Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE71_LEIMA

TriTrypDb:

LmjF.17.1200 , LMJLV39_170019400 , LMJSD75_170019100

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QE71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	215	217	PF00675	0.698
CLV_NRD_NRD_1	248	250	PF00675	0.796
CLV_NRD_NRD_1	260	262	PF00675	0.653
CLV_NRD_NRD_1	380	382	PF00675	0.408
CLV_NRD_NRD_1	461	463	PF00675	0.839
CLV_NRD_NRD_1	575	577	PF00675	0.677
CLV_NRD_NRD_1	605	607	PF00675	0.675
CLV_NRD_NRD_1	647	649	PF00675	0.847
CLV_NRD_NRD_1	653	655	PF00675	0.774
CLV_NRD_NRD_1	677	679	PF00675	0.721
CLV_NRD_NRD_1	686	688	PF00675	0.622
CLV_NRD_NRD_1	736	738	PF00675	0.701
CLV_PCSK_KEX2_1	215	217	PF00082	0.698
CLV_PCSK_KEX2_1	248	250	PF00082	0.796
CLV_PCSK_KEX2_1	303	305	PF00082	0.530
CLV_PCSK_KEX2_1	321	323	PF00082	0.464
CLV_PCSK_KEX2_1	380	382	PF00082	0.539
CLV_PCSK_KEX2_1	461	463	PF00082	0.826
CLV_PCSK_KEX2_1	574	576	PF00082	0.690
CLV_PCSK_KEX2_1	604	606	PF00082	0.634
CLV_PCSK_KEX2_1	647	649	PF00082	0.853
CLV_PCSK_KEX2_1	653	655	PF00082	0.768
CLV_PCSK_KEX2_1	677	679	PF00082	0.721
CLV_PCSK_KEX2_1	686	688	PF00082	0.622
CLV_PCSK_KEX2_1	736	738	PF00082	0.703
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.530
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.464
CLV_PCSK_PC7_1	673	679	PF00082	0.718
CLV_PCSK_SKI1_1	318	322	PF00082	0.483
CLV_PCSK_SKI1_1	609	613	PF00082	0.668
CLV_PCSK_SKI1_1	664	668	PF00082	0.688
DEG_Nend_UBRbox_1	1	4	PF02207	0.665
DEG_SPOP_SBC_1	149	153	PF00917	0.651
DEG_SPOP_SBC_1	568	572	PF00917	0.687
DEG_SPOP_SBC_1	577	581	PF00917	0.611
DOC_CKS1_1	565	570	PF01111	0.675
DOC_MAPK_gen_1	686	694	PF00069	0.642
DOC_MIT_MIM_1	383	392	PF04212	0.529
DOC_PP1_RVXF_1	483	489	PF00149	0.644
DOC_PP2B_LxvP_1	126	129	PF13499	0.733
DOC_PP4_FxxP_1	118	121	PF00568	0.688
DOC_USP7_MATH_1	149	153	PF00917	0.651
DOC_USP7_MATH_1	209	213	PF00917	0.651
DOC_USP7_MATH_1	35	39	PF00917	0.667
DOC_USP7_MATH_1	481	485	PF00917	0.710
DOC_USP7_MATH_1	500	504	PF00917	0.598
DOC_USP7_MATH_1	537	541	PF00917	0.786
DOC_USP7_MATH_1	568	572	PF00917	0.670
DOC_USP7_MATH_1	584	588	PF00917	0.578
DOC_USP7_MATH_1	611	615	PF00917	0.705
DOC_USP7_MATH_1	634	638	PF00917	0.650
DOC_USP7_MATH_1	65	69	PF00917	0.619
DOC_USP7_MATH_1	693	697	PF00917	0.563
DOC_USP7_MATH_1	740	744	PF00917	0.762
DOC_USP7_MATH_1	745	749	PF00917	0.691
DOC_USP7_UBL2_3	469	473	PF12436	0.567
DOC_WW_Pin1_4	116	121	PF00397	0.713
DOC_WW_Pin1_4	182	187	PF00397	0.688
DOC_WW_Pin1_4	433	438	PF00397	0.533
DOC_WW_Pin1_4	448	453	PF00397	0.537
DOC_WW_Pin1_4	479	484	PF00397	0.656
DOC_WW_Pin1_4	564	569	PF00397	0.677
DOC_WW_Pin1_4	642	647	PF00397	0.711
DOC_WW_Pin1_4	66	71	PF00397	0.638
