Protein SDA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein SDA1

Gene product:

NUC130/3NT domain/SDA1, putative

Species:

Leishmania major

UniProt:

Q4QE53_LEIMA

TriTrypDb:

LmjF.17.1370 , LMJLV39_170021200 , LMJSD75_170020900

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QE53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE53

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	9
GO:0000055	ribosomal large subunit export from nucleus	4	9
GO:0006810	transport	3	9
GO:0006913	nucleocytoplasmic transport	5	9
GO:0006996	organelle organization	4	9
GO:0007010	cytoskeleton organization	5	9
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0016043	cellular component organization	3	9
GO:0022613	ribonucleoprotein complex biogenesis	4	9
GO:0030029	actin filament-based process	2	9
GO:0030036	actin cytoskeleton organization	3	9
GO:0031503	protein-containing complex localization	2	9
GO:0033036	macromolecule localization	2	9
GO:0033750	ribosome localization	3	9
GO:0042273	ribosomal large subunit biogenesis	5	9
GO:0044085	cellular component biogenesis	3	9
GO:0045184	establishment of protein localization	3	9
GO:0046907	intracellular transport	3	9
GO:0051168	nuclear export	6	9
GO:0051169	nuclear transport	4	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051640	organelle localization	2	9
GO:0051641	cellular localization	2	9
GO:0051649	establishment of localization in cell	3	9
GO:0051656	establishment of organelle localization	3	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.448
CLV_C14_Caspase3-7	512	516	PF00656	0.369
CLV_C14_Caspase3-7	523	527	PF00656	0.306
CLV_C14_Caspase3-7	532	536	PF00656	0.260
CLV_C14_Caspase3-7	540	544	PF00656	0.223
CLV_C14_Caspase3-7	571	575	PF00656	0.451
CLV_C14_Caspase3-7	605	609	PF00656	0.360
CLV_C14_Caspase3-7	612	616	PF00656	0.361
CLV_C14_Caspase3-7	683	687	PF00656	0.329
CLV_NRD_NRD_1	130	132	PF00675	0.385
CLV_NRD_NRD_1	142	144	PF00675	0.422
CLV_NRD_NRD_1	18	20	PF00675	0.459
CLV_NRD_NRD_1	189	191	PF00675	0.427
CLV_NRD_NRD_1	275	277	PF00675	0.491
CLV_NRD_NRD_1	432	434	PF00675	0.229
CLV_NRD_NRD_1	743	745	PF00675	0.385
CLV_NRD_NRD_1	792	794	PF00675	0.375
CLV_NRD_NRD_1	802	804	PF00675	0.302
CLV_PCSK_FUR_1	16	20	PF00082	0.441
CLV_PCSK_FUR_1	741	745	PF00082	0.459
CLV_PCSK_FUR_1	858	862	PF00082	0.327
CLV_PCSK_KEX2_1	158	160	PF00082	0.549
CLV_PCSK_KEX2_1	18	20	PF00082	0.459
CLV_PCSK_KEX2_1	188	190	PF00082	0.426
CLV_PCSK_KEX2_1	262	264	PF00082	0.477
CLV_PCSK_KEX2_1	268	270	PF00082	0.476
CLV_PCSK_KEX2_1	275	277	PF00082	0.491
CLV_PCSK_KEX2_1	412	414	PF00082	0.411
CLV_PCSK_KEX2_1	432	434	PF00082	0.132
