Inositol-1-monophosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myo-inositol-1(or 4)-monophosphatase 1, putative

Species:

Leishmania major

UniProt:

Q4QE50_LEIMA

TriTrypDb:

LmjF.17.1390 , LMJLV39_170021500 , LMJSD75_170021200

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE50

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006020	inositol metabolic process	4	11
GO:0006021	inositol biosynthetic process	5	11
GO:0006066	alcohol metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016051	carbohydrate biosynthetic process	4	11
GO:0016311	dephosphorylation	5	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019751	polyol metabolic process	4	12
GO:0034637	obsolete cellular carbohydrate biosynthetic process	4	11
GO:0043647	inositol phosphate metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044262	obsolete cellular carbohydrate metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0044283	small molecule biosynthetic process	3	11
GO:0046164	alcohol catabolic process	4	12
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0046174	polyol catabolic process	5	12
GO:0046434	organophosphate catabolic process	4	12
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	12
GO:0046855	obsolete inositol phosphate dephosphorylation	5	12
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071545	inositol phosphate catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901616	organic hydroxy compound catabolic process	4	12
GO:1901617	organic hydroxy compound biosynthetic process	4	11
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	7
GO:0090407	organophosphate biosynthetic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008934	inositol monophosphate 1-phosphatase activity	8	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0052745	inositol phosphate phosphatase activity	6	11
GO:0052832	inositol monophosphate 3-phosphatase activity	8	11
GO:0052833	inositol monophosphate 4-phosphatase activity	8	11
GO:0052834	inositol monophosphate phosphatase activity	7	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.347
CLV_C14_Caspase3-7	173	177	PF00656	0.231
CLV_C14_Caspase3-7	246	250	PF00656	0.413
CLV_NRD_NRD_1	120	122	PF00675	0.452
CLV_PCSK_SKI1_1	144	148	PF00082	0.444
DOC_CKS1_1	70	75	PF01111	0.382
DOC_MAPK_gen_1	121	128	PF00069	0.452
DOC_MAPK_gen_1	58	67	PF00069	0.452
DOC_MAPK_MEF2A_6	121	128	PF00069	0.427
DOC_MAPK_MEF2A_6	268	275	PF00069	0.510
DOC_USP7_MATH_1	178	182	PF00917	0.353
DOC_WW_Pin1_4	69	74	PF00397	0.300
LIG_14-3-3_CanoR_1	152	158	PF00244	0.327
LIG_14-3-3_CanoR_1	162	166	PF00244	0.335
LIG_14-3-3_CanoR_1	20	28	PF00244	0.393
LIG_14-3-3_CanoR_1	280	284	PF00244	0.401
LIG_BIR_III_4	13	17	PF00653	0.524
LIG_CtBP_PxDLS_1	270	276	PF00389	0.402
LIG_deltaCOP1_diTrp_1	216	226	PF00928	0.425
LIG_FHA_1	35	41	PF00498	0.410
LIG_FHA_1	91	97	PF00498	0.304
LIG_FHA_2	171	177	PF00498	0.416
LIG_FHA_2	3	9	PF00498	0.380
LIG_FHA_2	52	58	PF00498	0.345
LIG_LIR_Gen_1	136	146	PF02991	0.309
LIG_LIR_Gen_1	72	82	PF02991	0.362
LIG_LIR_Nem_3	136	141	PF02991	0.309
LIG_LIR_Nem_3	72	78	PF02991	0.322
LIG_SH2_CRK	75	79	PF00017	0.339
LIG_SH3_3	126	132	PF00018	0.305
LIG_SH3_3	67	73	PF00018	0.434
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.365
LIG_SUMO_SIM_par_1	231	237	PF11976	0.382
MOD_CK1_1	247	253	PF00069	0.457
MOD_CK2_1	2	8	PF00069	0.526
MOD_CK2_1	51	57	PF00069	0.419
MOD_DYRK1A_RPxSP_1	69	73	PF00069	0.390
MOD_GlcNHglycan	170	173	PF01048	0.431
MOD_GlcNHglycan	201	204	PF01048	0.348
MOD_GSK3_1	153	160	PF00069	0.327
MOD_GSK3_1	168	175	PF00069	0.296
MOD_GSK3_1	247	254	PF00069	0.340
MOD_GSK3_1	260	267	PF00069	0.310
MOD_GSK3_1	279	286	PF00069	0.387
MOD_N-GLC_1	199	204	PF02516	0.413
MOD_NEK2_1	112	117	PF00069	0.370
MOD_NEK2_1	157	162	PF00069	0.347
MOD_NEK2_1	168	173	PF00069	0.279
MOD_NEK2_1	251	256	PF00069	0.352
MOD_NEK2_1	264	269	PF00069	0.290
MOD_NEK2_2	101	106	PF00069	0.218
MOD_PIKK_1	51	57	PF00454	0.297
MOD_PKA_2	161	167	PF00069	0.334
MOD_PKA_2	279	285	PF00069	0.408
MOD_Plk_1	271	277	PF00069	0.467
MOD_Plk_4	153	159	PF00069	0.341
MOD_Plk_4	161	167	PF00069	0.286
