Putative L-gulonolactone oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-galactonolactone oxidase, putative

Species:

Leishmania major

UniProt:

Q4QE54_LEIMA

TriTrypDb:

LmjF.17.1360 , LMJLV39_170021000 , LMJSD75_170020700

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0016020	membrane	2	12
GO:0020015	glycosome	7	2
GO:0020022	acidocalcisome	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QE54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE54

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0005996	monosaccharide metabolic process	3	2
GO:0006082	organic acid metabolic process	3	2
GO:0006766	vitamin metabolic process	3	2
GO:0006767	water-soluble vitamin metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009110	vitamin biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0016051	carbohydrate biosynthetic process	4	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0019852	L-ascorbic acid metabolic process	4	2
GO:0019853	L-ascorbic acid biosynthetic process	5	2
GO:0042364	water-soluble vitamin biosynthetic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046364	monosaccharide biosynthetic process	4	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901334	lactone metabolic process	4	2
GO:1901336	lactone biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003885	D-arabinono-1,4-lactone oxidase activity	5	12
GO:0005488	binding	1	12
GO:0010181	FMN binding	4	2
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	3
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	3
GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	4	12
GO:0032553	ribonucleotide binding	3	2
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050024	L-galactonolactone oxidase activity	5	3
GO:0050105	L-gulonolactone oxidase activity	5	5
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0071949	FAD binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.338
CLV_NRD_NRD_1	328	330	PF00675	0.265
CLV_NRD_NRD_1	427	429	PF00675	0.416
CLV_NRD_NRD_1	473	475	PF00675	0.372
CLV_NRD_NRD_1	8	10	PF00675	0.538
CLV_PCSK_KEX2_1	328	330	PF00082	0.356
CLV_PCSK_KEX2_1	427	429	PF00082	0.416
CLV_PCSK_KEX2_1	472	474	PF00082	0.390
CLV_PCSK_KEX2_1	8	10	PF00082	0.506
CLV_PCSK_SKI1_1	141	145	PF00082	0.387
CLV_PCSK_SKI1_1	200	204	PF00082	0.470
CLV_PCSK_SKI1_1	290	294	PF00082	0.339
CLV_PCSK_SKI1_1	328	332	PF00082	0.343
CLV_PCSK_SKI1_1	455	459	PF00082	0.377
CLV_Separin_Metazoa	38	42	PF03568	0.377
CLV_Separin_Metazoa	95	99	PF03568	0.338
DEG_MDM2_SWIB_1	481	489	PF02201	0.308
DEG_SPOP_SBC_1	236	240	PF00917	0.469
DOC_CDC14_PxL_1	242	250	PF14671	0.616
DOC_CYCLIN_yCln2_LP_2	384	390	PF00134	0.428
DOC_MAPK_MEF2A_6	379	386	PF00069	0.393
DOC_MAPK_MEF2A_6	406	415	PF00069	0.308
DOC_MAPK_MEF2A_6	98	107	PF00069	0.416
DOC_MAPK_NFAT4_5	379	387	PF00069	0.428
