Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QE73_LEIMA

TriTrypDb:

LmjF.17.1180 , LMJLV39_170019100 , LMJLV39_170019200 , LMJSD75_170018900

Length:

945

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.679
CLV_C14_Caspase3-7	605	609	PF00656	0.734
CLV_C14_Caspase3-7	718	722	PF00656	0.782
CLV_C14_Caspase3-7	775	779	PF00656	0.618
CLV_NRD_NRD_1	135	137	PF00675	0.673
CLV_NRD_NRD_1	146	148	PF00675	0.587
CLV_NRD_NRD_1	422	424	PF00675	0.734
CLV_NRD_NRD_1	448	450	PF00675	0.684
CLV_NRD_NRD_1	486	488	PF00675	0.565
CLV_NRD_NRD_1	529	531	PF00675	0.631
CLV_NRD_NRD_1	653	655	PF00675	0.709
CLV_NRD_NRD_1	763	765	PF00675	0.794
CLV_NRD_NRD_1	863	865	PF00675	0.652
CLV_NRD_NRD_1	917	919	PF00675	0.643
CLV_NRD_NRD_1	928	930	PF00675	0.563
CLV_PCSK_FUR_1	567	571	PF00082	0.708
CLV_PCSK_KEX2_1	135	137	PF00082	0.673
CLV_PCSK_KEX2_1	146	148	PF00082	0.587
CLV_PCSK_KEX2_1	422	424	PF00082	0.734
CLV_PCSK_KEX2_1	448	450	PF00082	0.684
CLV_PCSK_KEX2_1	486	488	PF00082	0.565
CLV_PCSK_KEX2_1	528	530	PF00082	0.671
CLV_PCSK_KEX2_1	569	571	PF00082	0.710
CLV_PCSK_KEX2_1	653	655	PF00082	0.709
CLV_PCSK_KEX2_1	762	764	PF00082	0.803
CLV_PCSK_KEX2_1	863	865	PF00082	0.656
CLV_PCSK_KEX2_1	917	919	PF00082	0.643
CLV_PCSK_KEX2_1	928	930	PF00082	0.563
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.710
CLV_PCSK_PC7_1	524	530	PF00082	0.666
CLV_PCSK_PC7_1	913	919	PF00082	0.640
CLV_PCSK_SKI1_1	2	6	PF00082	0.637
CLV_PCSK_SKI1_1	434	438	PF00082	0.595
CLV_PCSK_SKI1_1	486	490	PF00082	0.647
CLV_PCSK_SKI1_1	524	528	PF00082	0.645
CLV_PCSK_SKI1_1	692	696	PF00082	0.721
CLV_PCSK_SKI1_1	704	708	PF00082	0.580
CLV_PCSK_SKI1_1	894	898	PF00082	0.598
CLV_Separin_Metazoa	782	786	PF03568	0.564
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DEG_SCF_FBW7_1	803	810	PF00400	0.630
DEG_SPOP_SBC_1	170	174	PF00917	0.659
DEG_SPOP_SBC_1	18	22	PF00917	0.571
DEG_SPOP_SBC_1	4	8	PF00917	0.659
DEG_SPOP_SBC_1	665	669	PF00917	0.664
DEG_SPOP_SBC_1	77	81	PF00917	0.643
DOC_CKS1_1	230	235	PF01111	0.672
DOC_CYCLIN_yCln2_LP_2	248	254	PF00134	0.712
DOC_MAPK_gen_1	135	143	PF00069	0.513
DOC_MAPK_MEF2A_6	39	47	PF00069	0.549
DOC_MAPK_MEF2A_6	68	75	PF00069	0.600
DOC_PP1_RVXF_1	382	389	PF00149	0.640
DOC_PP2B_LxvP_1	192	195	PF13499	0.652
DOC_PP2B_LxvP_1	248	251	PF13499	0.704
DOC_PP2B_LxvP_1	27	30	PF13499	0.655
DOC_PP2B_LxvP_1	304	307	PF13499	0.728
DOC_PP2B_LxvP_1	458	461	PF13499	0.595
DOC_PP2B_LxvP_1	463	466	PF13499	0.516
DOC_PP2B_LxvP_1	623	626	PF13499	0.705
DOC_PP4_FxxP_1	694	697	PF00568	0.637
DOC_USP7_MATH_1	108	112	PF00917	0.672
DOC_USP7_MATH_1	170	174	PF00917	0.585
DOC_USP7_MATH_1	208	212	PF00917	0.697
DOC_USP7_MATH_1	223	227	PF00917	0.715
