LeishMANIAdb
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IQ calmodulin-binding motif family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
IQ calmodulin-binding motif family protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QE51_LEIMA
TriTrypDb:
LmjF.17.1380 * , LMJLV39_170021400 * , LMJSD75_170021100 *
Length:
692

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005930 axoneme 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

Q4QE51
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE51

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 444 448 PF00656 0.682
CLV_NRD_NRD_1 183 185 PF00675 0.779
CLV_NRD_NRD_1 35 37 PF00675 0.707
CLV_NRD_NRD_1 411 413 PF00675 0.512
CLV_NRD_NRD_1 422 424 PF00675 0.508
CLV_NRD_NRD_1 469 471 PF00675 0.487
CLV_NRD_NRD_1 513 515 PF00675 0.462
CLV_NRD_NRD_1 53 55 PF00675 0.504
CLV_NRD_NRD_1 531 533 PF00675 0.414
CLV_NRD_NRD_1 559 561 PF00675 0.323
CLV_NRD_NRD_1 565 567 PF00675 0.465
CLV_NRD_NRD_1 627 629 PF00675 0.525
CLV_NRD_NRD_1 642 644 PF00675 0.580
CLV_NRD_NRD_1 655 657 PF00675 0.546
CLV_NRD_NRD_1 686 688 PF00675 0.597
CLV_PCSK_FUR_1 684 688 PF00082 0.542
CLV_PCSK_KEX2_1 35 37 PF00082 0.707
CLV_PCSK_KEX2_1 411 413 PF00082 0.514
CLV_PCSK_KEX2_1 53 55 PF00082 0.500
CLV_PCSK_KEX2_1 531 533 PF00082 0.519
CLV_PCSK_KEX2_1 559 561 PF00082 0.341
CLV_PCSK_KEX2_1 565 567 PF00082 0.488
CLV_PCSK_KEX2_1 627 629 PF00082 0.554
CLV_PCSK_KEX2_1 642 644 PF00082 0.581
CLV_PCSK_KEX2_1 655 657 PF00082 0.537
CLV_PCSK_KEX2_1 666 668 PF00082 0.506
CLV_PCSK_KEX2_1 686 688 PF00082 0.321
CLV_PCSK_PC1ET2_1 666 668 PF00082 0.628
CLV_PCSK_SKI1_1 185 189 PF00082 0.755
CLV_PCSK_SKI1_1 235 239 PF00082 0.503
CLV_PCSK_SKI1_1 412 416 PF00082 0.534
CLV_PCSK_SKI1_1 559 563 PF00082 0.398
CLV_PCSK_SKI1_1 656 660 PF00082 0.546
CLV_PCSK_SKI1_1 686 690 PF00082 0.598
CLV_PCSK_SKI1_1 90 94 PF00082 0.602
DEG_APCC_DBOX_1 130 138 PF00400 0.598
DEG_Nend_UBRbox_2 1 3 PF02207 0.512
DOC_CYCLIN_yCln2_LP_2 43 49 PF00134 0.636
DOC_CYCLIN_yCln2_LP_2 96 102 PF00134 0.696
DOC_MAPK_gen_1 423 433 PF00069 0.585
DOC_MAPK_gen_1 642 649 PF00069 0.522
DOC_MAPK_gen_1 681 691 PF00069 0.599
DOC_MAPK_MEF2A_6 426 435 PF00069 0.595
DOC_MAPK_RevD_3 500 515 PF00069 0.530
DOC_PP1_RVXF_1 449 456 PF00149 0.463
DOC_PP2B_LxvP_1 168 171 PF13499 0.717
DOC_PP2B_LxvP_1 354 357 PF13499 0.734
DOC_PP2B_LxvP_1 96 99 PF13499 0.673
DOC_PP4_FxxP_1 116 119 PF00568 0.631
DOC_PP4_FxxP_1 95 98 PF00568 0.579
DOC_SPAK_OSR1_1 633 637 PF12202 0.480
DOC_USP7_MATH_1 127 131 PF00917 0.617
DOC_USP7_MATH_1 221 225 PF00917 0.720
DOC_USP7_MATH_1 313 317 PF00917 0.578
DOC_USP7_MATH_1 345 349 PF00917 0.667
DOC_USP7_MATH_1 71 75 PF00917 0.548
DOC_WW_Pin1_4 185 190 PF00397 0.733
DOC_WW_Pin1_4 201 206 PF00397 0.586
DOC_WW_Pin1_4 292 297 PF00397 0.690
DOC_WW_Pin1_4 309 314 PF00397 0.592
