Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QE72_LEIMA

TriTrypDb:

LmjF.17.1190 , LMJLV39_170019300 , LMJSD75_170019000

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	443	447	PF00656	0.609
CLV_C14_Caspase3-7	86	90	PF00656	0.635
CLV_MEL_PAP_1	475	481	PF00089	0.522
CLV_NRD_NRD_1	317	319	PF00675	0.721
CLV_NRD_NRD_1	361	363	PF00675	0.718
CLV_NRD_NRD_1	469	471	PF00675	0.764
CLV_NRD_NRD_1	477	479	PF00675	0.618
CLV_NRD_NRD_1	572	574	PF00675	0.765
CLV_NRD_NRD_1	583	585	PF00675	0.561
CLV_NRD_NRD_1	76	78	PF00675	0.672
CLV_PCSK_FUR_1	580	584	PF00082	0.618
CLV_PCSK_KEX2_1	317	319	PF00082	0.721
CLV_PCSK_KEX2_1	361	363	PF00082	0.718
CLV_PCSK_KEX2_1	469	471	PF00082	0.747
CLV_PCSK_KEX2_1	477	479	PF00082	0.641
CLV_PCSK_KEX2_1	582	584	PF00082	0.774
CLV_PCSK_KEX2_1	588	590	PF00082	0.708
CLV_PCSK_KEX2_1	76	78	PF00082	0.672
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.788
CLV_PCSK_PC7_1	584	590	PF00082	0.707
CLV_PCSK_SKI1_1	25	29	PF00082	0.692
CLV_PCSK_SKI1_1	538	542	PF00082	0.668
CLV_PCSK_SKI1_1	563	567	PF00082	0.722
CLV_PCSK_SKI1_1	583	587	PF00082	0.745
DEG_SPOP_SBC_1	194	198	PF00917	0.613
DEG_SPOP_SBC_1	300	304	PF00917	0.754
DEG_SPOP_SBC_1	511	515	PF00917	0.705
DOC_CKS1_1	321	326	PF01111	0.770
DOC_MAPK_gen_1	76	83	PF00069	0.630
DOC_MAPK_MEF2A_6	201	210	PF00069	0.652
DOC_MAPK_MEF2A_6	555	564	PF00069	0.647
DOC_MAPK_MEF2A_6	76	85	PF00069	0.629
DOC_PP1_RVXF_1	475	482	PF00149	0.521
DOC_PP2B_LxvP_1	15	18	PF13499	0.644
DOC_USP7_MATH_1	158	162	PF00917	0.561
DOC_USP7_MATH_1	278	282	PF00917	0.674
DOC_USP7_MATH_1	301	305	PF00917	0.709
DOC_USP7_MATH_1	337	341	PF00917	0.803
DOC_USP7_MATH_1	346	350	PF00917	0.628
DOC_USP7_MATH_1	401	405	PF00917	0.788
DOC_USP7_MATH_1	424	428	PF00917	0.747
DOC_USP7_MATH_1	507	511	PF00917	0.704
DOC_USP7_MATH_1	512	516	PF00917	0.561
DOC_USP7_MATH_1	533	537	PF00917	0.706
DOC_USP7_MATH_1	652	656	PF00917	0.668
DOC_USP7_MATH_1	670	674	PF00917	0.551
DOC_USP7_MATH_1	704	708	PF00917	0.614
DOC_WW_Pin1_4	18	23	PF00397	0.786
DOC_WW_Pin1_4	196	201	PF00397	0.694
DOC_WW_Pin1_4	320	325	PF00397	0.812
DOC_WW_Pin1_4	327	332	PF00397	0.683
DOC_WW_Pin1_4	344	349	PF00397	0.689
DOC_WW_Pin1_4	393	398	PF00397	0.784
DOC_WW_Pin1_4	447	452	PF00397	0.671
DOC_WW_Pin1_4	619	624	PF00397	0.622
