263	266	PF00928	0.293
TRG_ENDOCYTIC_2	328	331	PF00928	0.334
TRG_ENDOCYTIC_2	430	433	PF00928	0.320
TRG_ENDOCYTIC_2	545	548	PF00928	0.320
TRG_ER_diArg_1	465	467	PF00400	0.281
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.498
TRG_PTS1	627	630	PF00515	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W2	Leptomonas seymouri	67%	98%
A0A0S4IQX2	Bodo saltans	44%	83%
A0A1X0NSQ3	Trypanosomatidae	52%	100%
A0A3R7KRK2	Trypanosoma rangeli	50%	100%
A0A3S7WUL7	Leishmania donovani	94%	100%
A2YGP6	Oryza sativa subsp. indica	33%	100%
A4H971	Leishmania braziliensis	84%	100%
A4HXJ3	Leishmania infantum	94%	100%
E9AR88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q09WE7	Glycine max	35%	100%
Q0GZS3	Cucumis melo	35%	100%
Q5W915	Pisum sativum	36%	100%
Q5Z8Y4	Oryza sativa subsp. japonica	33%	100%
Q9C5I1	Arabidopsis thaliana	36%	100%
V5DFP2	Trypanosoma cruzi	51%	100%