DOC_WW_Pin1_4	680	685	PF00397	0.708
DOC_WW_Pin1_4	712	717	PF00397	0.693
LIG_14-3-3_CanoR_1	107	115	PF00244	0.706
LIG_14-3-3_CanoR_1	155	163	PF00244	0.572
LIG_14-3-3_CanoR_1	215	223	PF00244	0.635
LIG_14-3-3_CanoR_1	225	231	PF00244	0.609
LIG_14-3-3_CanoR_1	242	250	PF00244	0.572
LIG_14-3-3_CanoR_1	254	264	PF00244	0.568
LIG_14-3-3_CanoR_1	506	511	PF00244	0.649
LIG_14-3-3_CanoR_1	555	563	PF00244	0.697
LIG_14-3-3_CanoR_1	569	574	PF00244	0.589
LIG_14-3-3_CanoR_1	575	584	PF00244	0.535
LIG_14-3-3_CanoR_1	653	660	PF00244	0.822
LIG_14-3-3_CanoR_1	677	684	PF00244	0.722
LIG_14-3-3_CanoR_1	700	704	PF00244	0.689
LIG_14-3-3_CanoR_1	758	764	PF00244	0.466
LIG_14-3-3_CanoR_1	811	819	PF00244	0.594
LIG_BIR_III_2	64	68	PF00653	0.645
LIG_BIR_III_4	622	626	PF00653	0.596
LIG_BRCT_BRCA1_1	246	250	PF00533	0.604
LIG_CtBP_PxDLS_1	41	45	PF00389	0.576
LIG_FHA_1	218	224	PF00498	0.569
LIG_FHA_1	558	564	PF00498	0.728
LIG_FHA_1	568	574	PF00498	0.624
LIG_FHA_1	70	76	PF00498	0.603
LIG_FHA_1	739	745	PF00498	0.739
LIG_FHA_1	774	780	PF00498	0.575
LIG_FHA_2	284	290	PF00498	0.564
LIG_FHA_2	403	409	PF00498	0.495
LIG_FHA_2	665	671	PF00498	0.670
LIG_MYND_1	182	186	PF01753	0.643
LIG_PCNA_yPIPBox_3	782	795	PF02747	0.518
LIG_PTAP_UEV_1	451	456	PF05743	0.572
LIG_RPA_C_Fungi	376	388	PF08784	0.405
LIG_SH2_GRB2like	163	166	PF00017	0.561
LIG_SH2_SRC	263	266	PF00017	0.626
LIG_SH2_STAT3	163	166	PF00017	0.561
LIG_SH2_STAT5	263	266	PF00017	0.626
LIG_SH3_2	806	811	PF14604	0.673
LIG_SH3_3	109	115	PF00018	0.683
LIG_SH3_3	119	125	PF00018	0.747
LIG_SH3_3	449	455	PF00018	0.574
LIG_SH3_3	550	556	PF00018	0.713
LIG_SH3_3	64	70	PF00018	0.676
LIG_SH3_3	643	649	PF00018	0.712
LIG_SH3_3	710	716	PF00018	0.637
LIG_SH3_3	803	809	PF00018	0.668
LIG_SH3_3	827	833	PF00018	0.580
LIG_SH3_5	83	87	PF00018	0.656
MOD_CDC14_SPxK_1	482	485	PF00782	0.616
MOD_CDC14_SPxK_1	645	648	PF00782	0.604
MOD_CDC14_SPxK_1	683	686	PF00782	0.660
MOD_CDK_SPK_2	564	569	PF00069	0.677
MOD_CDK_SPK_2	642	647	PF00069	0.689
MOD_CDK_SPxK_1	479	485	PF00069	0.659
MOD_CDK_SPxK_1	642	648	PF00069	0.713
MOD_CDK_SPxK_1	680	686	PF00069	0.664
MOD_CDK_SPxxK_3	680	687	PF00069	0.708
MOD_CK1_1	13	19	PF00069	0.686
MOD_CK1_1	151	157	PF00069	0.804
MOD_CK1_1	200	206	PF00069	0.661
MOD_CK1_1	229	235	PF00069	0.635
MOD_CK1_1	255	261	PF00069	0.634
MOD_CK1_1	425	431	PF00069	0.592
MOD_CK1_1	540	546	PF00069	0.637
MOD_CK1_1	579	585	PF00069	0.719
MOD_CK1_1	587	593	PF00069	0.655
MOD_CK1_1	637	643	PF00069	0.631
MOD_CK1_1	656	662	PF00069	0.681
MOD_CK1_1	68	74	PF00069	0.702
MOD_CK1_1	680	686	PF00069	0.657
MOD_CK1_1	715	721	PF00069	0.666
MOD_CK1_1	730	736	PF00069	0.541
MOD_CK1_1	748	754	PF00069	0.654
MOD_CK1_1	775	781	PF00069	0.570
MOD_CK1_1	790	796	PF00069	0.549