CLV_PCSK_KEX2_1	582	584	PF00082	0.360
CLV_PCSK_KEX2_1	743	745	PF00082	0.395
CLV_PCSK_KEX2_1	753	755	PF00082	0.353
CLV_PCSK_KEX2_1	777	779	PF00082	0.327
CLV_PCSK_KEX2_1	802	804	PF00082	0.354
CLV_PCSK_KEX2_1	818	820	PF00082	0.272
CLV_PCSK_KEX2_1	827	829	PF00082	0.327
CLV_PCSK_KEX2_1	860	862	PF00082	0.327
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.446
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.485
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.476
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.491
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.411
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.360
CLV_PCSK_PC1ET2_1	743	745	PF00082	0.375
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.353
CLV_PCSK_PC1ET2_1	777	779	PF00082	0.327
CLV_PCSK_PC1ET2_1	818	820	PF00082	0.327
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.327
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.408
CLV_PCSK_PC7_1	408	414	PF00082	0.392
CLV_PCSK_SKI1_1	132	136	PF00082	0.393
CLV_PCSK_SKI1_1	214	218	PF00082	0.379
CLV_PCSK_SKI1_1	255	259	PF00082	0.532
CLV_PCSK_SKI1_1	265	269	PF00082	0.439
CLV_PCSK_SKI1_1	272	276	PF00082	0.387
CLV_PCSK_SKI1_1	717	721	PF00082	0.360
CLV_PCSK_SKI1_1	782	786	PF00082	0.392
CLV_PCSK_SKI1_1	853	857	PF00082	0.334
CLV_PCSK_SKI1_1	94	98	PF00082	0.320
CLV_Separin_Metazoa	79	83	PF03568	0.462
DEG_APCC_DBOX_1	217	225	PF00400	0.403
DEG_APCC_DBOX_1	6	14	PF00400	0.430
DEG_APCC_DBOX_1	818	826	PF00400	0.327
DEG_Kelch_Keap1_1	515	520	PF01344	0.392
DEG_SPOP_SBC_1	514	518	PF00917	0.385
DEG_SPOP_SBC_1	707	711	PF00917	0.423
DOC_ANK_TNKS_1	571	578	PF00023	0.385
DOC_CDC14_PxL_1	483	491	PF14671	0.322
DOC_CYCLIN_RxL_1	126	136	PF00134	0.468
DOC_MAPK_DCC_7	290	298	PF00069	0.448
DOC_MAPK_gen_1	126	135	PF00069	0.401
DOC_MAPK_HePTP_8	174	186	PF00069	0.379
DOC_MAPK_MEF2A_6	177	186	PF00069	0.373
DOC_MAPK_MEF2A_6	68	76	PF00069	0.408
DOC_PP1_RVXF_1	851	858	PF00149	0.327
DOC_PP2B_LxvP_1	222	225	PF13499	0.444
DOC_PP2B_LxvP_1	340	343	PF13499	0.549
DOC_PP4_MxPP_1	373	376	PF00568	0.394
DOC_SPAK_OSR1_1	319	323	PF12202	0.412
DOC_USP7_MATH_1	542	546	PF00917	0.320
DOC_USP7_UBL2_3	128	132	PF12436	0.481
DOC_USP7_UBL2_3	249	253	PF12436	0.488
DOC_USP7_UBL2_3	255	259	PF12436	0.510
DOC_USP7_UBL2_3	794	798	PF12436	0.345
DOC_USP7_UBL2_3	804	808	PF12436	0.309
DOC_USP7_UBL2_3	848	852	PF12436	0.328
DOC_USP7_UBL2_3	856	860	PF12436	0.329
DOC_WW_Pin1_4	207	212	PF00397	0.559
DOC_WW_Pin1_4	693	698	PF00397	0.268
LIG_14-3-3_CanoR_1	189	198	PF00244	0.484
LIG_14-3-3_CanoR_1	226	231	PF00244	0.610
LIG_14-3-3_CanoR_1	315	322	PF00244	0.360