DOC_USP7_MATH_1	256	260	PF00917	0.688
DOC_USP7_MATH_1	268	272	PF00917	0.667
DOC_USP7_MATH_1	366	370	PF00917	0.832
DOC_USP7_MATH_1	515	519	PF00917	0.498
DOC_USP7_MATH_1	54	58	PF00917	0.641
DOC_USP7_MATH_1	629	633	PF00917	0.792
DOC_USP7_MATH_1	666	670	PF00917	0.773
DOC_USP7_MATH_1	681	685	PF00917	0.586
DOC_USP7_MATH_1	706	710	PF00917	0.756
DOC_USP7_MATH_1	770	774	PF00917	0.606
DOC_USP7_MATH_1	821	825	PF00917	0.668
DOC_USP7_MATH_1	842	846	PF00917	0.608
DOC_USP7_MATH_1	871	875	PF00917	0.657
DOC_USP7_MATH_1	876	880	PF00917	0.642
DOC_USP7_MATH_2	205	211	PF00917	0.574
DOC_WW_Pin1_4	190	195	PF00397	0.684
DOC_WW_Pin1_4	22	27	PF00397	0.656
DOC_WW_Pin1_4	229	234	PF00397	0.655
DOC_WW_Pin1_4	254	259	PF00397	0.747
DOC_WW_Pin1_4	316	321	PF00397	0.755
DOC_WW_Pin1_4	362	367	PF00397	0.796
DOC_WW_Pin1_4	456	461	PF00397	0.693
DOC_WW_Pin1_4	611	616	PF00397	0.857
DOC_WW_Pin1_4	693	698	PF00397	0.615
DOC_WW_Pin1_4	803	808	PF00397	0.644
DOC_WW_Pin1_4	814	819	PF00397	0.608
DOC_WW_Pin1_4	824	829	PF00397	0.581
DOC_WW_Pin1_4	902	907	PF00397	0.574
DOC_WW_Pin1_4	933	938	PF00397	0.591
DOC_WW_Pin1_4	939	944	PF00397	0.550
LIG_14-3-3_CanoR_1	135	141	PF00244	0.710
LIG_14-3-3_CanoR_1	16	26	PF00244	0.600
LIG_14-3-3_CanoR_1	384	389	PF00244	0.687
LIG_14-3-3_CanoR_1	486	495	PF00244	0.566
LIG_14-3-3_CanoR_1	583	593	PF00244	0.715
LIG_14-3-3_CanoR_1	653	658	PF00244	0.658
LIG_14-3-3_CanoR_1	785	789	PF00244	0.567
LIG_14-3-3_CanoR_1	813	818	PF00244	0.612
LIG_14-3-3_CanoR_1	917	921	PF00244	0.605
LIG_14-3-3_CanoR_1	939	943	PF00244	0.565
LIG_APCC_Cbox_2	889	895	PF00515	0.625
LIG_BIR_III_2	804	808	PF00653	0.558
LIG_EVH1_1	623	627	PF00568	0.602
LIG_FHA_1	19	25	PF00498	0.667
LIG_FHA_1	480	486	PF00498	0.500
LIG_FHA_1	552	558	PF00498	0.703
LIG_FHA_1	585	591	PF00498	0.680
LIG_FHA_1	59	65	PF00498	0.644
LIG_FHA_1	97	103	PF00498	0.653
LIG_FHA_2	435	441	PF00498	0.618
LIG_FHA_2	656	662	PF00498	0.683
LIG_FHA_2	773	779	PF00498	0.624
LIG_GSK3_LRP6_1	316	321	PF00069	0.620
LIG_LIR_Apic_2	669	675	PF02991	0.717
LIG_LIR_Apic_2	691	697	PF02991	0.657
LIG_LIR_Gen_1	196	206	PF02991	0.665
LIG_LIR_Gen_1	505	515	PF02991	0.426
LIG_LIR_Gen_1	787	796	PF02991	0.665
LIG_LIR_Nem_3	139	143	PF02991	0.502
LIG_LIR_Nem_3	196	202	PF02991	0.660
LIG_LIR_Nem_3	505	510	PF02991	0.427
LIG_LIR_Nem_3	787	791	PF02991	0.667
LIG_MYND_1	615	619	PF01753	0.692
LIG_MYND_1	621	625	PF01753	0.698
LIG_MYND_3	592	596	PF01753	0.678
LIG_SH2_CRK	859	863	PF00017	0.697
LIG_SH2_SRC	148	151	PF00017	0.492
LIG_SH2_STAP1	148	152	PF00017	0.689
LIG_SH2_STAP1	639	643	PF00017	0.574
LIG_SH2_STAT5	183	186	PF00017	0.726
LIG_SH2_STAT5	585	588	PF00017	0.569
LIG_SH2_STAT5	934	937	PF00017	0.610
LIG_SH3_3	111	117	PF00018	0.677
