Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QE74_LEIMA

TriTrypDb:

LmjF.17.1170 , LMJLV39_170019000 , LMJSD75_170018800

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.595
CLV_C14_Caspase3-7	69	73	PF00656	0.657
CLV_NRD_NRD_1	142	144	PF00675	0.608
CLV_NRD_NRD_1	146	148	PF00675	0.583
CLV_NRD_NRD_1	243	245	PF00675	0.687
CLV_NRD_NRD_1	547	549	PF00675	0.537
CLV_NRD_NRD_1	585	587	PF00675	0.587
CLV_PCSK_KEX2_1	142	144	PF00082	0.636
CLV_PCSK_KEX2_1	146	148	PF00082	0.590
CLV_PCSK_KEX2_1	547	549	PF00082	0.533
CLV_PCSK_KEX2_1	585	587	PF00082	0.587
CLV_PCSK_PC7_1	142	148	PF00082	0.712
CLV_PCSK_SKI1_1	10	14	PF00082	0.542
CLV_PCSK_SKI1_1	250	254	PF00082	0.602
CLV_PCSK_SKI1_1	437	441	PF00082	0.588
CLV_PCSK_SKI1_1	492	496	PF00082	0.586
DEG_Nend_UBRbox_3	1	3	PF02207	0.626
DEG_SPOP_SBC_1	156	160	PF00917	0.625
DEG_SPOP_SBC_1	337	341	PF00917	0.680
DEG_SPOP_SBC_1	355	359	PF00917	0.565
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.725
DOC_MAPK_DCC_7	255	264	PF00069	0.565
DOC_MAPK_gen_1	244	251	PF00069	0.568
DOC_MAPK_gen_1	282	292	PF00069	0.690
DOC_MAPK_gen_1	585	592	PF00069	0.523
DOC_MAPK_MEF2A_6	255	264	PF00069	0.565
DOC_PP1_RVXF_1	246	252	PF00149	0.526
DOC_PP2B_LxvP_1	122	125	PF13499	0.573
DOC_USP7_MATH_1	219	223	PF00917	0.739
DOC_USP7_MATH_1	376	380	PF00917	0.641
DOC_USP7_MATH_1	385	389	PF00917	0.681
DOC_USP7_MATH_1	394	398	PF00917	0.542
DOC_USP7_MATH_1	490	494	PF00917	0.507
DOC_USP7_MATH_1	514	518	PF00917	0.647
DOC_USP7_MATH_1	77	81	PF00917	0.719
DOC_WW_Pin1_4	280	285	PF00397	0.770
DOC_WW_Pin1_4	348	353	PF00397	0.777
DOC_WW_Pin1_4	357	362	PF00397	0.664
DOC_WW_Pin1_4	367	372	PF00397	0.505
DOC_WW_Pin1_4	381	386	PF00397	0.550
DOC_WW_Pin1_4	81	86	PF00397	0.703
LIG_14-3-3_CanoR_1	153	157	PF00244	0.682
LIG_14-3-3_CanoR_1	211	217	PF00244	0.598
LIG_14-3-3_CanoR_1	343	349	PF00244	0.697
LIG_14-3-3_CanoR_1	396	401	PF00244	0.622
LIG_14-3-3_CanoR_1	437	445	PF00244	0.614
LIG_14-3-3_CanoR_1	456	463	PF00244	0.634
LIG_14-3-3_CanoR_1	464	472	PF00244	0.488
LIG_14-3-3_CanoR_1	52	57	PF00244	0.651
LIG_14-3-3_CanoR_1	567	571	PF00244	0.635
LIG_BIR_III_4	409	413	PF00653	0.661
LIG_BRCT_BRCA1_1	172	176	PF00533	0.531
LIG_BRCT_BRCA1_1	597	601	PF00533	0.670
LIG_deltaCOP1_diTrp_1	106	116	PF00928	0.636
LIG_FHA_1	132	138	PF00498	0.669
LIG_FHA_1	314	320	PF00498	0.664
LIG_FHA_1	368	374	PF00498	0.663
LIG_FHA_1	4	10	PF00498	0.680
LIG_FHA_1	420	426	PF00498	0.679
LIG_FHA_1	467	473	PF00498	0.639