DOC_WW_Pin1_4	67	72	PF00397	0.678
DOC_WW_Pin1_4	680	685	PF00397	0.778
LIG_14-3-3_CanoR_1	164	170	PF00244	0.706
LIG_14-3-3_CanoR_1	296	301	PF00244	0.697
LIG_14-3-3_CanoR_1	47	53	PF00244	0.621
LIG_14-3-3_CanoR_1	477	482	PF00244	0.741
LIG_14-3-3_CanoR_1	628	633	PF00244	0.782
LIG_14-3-3_CanoR_1	643	652	PF00244	0.547
LIG_Actin_WH2_2	547	565	PF00022	0.645
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BRCT_BRCA1_1	513	517	PF00533	0.703
LIG_BRCT_BRCA1_1	633	637	PF00533	0.667
LIG_Clathr_ClatBox_1	54	58	PF01394	0.662
LIG_CSL_BTD_1	321	324	PF09270	0.769
LIG_deltaCOP1_diTrp_1	548	558	PF00928	0.633
LIG_eIF4E_1	559	565	PF01652	0.663
LIG_FHA_1	161	167	PF00498	0.625
LIG_FHA_1	239	245	PF00498	0.751
LIG_FHA_1	287	293	PF00498	0.743
LIG_FHA_1	300	306	PF00498	0.588
LIG_FHA_1	321	327	PF00498	0.758
LIG_FHA_1	340	346	PF00498	0.540
LIG_FHA_1	487	493	PF00498	0.693
LIG_FHA_1	663	669	PF00498	0.708
LIG_FHA_2	124	130	PF00498	0.691
LIG_FHA_2	197	203	PF00498	0.639
LIG_FHA_2	435	441	PF00498	0.726
LIG_FHA_2	77	83	PF00498	0.680
LIG_FHA_2	8	14	PF00498	0.697
LIG_HP1_1	112	116	PF01393	0.639
LIG_LIR_Gen_1	50	59	PF02991	0.706
LIG_LIR_Gen_1	548	559	PF02991	0.675
LIG_LIR_Nem_3	167	173	PF02991	0.678
LIG_LIR_Nem_3	50	55	PF02991	0.707
LIG_LIR_Nem_3	548	554	PF02991	0.675
LIG_LYPXL_yS_3	559	562	PF13949	0.652
LIG_PDZ_Class_2	712	717	PF00595	0.669
LIG_PTB_Apo_2	553	560	PF02174	0.630
LIG_PTB_Phospho_1	553	559	PF10480	0.628
LIG_Rb_pABgroove_1	113	121	PF01858	0.727
LIG_SH2_NCK_1	265	269	PF00017	0.706
LIG_SH2_STAT3	549	552	PF00017	0.644
LIG_SH2_STAT5	549	552	PF00017	0.644
LIG_SH3_1	105	111	PF00018	0.602
LIG_SH3_3	105	111	PF00018	0.602
LIG_SH3_3	249	255	PF00018	0.753
LIG_SH3_3	318	324	PF00018	0.769
LIG_SH3_3	391	397	PF00018	0.636
LIG_SUMO_SIM_par_1	296	304	PF11976	0.751
LIG_SUMO_SIM_par_1	53	58	PF11976	0.663
LIG_TRAF2_1	100	103	PF00917	0.660
LIG_TRAF2_1	11	14	PF00917	0.664
LIG_TRAF2_1	437	440	PF00917	0.780
LIG_UBA3_1	417	423	PF00899	0.677
MOD_CDK_SPK_2	196	201	PF00069	0.638
MOD_CDK_SPxxK_3	18	25	PF00069	0.727
MOD_CK1_1	123	129	PF00069	0.724
MOD_CK1_1	165	171	PF00069	0.674
MOD_CK1_1	174	180	PF00069	0.676
MOD_CK1_1	246	252	PF00069	0.751
MOD_CK1_1	261	267	PF00069	0.601
MOD_CK1_1	273	279	PF00069	0.768
MOD_CK1_1	299	305	PF00069	0.698
MOD_CK1_1	340	346	PF00069	0.769