MOD_Plk_4	279	285	PF00069	0.486
MOD_Plk_4	28	34	PF00069	0.277
MOD_Plk_4	90	96	PF00069	0.330
MOD_ProDKin_1	69	75	PF00069	0.300
MOD_SUMO_rev_2	29	37	PF00179	0.394
TRG_DiLeu_BaEn_3	62	68	PF01217	0.339
TRG_ENDOCYTIC_2	75	78	PF00928	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0F6B4W4	Salmonella typhimurium (strain 14028s / SGSC 2262)	30%	100%
A0A0N0P7R4	Leptomonas seymouri	59%	100%
A0A0S4J704	Bodo saltans	45%	100%
A0A0S4J9K7	Bodo saltans	37%	91%
A0A1X0NSL5	Trypanosomatidae	45%	99%
A0A1X0NTZ6	Trypanosomatidae	30%	76%
A0A3R7LSW3	Trypanosoma rangeli	54%	100%
A0A3S7WUM5	Leishmania donovani	92%	100%
A0A422NRH4	Trypanosoma rangeli	26%	79%
A0QX86	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	100%
A4H996	Leishmania braziliensis	78%	100%
A4HXL7	Leishmania infantum	91%	100%
B4ED80	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	35%	100%
C9ZPB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZXW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	79%
E9ARB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O14732	Homo sapiens	31%	100%
O33832	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	36%	100%
O49071	Mesembryanthemum crystallinum	36%	100%
O53907	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
O55023	Mus musculus	29%	100%
O67791	Aquifex aeolicus (strain VF5)	29%	100%
O77591	Sus scrofa	32%	100%
P0ADG4	Escherichia coli (strain K12)	31%	100%
P0ADG5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
P0ADG6	Escherichia coli O157:H7	31%	100%
P11634	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	85%
P20456	Bos taurus	33%	100%
P25416	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	87%
P26264	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	100%
P29218	Homo sapiens	34%	100%
P29219	Xenopus laevis	31%	100%
P29785	Streptomyces griseus	25%	100%
P38710	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	98%
P44332	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P44333	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	100%
P46813	Mycobacterium leprae (strain TN)	30%	99%
P54926	Solanum lycopersicum	38%	100%
P54927	Solanum lycopersicum	42%	100%
P54928	Solanum lycopersicum	40%	100%
P56160	Chlorobaculum parvum (strain DSM 263 / NCIMB 8327)	30%	100%
P57372	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	26%	100%
P58537	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
P65166	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	99%
P70714	Aggregatibacter actinomycetemcomitans	26%	100%
P74158	Synechocystis sp. (strain PCC 6803 / Kazusa)	32%	100%
P97697	Rattus norvegicus	30%	100%
P9WKI8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	99%
P9WKI9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	99%
Q05533	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	99%
Q19420	Caenorhabditis elegans	29%	100%
Q45499	Bacillus subtilis (strain 168)	30%	100%
Q54U72	Dictyostelium discoideum	38%	100%
Q5R4X0	Pongo abelii	34%	100%
Q6NPM8	Arabidopsis thaliana	28%	83%
Q87BG1	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	31%	100%
Q89AK9	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	27%	100%
Q8CIN7	Rattus norvegicus	30%	99%
Q8NS80	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	100%
Q8Z153	Salmonella typhi	31%	100%
Q91UZ5	Mus musculus	30%	99%
Q92M71	Rhizobium meliloti (strain 1021)	35%	100%
Q94F00	Arabidopsis thaliana	32%	78%
Q98F59	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	34%	100%
Q9A3D5	Caulobacter vibrioides (strain ATCC 19089 / CB15)	29%	100%
Q9CNV8	Pasteurella multocida (strain Pm70)	33%	100%
Q9HXI4	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	34%	100%
Q9JU03	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	31%	100%
Q9JZ07	Neisseria meningitidis serogroup B (strain MC58)	31%	100%
Q9K4B1	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	31%	100%
Q9KTY5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	32%	100%
Q9M8S8	Arabidopsis thaliana	40%	100%
Q9PAM0	Xylella fastidiosa (strain 9a5c)	32%	100%
V5B4K7	Trypanosoma cruzi	32%	79%
V5BJH0	Trypanosoma cruzi	53%	100%