LIG_FHA_1	501	507	PF00498	0.585
LIG_FHA_1	52	58	PF00498	0.685
LIG_FHA_1	82	88	PF00498	0.730
LIG_FHA_2	234	240	PF00498	0.584
LIG_FHA_2	364	370	PF00498	0.586
LIG_FHA_2	450	456	PF00498	0.638
LIG_HP1_1	260	264	PF01393	0.658
LIG_LIR_Gen_1	113	124	PF02991	0.686
LIG_LIR_Nem_3	104	110	PF02991	0.548
LIG_LIR_Nem_3	113	119	PF02991	0.613
LIG_LIR_Nem_3	173	179	PF02991	0.533
LIG_LIR_Nem_3	508	512	PF02991	0.597
LIG_NRBOX	540	546	PF00104	0.638
LIG_PTB_Apo_2	265	272	PF02174	0.678
LIG_PTB_Phospho_1	265	271	PF10480	0.676
LIG_SH2_CRK	509	513	PF00017	0.561
LIG_SH2_SRC	287	290	PF00017	0.649
LIG_SH2_STAP1	502	506	PF00017	0.519
LIG_SH2_STAT5	32	35	PF00017	0.654
LIG_SH2_STAT5	502	505	PF00017	0.590
LIG_SH3_1	585	591	PF00018	0.621
LIG_SH3_2	588	593	PF14604	0.636
LIG_SH3_3	213	219	PF00018	0.588
LIG_SH3_3	254	260	PF00018	0.575
LIG_SH3_3	287	293	PF00018	0.639
LIG_SH3_3	327	333	PF00018	0.622
LIG_SH3_3	349	355	PF00018	0.725
LIG_SH3_3	527	533	PF00018	0.723
LIG_SH3_3	585	591	PF00018	0.653
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.488
LIG_TRAF2_1	149	152	PF00917	0.643
LIG_TRAF2_1	485	488	PF00917	0.541
LIG_WW_3	331	335	PF00397	0.606
MOD_CDK_SPK_2	280	285	PF00069	0.721
MOD_CDK_SPxxK_3	357	364	PF00069	0.683
MOD_CK1_1	155	161	PF00069	0.680
MOD_CK1_1	162	168	PF00069	0.597
MOD_CK1_1	170	176	PF00069	0.474
MOD_CK1_1	200	206	PF00069	0.606
MOD_CK1_1	222	228	PF00069	0.750
MOD_CK1_1	304	310	PF00069	0.811
MOD_CK1_1	321	327	PF00069	0.557
MOD_CK1_1	351	357	PF00069	0.699
MOD_CK1_1	367	373	PF00069	0.639
MOD_CK1_1	379	385	PF00069	0.608
MOD_CK1_1	386	392	PF00069	0.589
MOD_CK1_1	415	421	PF00069	0.649
MOD_CK1_1	427	433	PF00069	0.613
MOD_CK1_1	458	464	PF00069	0.693
MOD_CK1_1	517	523	PF00069	0.626
MOD_CK1_1	66	72	PF00069	0.605
MOD_CK2_1	203	209	PF00069	0.595
MOD_CK2_1	363	369	PF00069	0.589
MOD_CK2_1	449	455	PF00069	0.637
MOD_GlcNHglycan	181	184	PF01048	0.707
MOD_GlcNHglycan	201	205	PF01048	0.643
MOD_GlcNHglycan	221	224	PF01048	0.650
MOD_GlcNHglycan	307	310	PF01048	0.715
MOD_GlcNHglycan	313	316	PF01048	0.732
MOD_GlcNHglycan	365	369	PF01048	0.749
MOD_GlcNHglycan	385	388	PF01048	0.561
MOD_GlcNHglycan	39	43	PF01048	0.632
MOD_GlcNHglycan	396	399	PF01048	0.673
MOD_GlcNHglycan	44	47	PF01048	0.660
MOD_GlcNHglycan	492	495	PF01048	0.539
MOD_GlcNHglycan	516	519	PF01048	0.590
MOD_GlcNHglycan	59	62	PF01048	0.660
MOD_GlcNHglycan	596	600	PF01048	0.710
MOD_GlcNHglycan	66	69	PF01048	0.614