DOC_PP1_RVXF_1	185	191	PF00149	0.491
DOC_PP4_FxxP_1	332	335	PF00568	0.338
DOC_PP4_FxxP_1	392	395	PF00568	0.455
DOC_USP7_MATH_1	125	129	PF00917	0.365
DOC_USP7_MATH_1	395	399	PF00917	0.416
DOC_USP7_UBL2_3	290	294	PF12436	0.457
DOC_WW_Pin1_4	260	265	PF00397	0.665
DOC_WW_Pin1_4	398	403	PF00397	0.308
DOC_WW_Pin1_4	488	493	PF00397	0.449
DOC_WW_Pin1_4	52	57	PF00397	0.308
LIG_14-3-3_CanoR_1	115	119	PF00244	0.394
LIG_14-3-3_CanoR_1	283	288	PF00244	0.508
LIG_14-3-3_CanoR_1	329	335	PF00244	0.428
LIG_14-3-3_CanoR_1	391	395	PF00244	0.412
LIG_14-3-3_CanoR_1	494	502	PF00244	0.465
LIG_Actin_WH2_2	149	167	PF00022	0.484
LIG_Actin_WH2_2	281	296	PF00022	0.549
LIG_APCC_Cbox_1	466	472	PF00515	0.377
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_Clathr_ClatBox_1	66	70	PF01394	0.385
LIG_CSL_BTD_1	221	224	PF09270	0.332
LIG_deltaCOP1_diTrp_1	463	468	PF00928	0.455
LIG_EVH1_1	245	249	PF00568	0.580
LIG_FHA_1	179	185	PF00498	0.430
LIG_FHA_1	237	243	PF00498	0.575
LIG_FHA_1	28	34	PF00498	0.410
LIG_FHA_1	296	302	PF00498	0.398
LIG_FHA_1	406	412	PF00498	0.316
LIG_FHA_2	251	257	PF00498	0.603
LIG_FHA_2	391	397	PF00498	0.343
LIG_FHA_2	458	464	PF00498	0.221
LIG_LIR_Apic_2	389	395	PF02991	0.455
LIG_LIR_Gen_1	347	356	PF02991	0.308
LIG_LIR_Gen_1	368	377	PF02991	0.365
LIG_LIR_Gen_1	431	440	PF02991	0.416
LIG_LIR_Gen_1	463	471	PF02991	0.455
LIG_LIR_Nem_3	227	233	PF02991	0.420
LIG_LIR_Nem_3	347	351	PF02991	0.308
LIG_LIR_Nem_3	368	373	PF02991	0.365
LIG_LIR_Nem_3	408	413	PF02991	0.307
LIG_LIR_Nem_3	431	436	PF02991	0.382
LIG_LIR_Nem_3	463	468	PF02991	0.459
LIG_PALB2_WD40_1	481	489	PF16756	0.428
LIG_Pex14_1	446	450	PF04695	0.308
LIG_Pex14_2	348	352	PF04695	0.308
LIG_Pex14_2	386	390	PF04695	0.311
LIG_Pex14_2	481	485	PF04695	0.308
LIG_PTB_Apo_2	321	328	PF02174	0.324
LIG_PTB_Apo_2	480	487	PF02174	0.428
LIG_PTB_Phospho_1	321	327	PF10480	0.324
LIG_SH2_GRB2like	322	325	PF00017	0.343
LIG_SH2_STAP1	311	315	PF00017	0.221
LIG_SH2_STAT5	113	116	PF00017	0.365
LIG_SH2_STAT5	139	142	PF00017	0.343
LIG_SH2_STAT5	295	298	PF00017	0.425
LIG_SH2_STAT5	322	325	PF00017	0.321
LIG_SH3_3	190	196	PF00018	0.514
LIG_SH3_3	243	249	PF00018	0.688
LIG_SH3_3	401	407	PF00018	0.377
LIG_SUMO_SIM_anti_2	284	289	PF11976	0.421
LIG_SUMO_SIM_anti_2	35	42	PF11976	0.379
LIG_SUMO_SIM_par_1	74	80	PF11976	0.364
LIG_TRAF2_1	266	269	PF00917	0.679
LIG_WRPW_2	416	419	PF00400	0.320
LIG_WW_2	246	249	PF00397	0.585
MOD_CDC14_SPxK_1	491	494	PF00782	0.516
MOD_CDK_SPxK_1	488	494	PF00069	0.494
MOD_CK1_1	2	8	PF00069	0.631
MOD_CK1_1	398	404	PF00069	0.428
MOD_CK1_1	55	61	PF00069	0.365
MOD_CK1_1	77	83	PF00069	0.428
MOD_CK2_1	26	32	PF00069	0.323
MOD_CK2_1	338	344	PF00069	0.369
MOD_GlcNHglycan	1	4	PF01048	0.663
MOD_GlcNHglycan	128	131	PF01048	0.308
MOD_GlcNHglycan	242	245	PF01048	0.668
MOD_GlcNHglycan	275	278	PF01048	0.755
MOD_GlcNHglycan	290	293	PF01048	0.314
