Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4QE59_LEIMA

TriTrypDb:

LmjF.17.1315

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 0
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	155	161	PF00089	0.628
CLV_MEL_PAP_1	291	297	PF00089	0.637
CLV_NRD_NRD_1	110	112	PF00675	0.643
CLV_NRD_NRD_1	124	126	PF00675	0.454
CLV_NRD_NRD_1	166	168	PF00675	0.630
CLV_NRD_NRD_1	8	10	PF00675	0.831
CLV_PCSK_FUR_1	121	125	PF00082	0.631
CLV_PCSK_FUR_1	5	9	PF00082	0.843
CLV_PCSK_KEX2_1	110	112	PF00082	0.643
CLV_PCSK_KEX2_1	123	125	PF00082	0.469
CLV_PCSK_KEX2_1	166	168	PF00082	0.630
CLV_PCSK_KEX2_1	212	214	PF00082	0.649
CLV_PCSK_KEX2_1	324	326	PF00082	0.653
CLV_PCSK_KEX2_1	7	9	PF00082	0.839
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.649
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.653
CLV_PCSK_SKI1_1	110	114	PF00082	0.643
CLV_PCSK_SKI1_1	124	128	PF00082	0.453
CLV_PCSK_SKI1_1	212	216	PF00082	0.645
CLV_PCSK_SKI1_1	284	288	PF00082	0.607
CLV_PCSK_SKI1_1	325	329	PF00082	0.647
CLV_PCSK_SKI1_1	517	521	PF00082	0.812
DEG_SCF_FBW7_1	199	206	PF00400	0.829
DEG_SPOP_SBC_1	251	255	PF00917	0.815
DOC_CKS1_1	200	205	PF01111	0.825
DOC_CKS1_1	232	237	PF01111	0.833
DOC_CKS1_1	299	304	PF01111	0.855
DOC_CYCLIN_RxL_1	106	115	PF00134	0.840
DOC_CYCLIN_RxL_1	210	219	PF00134	0.839
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.837
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.834
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.622
DOC_MAPK_DCC_7	415	424	PF00069	0.650
DOC_MAPK_DCC_7	43	53	PF00069	0.622
DOC_MAPK_FxFP_2	29	32	PF00069	0.765
DOC_MAPK_FxFP_2	492	495	PF00069	0.612
DOC_MAPK_gen_1	147	156	PF00069	0.834
DOC_MAPK_gen_1	166	172	PF00069	0.587
DOC_MAPK_gen_1	387	396	PF00069	0.527
DOC_MAPK_gen_1	460	469	PF00069	0.735
DOC_MAPK_MEF2A_6	360	369	PF00069	0.775
DOC_MAPK_MEF2A_6	415	424	PF00069	0.650
DOC_MAPK_MEF2A_6	43	51	PF00069	0.622
DOC_MAPK_MEF2A_6	460	469	PF00069	0.735
DOC_PP1_RVXF_1	156	162	PF00149	0.828
DOC_PP2B_LxvP_1	45	48	PF13499	0.624
DOC_PP2B_LxvP_1	503	506	PF13499	0.610
DOC_PP2B_LxvP_1	51	54	PF13499	0.544
DOC_PP4_FxxP_1	29	32	PF00568	0.765
DOC_PP4_FxxP_1	447	450	PF00568	0.549
DOC_PP4_FxxP_1	492	495	PF00568	0.612
DOC_SPAK_OSR1_1	368	372	PF12202	0.650
DOC_USP7_MATH_1	12	16	PF00917	0.757
DOC_USP7_MATH_1	201	205	PF00917	0.826
DOC_USP7_MATH_1	323	327	PF00917	0.851
DOC_USP7_MATH_1	78	82	PF00917	0.828
DOC_WW_Pin1_4	112	117	PF00397	0.837
DOC_WW_Pin1_4	199	204	PF00397	0.827
DOC_WW_Pin1_4	216	221	PF00397	0.618
DOC_WW_Pin1_4	231	236	PF00397	0.645
DOC_WW_Pin1_4	298	303	PF00397	0.856
DOC_WW_Pin1_4	476	481	PF00397	0.549
DOC_WW_Pin1_4	74	79	PF00397	0.794
DOC_WW_Pin1_4	91	96	PF00397	0.620
LIG_14-3-3_CanoR_1	158	162	PF00244	0.828
LIG_14-3-3_CanoR_1	188	196	PF00244	0.835
LIG_14-3-3_CanoR_1	284	290	PF00244	0.809
LIG_14-3-3_CanoR_1	309	318	PF00244	0.864
LIG_14-3-3_CanoR_1	360	365	PF00244	0.788
