Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QE60_LEIMA

TriTrypDb:

LmjF.17.1310 , LMJLV39_170020500 , LMJSD75_170020200

Length:

1048

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE60

Function

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Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.659
CLV_C14_Caspase3-7	57	61	PF00656	0.488
CLV_MEL_PAP_1	343	349	PF00089	0.442
CLV_NRD_NRD_1	1041	1043	PF00675	0.378
CLV_NRD_NRD_1	160	162	PF00675	0.403
CLV_NRD_NRD_1	168	170	PF00675	0.379
CLV_NRD_NRD_1	185	187	PF00675	0.473
CLV_NRD_NRD_1	561	563	PF00675	0.761
CLV_NRD_NRD_1	799	801	PF00675	0.526
CLV_NRD_NRD_1	855	857	PF00675	0.588

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R1	Leptomonas seymouri	56%	100%
A0A0S4J6V1	Bodo saltans	33%	100%
A0A1X0NSN0	Trypanosomatidae	33%	100%
A0A3Q8IE30	Leishmania donovani	91%	100%
A0A3R7LJI9	Trypanosoma rangeli	37%	100%
A4H976	Leishmania braziliensis	73%	100%
A4HXK8	Leishmania infantum	91%	100%
C9ZP99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ARA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BET6	Trypanosoma cruzi	35%	100%

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