MOD_CK1_1	810	816	PF00069	0.638
MOD_CK1_1	821	827	PF00069	0.552
MOD_CK2_1	283	289	PF00069	0.484
MOD_CK2_1	402	408	PF00069	0.493
MOD_CK2_1	425	431	PF00069	0.461
MOD_CK2_1	540	546	PF00069	0.628
MOD_CK2_1	626	632	PF00069	0.675
MOD_CK2_1	89	95	PF00069	0.637
MOD_DYRK1A_RPxSP_1	712	716	PF00069	0.604
MOD_GlcNHglycan	12	15	PF01048	0.650
MOD_GlcNHglycan	18	21	PF01048	0.611
MOD_GlcNHglycan	211	214	PF01048	0.689
MOD_GlcNHglycan	217	220	PF01048	0.636
MOD_GlcNHglycan	244	247	PF01048	0.625
MOD_GlcNHglycan	344	347	PF01048	0.767
MOD_GlcNHglycan	424	427	PF01048	0.563
MOD_GlcNHglycan	502	505	PF01048	0.737
MOD_GlcNHglycan	522	525	PF01048	0.573
MOD_GlcNHglycan	539	542	PF01048	0.759
MOD_GlcNHglycan	54	57	PF01048	0.649
MOD_GlcNHglycan	557	560	PF01048	0.717
MOD_GlcNHglycan	588	592	PF01048	0.722
MOD_GlcNHglycan	594	597	PF01048	0.700
MOD_GlcNHglycan	601	604	PF01048	0.649
MOD_GlcNHglycan	628	631	PF01048	0.679
MOD_GlcNHglycan	638	642	PF01048	0.729
MOD_GlcNHglycan	661	664	PF01048	0.709
MOD_GlcNHglycan	679	682	PF01048	0.589
MOD_GlcNHglycan	688	691	PF01048	0.621
MOD_GlcNHglycan	705	708	PF01048	0.574
MOD_GlcNHglycan	738	741	PF01048	0.702
MOD_GlcNHglycan	750	753	PF01048	0.653
MOD_GlcNHglycan	763	766	PF01048	0.601
MOD_GlcNHglycan	768	771	PF01048	0.496
MOD_GlcNHglycan	782	785	PF01048	0.573
MOD_GlcNHglycan	79	82	PF01048	0.667
MOD_GlcNHglycan	814	817	PF01048	0.700
MOD_GlcNHglycan	820	823	PF01048	0.551
MOD_GlcNHglycan	91	94	PF01048	0.576
MOD_GSK3_1	151	158	PF00069	0.776
MOD_GSK3_1	197	204	PF00069	0.666
MOD_GSK3_1	224	231	PF00069	0.615
MOD_GSK3_1	240	247	PF00069	0.514
MOD_GSK3_1	248	255	PF00069	0.650
MOD_GSK3_1	263	270	PF00069	0.524
MOD_GSK3_1	468	475	PF00069	0.694
MOD_GSK3_1	500	507	PF00069	0.673
MOD_GSK3_1	540	547	PF00069	0.652
MOD_GSK3_1	564	571	PF00069	0.755
MOD_GSK3_1	579	586	PF00069	0.582
MOD_GSK3_1	592	599	PF00069	0.692
MOD_GSK3_1	637	644	PF00069	0.653
MOD_GSK3_1	65	72	PF00069	0.786
MOD_GSK3_1	652	659	PF00069	0.569
MOD_GSK3_1	664	671	PF00069	0.608
MOD_GSK3_1	673	680	PF00069	0.614
MOD_GSK3_1	699	706	PF00069	0.630
MOD_GSK3_1	723	730	PF00069	0.749
MOD_GSK3_1	73	80	PF00069	0.713
MOD_GSK3_1	736	743	PF00069	0.655
MOD_GSK3_1	748	755	PF00069	0.585
MOD_GSK3_1	768	775	PF00069	0.509
MOD_GSK3_1	780	787	PF00069	0.704
MOD_N-GLC_1	130	135	PF02516	0.707
MOD_N-GLC_1	201	206	PF02516	0.685
MOD_N-GLC_1	730	735	PF02516	0.687
MOD_N-GLC_1	766	771	PF02516	0.523
MOD_N-GLC_1	784	789	PF02516	0.770
MOD_NEK2_1	252	257	PF00069	0.618
MOD_NEK2_1	364	369	PF00069	0.550
MOD_NEK2_1	422	427	PF00069	0.553
MOD_NEK2_1	544	549	PF00069	0.711
MOD_NEK2_1	557	562	PF00069	0.597
MOD_NEK2_1	699	704	PF00069	0.693
MOD_NEK2_1	812	817	PF00069	0.748
MOD_NEK2_2	745	750	PF00069	0.682
