MSP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QE70_LEIMA

TriTrypDb:

LmjF.17.1210 , LMJLV39_170019500 , LMJSD75_170019200

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	6
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	6
GO:0031090	organelle membrane	3	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QE70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE70

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022406	membrane docking	2	2
GO:0051179	localization	1	2
GO:0051640	organelle localization	2	2
GO:0051643	endoplasmic reticulum localization	3	2
GO:0061024	membrane organization	4	2
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090158	endoplasmic reticulum membrane organization	5	2
GO:0140056	organelle localization by membrane tethering	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.587
CLV_NRD_NRD_1	32	34	PF00675	0.507
CLV_PCSK_KEX2_1	171	173	PF00082	0.484
CLV_PCSK_KEX2_1	32	34	PF00082	0.559
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.824
DEG_SPOP_SBC_1	211	215	PF00917	0.730
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.479
DOC_MAPK_gen_1	126	133	PF00069	0.687
DOC_MAPK_MEF2A_6	38	45	PF00069	0.624
DOC_MAPK_MEF2A_6	86	95	PF00069	0.635
DOC_PP2B_LxvP_1	398	401	PF13499	0.481
DOC_PP2B_PxIxI_1	40	46	PF00149	0.546
DOC_PP4_FxxP_1	182	185	PF00568	0.667
DOC_PP4_FxxP_1	52	55	PF00568	0.635
DOC_USP7_MATH_1	101	105	PF00917	0.635
DOC_USP7_MATH_1	211	215	PF00917	0.798
DOC_USP7_UBL2_3	255	259	PF12436	0.754
DOC_WW_Pin1_4	141	146	PF00397	0.722
DOC_WW_Pin1_4	171	176	PF00397	0.756
DOC_WW_Pin1_4	365	370	PF00397	0.586
LIG_14-3-3_CanoR_1	103	109	PF00244	0.635
LIG_14-3-3_CanoR_1	126	132	PF00244	0.687
LIG_14-3-3_CanoR_1	298	308	PF00244	0.589
LIG_14-3-3_CanoR_1	4	8	PF00244	0.784
LIG_DLG_GKlike_1	8	16	PF00625	0.636
LIG_EVH1_2	53	57	PF00568	0.635
LIG_FHA_1	11	17	PF00498	0.724
LIG_FHA_1	217	223	PF00498	0.728
LIG_FHA_2	105	111	PF00498	0.635
LIG_FHA_2	135	141	PF00498	0.600
LIG_FHA_2	168	174	PF00498	0.727
LIG_FHA_2	335	341	PF00498	0.473
LIG_FHA_2	411	417	PF00498	0.565
LIG_Integrin_RGD_1	155	157	PF01839	0.521
LIG_LIR_Apic_2	181	185	PF02991	0.665
LIG_LIR_Apic_2	321	325	PF02991	0.553
LIG_LIR_Apic_2	337	342	PF02991	0.443
LIG_LIR_Apic_2	448	454	PF02991	0.560
LIG_LIR_Gen_1	102	111	PF02991	0.635
LIG_LIR_Gen_1	147	154	PF02991	0.708
LIG_LIR_Nem_3	102	108	PF02991	0.635
LIG_LIR_Nem_3	147	152	PF02991	0.585
LIG_LIR_Nem_3	186	190	PF02991	0.753
LIG_LIR_Nem_3	393	398	PF02991	0.490
LIG_MYND_1	141	145	PF01753	0.719
LIG_NRBOX	147	153	PF00104	0.644
LIG_Pex14_1	268	272	PF04695	0.405
