IQ calmodulin-binding motif family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE51_LEIMA

TriTrypDb:

LmjF.17.1380 , LMJLV39_170021400 , LMJSD75_170021100

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QE51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	444	448	PF00656	0.682
CLV_NRD_NRD_1	183	185	PF00675	0.779
CLV_NRD_NRD_1	35	37	PF00675	0.707
CLV_NRD_NRD_1	411	413	PF00675	0.512
CLV_NRD_NRD_1	422	424	PF00675	0.508
CLV_NRD_NRD_1	469	471	PF00675	0.487
CLV_NRD_NRD_1	513	515	PF00675	0.462
CLV_NRD_NRD_1	53	55	PF00675	0.504
CLV_NRD_NRD_1	531	533	PF00675	0.414
CLV_NRD_NRD_1	559	561	PF00675	0.323
CLV_NRD_NRD_1	565	567	PF00675	0.465
CLV_NRD_NRD_1	627	629	PF00675	0.525
CLV_NRD_NRD_1	642	644	PF00675	0.580
CLV_NRD_NRD_1	655	657	PF00675	0.546
CLV_NRD_NRD_1	686	688	PF00675	0.597
CLV_PCSK_FUR_1	684	688	PF00082	0.542
CLV_PCSK_KEX2_1	35	37	PF00082	0.707
CLV_PCSK_KEX2_1	411	413	PF00082	0.514
CLV_PCSK_KEX2_1	53	55	PF00082	0.500
CLV_PCSK_KEX2_1	531	533	PF00082	0.519
CLV_PCSK_KEX2_1	559	561	PF00082	0.341
CLV_PCSK_KEX2_1	565	567	PF00082	0.488
CLV_PCSK_KEX2_1	627	629	PF00082	0.554
CLV_PCSK_KEX2_1	642	644	PF00082	0.581
CLV_PCSK_KEX2_1	655	657	PF00082	0.537
CLV_PCSK_KEX2_1	666	668	PF00082	0.506
CLV_PCSK_KEX2_1	686	688	PF00082	0.321
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.628
CLV_PCSK_SKI1_1	185	189	PF00082	0.755
CLV_PCSK_SKI1_1	235	239	PF00082	0.503
CLV_PCSK_SKI1_1	412	416	PF00082	0.534
CLV_PCSK_SKI1_1	559	563	PF00082	0.398
CLV_PCSK_SKI1_1	656	660	PF00082	0.546
CLV_PCSK_SKI1_1	686	690	PF00082	0.598
CLV_PCSK_SKI1_1	90	94	PF00082	0.602
DEG_APCC_DBOX_1	130	138	PF00400	0.598
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.696
DOC_MAPK_gen_1	423	433	PF00069	0.585
DOC_MAPK_gen_1	642	649	PF00069	0.522
DOC_MAPK_gen_1	681	691	PF00069	0.599
DOC_MAPK_MEF2A_6	426	435	PF00069	0.595
DOC_MAPK_RevD_3	500	515	PF00069	0.530
DOC_PP1_RVXF_1	449	456	PF00149	0.463
DOC_PP2B_LxvP_1	168	171	PF13499	0.717
DOC_PP2B_LxvP_1	354	357	PF13499	0.734
DOC_PP2B_LxvP_1	96	99	PF13499	0.673
DOC_PP4_FxxP_1	116	119	PF00568	0.631
DOC_PP4_FxxP_1	95	98	PF00568	0.579
DOC_SPAK_OSR1_1	633	637	PF12202	0.480
DOC_USP7_MATH_1	127	131	PF00917	0.617
DOC_USP7_MATH_1	221	225	PF00917	0.720
DOC_USP7_MATH_1	313	317	PF00917	0.578
DOC_USP7_MATH_1	345	349	PF00917	0.667
DOC_USP7_MATH_1	71	75	PF00917	0.548
DOC_WW_Pin1_4	185	190	PF00397	0.733
DOC_WW_Pin1_4	201	206	PF00397	0.586
DOC_WW_Pin1_4	292	297	PF00397	0.690
DOC_WW_Pin1_4	309	314	PF00397	0.592
DOC_WW_Pin1_4	94	99	PF00397	0.677
LIG_14-3-3_CanoR_1	25	29	PF00244	0.666
LIG_14-3-3_CanoR_1	262	271	PF00244	0.569
LIG_14-3-3_CanoR_1	499	508	PF00244	0.577
LIG_14-3-3_CanoR_1	53	60	PF00244	0.656