LIG_14-3-3_CanoR_1	368	378	PF00244	0.549
LIG_14-3-3_CanoR_1	415	420	PF00244	0.765
LIG_14-3-3_CanoR_1	7	16	PF00244	0.780
LIG_14-3-3_CanoR_1	82	86	PF00244	0.836
LIG_14-3-3_CanoR_1	89	95	PF00244	0.748
LIG_14-3-3_CanoR_1	98	103	PF00244	0.650
LIG_Actin_WH2_2	203	218	PF00022	0.839
LIG_BRCT_BRCA1_1	221	225	PF00533	0.840
LIG_BRCT_BRCA1_1	27	31	PF00533	0.758
LIG_BRCT_BRCA1_1	342	346	PF00533	0.843
LIG_BRCT_BRCA1_1	388	392	PF00533	0.522
LIG_BRCT_BRCA1_1	431	435	PF00533	0.549
LIG_BRCT_BRCA1_1	443	447	PF00533	0.300
LIG_BRCT_BRCA1_1	451	455	PF00533	0.199
LIG_BRCT_BRCA1_1	480	484	PF00533	0.549
LIG_BRCT_BRCA1_1	93	97	PF00533	0.834
LIG_CtBP_PxDLS_1	428	432	PF00389	0.549
LIG_EH1_1	368	376	PF00400	0.650
LIG_FHA_1	15	21	PF00498	0.744
LIG_FHA_1	204	210	PF00498	0.842
LIG_FHA_1	232	238	PF00498	0.834
LIG_FHA_1	286	292	PF00498	0.815
LIG_FHA_1	97	103	PF00498	0.849
LIG_FHA_2	144	150	PF00498	0.841
LIG_FHA_2	326	332	PF00498	0.844
LIG_FHA_2	354	360	PF00498	0.829
LIG_GBD_Chelix_1	461	469	PF00786	0.735
LIG_GSK3_LRP6_1	199	205	PF00069	0.827
LIG_LIR_Apic_2	28	32	PF02991	0.765
LIG_LIR_Apic_2	444	450	PF02991	0.449
LIG_LIR_Apic_2	490	495	PF02991	0.608
LIG_LIR_Gen_1	160	169	PF02991	0.826
LIG_LIR_Gen_1	17	27	PF02991	0.736
LIG_LIR_Gen_1	42	52	PF02991	0.623
LIG_LIR_Gen_1	432	442	PF02991	0.549
LIG_LIR_Nem_3	115	120	PF02991	0.834
LIG_LIR_Nem_3	160	164	PF02991	0.827
LIG_LIR_Nem_3	17	22	PF02991	0.741
LIG_LIR_Nem_3	177	183	PF02991	0.611
LIG_LIR_Nem_3	234	239	PF02991	0.833
LIG_LIR_Nem_3	247	252	PF02991	0.662
LIG_LIR_Nem_3	28	34	PF02991	0.574
LIG_LIR_Nem_3	42	47	PF02991	0.449
LIG_LIR_Nem_3	432	438	PF02991	0.549
LIG_LIR_Nem_3	445	451	PF02991	0.322
LIG_LIR_Nem_3	481	487	PF02991	0.549
LIG_MYND_1	497	501	PF01753	0.597
LIG_MYND_1	50	54	PF01753	0.619
LIG_NRBOX	282	288	PF00104	0.806
LIG_NRBOX	464	470	PF00104	0.784
LIG_PCNA_yPIPBox_3	147	155	PF02747	0.835
LIG_Pex14_1	19	23	PF04695	0.739
LIG_Pex14_2	168	172	PF04695	0.822
LIG_Pex14_2	29	33	PF04695	0.764
LIG_Pex14_2	388	392	PF04695	0.522
LIG_Pex14_2	447	451	PF04695	0.549
LIG_SH2_PTP2	376	379	PF00017	0.549
LIG_SH2_PTP2	380	383	PF00017	0.480
LIG_SH2_SRC	376	379	PF00017	0.549
LIG_SH2_SRC	380	383	PF00017	0.480
LIG_SH2_STAP1	252	256	PF00017	0.813
LIG_SH2_STAT5	252	255	PF00017	0.815
LIG_SH2_STAT5	376	379	PF00017	0.549
LIG_SH2_STAT5	380	383	PF00017	0.480
LIG_SH2_STAT5	384	387	PF00017	0.410
LIG_SH3_1	494	500	PF00018	0.600
LIG_SH3_3	138	144	PF00018	0.840
LIG_SH3_3	193	199	PF00018	0.844
LIG_SH3_3	217	223	PF00018	0.829
LIG_SH3_3	232	238	PF00018	0.647
LIG_SH3_3	296	302	PF00018	0.851
LIG_SH3_3	333	339	PF00018	0.831
LIG_SH3_3	494	500	PF00018	0.600
LIG_SH3_3	63	69	PF00018	0.549
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.839
LIG_SUMO_SIM_anti_2	430	435	PF11976	0.549
LIG_SUMO_SIM_par_1	427	432	PF11976	0.549
LIG_SUMO_SIM_par_1	474	479	PF11976	0.549
LIG_TYR_ITIM	374	379	PF00017	0.549
LIG_WRC_WIRS_1	26	31	PF05994	0.752
