SSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Organic solute transport protein 1, putative

Species:

Leishmania major

UniProt:

Q4QE65_LEIMA

TriTrypDb:

LmjF.17.1260 , LMJLV39_170020000 , LMJSD75_170019700

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.317
CLV_NRD_NRD_1	238	240	PF00675	0.601
CLV_NRD_NRD_1	87	89	PF00675	0.466
CLV_PCSK_KEX2_1	139	141	PF00082	0.377
CLV_PCSK_KEX2_1	157	159	PF00082	0.400
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.369
CLV_PCSK_SKI1_1	139	143	PF00082	0.406
CLV_PCSK_SKI1_1	158	162	PF00082	0.295
CLV_PCSK_SKI1_1	191	195	PF00082	0.517
CLV_PCSK_SKI1_1	411	415	PF00082	0.558
DEG_APCC_DBOX_1	105	113	PF00400	0.348
DEG_SPOP_SBC_1	73	77	PF00917	0.333
DOC_CKS1_1	312	317	PF01111	0.741
DOC_CYCLIN_RxL_1	155	165	PF00134	0.411
DOC_CYCLIN_RxL_1	408	418	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.324
DOC_MAPK_gen_1	157	163	PF00069	0.291
DOC_MAPK_gen_1	167	175	PF00069	0.352
DOC_MAPK_MEF2A_6	167	175	PF00069	0.305
DOC_PP2B_LxvP_1	290	293	PF13499	0.582
DOC_PP4_FxxP_1	187	190	PF00568	0.472
DOC_PP4_FxxP_1	194	197	PF00568	0.450
DOC_PP4_FxxP_1	218	221	PF00568	0.564
DOC_PP4_FxxP_1	309	312	PF00568	0.596
DOC_PP4_FxxP_1	420	423	PF00568	0.680
DOC_PP4_FxxP_1	56	59	PF00568	0.216
DOC_USP7_MATH_1	132	136	PF00917	0.372
DOC_USP7_MATH_1	232	236	PF00917	0.566
DOC_USP7_MATH_1	261	265	PF00917	0.604
DOC_USP7_MATH_1	310	314	PF00917	0.616
DOC_USP7_MATH_1	361	365	PF00917	0.667
DOC_USP7_MATH_1	372	376	PF00917	0.675
DOC_USP7_MATH_1	384	388	PF00917	0.663
DOC_USP7_MATH_1	73	77	PF00917	0.321
DOC_USP7_MATH_2	423	429	PF00917	0.519
DOC_WW_Pin1_4	193	198	PF00397	0.524
DOC_WW_Pin1_4	308	313	PF00397	0.729
DOC_WW_Pin1_4	390	395	PF00397	0.720
DOC_WW_Pin1_4	419	424	PF00397	0.639
LIG_14-3-3_CanoR_1	143	149	PF00244	0.311
LIG_14-3-3_CanoR_1	157	161	PF00244	0.254
LIG_14-3-3_CanoR_1	170	174	PF00244	0.286
LIG_14-3-3_CanoR_1	244	252	PF00244	0.397
LIG_14-3-3_CanoR_1	287	291	PF00244	0.625
LIG_14-3-3_CanoR_1	34	39	PF00244	0.427
LIG_14-3-3_CanoR_1	400	406	PF00244	0.607
LIG_14-3-3_CanoR_1	81	87	PF00244	0.392
LIG_APCC_ABBA_1	171	176	PF00400	0.404
LIG_APCC_ABBA_1	354	359	PF00400	0.495
LIG_APCC_ABBAyCdc20_2	170	176	PF00400	0.404
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_BIR_III_4	430	434	PF00653	0.671
LIG_BRCT_BRCA1_1	183	187	PF00533	0.400
LIG_BRCT_BRCA1_1	246	250	PF00533	0.446
LIG_EVH1_1	225	229	PF00568	0.552
LIG_FHA_1	366	372	PF00498	0.542
LIG_FHA_1	391	397	PF00498	0.703
LIG_FHA_1	47	53	PF00498	0.379
LIG_FHA_1	63	69	PF00498	0.246
LIG_FHA_2	440	446	PF00498	0.576
LIG_LIR_Apic_2	184	190	PF02991	0.362
LIG_LIR_Apic_2	192	197	PF02991	0.394
LIG_LIR_Apic_2	217	221	PF02991	0.599
LIG_LIR_Apic_2	307	312	PF02991	0.598
LIG_LIR_Apic_2	418	423	PF02991	0.674
LIG_LIR_Apic_2	54	59	PF02991	0.216
LIG_LIR_Gen_1	5	15	PF02991	0.355
LIG_LIR_Gen_1	92	103	PF02991	0.385
LIG_LIR_Nem_3	247	253	PF02991	0.505
LIG_LIR_Nem_3	5	11	PF02991	0.358
LIG_LIR_Nem_3	92	98	PF02991	0.417
LIG_MAD2	124	132	PF02301	0.372
LIG_PDZ_Class_3	448	453	PF00595	0.651
LIG_Pex14_2	47	51	PF04695	0.343
LIG_PTB_Apo_2	50	57	PF02174	0.352
LIG_Rb_pABgroove_1	85	93	PF01858	0.378