LIG_SH2_CRK	322	326	PF00017	0.553
LIG_SH2_CRK	339	343	PF00017	0.438
LIG_SH2_NCK_1	322	326	PF00017	0.479
LIG_SH2_NCK_1	339	343	PF00017	0.513
LIG_SH2_PTP2	187	190	PF00017	0.754
LIG_SH2_SRC	187	190	PF00017	0.696
LIG_SH2_SRC	375	378	PF00017	0.553
LIG_SH2_SRC	446	449	PF00017	0.555
LIG_SH2_STAT3	432	435	PF00017	0.524
LIG_SH2_STAT5	168	171	PF00017	0.709
LIG_SH2_STAT5	187	190	PF00017	0.531
LIG_SH2_STAT5	322	325	PF00017	0.552
LIG_SH2_STAT5	87	90	PF00017	0.635
LIG_SH3_1	322	328	PF00018	0.552
LIG_SH3_3	186	192	PF00018	0.764
LIG_SH3_3	322	328	PF00018	0.637
LIG_SH3_3	368	374	PF00018	0.566
LIG_SH3_3	398	404	PF00018	0.579
LIG_SH3_3	48	54	PF00018	0.635
LIG_SH3_3	85	91	PF00018	0.563
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.529
LIG_SUMO_SIM_par_1	275	280	PF11976	0.446
LIG_TRAF2_1	382	385	PF00917	0.601
LIG_TRAF2_1	419	422	PF00917	0.560
LIG_WRC_WIRS_1	179	184	PF05994	0.665
LIG_WW_1	184	187	PF00397	0.736
MOD_CDK_SPK_2	141	146	PF00069	0.722
MOD_CK1_1	104	110	PF00069	0.635
MOD_CK1_1	20	26	PF00069	0.712
MOD_CK1_1	210	216	PF00069	0.790
MOD_CK1_1	3	9	PF00069	0.683
MOD_CK2_1	410	416	PF00069	0.563
MOD_CK2_1	436	442	PF00069	0.520
MOD_CK2_1	8	14	PF00069	0.810
MOD_GlcNHglycan	20	23	PF01048	0.538
MOD_GlcNHglycan	203	206	PF01048	0.653
MOD_GlcNHglycan	209	212	PF01048	0.588
MOD_GlcNHglycan	304	307	PF01048	0.845
MOD_GlcNHglycan	99	102	PF01048	0.369
MOD_GSK3_1	135	142	PF00069	0.696
MOD_GSK3_1	167	174	PF00069	0.722
MOD_GSK3_1	203	210	PF00069	0.818
MOD_GSK3_1	212	219	PF00069	0.716
MOD_GSK3_1	97	104	PF00069	0.625
MOD_N-GLC_1	68	73	PF02516	0.435
MOD_N-GLC_1	8	13	PF02516	0.580
MOD_NEK2_1	127	132	PF00069	0.682
MOD_NEK2_1	18	23	PF00069	0.693
MOD_NEK2_1	299	304	PF00069	0.528
MOD_NEK2_2	178	183	PF00069	0.717
MOD_NEK2_2	260	265	PF00069	0.588
MOD_PIKK_1	120	126	PF00454	0.665
MOD_PIKK_1	346	352	PF00454	0.515
MOD_PIKK_1	410	416	PF00454	0.610
MOD_PIKK_1	78	84	PF00454	0.635
MOD_PKA_2	127	133	PF00069	0.683
MOD_PKA_2	3	9	PF00069	0.782
MOD_PKA_2	436	442	PF00069	0.432
MOD_Plk_1	320	326	PF00069	0.465
MOD_Plk_1	426	432	PF00069	0.454
MOD_Plk_1	8	14	PF00069	0.634
MOD_Plk_4	178	184	PF00069	0.666
MOD_ProDKin_1	141	147	PF00069	0.721
MOD_ProDKin_1	171	177	PF00069	0.758
MOD_ProDKin_1	365	371	PF00069	0.584
MOD_SUMO_for_1	43	46	PF00179	0.635
TRG_DiLeu_BaEn_1	46	51	PF01217	0.635
TRG_ENDOCYTIC_2	187	190	PF00928	0.754
TRG_ER_diArg_1	32	34	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H717	Leishmania donovani	85%	100%
A4H978	Leishmania braziliensis	65%	100%
A4HXJ8	Leishmania infantum	86%	100%
E9AR93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%