MOD_GSK3_1	1	8	PF00069	0.603
MOD_GSK3_1	151	158	PF00069	0.650
MOD_GSK3_1	160	167	PF00069	0.552
MOD_GSK3_1	171	178	PF00069	0.636
MOD_GSK3_1	189	196	PF00069	0.699
MOD_GSK3_1	200	207	PF00069	0.691
MOD_GSK3_1	218	225	PF00069	0.640
MOD_GSK3_1	301	308	PF00069	0.649
MOD_GSK3_1	338	345	PF00069	0.771
MOD_GSK3_1	351	358	PF00069	0.622
MOD_GSK3_1	360	367	PF00069	0.671
MOD_GSK3_1	376	383	PF00069	0.560
MOD_GSK3_1	38	45	PF00069	0.692
MOD_GSK3_1	385	392	PF00069	0.681
MOD_GSK3_1	396	403	PF00069	0.517
MOD_GSK3_1	415	422	PF00069	0.645
MOD_GSK3_1	424	431	PF00069	0.627
MOD_GSK3_1	450	457	PF00069	0.639
MOD_GSK3_1	513	520	PF00069	0.679
MOD_GSK3_1	77	84	PF00069	0.743
MOD_N-GLC_1	187	192	PF02516	0.711
MOD_NEK2_1	1	6	PF00069	0.698
MOD_NEK2_1	164	169	PF00069	0.624
MOD_NEK2_1	24	29	PF00069	0.545
MOD_NEK2_1	301	306	PF00069	0.750
MOD_NEK2_1	344	349	PF00069	0.670
MOD_NEK2_1	377	382	PF00069	0.616
MOD_NEK2_1	400	405	PF00069	0.712
MOD_NEK2_1	57	62	PF00069	0.755
MOD_PIKK_1	110	116	PF00454	0.607
MOD_PKA_1	244	250	PF00069	0.573
MOD_PKA_2	152	158	PF00069	0.587
MOD_PKA_2	305	311	PF00069	0.678
MOD_PKA_2	342	348	PF00069	0.727
MOD_PKA_2	363	369	PF00069	0.589
MOD_PKA_2	455	461	PF00069	0.803
MOD_PKA_2	463	469	PF00069	0.630
MOD_PKA_2	472	478	PF00069	0.553
MOD_PKA_2	51	57	PF00069	0.588
MOD_PKA_2	566	572	PF00069	0.627
MOD_Plk_1	151	157	PF00069	0.517
MOD_Plk_1	238	244	PF00069	0.586
MOD_Plk_1	301	307	PF00069	0.614
MOD_Plk_4	171	177	PF00069	0.711
MOD_Plk_4	415	421	PF00069	0.721
MOD_Plk_4	46	52	PF00069	0.646
MOD_Plk_4	566	572	PF00069	0.515
MOD_Plk_4	66	72	PF00069	0.697
MOD_ProDKin_1	280	286	PF00069	0.772
MOD_ProDKin_1	348	354	PF00069	0.776
MOD_ProDKin_1	357	363	PF00069	0.663
MOD_ProDKin_1	367	373	PF00069	0.508
MOD_ProDKin_1	381	387	PF00069	0.551
MOD_ProDKin_1	81	87	PF00069	0.702
TRG_DiLeu_BaEn_1	540	545	PF01217	0.523
TRG_ENDOCYTIC_2	107	110	PF00928	0.582
TRG_ENDOCYTIC_2	287	290	PF00928	0.619
TRG_ENDOCYTIC_2	509	512	PF00928	0.595
TRG_ER_diArg_1	145	147	PF00400	0.735
TRG_ER_diArg_1	470	473	PF00400	0.676
TRG_ER_diArg_1	547	549	PF00400	0.656
TRG_ER_diArg_1	585	587	PF00400	0.727
TRG_NLS_MonoExtC_3	146	152	PF00514	0.513
TRG_NLS_MonoExtN_4	146	151	PF00514	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEN2	Leptomonas seymouri	29%	70%
A0A3S7WUL8	Leishmania donovani	82%	100%
A4H972	Leishmania braziliensis	54%	99%
A4HXJ4	Leishmania infantum	83%	100%
E9AR89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%