LIG_14-3-3_CanoR_1	531	540	PF00244	0.459
LIG_14-3-3_CanoR_1	566	572	PF00244	0.489
LIG_14-3-3_CanoR_1	587	593	PF00244	0.454
LIG_14-3-3_CanoR_1	667	672	PF00244	0.657
LIG_14-3-3_CanoR_1	85	90	PF00244	0.594
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.528
LIG_BRCT_BRCA1_1	265	269	PF00533	0.531
LIG_CaM_IQ_9	388	403	PF13499	0.482
LIG_CaM_IQ_9	486	501	PF13499	0.482
LIG_CaM_IQ_9	523	539	PF13499	0.418
LIG_CaM_IQ_9	546	562	PF13499	0.494
LIG_CaM_IQ_9	607	622	PF13499	0.531
LIG_deltaCOP1_diTrp_1	371	377	PF00928	0.594
LIG_deltaCOP1_diTrp_1	586	592	PF00928	0.387
LIG_FHA_1	124	130	PF00498	0.709
LIG_FHA_1	163	169	PF00498	0.673
LIG_FHA_1	186	192	PF00498	0.757
LIG_FHA_2	177	183	PF00498	0.750
LIG_FHA_2	321	327	PF00498	0.520
LIG_FHA_2	332	338	PF00498	0.470
LIG_Integrin_RGD_1	299	301	PF01839	0.769
LIG_LIR_Apic_2	114	119	PF02991	0.626
LIG_LIR_Gen_1	110	121	PF02991	0.672
LIG_LIR_Gen_1	132	142	PF02991	0.571
LIG_LIR_Gen_1	586	595	PF02991	0.570
LIG_LIR_Nem_3	110	116	PF02991	0.726
LIG_LIR_Nem_3	132	138	PF02991	0.571
LIG_LIR_Nem_3	528	533	PF02991	0.495
LIG_LIR_Nem_3	551	556	PF02991	0.581
LIG_LIR_Nem_3	586	592	PF02991	0.578
LIG_LIR_Nem_3	88	92	PF02991	0.518
LIG_MYND_1	94	98	PF01753	0.581
LIG_PCNA_yPIPBox_3	76	90	PF02747	0.623
LIG_Pex14_1	588	592	PF04695	0.385
LIG_REV1ctd_RIR_1	453	463	PF16727	0.526
LIG_SH2_SRC	363	366	PF00017	0.617
LIG_SH2_STAP1	589	593	PF00017	0.545
LIG_SH2_STAT3	533	536	PF00017	0.547
LIG_SH2_STAT5	270	273	PF00017	0.511
LIG_SH2_STAT5	306	309	PF00017	0.675
LIG_SH2_STAT5	363	366	PF00017	0.617
LIG_SH2_STAT5	533	536	PF00017	0.551
LIG_SH3_2	98	103	PF14604	0.636
LIG_SH3_3	206	212	PF00018	0.741
LIG_SH3_3	95	101	PF00018	0.600
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.584
LIG_TRAF2_1	199	202	PF00917	0.670
LIG_TRAF2_1	247	250	PF00917	0.499
LIG_TRAF2_1	273	276	PF00917	0.603
LIG_TRAF2_1	323	326	PF00917	0.615
LIG_WRC_WIRS_1	223	228	PF05994	0.573
LIG_WRC_WIRS_1	28	33	PF05994	0.670
LIG_WRC_WIRS_1	589	594	PF05994	0.496
LIG_WRC_WIRS_1	89	94	PF05994	0.532
LIG_WRPW_2	92	95	PF00400	0.595
MOD_CDK_SPxxK_3	185	192	PF00069	0.550
MOD_CDK_SPxxK_3	292	299	PF00069	0.672
MOD_CK1_1	125	131	PF00069	0.638
MOD_CK1_1	23	29	PF00069	0.613
MOD_CK1_1	295	301	PF00069	0.662
MOD_CK1_1	55	61	PF00069	0.700
MOD_CK1_1	8	14	PF00069	0.589
MOD_CK2_1	176	182	PF00069	0.708
MOD_CK2_1	311	317	PF00069	0.740
MOD_CK2_1	320	326	PF00069	0.633
MOD_CK2_1	345	351	PF00069	0.701
MOD_GlcNHglycan	176	179	PF01048	0.723
MOD_GlcNHglycan	229	232	PF01048	0.615
MOD_GlcNHglycan	241	244	PF01048	0.530
MOD_GlcNHglycan	360	363	PF01048	0.616
MOD_GlcNHglycan	385	388	PF01048	0.477
MOD_GlcNHglycan	419	422	PF01048	0.589
MOD_GlcNHglycan	443	446	PF01048	0.684
MOD_GlcNHglycan	572	576	PF01048	0.539
