Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE64_LEIMA

TriTrypDb:

LmjF.17.1270 , LMJLV39_170020100 , LMJSD75_170019800

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE64

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0051536	iron-sulfur cluster binding	3	7
GO:0051540	metal cluster binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.401
CLV_C14_Caspase3-7	221	225	PF00656	0.399
CLV_NRD_NRD_1	301	303	PF00675	0.522
CLV_NRD_NRD_1	49	51	PF00675	0.757
CLV_NRD_NRD_1	81	83	PF00675	0.504
CLV_NRD_NRD_1	93	95	PF00675	0.501
CLV_PCSK_FUR_1	258	262	PF00082	0.658
CLV_PCSK_KEX2_1	260	262	PF00082	0.651
CLV_PCSK_KEX2_1	28	30	PF00082	0.547
CLV_PCSK_KEX2_1	301	303	PF00082	0.564
CLV_PCSK_KEX2_1	49	51	PF00082	0.679
CLV_PCSK_KEX2_1	81	83	PF00082	0.507
CLV_PCSK_KEX2_1	93	95	PF00082	0.509
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.651
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DOC_CDC14_PxL_1	31	39	PF14671	0.590
DOC_CYCLIN_yCln2_LP_2	185	188	PF00134	0.427
DOC_MAPK_gen_1	109	117	PF00069	0.441
DOC_MAPK_MEF2A_6	111	119	PF00069	0.409
DOC_MAPK_MEF2A_6	130	139	PF00069	0.401
DOC_MAPK_MEF2A_6	200	209	PF00069	0.565
DOC_PP1_RVXF_1	272	278	PF00149	0.582
DOC_PP2B_LxvP_1	185	188	PF13499	0.409
DOC_PP2B_LxvP_1	2	5	PF13499	0.507
DOC_USP7_MATH_1	162	166	PF00917	0.519
DOC_USP7_MATH_1	87	91	PF00917	0.481
DOC_USP7_UBL2_3	109	113	PF12436	0.446
LIG_14-3-3_CanoR_1	200	207	PF00244	0.491
LIG_14-3-3_CanoR_1	212	219	PF00244	0.290
LIG_14-3-3_CanoR_1	52	61	PF00244	0.525
LIG_14-3-3_CanoR_1	93	101	PF00244	0.527
LIG_Actin_WH2_2	223	241	PF00022	0.421
LIG_CaM_IQ_9	44	60	PF13499	0.532
LIG_DCNL_PONY_1	1	4	PF03556	0.518
LIG_FHA_1	110	116	PF00498	0.539
LIG_FHA_1	218	224	PF00498	0.375
LIG_FHA_1	233	239	PF00498	0.574
LIG_FHA_2	139	145	PF00498	0.385
LIG_FHA_2	271	277	PF00498	0.505
LIG_FHA_2	306	312	PF00498	0.526
LIG_LIR_Apic_2	131	135	PF02991	0.425
LIG_LIR_Gen_1	192	201	PF02991	0.449
LIG_LIR_Gen_1	280	289	PF02991	0.493
LIG_LIR_Gen_1	295	304	PF02991	0.491
LIG_LIR_Nem_3	192	196	PF02991	0.385
LIG_LIR_Nem_3	243	248	PF02991	0.511
LIG_LIR_Nem_3	263	268	PF02991	0.402
LIG_LIR_Nem_3	280	284	PF02991	0.449
LIG_LIR_Nem_3	287	292	PF02991	0.442
LIG_LIR_Nem_3	295	300	PF02991	0.479
LIG_LIR_Nem_3	311	316	PF02991	0.509
LIG_Pex14_1	285	289	PF04695	0.472
LIG_Pex14_2	209	213	PF04695	0.507
LIG_Pex14_2	277	281	PF04695	0.536
LIG_SH2_CRK	193	197	PF00017	0.399
LIG_SH2_CRK	31	35	PF00017	0.519
LIG_SH2_GRB2like	297	300	PF00017	0.627
LIG_SH2_NCK_1	38	42	PF00017	0.533
LIG_SH2_SRC	289	292	PF00017	0.503
LIG_SH2_STAT5	193	196	PF00017	0.393
LIG_SH3_1	261	267	PF00018	0.530
LIG_SH3_3	261	267	PF00018	0.530
LIG_SH3_3	272	278	PF00018	0.503
LIG_TYR_ITSM	285	292	PF00017	0.594
LIG_ULM_U2AF65_1	49	54	PF00076	0.684
MOD_CK1_1	80	86	PF00069	0.461
MOD_CK2_1	305	311	PF00069	0.554
MOD_GlcNHglycan	144	148	PF01048	0.416
MOD_GlcNHglycan	24	27	PF01048	0.529
MOD_GlcNHglycan	82	85	PF01048	0.555
MOD_GSK3_1	105	112	PF00069	0.553
MOD_N-GLC_1	115	120	PF02516	0.335
MOD_NEK2_1	22	27	PF00069	0.619
MOD_NEK2_1	238	243	PF00069	0.559
MOD_NEK2_1	284	289	PF00069	0.580
MOD_NEK2_1	44	49	PF00069	0.526
MOD_NEK2_1	77	82	PF00069	0.642
MOD_PIKK_1	44	50	PF00454	0.535
MOD_PIKK_1	93	99	PF00454	0.501
MOD_PKA_1	93	99	PF00069	0.526
MOD_PKA_2	199	205	PF00069	0.498
MOD_PKA_2	211	217	PF00069	0.292
MOD_PKA_2	238	244	PF00069	0.514
MOD_PKA_2	51	57	PF00069	0.610
MOD_PKA_2	77	83	PF00069	0.513
MOD_PKA_2	93	99	PF00069	0.445
MOD_Plk_1	115	121	PF00069	0.335
MOD_Plk_1	135	141	PF00069	0.336
MOD_Plk_1	191	197	PF00069	0.394
MOD_Plk_1	205	211	PF00069	0.401
MOD_Plk_1	87	93	PF00069	0.477
MOD_Plk_2-3	178	184	PF00069	0.415
MOD_Plk_4	138	144	PF00069	0.372
MOD_Plk_4	17	23	PF00069	0.516
MOD_SUMO_rev_2	102	110	PF00179	0.546
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.449
TRG_ENDOCYTIC_2	193	196	PF00928	0.393
TRG_ENDOCYTIC_2	289	292	PF00928	0.447
TRG_ENDOCYTIC_2	297	300	PF00928	0.495
TRG_ENDOCYTIC_2	31	34	PF00928	0.521
TRG_ENDOCYTIC_2	38	41	PF00928	0.515
TRG_ER_diArg_1	300	302	PF00400	0.554
TRG_ER_diArg_1	49	52	PF00400	0.689
TRG_ER_diArg_1	93	95	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS7	Leptomonas seymouri	86%	100%
A0A0S4JAC0	Bodo saltans	68%	100%
A0A1X0NSZ4	Trypanosomatidae	83%	100%
A0A3Q8IAU8	Leishmania donovani	97%	100%
A4H986	Leishmania braziliensis	93%	100%
A4HXK4	Leishmania infantum	97%	100%
C9ZP94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	98%
E9AR99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BET1	Trypanosoma cruzi	84%	100%