Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE57_LEIMA

TriTrypDb:

LmjF.17.1330 , LMJLV39_170020700 , LMJSD75_170020400

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q4QE57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE57

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	116	120	PF00082	0.387
DEG_APCC_DBOX_1	79	87	PF00400	0.674
DEG_SPOP_SBC_1	58	62	PF00917	0.747
DOC_AGCK_PIF_2	103	108	PF00069	0.626
DOC_CDC14_PxL_1	50	58	PF14671	0.679
DOC_MAPK_MEF2A_6	49	58	PF00069	0.630
DOC_PP2B_LxvP_1	144	147	PF13499	0.428
DOC_PP2B_LxvP_1	203	206	PF13499	0.625
DOC_WW_Pin1_4	109	114	PF00397	0.639
DOC_WW_Pin1_4	130	135	PF00397	0.443

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ4	Leptomonas seymouri	77%	100%
A0A0S4J5W5	Bodo saltans	51%	100%
A0A1X0NSN8	Trypanosomatidae	61%	98%
A0A3Q8I9U7	Leishmania donovani	94%	100%
A0A422NB46	Trypanosoma rangeli	68%	100%
A4H989	Leishmania braziliensis	92%	100%
A4HXL0	Leishmania infantum	94%	100%
C9ZPA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ARA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5AZF8	Trypanosoma cruzi	69%	100%

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