DOC_WW_Pin1_4 94 99 PF00397 0.677
LIG_14-3-3_CanoR_1 25 29 PF00244 0.666
LIG_14-3-3_CanoR_1 262 271 PF00244 0.569
LIG_14-3-3_CanoR_1 499 508 PF00244 0.577
LIG_14-3-3_CanoR_1 53 60 PF00244 0.656
LIG_14-3-3_CanoR_1 531 540 PF00244 0.459
LIG_14-3-3_CanoR_1 566 572 PF00244 0.489
LIG_14-3-3_CanoR_1 587 593 PF00244 0.454
LIG_14-3-3_CanoR_1 667 672 PF00244 0.657
LIG_14-3-3_CanoR_1 85 90 PF00244 0.594
LIG_APCC_ABBAyCdc20_2 103 109 PF00400 0.528
LIG_BRCT_BRCA1_1 265 269 PF00533 0.531
LIG_CaM_IQ_9 388 403 PF13499 0.482
LIG_CaM_IQ_9 486 501 PF13499 0.482
LIG_CaM_IQ_9 523 539 PF13499 0.418
LIG_CaM_IQ_9 546 562 PF13499 0.494
LIG_CaM_IQ_9 607 622 PF13499 0.531
LIG_deltaCOP1_diTrp_1 371 377 PF00928 0.594
LIG_deltaCOP1_diTrp_1 586 592 PF00928 0.387
LIG_FHA_1 124 130 PF00498 0.709
LIG_FHA_1 163 169 PF00498 0.673
LIG_FHA_1 186 192 PF00498 0.757
LIG_FHA_2 177 183 PF00498 0.750
LIG_FHA_2 321 327 PF00498 0.520
LIG_FHA_2 332 338 PF00498 0.470
LIG_Integrin_RGD_1 299 301 PF01839 0.769
LIG_LIR_Apic_2 114 119 PF02991 0.626
LIG_LIR_Gen_1 110 121 PF02991 0.672
LIG_LIR_Gen_1 132 142 PF02991 0.571
LIG_LIR_Gen_1 586 595 PF02991 0.570
LIG_LIR_Nem_3 110 116 PF02991 0.726
LIG_LIR_Nem_3 132 138 PF02991 0.571
LIG_LIR_Nem_3 528 533 PF02991 0.495
LIG_LIR_Nem_3 551 556 PF02991 0.581
LIG_LIR_Nem_3 586 592 PF02991 0.578
LIG_LIR_Nem_3 88 92 PF02991 0.518
LIG_MYND_1 94 98 PF01753 0.581
LIG_PCNA_yPIPBox_3 76 90 PF02747 0.623
LIG_Pex14_1 588 592 PF04695 0.385
LIG_REV1ctd_RIR_1 453 463 PF16727 0.526
LIG_SH2_SRC 363 366 PF00017 0.617
LIG_SH2_STAP1 589 593 PF00017 0.545
LIG_SH2_STAT3 533 536 PF00017 0.547
LIG_SH2_STAT5 270 273 PF00017 0.511
LIG_SH2_STAT5 306 309 PF00017 0.675
LIG_SH2_STAT5 363 366 PF00017 0.617
LIG_SH2_STAT5 533 536 PF00017 0.551
LIG_SH3_2 98 103 PF14604 0.636
LIG_SH3_3 206 212 PF00018 0.741
LIG_SH3_3 95 101 PF00018 0.600
LIG_SUMO_SIM_anti_2 276 282 PF11976 0.584
LIG_TRAF2_1 199 202 PF00917 0.670
LIG_TRAF2_1 247 250 PF00917 0.499
LIG_TRAF2_1 273 276 PF00917 0.603
LIG_TRAF2_1 323 326 PF00917 0.615
LIG_WRC_WIRS_1 223 228 PF05994 0.573
LIG_WRC_WIRS_1 28 33 PF05994 0.670
LIG_WRC_WIRS_1 589 594 PF05994 0.496
LIG_WRC_WIRS_1 89 94 PF05994 0.532
LIG_WRPW_2 92 95 PF00400 0.595
MOD_CDK_SPxxK_3 185 192 PF00069 0.550
MOD_CDK_SPxxK_3 292 299 PF00069 0.672
MOD_CK1_1 125 131 PF00069 0.638
MOD_CK1_1 23 29 PF00069 0.613
MOD_CK1_1 295 301 PF00069 0.662
MOD_CK1_1 55 61 PF00069 0.700
MOD_CK1_1 8 14 PF00069 0.589
MOD_CK2_1 176 182 PF00069 0.708
MOD_CK2_1 311 317 PF00069 0.740
MOD_CK2_1 320 326 PF00069 0.633
MOD_CK2_1 345 351 PF00069 0.701
MOD_GlcNHglycan 176 179 PF01048 0.723
MOD_GlcNHglycan 229 232 PF01048 0.615
MOD_GlcNHglycan 241 244 PF01048 0.530
MOD_GlcNHglycan 360 363 PF01048 0.616
MOD_GlcNHglycan 385 388 PF01048 0.477
MOD_GlcNHglycan 419 422 PF01048 0.589
MOD_GlcNHglycan 443 446 PF01048 0.684
MOD_GlcNHglycan 572 576 PF01048 0.539