LIG_14-3-3_CanoR_1	332	340	PF00244	0.391
LIG_14-3-3_CanoR_1	36	43	PF00244	0.500
LIG_14-3-3_CanoR_1	394	402	PF00244	0.548
LIG_14-3-3_CanoR_1	717	724	PF00244	0.305
LIG_14-3-3_CanoR_1	793	801	PF00244	0.408
LIG_Actin_WH2_2	69	84	PF00022	0.408
LIG_APCC_ABBA_1	116	121	PF00400	0.398
LIG_APCC_ABBA_1	446	451	PF00400	0.360
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BIR_III_1	1	5	PF00653	0.550
LIG_BIR_III_3	1	5	PF00653	0.550
LIG_BIR_III_4	574	578	PF00653	0.385
LIG_BRCT_BRCA1_1	316	320	PF00533	0.456
LIG_BRCT_BRCA1_1	795	799	PF00533	0.408
LIG_CtBP_PxDLS_1	664	668	PF00389	0.229
LIG_CtBP_PxDLS_1	90	94	PF00389	0.346
LIG_FAT_LD_1	306	314	PF03623	0.396
LIG_FHA_1	113	119	PF00498	0.477
LIG_FHA_1	134	140	PF00498	0.465
LIG_FHA_1	195	201	PF00498	0.374
LIG_FHA_1	208	214	PF00498	0.384
LIG_FHA_1	358	364	PF00498	0.410
LIG_FHA_1	399	405	PF00498	0.385
LIG_FHA_1	471	477	PF00498	0.357
LIG_FHA_1	7	13	PF00498	0.438
LIG_FHA_1	708	714	PF00498	0.346
LIG_FHA_2	15	21	PF00498	0.432
LIG_FHA_2	226	232	PF00498	0.546
LIG_FHA_2	331	337	PF00498	0.394
LIG_FHA_2	404	410	PF00498	0.381
LIG_FHA_2	521	527	PF00498	0.458
LIG_FHA_2	571	577	PF00498	0.455
LIG_FHA_2	654	660	PF00498	0.430
LIG_FHA_2	718	724	PF00498	0.360
LIG_FHA_2	810	816	PF00498	0.327
LIG_GBD_Chelix_1	305	313	PF00786	0.301
LIG_Integrin_RGD_1	433	435	PF01839	0.327
LIG_LIR_Apic_2	349	354	PF02991	0.416
LIG_LIR_Gen_1	490	500	PF02991	0.359
LIG_LIR_Gen_1	535	546	PF02991	0.408
LIG_LIR_Gen_1	637	647	PF02991	0.466
LIG_LIR_Gen_1	679	688	PF02991	0.361
LIG_LIR_Gen_1	721	730	PF02991	0.327
LIG_LIR_Nem_3	113	119	PF02991	0.395
LIG_LIR_Nem_3	451	456	PF02991	0.360
LIG_LIR_Nem_3	490	496	PF02991	0.359
LIG_LIR_Nem_3	535	541	PF02991	0.408
LIG_LIR_Nem_3	637	643	PF02991	0.466
LIG_LIR_Nem_3	679	684	PF02991	0.361
LIG_LIR_Nem_3	721	727	PF02991	0.327
LIG_LRP6_Inhibitor_1	402	408	PF00058	0.382
LIG_LYPXL_S_1	452	456	PF13949	0.327
LIG_LYPXL_yS_3	453	456	PF13949	0.327
LIG_MYND_1	454	458	PF01753	0.327
LIG_MYND_1	557	561	PF01753	0.408
LIG_PALB2_WD40_1	676	684	PF16756	0.462
LIG_PCNA_yPIPBox_3	297	310	PF02747	0.317
LIG_Pex14_2	116	120	PF04695	0.379
LIG_PTB_Apo_2	46	53	PF02174	0.422
LIG_SH2_GRB2like	326	329	PF00017	0.402
LIG_SH2_NCK_1	483	487	PF00017	0.322
LIG_SH2_SRC	326	329	PF00017	0.402
LIG_SH2_STAT3	278	281	PF00017	0.559
LIG_SH2_STAT5	326	329	PF00017	0.370
LIG_SH2_STAT5	483	486	PF00017	0.322
LIG_SH2_STAT5	58	61	PF00017	0.346
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.360
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.365
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.425
LIG_SUMO_SIM_par_1	180	185	PF11976	0.363
LIG_SUMO_SIM_par_1	193	202	PF11976	0.350
