CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidylyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QE56_LEIMA

TriTrypDb:

LmjF.17.1340 , LMJLV39_170020800 , LMJSD75_170020500

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE56

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009117	nucleotide metabolic process	5	2
GO:0009165	nucleotide biosynthetic process	6	2
GO:0009435	NAD biosynthetic process	8	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019359	nicotinamide nucleotide biosynthetic process	7	2
GO:0019362	pyridine nucleotide metabolic process	5	2
GO:0019363	pyridine nucleotide biosynthetic process	6	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046496	nicotinamide nucleotide metabolic process	6	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072524	pyridine-containing compound metabolic process	4	2
GO:0072525	pyridine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	3
GO:0003824	catalytic activity	1	10
GO:0004515	nicotinate-nucleotide adenylyltransferase activity	6	3
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016779	nucleotidyltransferase activity	4	5
GO:0070566	adenylyltransferase activity	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.518
CLV_NRD_NRD_1	105	107	PF00675	0.276
CLV_NRD_NRD_1	161	163	PF00675	0.286
CLV_PCSK_KEX2_1	161	163	PF00082	0.286
CLV_PCSK_KEX2_1	67	69	PF00082	0.307
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.307
CLV_PCSK_SKI1_1	106	110	PF00082	0.235
CLV_PCSK_SKI1_1	129	133	PF00082	0.292
CLV_PCSK_SKI1_1	164	168	PF00082	0.267
CLV_PCSK_SKI1_1	189	193	PF00082	0.245
CLV_PCSK_SKI1_1	278	282	PF00082	0.462
CLV_PCSK_SKI1_1	286	290	PF00082	0.430
CLV_PCSK_SKI1_1	303	307	PF00082	0.316
CLV_PCSK_SKI1_1	76	80	PF00082	0.315
DOC_CYCLIN_RxL_1	186	194	PF00134	0.445
DOC_MAPK_gen_1	161	167	PF00069	0.503
DOC_PP1_RVXF_1	162	168	PF00149	0.471
DOC_PP4_FxxP_1	177	180	PF00568	0.449
DOC_PP4_FxxP_1	249	252	PF00568	0.503
DOC_PP4_FxxP_1	82	85	PF00568	0.445
DOC_USP7_MATH_1	24	28	PF00917	0.597
DOC_USP7_MATH_1	280	284	PF00917	0.509
DOC_USP7_MATH_1	293	297	PF00917	0.343
DOC_USP7_MATH_1	66	70	PF00917	0.521
DOC_USP7_MATH_2	30	36	PF00917	0.496
DOC_WW_Pin1_4	26	31	PF00397	0.553
DOC_WW_Pin1_4	267	272	PF00397	0.416
DOC_WW_Pin1_4	81	86	PF00397	0.428
LIG_APCC_ABBA_1	198	203	PF00400	0.496
LIG_BIR_III_4	88	92	PF00653	0.474
LIG_CSL_BTD_1	177	180	PF09270	0.454
LIG_FHA_1	11	17	PF00498	0.435
LIG_FHA_1	128	134	PF00498	0.445
LIG_FHA_1	219	225	PF00498	0.561
LIG_LIR_Apic_2	175	180	PF02991	0.429
LIG_LIR_Apic_2	248	252	PF02991	0.435
LIG_LIR_Apic_2	88	93	PF02991	0.512
LIG_LIR_Gen_1	172	180	PF02991	0.444
LIG_LIR_Gen_1	193	200	PF02991	0.420
LIG_LIR_Gen_1	213	223	PF02991	0.385
LIG_LIR_Gen_1	243	252	PF02991	0.510
LIG_LIR_LC3C_4	194	199	PF02991	0.473
LIG_LIR_Nem_3	130	134	PF02991	0.493
LIG_LIR_Nem_3	172	177	PF02991	0.456
LIG_LIR_Nem_3	193	198	PF02991	0.510
LIG_LIR_Nem_3	213	218	PF02991	0.329
LIG_LIR_Nem_3	243	249	PF02991	0.510
LIG_LIR_Nem_3	299	304	PF02991	0.396
LIG_LIR_Nem_3	51	55	PF02991	0.437
LIG_NRBOX	187	193	PF00104	0.445
LIG_PCNA_yPIPBox_3	278	289	PF02747	0.444
LIG_Pex14_2	174	178	PF04695	0.510
LIG_SH2_CRK	301	305	PF00017	0.389
LIG_SH2_CRK	90	94	PF00017	0.510
LIG_SH2_SRC	145	148	PF00017	0.435
LIG_SH2_STAP1	242	246	PF00017	0.471
LIG_SH2_STAT5	22	25	PF00017	0.534
LIG_SH2_STAT5	242	245	PF00017	0.510
LIG_TRAF2_1	136	139	PF00917	0.526
LIG_WRC_WIRS_1	128	133	PF05994	0.438
LIG_WRC_WIRS_1	174	179	PF05994	0.437
LIG_WRC_WIRS_1	192	197	PF05994	0.508
LIG_WRC_WIRS_1	246	251	PF05994	0.435
MOD_CK1_1	240	246	PF00069	0.508
MOD_CK2_1	26	32	PF00069	0.576
MOD_CK2_1	293	299	PF00069	0.419
MOD_GlcNHglycan	249	252	PF01048	0.325
MOD_GlcNHglycan	96	99	PF01048	0.298
MOD_GSK3_1	32	39	PF00069	0.625
MOD_NEK2_1	173	178	PF00069	0.437
MOD_NEK2_1	191	196	PF00069	0.526
MOD_NEK2_2	127	132	PF00069	0.471
MOD_PIKK_1	237	243	PF00454	0.550
MOD_PIKK_1	32	38	PF00454	0.566
MOD_Plk_1	237	243	PF00069	0.470
MOD_Plk_4	173	179	PF00069	0.433
MOD_Plk_4	293	299	PF00069	0.326
MOD_ProDKin_1	26	32	PF00069	0.555
MOD_ProDKin_1	267	273	PF00069	0.422
MOD_ProDKin_1	81	87	PF00069	0.428
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.527
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.561
TRG_ENDOCYTIC_2	301	304	PF00928	0.460
TRG_ER_diArg_1	161	164	PF00400	0.496
TRG_NES_CRM1_1	190	203	PF08389	0.486
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK8	Leptomonas seymouri	55%	100%
A0A0S4J2V8	Bodo saltans	37%	100%
A0A3Q8ICX3	Leishmania donovani	93%	100%
A0A3R7KAJ0	Trypanosoma rangeli	38%	100%
A4H990	Leishmania braziliensis	77%	100%
A4HXL1	Leishmania infantum	93%	100%
A4IH61	Xenopus tropicalis	27%	100%
E9ARA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P91851	Caenorhabditis elegans	26%	100%
Q96T66	Homo sapiens	30%	100%
V5BNX9	Trypanosoma cruzi	39%	100%