MOD_PIKK_1	130	136	PF00454	0.697
MOD_PIKK_1	197	203	PF00454	0.599
MOD_PIKK_1	255	261	PF00454	0.628
MOD_PIKK_1	544	550	PF00454	0.722
MOD_PIKK_1	579	585	PF00454	0.676
MOD_PIKK_1	668	674	PF00454	0.680
MOD_PK_1	281	287	PF00069	0.551
MOD_PK_1	473	479	PF00069	0.653
MOD_PK_1	506	512	PF00069	0.649
MOD_PK_1	569	575	PF00069	0.614
MOD_PK_1	647	653	PF00069	0.715
MOD_PK_1	723	729	PF00069	0.624
MOD_PKA_1	215	221	PF00069	0.691
MOD_PKA_1	248	254	PF00069	0.692
MOD_PKA_1	461	467	PF00069	0.715
MOD_PKA_1	605	611	PF00069	0.673
MOD_PKA_1	647	653	PF00069	0.715
MOD_PKA_1	677	683	PF00069	0.705
MOD_PKA_1	686	692	PF00069	0.636
MOD_PKA_1	736	742	PF00069	0.704
MOD_PKA_2	106	112	PF00069	0.675
MOD_PKA_2	215	221	PF00069	0.658
MOD_PKA_2	224	230	PF00069	0.573
MOD_PKA_2	241	247	PF00069	0.503
MOD_PKA_2	248	254	PF00069	0.676
MOD_PKA_2	328	334	PF00069	0.568
MOD_PKA_2	461	467	PF00069	0.715
MOD_PKA_2	544	550	PF00069	0.730
MOD_PKA_2	568	574	PF00069	0.717
MOD_PKA_2	605	611	PF00069	0.682
MOD_PKA_2	647	653	PF00069	0.778
MOD_PKA_2	672	678	PF00069	0.746
MOD_PKA_2	686	692	PF00069	0.595
MOD_PKA_2	699	705	PF00069	0.570
MOD_PKA_2	736	742	PF00069	0.704
MOD_PKA_2	810	816	PF00069	0.749
MOD_PKB_1	574	582	PF00069	0.679
MOD_Plk_1	201	207	PF00069	0.688
MOD_Plk_1	264	270	PF00069	0.600
MOD_Plk_1	288	294	PF00069	0.507
MOD_Plk_1	493	499	PF00069	0.634
MOD_Plk_1	787	793	PF00069	0.599
MOD_Plk_4	288	294	PF00069	0.507
MOD_Plk_4	425	431	PF00069	0.526
MOD_Plk_4	723	729	PF00069	0.765
MOD_Plk_4	775	781	PF00069	0.631
MOD_Plk_4	790	796	PF00069	0.604
MOD_ProDKin_1	116	122	PF00069	0.714
MOD_ProDKin_1	182	188	PF00069	0.688
MOD_ProDKin_1	433	439	PF00069	0.538
MOD_ProDKin_1	448	454	PF00069	0.538
MOD_ProDKin_1	479	485	PF00069	0.659
MOD_ProDKin_1	564	570	PF00069	0.677
MOD_ProDKin_1	642	648	PF00069	0.713
MOD_ProDKin_1	66	72	PF00069	0.643
MOD_ProDKin_1	680	686	PF00069	0.708
MOD_ProDKin_1	712	718	PF00069	0.693
MOD_SUMO_rev_2	408	418	PF00179	0.516
TRG_DiLeu_BaEn_1	408	413	PF01217	0.524
TRG_DiLeu_BaEn_4	325	331	PF01217	0.448
TRG_DiLeu_BaLyEn_6	803	808	PF01217	0.671
TRG_DiLeu_LyEn_5	408	413	PF01217	0.524
TRG_ENDOCYTIC_2	424	427	PF00928	0.705
TRG_ER_diArg_1	214	216	PF00400	0.634
TRG_ER_diArg_1	248	250	PF00400	0.743
TRG_ER_diArg_1	380	382	PF00400	0.408
TRG_ER_diArg_1	409	412	PF00400	0.610
TRG_ER_diArg_1	461	463	PF00400	0.843
TRG_ER_diArg_1	573	576	PF00400	0.686
TRG_ER_diArg_1	604	606	PF00400	0.652
TRG_ER_diArg_1	646	648	PF00400	0.831
TRG_ER_diArg_1	756	759	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJI6	Leishmania donovani	86%	97%
A4H974	Leishmania braziliensis	56%	97%
A4HXJ7	Leishmania infantum	86%	97%
E9AR92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%