MOD_CK1_1	356	362	PF00069	0.695
MOD_CK1_1	460	466	PF00069	0.773
MOD_CK1_1	480	486	PF00069	0.539
MOD_CK1_1	510	516	PF00069	0.683
MOD_CK1_1	613	619	PF00069	0.572
MOD_CK1_1	631	637	PF00069	0.692
MOD_CK1_1	67	73	PF00069	0.793
MOD_CK1_1	673	679	PF00069	0.756
MOD_CK1_1	98	104	PF00069	0.692
MOD_CK2_1	127	133	PF00069	0.701
MOD_CK2_1	18	24	PF00069	0.726
MOD_CK2_1	260	266	PF00069	0.660
MOD_CK2_1	304	310	PF00069	0.773
MOD_CK2_1	434	440	PF00069	0.773
MOD_CK2_1	47	53	PF00069	0.705
MOD_CK2_1	7	13	PF00069	0.682
MOD_CK2_1	76	82	PF00069	0.696
MOD_Cter_Amidation	74	77	PF01082	0.624
MOD_GlcNHglycan	1	4	PF01048	0.695
MOD_GlcNHglycan	126	129	PF01048	0.653
MOD_GlcNHglycan	136	139	PF01048	0.738
MOD_GlcNHglycan	149	152	PF01048	0.603
MOD_GlcNHglycan	235	238	PF01048	0.700
MOD_GlcNHglycan	280	283	PF01048	0.736
MOD_GlcNHglycan	33	37	PF01048	0.650
MOD_GlcNHglycan	39	42	PF01048	0.592
MOD_GlcNHglycan	403	406	PF01048	0.825
MOD_GlcNHglycan	457	460	PF01048	0.672
MOD_GlcNHglycan	462	465	PF01048	0.608
MOD_GlcNHglycan	493	496	PF01048	0.701
MOD_GlcNHglycan	502	505	PF01048	0.630
MOD_GlcNHglycan	509	512	PF01048	0.570
MOD_GlcNHglycan	570	573	PF01048	0.767
MOD_GlcNHglycan	590	593	PF01048	0.768
MOD_GlcNHglycan	595	598	PF01048	0.761
MOD_GlcNHglycan	612	615	PF01048	0.515
MOD_GlcNHglycan	633	636	PF01048	0.575
MOD_GlcNHglycan	647	650	PF01048	0.610
MOD_GlcNHglycan	66	69	PF01048	0.804
MOD_GlcNHglycan	678	681	PF01048	0.720
MOD_GlcNHglycan	706	709	PF01048	0.711
MOD_GlcNHglycan	97	100	PF01048	0.717
MOD_GSK3_1	120	127	PF00069	0.710
MOD_GSK3_1	158	165	PF00069	0.731
MOD_GSK3_1	168	175	PF00069	0.614
MOD_GSK3_1	208	215	PF00069	0.698
MOD_GSK3_1	228	235	PF00069	0.719
MOD_GSK3_1	243	250	PF00069	0.579
MOD_GSK3_1	254	261	PF00069	0.605
MOD_GSK3_1	266	273	PF00069	0.628
MOD_GSK3_1	296	303	PF00069	0.709
MOD_GSK3_1	326	333	PF00069	0.757
MOD_GSK3_1	336	343	PF00069	0.686
MOD_GSK3_1	389	396	PF00069	0.833
MOD_GSK3_1	473	480	PF00069	0.764
MOD_GSK3_1	482	489	PF00069	0.615
MOD_GSK3_1	496	503	PF00069	0.599
MOD_GSK3_1	506	513	PF00069	0.626
MOD_GSK3_1	515	522	PF00069	0.535
MOD_GSK3_1	593	600	PF00069	0.785
MOD_GSK3_1	602	609	PF00069	0.660
MOD_GSK3_1	668	675	PF00069	0.746
MOD_GSK3_1	676	683	PF00069	0.666
MOD_N-GLC_1	47	52	PF02516	0.769
MOD_N-GLC_1	673	678	PF02516	0.710