LIG_SUMO_SIM_par_1	360	366	PF11976	0.433
LIG_SUMO_SIM_par_1	590	596	PF11976	0.399
LIG_SUMO_SIM_par_1	661	668	PF11976	0.325
LIG_TRAF2_1	545	548	PF00917	0.462
LIG_TRAF2_1	656	659	PF00917	0.344
LIG_TYR_ITIM	324	329	PF00017	0.405
LIG_TYR_ITIM	491	496	PF00017	0.423
LIG_UBA3_1	101	107	PF00899	0.403
LIG_UBA3_1	422	430	PF00899	0.327
LIG_UBA3_1	822	827	PF00899	0.327
MOD_CDK_SPK_2	693	698	PF00069	0.268
MOD_CDK_SPxxK_3	207	214	PF00069	0.537
MOD_CK1_1	207	213	PF00069	0.402
MOD_CK1_1	38	44	PF00069	0.500
MOD_CK1_1	392	398	PF00069	0.470
MOD_CK1_1	507	513	PF00069	0.357
MOD_CK1_1	593	599	PF00069	0.373
MOD_CK1_1	603	609	PF00069	0.284
MOD_CK1_1	701	707	PF00069	0.387
MOD_CK1_1	708	714	PF00069	0.438
MOD_CK1_1	736	742	PF00069	0.360
MOD_CK2_1	258	264	PF00069	0.579
MOD_CK2_1	330	336	PF00069	0.375
MOD_CK2_1	403	409	PF00069	0.381
MOD_CK2_1	502	508	PF00069	0.426
MOD_CK2_1	514	520	PF00069	0.299
MOD_CK2_1	522	528	PF00069	0.396
MOD_CK2_1	541	547	PF00069	0.175
MOD_CK2_1	624	630	PF00069	0.392
MOD_CK2_1	641	647	PF00069	0.379
MOD_CK2_1	652	658	PF00069	0.352
MOD_CK2_1	794	800	PF00069	0.327
MOD_CK2_1	809	815	PF00069	0.327
MOD_Cter_Amidation	741	744	PF01082	0.385
MOD_GlcNHglycan	365	368	PF01048	0.461
MOD_GlcNHglycan	38	41	PF01048	0.497
MOD_GlcNHglycan	395	398	PF01048	0.556
MOD_GlcNHglycan	502	507	PF01048	0.380
MOD_GlcNHglycan	517	520	PF01048	0.319
MOD_GlcNHglycan	543	547	PF01048	0.456
MOD_GlcNHglycan	567	570	PF01048	0.371
MOD_GlcNHglycan	598	601	PF01048	0.283
MOD_GlcNHglycan	604	608	PF01048	0.428
MOD_GlcNHglycan	667	670	PF01048	0.359
MOD_GlcNHglycan	675	678	PF01048	0.437
MOD_GSK3_1	108	115	PF00069	0.419
MOD_GSK3_1	133	140	PF00069	0.387
MOD_GSK3_1	190	197	PF00069	0.439
MOD_GSK3_1	389	396	PF00069	0.423
MOD_GSK3_1	502	509	PF00069	0.339
MOD_GSK3_1	520	527	PF00069	0.444
MOD_GSK3_1	596	603	PF00069	0.362
MOD_GSK3_1	682	689	PF00069	0.317
MOD_GSK3_1	698	705	PF00069	0.355
MOD_GSK3_1	707	714	PF00069	0.332
MOD_GSK3_1	729	736	PF00069	0.346
MOD_GSK3_1	804	811	PF00069	0.327
MOD_LATS_1	34	40	PF00433	0.405
MOD_N-GLC_1	14	19	PF02516	0.436
MOD_N-GLC_1	691	696	PF02516	0.362
MOD_N-GLC_1	809	814	PF02516	0.327
MOD_NEK2_1	133	138	PF00069	0.419
MOD_NEK2_1	163	168	PF00069	0.428
MOD_NEK2_1	267	272	PF00069	0.599
MOD_NEK2_1	35	40	PF00069	0.408
MOD_NEK2_1	357	362	PF00069	0.423
MOD_NEK2_1	363	368	PF00069	0.385
MOD_NEK2_1	382	387	PF00069	0.383
MOD_NEK2_1	461	466	PF00069	0.359
MOD_NEK2_1	6	11	PF00069	0.422
MOD_NEK2_1	602	607	PF00069	0.462
MOD_NEK2_1	665	670	PF00069	0.229
MOD_NEK2_1	809	814	PF00069	0.355
MOD_NEK2_1	81	86	PF00069	0.359
MOD_NEK2_1	823	828	PF00069	0.327
MOD_NEK2_1	836	841	PF00069	0.285