LIG_SH3_3	199	205	PF00018	0.581
LIG_SH3_3	314	320	PF00018	0.813
LIG_SH3_3	326	332	PF00018	0.650
LIG_SH3_3	369	375	PF00018	0.747
LIG_SH3_3	44	50	PF00018	0.643
LIG_SH3_3	554	560	PF00018	0.741
LIG_SH3_3	612	618	PF00018	0.800
LIG_SH3_3	621	627	PF00018	0.668
LIG_SH3_3	817	823	PF00018	0.595
LIG_SUMO_SIM_anti_2	545	551	PF11976	0.603
LIG_SUMO_SIM_anti_2	72	77	PF11976	0.608
LIG_SUMO_SIM_par_1	332	338	PF11976	0.581
LIG_SUMO_SIM_par_1	40	46	PF11976	0.636
LIG_SxIP_EBH_1	135	147	PF03271	0.510
LIG_TRAF2_1	471	474	PF00917	0.451
LIG_TRAF2_1	92	95	PF00917	0.622
LIG_WW_2	322	325	PF00397	0.798
LIG_WW_2	615	618	PF00397	0.640
LIG_WW_3	459	463	PF00397	0.675
MOD_CDC14_SPxK_1	257	260	PF00782	0.694
MOD_CDC14_SPxK_1	459	462	PF00782	0.675
MOD_CDC14_SPxK_1	936	939	PF00782	0.586
MOD_CDK_SPxK_1	254	260	PF00069	0.696
MOD_CDK_SPxK_1	456	462	PF00069	0.692
MOD_CDK_SPxK_1	933	939	PF00069	0.592
MOD_CK1_1	158	164	PF00069	0.709
MOD_CK1_1	193	199	PF00069	0.785
MOD_CK1_1	282	288	PF00069	0.758
MOD_CK1_1	3	9	PF00069	0.658
MOD_CK1_1	305	311	PF00069	0.787
MOD_CK1_1	578	584	PF00069	0.797
MOD_CK1_1	58	64	PF00069	0.723
MOD_CK1_1	599	605	PF00069	0.796
MOD_CK1_1	610	616	PF00069	0.709
MOD_CK1_1	693	699	PF00069	0.682
MOD_CK1_1	717	723	PF00069	0.765
MOD_CK1_1	724	730	PF00069	0.710
MOD_CK1_1	768	774	PF00069	0.710
MOD_CK1_1	787	793	PF00069	0.504
MOD_CK1_1	824	830	PF00069	0.702
MOD_CK1_1	916	922	PF00069	0.604
MOD_CK1_1	938	944	PF00069	0.602
MOD_CK2_1	296	302	PF00069	0.651
MOD_CK2_1	434	440	PF00069	0.625
MOD_CK2_1	599	605	PF00069	0.740
MOD_Cter_Amidation	144	147	PF01082	0.591
MOD_Cter_Amidation	446	449	PF01082	0.683
MOD_Cter_Amidation	651	654	PF01082	0.710
MOD_GlcNHglycan	110	113	PF01048	0.680
MOD_GlcNHglycan	130	133	PF01048	0.430
MOD_GlcNHglycan	2	5	PF01048	0.655
MOD_GlcNHglycan	287	290	PF01048	0.765
MOD_GlcNHglycan	452	455	PF01048	0.687
MOD_GlcNHglycan	516	520	PF01048	0.579
MOD_GlcNHglycan	561	564	PF01048	0.766
MOD_GlcNHglycan	575	578	PF01048	0.552
MOD_GlcNHglycan	600	604	PF01048	0.735
MOD_GlcNHglycan	631	634	PF01048	0.698
MOD_GlcNHglycan	650	653	PF01048	0.581
MOD_GlcNHglycan	685	688	PF01048	0.687
MOD_GlcNHglycan	737	740	PF01048	0.664
MOD_GlcNHglycan	823	826	PF01048	0.694
MOD_GlcNHglycan	844	847	PF01048	0.609
MOD_GlcNHglycan	873	876	PF01048	0.668
MOD_GlcNHglycan	878	881	PF01048	0.627
MOD_GSK3_1	12	19	PF00069	0.612
MOD_GSK3_1	193	200	PF00069	0.737
MOD_GSK3_1	281	288	PF00069	0.632
MOD_GSK3_1	3	10	PF00069	0.660
MOD_GSK3_1	307	314	PF00069	0.766
MOD_GSK3_1	362	369	PF00069	0.800
MOD_GSK3_1	434	441	PF00069	0.710
MOD_GSK3_1	450	457	PF00069	0.574
MOD_GSK3_1	54	61	PF00069	0.725
MOD_GSK3_1	606	613	PF00069	0.813