MOD_GlcNHglycan	659	662	PF01048	0.461
MOD_GlcNHglycan	7	10	PF01048	0.524
MOD_GSK3_1	123	130	PF00069	0.708
MOD_GSK3_1	158	165	PF00069	0.575
MOD_GSK3_1	170	177	PF00069	0.681
MOD_GSK3_1	19	26	PF00069	0.639
MOD_GSK3_1	193	200	PF00069	0.705
MOD_GSK3_1	217	224	PF00069	0.702
MOD_GSK3_1	309	316	PF00069	0.608
MOD_GSK3_1	345	352	PF00069	0.680
MOD_GSK3_1	4	11	PF00069	0.543
MOD_GSK3_1	436	443	PF00069	0.588
MOD_GSK3_1	48	55	PF00069	0.692
MOD_GSK3_1	567	574	PF00069	0.545
MOD_GSK3_1	81	88	PF00069	0.553
MOD_NEK2_1	142	147	PF00069	0.627
MOD_NEK2_1	158	163	PF00069	0.592
MOD_NEK2_1	20	25	PF00069	0.740
MOD_NEK2_1	217	222	PF00069	0.641
MOD_NEK2_1	331	336	PF00069	0.621
MOD_NEK2_1	349	354	PF00069	0.553
MOD_NEK2_1	373	378	PF00069	0.645
MOD_NEK2_1	4	9	PF00069	0.577
MOD_NEK2_1	415	420	PF00069	0.574
MOD_NEK2_1	48	53	PF00069	0.618
MOD_NEK2_1	525	530	PF00069	0.523
MOD_NEK2_1	659	664	PF00069	0.611
MOD_NEK2_2	345	350	PF00069	0.520
MOD_NEK2_2	61	66	PF00069	0.570
MOD_OFUCOSY	522	529	PF10250	0.519
MOD_PIKK_1	72	78	PF00454	0.585
MOD_PKA_1	35	41	PF00069	0.602
MOD_PKA_1	531	537	PF00069	0.493
MOD_PKA_1	627	633	PF00069	0.595
MOD_PKA_2	122	128	PF00069	0.693
MOD_PKA_2	24	30	PF00069	0.728
MOD_PKA_2	263	269	PF00069	0.571
MOD_PKA_2	35	41	PF00069	0.570
MOD_PKA_2	52	58	PF00069	0.518
MOD_PKA_2	531	537	PF00069	0.420
MOD_PKA_2	627	633	PF00069	0.600
MOD_Plk_1	142	148	PF00069	0.666
MOD_Plk_1	446	452	PF00069	0.523
MOD_Plk_2-3	197	203	PF00069	0.670
MOD_Plk_4	176	182	PF00069	0.746
MOD_Plk_4	548	554	PF00069	0.521
MOD_Plk_4	588	594	PF00069	0.522
MOD_ProDKin_1	185	191	PF00069	0.733
MOD_ProDKin_1	201	207	PF00069	0.586
MOD_ProDKin_1	292	298	PF00069	0.693
MOD_ProDKin_1	309	315	PF00069	0.589
MOD_ProDKin_1	94	100	PF00069	0.683
MOD_SUMO_for_1	256	259	PF00179	0.546
MOD_SUMO_for_1	321	324	PF00179	0.614
MOD_SUMO_rev_2	418	425	PF00179	0.490
TRG_ENDOCYTIC_2	589	592	PF00928	0.577
TRG_ENDOCYTIC_2	89	92	PF00928	0.529
TRG_ER_diArg_1	398	401	PF00400	0.493
TRG_ER_diArg_1	40	43	PF00400	0.763
TRG_ER_diArg_1	52	54	PF00400	0.635
TRG_ER_diArg_1	530	532	PF00400	0.529
TRG_ER_diArg_1	540	543	PF00400	0.395
TRG_ER_diArg_1	559	561	PF00400	0.475
TRG_ER_diArg_1	565	567	PF00400	0.480
TRG_ER_diArg_1	627	629	PF00400	0.541
TRG_ER_diArg_1	642	644	PF00400	0.592
TRG_ER_diArg_1	683	686	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D9	Leptomonas seymouri	46%	93%
A0A0S4J9A9	Bodo saltans	28%	78%
A0A1X0NSM4	Trypanosomatidae	27%	90%
A0A3R7K6T1	Trypanosoma rangeli	28%	93%
A0A3S7WUM7	Leishmania donovani	90%	100%
A4H995	Leishmania braziliensis	67%	100%
A4HXL6	Leishmania infantum	91%	86%
E9ARB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	82%
V5DFR3	Trypanosoma cruzi	29%	100%