MOD_NEK2_1	162	167	PF00069	0.649
MOD_NEK2_1	172	177	PF00069	0.602
MOD_NEK2_1	195	200	PF00069	0.699
MOD_NEK2_1	232	237	PF00069	0.736
MOD_NEK2_1	238	243	PF00069	0.688
MOD_NEK2_1	313	318	PF00069	0.762
MOD_NEK2_1	326	331	PF00069	0.758
MOD_NEK2_1	341	346	PF00069	0.583
MOD_NEK2_1	387	392	PF00069	0.638
MOD_NEK2_1	455	460	PF00069	0.769
MOD_NEK2_1	481	486	PF00069	0.739
MOD_NEK2_1	487	492	PF00069	0.680
MOD_NEK2_1	496	501	PF00069	0.565
MOD_NEK2_1	519	524	PF00069	0.630
MOD_NEK2_1	66	71	PF00069	0.681
MOD_NEK2_1	668	673	PF00069	0.742
MOD_NEK2_1	95	100	PF00069	0.693
MOD_NEK2_2	512	517	PF00069	0.723
MOD_NEK2_2	662	667	PF00069	0.624
MOD_PIKK_1	174	180	PF00454	0.739
MOD_PIKK_1	523	529	PF00454	0.681
MOD_PIKK_1	533	539	PF00454	0.706
MOD_PK_1	296	302	PF00069	0.698
MOD_PK_1	628	634	PF00069	0.675
MOD_PKA_1	477	483	PF00069	0.720
MOD_PKA_1	588	594	PF00069	0.683
MOD_PKA_1	76	82	PF00069	0.628
MOD_PKA_2	123	129	PF00069	0.769
MOD_PKA_2	477	483	PF00069	0.720
MOD_PKA_2	588	594	PF00069	0.651
MOD_PKA_2	642	648	PF00069	0.767
MOD_PKA_2	76	82	PF00069	0.691
MOD_PKB_1	628	636	PF00069	0.674
MOD_Plk_1	25	31	PF00069	0.688
MOD_Plk_1	356	362	PF00069	0.672
MOD_Plk_1	47	53	PF00069	0.705
MOD_Plk_1	519	525	PF00069	0.680
MOD_Plk_4	165	171	PF00069	0.672
MOD_Plk_4	416	422	PF00069	0.541
MOD_Plk_4	477	483	PF00069	0.747
MOD_Plk_4	487	493	PF00069	0.609
MOD_Plk_4	512	518	PF00069	0.700
MOD_Plk_4	519	525	PF00069	0.605
MOD_ProDKin_1	18	24	PF00069	0.789
MOD_ProDKin_1	196	202	PF00069	0.696
MOD_ProDKin_1	320	326	PF00069	0.813
MOD_ProDKin_1	327	333	PF00069	0.681
MOD_ProDKin_1	344	350	PF00069	0.691
MOD_ProDKin_1	393	399	PF00069	0.784
MOD_ProDKin_1	447	453	PF00069	0.668
MOD_ProDKin_1	619	625	PF00069	0.621
MOD_ProDKin_1	67	73	PF00069	0.676
MOD_ProDKin_1	680	686	PF00069	0.775
MOD_SUMO_rev_2	98	107	PF00179	0.658
TRG_ENDOCYTIC_2	559	562	PF00928	0.652
TRG_ENDOCYTIC_2	697	700	PF00928	0.705
TRG_ER_diArg_1	360	362	PF00400	0.720
TRG_ER_diArg_1	477	479	PF00400	0.724
TRG_ER_diArg_1	580	583	PF00400	0.759
TRG_ER_diArg_1	627	630	PF00400	0.651
TRG_ER_diArg_1	76	78	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUL3	Leishmania donovani	90%	100%
A4HXJ6	Leishmania infantum	91%	100%
E9AI56	Leishmania braziliensis	60%	99%
E9AR91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%