MOD_GSK3_1	679	686	PF00069	0.787
MOD_GSK3_1	715	722	PF00069	0.715
MOD_GSK3_1	726	733	PF00069	0.647
MOD_GSK3_1	766	773	PF00069	0.713
MOD_GSK3_1	803	810	PF00069	0.630
MOD_GSK3_1	819	826	PF00069	0.560
MOD_GSK3_1	867	874	PF00069	0.659
MOD_GSK3_1	908	915	PF00069	0.599
MOD_GSK3_1	935	942	PF00069	0.601
MOD_GSK3_1	96	103	PF00069	0.530
MOD_LATS_1	14	20	PF00433	0.672
MOD_N-GLC_1	127	132	PF02516	0.631
MOD_N-GLC_1	366	371	PF02516	0.818
MOD_N-GLC_1	724	729	PF02516	0.726
MOD_NEK2_1	171	176	PF00069	0.720
MOD_NEK2_1	382	387	PF00069	0.699
MOD_NEK2_1	5	10	PF00069	0.664
MOD_NEK2_1	548	553	PF00069	0.625
MOD_NEK2_1	598	603	PF00069	0.664
MOD_NEK2_1	690	695	PF00069	0.642
MOD_NEK2_1	784	789	PF00069	0.601
MOD_NEK2_1	907	912	PF00069	0.631
MOD_NEK2_1	96	101	PF00069	0.631
MOD_NEK2_2	332	337	PF00069	0.620
MOD_PIKK_1	279	285	PF00454	0.783
MOD_PIKK_1	548	554	PF00454	0.667
MOD_PKA_1	486	492	PF00069	0.565
MOD_PKA_1	653	659	PF00069	0.632
MOD_PKA_2	12	18	PF00069	0.607
MOD_PKA_2	479	485	PF00069	0.579
MOD_PKA_2	486	492	PF00069	0.580
MOD_PKA_2	495	501	PF00069	0.446
MOD_PKA_2	572	578	PF00069	0.711
MOD_PKA_2	653	659	PF00069	0.693
MOD_PKA_2	766	772	PF00069	0.713
MOD_PKA_2	784	790	PF00069	0.512
MOD_PKA_2	842	848	PF00069	0.578
MOD_PKA_2	912	918	PF00069	0.604
MOD_PKA_2	938	944	PF00069	0.567
MOD_PKB_1	462	470	PF00069	0.588
MOD_Plk_1	438	444	PF00069	0.647
MOD_Plk_1	690	696	PF00069	0.735
MOD_Plk_1	730	736	PF00069	0.571
MOD_Plk_1	907	913	PF00069	0.621
MOD_Plk_2-3	908	914	PF00069	0.632
MOD_Plk_4	171	177	PF00069	0.708
MOD_Plk_4	262	268	PF00069	0.779
MOD_Plk_4	784	790	PF00069	0.670
MOD_ProDKin_1	190	196	PF00069	0.688
MOD_ProDKin_1	22	28	PF00069	0.656
MOD_ProDKin_1	229	235	PF00069	0.653
MOD_ProDKin_1	254	260	PF00069	0.749
MOD_ProDKin_1	316	322	PF00069	0.755
MOD_ProDKin_1	362	368	PF00069	0.800
MOD_ProDKin_1	456	462	PF00069	0.692
MOD_ProDKin_1	611	617	PF00069	0.856
MOD_ProDKin_1	693	699	PF00069	0.612
MOD_ProDKin_1	803	809	PF00069	0.643
MOD_ProDKin_1	814	820	PF00069	0.611
MOD_ProDKin_1	824	830	PF00069	0.574
MOD_ProDKin_1	902	908	PF00069	0.577
MOD_ProDKin_1	933	939	PF00069	0.592
TRG_DiLeu_BaEn_4	505	511	PF01217	0.621
TRG_ER_diArg_1	135	138	PF00400	0.586
TRG_ER_diArg_1	146	148	PF00400	0.571
TRG_ER_diArg_1	461	464	PF00400	0.666
TRG_ER_diArg_1	485	487	PF00400	0.566
TRG_ER_diArg_1	527	530	PF00400	0.669
TRG_ER_diArg_1	653	655	PF00400	0.709
TRG_ER_diArg_1	762	764	PF00400	0.808
TRG_ER_diArg_1	862	864	PF00400	0.656
TRG_ER_diArg_1	928	930	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUT3	Leishmania donovani	86%	100%
A4H973	Leishmania braziliensis	55%	100%
A4HXJ5	Leishmania infantum	86%	100%
E9AR90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%