MOD_GlcNHglycan 659 662 PF01048 0.461
MOD_GlcNHglycan 7 10 PF01048 0.524
MOD_GSK3_1 123 130 PF00069 0.708
MOD_GSK3_1 158 165 PF00069 0.575
MOD_GSK3_1 170 177 PF00069 0.681
MOD_GSK3_1 19 26 PF00069 0.639
MOD_GSK3_1 193 200 PF00069 0.705
MOD_GSK3_1 217 224 PF00069 0.702
MOD_GSK3_1 309 316 PF00069 0.608
MOD_GSK3_1 345 352 PF00069 0.680
MOD_GSK3_1 4 11 PF00069 0.543
MOD_GSK3_1 436 443 PF00069 0.588
MOD_GSK3_1 48 55 PF00069 0.692
MOD_GSK3_1 567 574 PF00069 0.545
MOD_GSK3_1 81 88 PF00069 0.553
MOD_NEK2_1 142 147 PF00069 0.627
MOD_NEK2_1 158 163 PF00069 0.592
MOD_NEK2_1 20 25 PF00069 0.740
MOD_NEK2_1 217 222 PF00069 0.641
MOD_NEK2_1 331 336 PF00069 0.621
MOD_NEK2_1 349 354 PF00069 0.553
MOD_NEK2_1 373 378 PF00069 0.645
MOD_NEK2_1 4 9 PF00069 0.577
MOD_NEK2_1 415 420 PF00069 0.574
MOD_NEK2_1 48 53 PF00069 0.618
MOD_NEK2_1 525 530 PF00069 0.523
MOD_NEK2_1 659 664 PF00069 0.611
MOD_NEK2_2 345 350 PF00069 0.520
MOD_NEK2_2 61 66 PF00069 0.570
MOD_OFUCOSY 522 529 PF10250 0.519
MOD_PIKK_1 72 78 PF00454 0.585
MOD_PKA_1 35 41 PF00069 0.602
MOD_PKA_1 531 537 PF00069 0.493
MOD_PKA_1 627 633 PF00069 0.595
MOD_PKA_2 122 128 PF00069 0.693
MOD_PKA_2 24 30 PF00069 0.728
MOD_PKA_2 263 269 PF00069 0.571
MOD_PKA_2 35 41 PF00069 0.570
MOD_PKA_2 52 58 PF00069 0.518
MOD_PKA_2 531 537 PF00069 0.420
MOD_PKA_2 627 633 PF00069 0.600
MOD_Plk_1 142 148 PF00069 0.666
MOD_Plk_1 446 452 PF00069 0.523
MOD_Plk_2-3 197 203 PF00069 0.670
MOD_Plk_4 176 182 PF00069 0.746
MOD_Plk_4 548 554 PF00069 0.521
MOD_Plk_4 588 594 PF00069 0.522
MOD_ProDKin_1 185 191 PF00069 0.733
MOD_ProDKin_1 201 207 PF00069 0.586
MOD_ProDKin_1 292 298 PF00069 0.693
MOD_ProDKin_1 309 315 PF00069 0.589
MOD_ProDKin_1 94 100 PF00069 0.683
MOD_SUMO_for_1 256 259 PF00179 0.546
MOD_SUMO_for_1 321 324 PF00179 0.614
MOD_SUMO_rev_2 418 425 PF00179 0.490
TRG_ENDOCYTIC_2 589 592 PF00928 0.577
TRG_ENDOCYTIC_2 89 92 PF00928 0.529
TRG_ER_diArg_1 398 401 PF00400 0.493
TRG_ER_diArg_1 40 43 PF00400 0.763
TRG_ER_diArg_1 52 54 PF00400 0.635
TRG_ER_diArg_1 530 532 PF00400 0.529
TRG_ER_diArg_1 540 543 PF00400 0.395
TRG_ER_diArg_1 559 561 PF00400 0.475
TRG_ER_diArg_1 565 567 PF00400 0.480
TRG_ER_diArg_1 627 629 PF00400 0.541
TRG_ER_diArg_1 642 644 PF00400 0.592
TRG_ER_diArg_1 683 686 PF00400 0.559
TRG_Pf-PMV_PEXEL_1 305 309 PF00026 0.589
TRG_Pf-PMV_PEXEL_1 560 564 PF00026 0.493
TRG_Pf-PMV_PEXEL_1 637 641 PF00026 0.515

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8D9 Leptomonas seymouri 46% 93%
A0A0S4J9A9 Bodo saltans 28% 78%
A0A1X0NSM4 Trypanosomatidae 27% 90%
A0A3R7K6T1 Trypanosoma rangeli 28% 93%
A0A3S7WUM7 Leishmania donovani 90% 100%
A4H995 Leishmania braziliensis 67% 100%
A4HXL6 Leishmania infantum 91% 86%
E9ARB2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 82%
V5DFR3 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS