Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE58_LEIMA

TriTrypDb:

LmjF.17.1320 , LMJLV39_170020600 , LMJSD75_170020300

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.748
CLV_NRD_NRD_1	124	126	PF00675	0.708
CLV_NRD_NRD_1	431	433	PF00675	0.585
CLV_PCSK_FUR_1	121	125	PF00082	0.709
CLV_PCSK_KEX2_1	123	125	PF00082	0.707
CLV_PCSK_KEX2_1	525	527	PF00082	0.480
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.480
CLV_PCSK_SKI1_1	390	394	PF00082	0.677
CLV_PCSK_SKI1_1	454	458	PF00082	0.593
DEG_Nend_UBRbox_3	1	3	PF02207	0.698
DEG_SCF_FBW7_1	145	151	PF00400	0.819
DEG_SCF_TRCP1_1	137	142	PF00400	0.821
DEG_SPOP_SBC_1	245	249	PF00917	0.604
DOC_CKS1_1	145	150	PF01111	0.818
DOC_CKS1_1	93	98	PF01111	0.764
DOC_PP4_FxxP_1	270	273	PF00568	0.692
DOC_PP4_FxxP_1	360	363	PF00568	0.677
DOC_USP7_MATH_1	154	158	PF00917	0.653
DOC_USP7_MATH_1	189	193	PF00917	0.594
DOC_USP7_MATH_1	245	249	PF00917	0.665
DOC_USP7_MATH_1	260	264	PF00917	0.728
DOC_USP7_MATH_1	310	314	PF00917	0.717
DOC_USP7_MATH_1	363	367	PF00917	0.724
DOC_USP7_MATH_1	482	486	PF00917	0.669
DOC_USP7_MATH_1	65	69	PF00917	0.773
DOC_USP7_UBL2_3	433	437	PF12436	0.548
DOC_WW_Pin1_4	125	130	PF00397	0.699
DOC_WW_Pin1_4	144	149	PF00397	0.801
DOC_WW_Pin1_4	190	195	PF00397	0.777
DOC_WW_Pin1_4	214	219	PF00397	0.733
DOC_WW_Pin1_4	224	229	PF00397	0.726
DOC_WW_Pin1_4	23	28	PF00397	0.679
DOC_WW_Pin1_4	250	255	PF00397	0.762
DOC_WW_Pin1_4	296	301	PF00397	0.758
DOC_WW_Pin1_4	355	360	PF00397	0.697
DOC_WW_Pin1_4	37	42	PF00397	0.697
DOC_WW_Pin1_4	459	464	PF00397	0.658
DOC_WW_Pin1_4	489	494	PF00397	0.629
DOC_WW_Pin1_4	56	61	PF00397	0.682
DOC_WW_Pin1_4	92	97	PF00397	0.706
LIG_14-3-3_CanoR_1	155	159	PF00244	0.635
LIG_14-3-3_CanoR_1	246	254	PF00244	0.600
LIG_14-3-3_CanoR_1	500	510	PF00244	0.508
LIG_14-3-3_CanoR_1	582	588	PF00244	0.752
LIG_14-3-3_CanoR_1	61	69	PF00244	0.695
LIG_BRCT_BRCA1_1	336	340	PF00533	0.728
LIG_BRCT_BRCA1_1	356	360	PF00533	0.655
LIG_BRCT_BRCA1_1	484	488	PF00533	0.654
LIG_EVH1_2	322	326	PF00568	0.685
LIG_FHA_1	387	393	PF00498	0.665
LIG_FHA_1	439	445	PF00498	0.533
LIG_FHA_1	544	550	PF00498	0.504
LIG_FHA_2	30	36	PF00498	0.681
LIG_FHA_2	392	398	PF00498	0.680
LIG_FHA_2	79	85	PF00498	0.703
LIG_LIR_Apic_2	105	109	PF02991	0.704
LIG_LIR_Apic_2	268	273	PF02991	0.684
LIG_LIR_Apic_2	299	305	PF02991	0.736
LIG_LIR_Apic_2	357	363	PF02991	0.575
LIG_LIR_Gen_1	485	496	PF02991	0.581
LIG_LIR_Gen_1	509	517	PF02991	0.469
LIG_LIR_Nem_3	36	42	PF02991	0.754
LIG_LIR_Nem_3	485	491	PF02991	0.591
LIG_LIR_Nem_3	509	513	PF02991	0.499
LIG_LIR_Nem_3	515	519	PF02991	0.504
LIG_LIR_Nem_3	523	527	PF02991	0.452
LIG_PDZ_Class_3	585	590	PF00595	0.641
LIG_PROFILIN_1	228	234	PF00235	0.718
LIG_PTB_Apo_2	216	223	PF02174	0.836
LIG_PTB_Phospho_1	216	222	PF10480	0.835
LIG_SH2_CRK	106	110	PF00017	0.703
LIG_SH2_SRC	23	26	PF00017	0.682
LIG_SH2_STAT3	196	199	PF00017	0.754
LIG_SH2_STAT3	345	348	PF00017	0.578
LIG_SH2_STAT3	527	530	PF00017	0.501
LIG_SH2_STAT5	222	225	PF00017	0.849
LIG_SH2_STAT5	354	357	PF00017	0.729
LIG_SH2_STAT5	502	505	PF00017	0.478
LIG_SH2_STAT5	527	530	PF00017	0.501
LIG_SH2_STAT5	57	60	PF00017	0.740
LIG_SH3_3	142	148	PF00018	0.722
LIG_SH3_3	225	231	PF00018	0.810
LIG_SH3_3	415	421	PF00018	0.567
LIG_SH3_3	463	469	PF00018	0.719
LIG_SH3_3	490	496	PF00018	0.562
LIG_SH3_3	90	96	PF00018	0.723
LIG_SUMO_SIM_par_1	275	280	PF11976	0.573
LIG_WRC_WIRS_1	521	526	PF05994	0.442
LIG_WW_2	232	235	PF00397	0.759
LIG_WW_3	152	156	PF00397	0.727
MOD_CDK_SPK_2	190	195	PF00069	0.629
MOD_CDK_SPK_2	56	61	PF00069	0.682
MOD_CDK_SPxxK_3	190	197	PF00069	0.749
MOD_CDK_SPxxK_3	92	99	PF00069	0.682
MOD_CK1_1	128	134	PF00069	0.723
MOD_CK1_1	135	141	PF00069	0.734
MOD_CK1_1	164	170	PF00069	0.745
MOD_CK1_1	201	207	PF00069	0.730
MOD_CK1_1	249	255	PF00069	0.726
MOD_CK1_1	313	319	PF00069	0.721
MOD_CK1_1	339	345	PF00069	0.777
MOD_CK1_1	366	372	PF00069	0.830
MOD_CK1_1	384	390	PF00069	0.632
MOD_CK1_1	40	46	PF00069	0.682
MOD_CK1_1	401	407	PF00069	0.590
MOD_CK1_1	408	414	PF00069	0.639
MOD_CK1_1	489	495	PF00069	0.619
MOD_CK1_1	59	65	PF00069	0.785
MOD_CK1_1	8	14	PF00069	0.702
MOD_CK1_1	91	97	PF00069	0.767
MOD_CK1_1	98	104	PF00069	0.679
MOD_CK2_1	464	470	PF00069	0.566
MOD_CK2_1	569	575	PF00069	0.542
MOD_CK2_1	65	71	PF00069	0.752
MOD_CK2_1	78	84	PF00069	0.603
MOD_DYRK1A_RPxSP_1	214	218	PF00069	0.835
MOD_GlcNHglycan	100	103	PF01048	0.676
MOD_GlcNHglycan	113	116	PF01048	0.623
MOD_GlcNHglycan	137	140	PF01048	0.781
MOD_GlcNHglycan	141	144	PF01048	0.819
MOD_GlcNHglycan	162	166	PF01048	0.753
MOD_GlcNHglycan	172	175	PF01048	0.693
MOD_GlcNHglycan	200	203	PF01048	0.795
MOD_GlcNHglycan	283	286	PF01048	0.712
MOD_GlcNHglycan	315	318	PF01048	0.748
MOD_GlcNHglycan	350	353	PF01048	0.727
MOD_GlcNHglycan	365	368	PF01048	0.822
MOD_GlcNHglycan	408	411	PF01048	0.763
MOD_GlcNHglycan	472	475	PF01048	0.693
MOD_GlcNHglycan	50	53	PF01048	0.753
MOD_GlcNHglycan	536	539	PF01048	0.586
MOD_GlcNHglycan	63	66	PF01048	0.676
MOD_GlcNHglycan	84	88	PF01048	0.768
MOD_GSK3_1	128	135	PF00069	0.737
MOD_GSK3_1	13	20	PF00069	0.629
MOD_GSK3_1	144	151	PF00069	0.642
MOD_GSK3_1	210	217	PF00069	0.743
MOD_GSK3_1	220	227	PF00069	0.730
MOD_GSK3_1	245	252	PF00069	0.738
MOD_GSK3_1	261	268	PF00069	0.767
MOD_GSK3_1	277	284	PF00069	0.773
MOD_GSK3_1	294	301	PF00069	0.610
MOD_GSK3_1	311	318	PF00069	0.706
MOD_GSK3_1	335	342	PF00069	0.749
MOD_GSK3_1	366	373	PF00069	0.698
MOD_GSK3_1	384	391	PF00069	0.669
MOD_GSK3_1	396	403	PF00069	0.704
MOD_GSK3_1	404	411	PF00069	0.492
MOD_GSK3_1	482	489	PF00069	0.646
MOD_GSK3_1	539	546	PF00069	0.513
MOD_GSK3_1	59	66	PF00069	0.673
MOD_GSK3_1	88	95	PF00069	0.717
MOD_N-GLC_1	486	491	PF02516	0.635
MOD_N-GLC_1	506	511	PF02516	0.557
MOD_NEK2_1	198	203	PF00069	0.730
MOD_NEK2_1	315	320	PF00069	0.668
MOD_NEK2_1	340	345	PF00069	0.711
MOD_NEK2_1	400	405	PF00069	0.796
MOD_NEK2_1	438	443	PF00069	0.539
MOD_NEK2_1	476	481	PF00069	0.753
MOD_NEK2_1	63	68	PF00069	0.689
MOD_NEK2_1	78	83	PF00069	0.720
MOD_NEK2_1	97	102	PF00069	0.689
MOD_NEK2_2	65	70	PF00069	0.671
MOD_PIKK_1	104	110	PF00454	0.597
MOD_PIKK_1	212	218	PF00454	0.735
MOD_PIKK_1	246	252	PF00454	0.761
MOD_PIKK_1	294	300	PF00454	0.711
MOD_PIKK_1	78	84	PF00454	0.821
MOD_PIKK_1	88	94	PF00454	0.801
MOD_PK_1	17	23	PF00069	0.658
MOD_PK_1	275	281	PF00069	0.690
MOD_PKA_2	154	160	PF00069	0.627
MOD_PKA_2	245	251	PF00069	0.604
MOD_PKA_2	98	104	PF00069	0.678
MOD_Plk_1	396	402	PF00069	0.758
MOD_Plk_1	486	492	PF00069	0.631
MOD_Plk_1	506	512	PF00069	0.525
MOD_Plk_1	563	569	PF00069	0.500
MOD_Plk_1	574	580	PF00069	0.654
MOD_Plk_4	154	160	PF00069	0.627
MOD_Plk_4	424	430	PF00069	0.674
MOD_Plk_4	539	545	PF00069	0.462
MOD_Plk_4	563	569	PF00069	0.508
MOD_ProDKin_1	125	131	PF00069	0.697
MOD_ProDKin_1	144	150	PF00069	0.803
MOD_ProDKin_1	190	196	PF00069	0.779
MOD_ProDKin_1	214	220	PF00069	0.730
MOD_ProDKin_1	224	230	PF00069	0.720
MOD_ProDKin_1	23	29	PF00069	0.679
MOD_ProDKin_1	250	256	PF00069	0.763
MOD_ProDKin_1	296	302	PF00069	0.761
MOD_ProDKin_1	355	361	PF00069	0.697
MOD_ProDKin_1	37	43	PF00069	0.698
MOD_ProDKin_1	459	465	PF00069	0.653
MOD_ProDKin_1	489	495	PF00069	0.619
MOD_ProDKin_1	56	62	PF00069	0.680
MOD_ProDKin_1	92	98	PF00069	0.709
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.566
TRG_ENDOCYTIC_2	510	513	PF00928	0.510
TRG_ER_diArg_1	122	125	PF00400	0.708
TRG_NES_CRM1_1	552	565	PF08389	0.621
TRG_Pf-PMV_PEXEL_1	526	530	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I056	Leptomonas seymouri	50%	90%
A0A3S7WUM9	Leishmania donovani	94%	100%
A4H977	Leishmania braziliensis	70%	87%
E9AGQ1	Leishmania infantum	93%	100%
E9ARA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%