LIG_REV1ctd_RIR_1	161	171	PF16727	0.378
LIG_SH2_CRK	91	95	PF00017	0.394
LIG_SH2_NCK_1	253	257	PF00017	0.470
LIG_SH2_NCK_1	91	95	PF00017	0.412
LIG_SH2_STAP1	253	257	PF00017	0.566
LIG_SH2_STAP1	329	333	PF00017	0.545
LIG_SH2_STAP1	91	95	PF00017	0.417
LIG_SH2_STAT5	188	191	PF00017	0.499
LIG_SH2_STAT5	208	211	PF00017	0.510
LIG_SH3_3	209	215	PF00018	0.538
LIG_SH3_3	223	229	PF00018	0.440
LIG_SH3_3	292	298	PF00018	0.610
LIG_SH3_3	309	315	PF00018	0.621
LIG_SH3_3	368	374	PF00018	0.710
LIG_SH3_3	391	397	PF00018	0.701
LIG_SUMO_SIM_anti_2	445	452	PF11976	0.613
LIG_SUMO_SIM_par_1	107	113	PF11976	0.308
LIG_SUMO_SIM_par_1	445	452	PF11976	0.570
LIG_TRAF2_1	405	408	PF00917	0.556
LIG_TYR_ITIM	93	98	PF00017	0.428
LIG_WW_3	227	231	PF00397	0.352
MOD_CDK_SPK_2	419	424	PF00069	0.639
MOD_CDK_SPxxK_3	195	202	PF00069	0.474
MOD_CK1_1	264	270	PF00069	0.708
MOD_CK1_1	311	317	PF00069	0.664
MOD_CK1_1	63	69	PF00069	0.446
MOD_CK1_1	75	81	PF00069	0.259
MOD_CK1_1	83	89	PF00069	0.119
MOD_CK2_1	132	138	PF00069	0.423
MOD_CK2_1	419	425	PF00069	0.627
MOD_GlcNHglycan	134	137	PF01048	0.462
MOD_GlcNHglycan	183	186	PF01048	0.433
MOD_GlcNHglycan	363	366	PF01048	0.707
MOD_GlcNHglycan	374	377	PF01048	0.645
MOD_GlcNHglycan	403	406	PF01048	0.628
MOD_GlcNHglycan	427	430	PF01048	0.705
MOD_GlcNHglycan	82	85	PF01048	0.450
MOD_GSK3_1	152	159	PF00069	0.457
MOD_GSK3_1	262	269	PF00069	0.668
MOD_GSK3_1	304	311	PF00069	0.671
MOD_GSK3_1	361	368	PF00069	0.653
MOD_GSK3_1	372	379	PF00069	0.678
MOD_GSK3_1	415	422	PF00069	0.632
MOD_GSK3_1	435	442	PF00069	0.656
MOD_GSK3_1	69	76	PF00069	0.281
MOD_NEK2_1	112	117	PF00069	0.362
MOD_NEK2_1	144	149	PF00069	0.378
MOD_NEK2_1	339	344	PF00069	0.609
MOD_NEK2_1	401	406	PF00069	0.670
MOD_NEK2_1	61	66	PF00069	0.376
MOD_NEK2_1	74	79	PF00069	0.299
MOD_NEK2_1	80	85	PF00069	0.238
MOD_PK_1	34	40	PF00069	0.394
MOD_PKA_2	156	162	PF00069	0.396
MOD_PKA_2	169	175	PF00069	0.345
MOD_PKA_2	181	187	PF00069	0.310
MOD_PKA_2	243	249	PF00069	0.397
MOD_PKA_2	286	292	PF00069	0.666
MOD_PKA_2	399	405	PF00069	0.580
MOD_PKA_2	80	86	PF00069	0.376
MOD_Plk_1	112	118	PF00069	0.305
MOD_Plk_4	169	175	PF00069	0.310
MOD_Plk_4	34	40	PF00069	0.334
MOD_Plk_4	63	69	PF00069	0.376
MOD_Plk_4	75	81	PF00069	0.241
MOD_ProDKin_1	193	199	PF00069	0.533
MOD_ProDKin_1	308	314	PF00069	0.728
MOD_ProDKin_1	390	396	PF00069	0.719
MOD_ProDKin_1	419	425	PF00069	0.644
TRG_DiLeu_BaEn_1	5	10	PF01217	0.368
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.583
TRG_ENDOCYTIC_2	100	103	PF00928	0.270
TRG_ENDOCYTIC_2	91	94	PF00928	0.332
TRG_ENDOCYTIC_2	95	98	PF00928	0.308
TRG_ER_diArg_1	236	239	PF00400	0.455
TRG_NES_CRM1_1	5	16	PF08389	0.441
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P0	Leptomonas seymouri	50%	99%
A0A0S4JB79	Bodo saltans	33%	100%
A0A3R7MAW0	Trypanosoma rangeli	35%	100%
A0A3S7WUM8	Leishmania donovani	89%	100%
A4H985	Leishmania braziliensis	71%	100%
A4HXK3	Leishmania infantum	88%	100%
C9ZP93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AR98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q8WVF1	Homo sapiens	30%	100%
V5BNX0	Trypanosoma cruzi	35%	100%