MOD_NEK2_1	97	102	PF00069	0.296
MOD_NEK2_2	403	408	PF00069	0.379
MOD_PIKK_1	352	358	PF00454	0.429
MOD_PIKK_1	41	47	PF00454	0.511
MOD_PIKK_1	593	599	PF00454	0.411
MOD_PIKK_1	729	735	PF00454	0.385
MOD_PIKK_1	826	832	PF00454	0.324
MOD_PK_1	226	232	PF00069	0.624
MOD_PK_1	698	704	PF00069	0.401
MOD_PKA_1	258	264	PF00069	0.499
MOD_PKA_1	777	783	PF00069	0.346
MOD_PKA_1	793	799	PF00069	0.358
MOD_PKA_1	804	810	PF00069	0.275
MOD_PKA_2	225	231	PF00069	0.568
MOD_PKA_2	314	320	PF00069	0.371
MOD_PKA_2	35	41	PF00069	0.463
MOD_PKA_2	393	399	PF00069	0.568
MOD_PKA_2	461	467	PF00069	0.345
MOD_PKA_2	6	12	PF00069	0.438
MOD_PKA_2	777	783	PF00069	0.376
MOD_PKA_2	81	87	PF00069	0.401
MOD_PKA_2	842	848	PF00069	0.408
MOD_PKB_1	188	196	PF00069	0.492
MOD_Plk_1	112	118	PF00069	0.400
MOD_Plk_1	126	132	PF00069	0.410
MOD_Plk_1	194	200	PF00069	0.404
MOD_Plk_2-3	194	200	PF00069	0.437
MOD_Plk_2-3	20	26	PF00069	0.535
MOD_Plk_2-3	520	526	PF00069	0.408
MOD_Plk_2-3	549	555	PF00069	0.417
MOD_Plk_2-3	641	647	PF00069	0.417
MOD_Plk_4	38	44	PF00069	0.459
MOD_Plk_4	6	12	PF00069	0.438
MOD_Plk_4	97	103	PF00069	0.408
MOD_ProDKin_1	207	213	PF00069	0.552
MOD_ProDKin_1	693	699	PF00069	0.268
MOD_SUMO_for_1	784	787	PF00179	0.392
MOD_SUMO_rev_2	849	857	PF00179	0.327
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.383
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.372
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.477
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.468
TRG_DiLeu_BaLyEn_6	714	719	PF01217	0.462
TRG_ENDOCYTIC_2	326	329	PF00928	0.402
TRG_ENDOCYTIC_2	345	348	PF00928	0.186
TRG_ENDOCYTIC_2	449	452	PF00928	0.342
TRG_ENDOCYTIC_2	453	456	PF00928	0.309
TRG_ENDOCYTIC_2	483	486	PF00928	0.306
TRG_ENDOCYTIC_2	493	496	PF00928	0.295
TRG_ER_diArg_1	16	19	PF00400	0.440
TRG_ER_diArg_1	187	190	PF00400	0.412
TRG_ER_diArg_1	583	586	PF00400	0.405
TRG_ER_diArg_1	801	803	PF00400	0.359
TRG_NLS_Bipartite_1	793	809	PF00514	0.341
TRG_NLS_MonoCore_2	802	807	PF00514	0.319
TRG_NLS_MonoExtC_3	581	587	PF00514	0.359
TRG_NLS_MonoExtC_3	803	808	PF00514	0.322
TRG_NLS_MonoExtN_4	580	586	PF00514	0.411
TRG_NLS_MonoExtN_4	802	809	PF00514	0.326
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	717	721	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R9	Leptomonas seymouri	73%	100%
A0A1X0NT40	Trypanosomatidae	70%	100%
A0A3S5H720	Leishmania donovani	94%	99%
A4H993	Leishmania braziliensis	84%	100%
A4HXL4	Leishmania infantum	94%	99%
C9ZPA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ARB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P53313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%