LIG_WRC_WIRS_1	435	440	PF05994	0.549
MOD_CDK_SPK_2	298	303	PF00069	0.856
MOD_CDK_SPxxK_3	91	98	PF00069	0.836
MOD_CK1_1	173	179	PF00069	0.824
MOD_CK1_1	191	197	PF00069	0.618
MOD_CK1_1	205	211	PF00069	0.665
MOD_CK1_1	219	225	PF00069	0.658
MOD_CK1_1	340	346	PF00069	0.843
MOD_CK1_1	81	87	PF00069	0.835
MOD_CK2_1	143	149	PF00069	0.841
MOD_CK2_1	309	315	PF00069	0.868
MOD_CK2_1	325	331	PF00069	0.645
MOD_CK2_1	353	359	PF00069	0.829
MOD_GlcNHglycan	190	193	PF01048	0.632
MOD_GlcNHglycan	254	257	PF01048	0.613
MOD_GlcNHglycan	259	262	PF01048	0.553
MOD_GSK3_1	170	177	PF00069	0.824
MOD_GSK3_1	187	194	PF00069	0.617
MOD_GSK3_1	199	206	PF00069	0.679
MOD_GSK3_1	219	226	PF00069	0.585
MOD_GSK3_1	285	292	PF00069	0.813
MOD_GSK3_1	294	301	PF00069	0.735
MOD_GSK3_1	305	312	PF00069	0.614
MOD_GSK3_1	337	344	PF00069	0.838
MOD_GSK3_1	35	42	PF00069	0.785
MOD_GSK3_1	437	444	PF00069	0.744
MOD_GSK3_1	476	483	PF00069	0.549
MOD_GSK3_1	495	502	PF00069	0.361
MOD_GSK3_1	74	81	PF00069	0.794
MOD_GSK3_1	8	15	PF00069	0.777
MOD_GSK3_1	98	105	PF00069	0.846
MOD_LATS_1	6	12	PF00433	0.802
MOD_N-GLC_1	340	345	PF02516	0.644
MOD_NEK2_1	119	124	PF00069	0.833
MOD_NEK2_1	182	187	PF00069	0.825
MOD_NEK2_1	225	230	PF00069	0.846
MOD_NEK2_1	250	255	PF00069	0.817
MOD_NEK2_1	262	267	PF00069	0.678
MOD_NEK2_1	285	290	PF00069	0.808
MOD_NEK2_1	369	374	PF00069	0.549
MOD_NEK2_1	429	434	PF00069	0.549
MOD_NEK2_1	468	473	PF00069	0.650
MOD_NEK2_1	487	492	PF00069	0.438
MOD_NEK2_2	279	284	PF00069	0.804
MOD_NEK2_2	442	447	PF00069	0.606
MOD_NEK2_2	480	485	PF00069	0.549
MOD_PK_1	415	421	PF00069	0.765
MOD_PKA_1	8	14	PF00069	0.784
MOD_PKA_2	157	163	PF00069	0.827
MOD_PKA_2	187	193	PF00069	0.827
MOD_PKA_2	305	311	PF00069	0.863
MOD_PKA_2	359	365	PF00069	0.793
MOD_PKA_2	36	42	PF00069	0.785
MOD_PKA_2	8	14	PF00069	0.784
MOD_PKA_2	81	87	PF00069	0.835
MOD_PKB_1	358	366	PF00069	0.794
MOD_Plk_4	174	180	PF00069	0.824
MOD_Plk_4	205	211	PF00069	0.840
MOD_Plk_4	429	435	PF00069	0.549
MOD_Plk_4	442	448	PF00069	0.287
MOD_Plk_4	480	486	PF00069	0.549
MOD_Plk_4	81	87	PF00069	0.835
MOD_ProDKin_1	112	118	PF00069	0.837
MOD_ProDKin_1	199	205	PF00069	0.827
MOD_ProDKin_1	216	222	PF00069	0.619
MOD_ProDKin_1	231	237	PF00069	0.645
MOD_ProDKin_1	298	304	PF00069	0.855
MOD_ProDKin_1	476	482	PF00069	0.549
MOD_ProDKin_1	74	80	PF00069	0.794
MOD_ProDKin_1	91	97	PF00069	0.622
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.837
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.824
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.803
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.650
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.621
TRG_ENDOCYTIC_2	376	379	PF00928	0.549
TRG_ENDOCYTIC_2	380	383	PF00928	0.480
TRG_ER_diArg_1	109	111	PF00400	0.834
TRG_ER_diArg_1	120	123	PF00400	0.695
TRG_ER_diArg_1	124	126	PF00400	0.641
TRG_ER_diArg_1	166	168	PF00400	0.830
TRG_ER_diArg_1	5	8	PF00400	0.823