MOD_GlcNHglycan	332	335	PF01048	0.360
MOD_GlcNHglycan	340	343	PF01048	0.318
MOD_GSK3_1	109	116	PF00069	0.317
MOD_GSK3_1	121	128	PF00069	0.279
MOD_GSK3_1	236	243	PF00069	0.547
MOD_GSK3_1	494	501	PF00069	0.560
MOD_GSK3_1	55	62	PF00069	0.357
MOD_GSK3_1	77	84	PF00069	0.381
MOD_N-GLC_1	273	278	PF02516	0.592
MOD_N-GLC_1	495	500	PF02516	0.426
MOD_NEK2_1	39	44	PF00069	0.455
MOD_NEK2_1	390	395	PF00069	0.393
MOD_NEK2_2	15	20	PF00069	0.566
MOD_PIKK_1	191	197	PF00454	0.499
MOD_PIKK_1	39	45	PF00454	0.431
MOD_PK_1	74	80	PF00069	0.324
MOD_PKA_1	8	14	PF00069	0.534
MOD_PKA_2	114	120	PF00069	0.407
MOD_PKA_2	338	344	PF00069	0.416
MOD_PKA_2	390	396	PF00069	0.319
MOD_PKA_2	405	411	PF00069	0.273
MOD_PKA_2	423	429	PF00069	0.308
MOD_PKA_2	8	14	PF00069	0.552
MOD_Plk_1	178	184	PF00069	0.458
MOD_Plk_1	281	287	PF00069	0.442
MOD_Plk_1	306	312	PF00069	0.422
MOD_Plk_2-3	344	350	PF00069	0.324
MOD_Plk_4	109	115	PF00069	0.308
MOD_Plk_4	306	312	PF00069	0.309
MOD_ProDKin_1	260	266	PF00069	0.666
MOD_ProDKin_1	398	404	PF00069	0.308
MOD_ProDKin_1	488	494	PF00069	0.453
MOD_ProDKin_1	52	58	PF00069	0.308
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.429
TRG_ENDOCYTIC_2	233	236	PF00928	0.511
TRG_ENDOCYTIC_2	430	433	PF00928	0.307
TRG_ER_diArg_1	327	329	PF00400	0.356
TRG_ER_diArg_1	471	474	PF00400	0.428
TRG_ER_diArg_1	8	10	PF00400	0.351
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA41	Leptomonas seymouri	61%	94%
A0A0S4J5V1	Bodo saltans	44%	92%
A0A1X0NU47	Trypanosomatidae	42%	91%
A0A3S5H719	Leishmania donovani	93%	100%
A0A422NB30	Trypanosoma rangeli	45%	99%
A4H992	Leishmania braziliensis	81%	100%
A4HXL3	Leishmania infantum	93%	100%
C9ZPA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9ARA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O47881	Brassica oleracea	23%	84%
O81030	Arabidopsis thaliana	22%	85%
O93852	Candida albicans (strain SC5314 / ATCC MYA-2876)	20%	90%
P10867	Rattus norvegicus	26%	100%
P54783	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	95%
P58710	Mus musculus	26%	100%
P9WIT2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WIT3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
Q2QXY1	Oryza sativa subsp. japonica	23%	86%
Q2RAP0	Oryza sativa subsp. japonica	24%	86%
Q3ZC33	Bos taurus	27%	100%
Q6CG88	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	95%
Q6CSY3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	96%
Q6FS20	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	23%	96%
Q6NQ66	Arabidopsis thaliana	22%	85%
Q752Y3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	94%
Q7SGY1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	90%
Q8HXW0	Sus scrofa	26%	100%
Q90YK3	Scyliorhinus torazame	26%	100%
Q9LYD8	Arabidopsis thaliana	21%	86%
Q9SU56	Arabidopsis thaliana	22%	82%
V5BEU1	Trypanosoma cruzi	46%	91%