Putative zinc-finger protein ZPR1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein ZPR1, putative

Species:

Leishmania major

UniProt:

Q4QE48_LEIMA

TriTrypDb:

LmjF.17.1410 , LMJLV39_170021700 , LMJSD75_170021400

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE48

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.260
CLV_NRD_NRD_1	272	274	PF00675	0.325
CLV_PCSK_KEX2_1	272	274	PF00082	0.287
CLV_PCSK_KEX2_1	331	333	PF00082	0.247
CLV_PCSK_KEX2_1	99	101	PF00082	0.301
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.247
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.315
CLV_PCSK_SKI1_1	232	236	PF00082	0.462
CLV_PCSK_SKI1_1	319	323	PF00082	0.221
CLV_PCSK_SKI1_1	332	336	PF00082	0.268
CLV_PCSK_SKI1_1	393	397	PF00082	0.286
DEG_APCC_DBOX_1	370	378	PF00400	0.438
DOC_MAPK_gen_1	316	324	PF00069	0.463
DOC_MAPK_gen_1	99	107	PF00069	0.449
DOC_MAPK_MEF2A_6	232	239	PF00069	0.478
DOC_MAPK_MEF2A_6	316	324	PF00069	0.463
DOC_PP2B_LxvP_1	132	135	PF13499	0.449
DOC_PP2B_LxvP_1	342	345	PF13499	0.438
DOC_PP2B_LxvP_1	432	435	PF13499	0.529
DOC_USP7_MATH_1	13	17	PF00917	0.672
DOC_USP7_MATH_1	200	204	PF00917	0.449
DOC_USP7_MATH_1	384	388	PF00917	0.487
DOC_WW_Pin1_4	6	11	PF00397	0.665
LIG_14-3-3_CanoR_1	33	37	PF00244	0.464
LIG_14-3-3_CanoR_1	61	70	PF00244	0.486
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_CaM_IQ_9	243	259	PF13499	0.557
LIG_FHA_1	122	128	PF00498	0.438
LIG_FHA_1	191	197	PF00498	0.448
LIG_FHA_1	260	266	PF00498	0.481
LIG_FHA_1	337	343	PF00498	0.412
LIG_FHA_1	411	417	PF00498	0.447
LIG_FHA_1	57	63	PF00498	0.449
LIG_FHA_2	193	199	PF00498	0.476
LIG_FHA_2	219	225	PF00498	0.436
LIG_FHA_2	226	232	PF00498	0.451
LIG_FHA_2	244	250	PF00498	0.553
LIG_FHA_2	392	398	PF00498	0.491
LIG_FHA_2	446	452	PF00498	0.576
LIG_LIR_Apic_2	203	207	PF02991	0.469
LIG_LIR_Apic_2	210	214	PF02991	0.488
LIG_LIR_Gen_1	120	130	PF02991	0.449
LIG_LIR_Gen_1	170	180	PF02991	0.445
LIG_LIR_Gen_1	255	265	PF02991	0.476
LIG_LIR_Gen_1	410	420	PF02991	0.525
LIG_LIR_Nem_3	120	125	PF02991	0.449
LIG_LIR_Nem_3	151	157	PF02991	0.543
LIG_LIR_Nem_3	170	175	PF02991	0.445
LIG_LIR_Nem_3	255	261	PF02991	0.522
LIG_LIR_Nem_3	298	302	PF02991	0.438
LIG_LIR_Nem_3	410	415	PF02991	0.525
LIG_MYND_1	214	218	PF01753	0.538
LIG_NRBOX	401	407	PF00104	0.449
LIG_Pex14_2	92	96	PF04695	0.449
LIG_SH2_CRK	154	158	PF00017	0.487
LIG_SH2_NCK_1	172	176	PF00017	0.515
LIG_SH2_PTP2	204	207	PF00017	0.524
LIG_SH2_SRC	204	207	PF00017	0.438
LIG_SH2_STAP1	103	107	PF00017	0.438
LIG_SH2_STAT3	103	106	PF00017	0.499
LIG_SH2_STAT3	286	289	PF00017	0.524
LIG_SH2_STAT5	204	207	PF00017	0.438
LIG_SH2_STAT5	276	279	PF00017	0.468
LIG_SH2_STAT5	286	289	PF00017	0.431
LIG_SH2_STAT5	299	302	PF00017	0.449
LIG_SH2_STAT5	36	39	PF00017	0.547
LIG_SH2_STAT5	424	427	PF00017	0.438
LIG_SH2_STAT5	447	450	PF00017	0.468
LIG_SH3_5	207	211	PF00018	0.582
LIG_SUMO_SIM_par_1	123	129	PF11976	0.524
LIG_SUMO_SIM_par_1	192	198	PF11976	0.499
LIG_SUMO_SIM_par_1	337	346	PF11976	0.495
LIG_SUMO_SIM_par_1	403	411	PF11976	0.487
LIG_SxIP_EBH_1	60	71	PF03271	0.432
LIG_TRAF2_1	246	249	PF00917	0.618
LIG_TRAF2_1	489	492	PF00917	0.725
LIG_UBA3_1	46	53	PF00899	0.417
LIG_UBA3_1	63	71	PF00899	0.413
LIG_WRC_WIRS_1	182	187	PF05994	0.506
LIG_WRC_WIRS_1	75	80	PF05994	0.438
MOD_CK1_1	184	190	PF00069	0.504
MOD_CK1_1	259	265	PF00069	0.588
MOD_CK1_1	32	38	PF00069	0.608
MOD_CK2_1	200	206	PF00069	0.438
MOD_CK2_1	218	224	PF00069	0.432
MOD_CK2_1	243	249	PF00069	0.572
MOD_CK2_1	358	364	PF00069	0.438
MOD_CK2_1	391	397	PF00069	0.480
MOD_CK2_1	445	451	PF00069	0.574
MOD_CK2_1	471	477	PF00069	0.600
MOD_CK2_1	73	79	PF00069	0.441
MOD_GlcNHglycan	14	18	PF01048	0.683
MOD_GlcNHglycan	154	157	PF01048	0.292
MOD_GlcNHglycan	186	189	PF01048	0.312
MOD_GlcNHglycan	386	389	PF01048	0.251
MOD_GSK3_1	117	124	PF00069	0.438
MOD_GSK3_1	32	39	PF00069	0.623
MOD_GSK3_1	334	341	PF00069	0.438
MOD_GSK3_1	359	366	PF00069	0.438
MOD_GSK3_1	9	16	PF00069	0.719
MOD_N-GLC_1	29	34	PF02516	0.541
MOD_NEK2_1	150	155	PF00069	0.513
MOD_NEK2_1	287	292	PF00069	0.438
MOD_NEK2_1	46	51	PF00069	0.524
MOD_NEK2_1	62	67	PF00069	0.390
MOD_NEK2_1	92	97	PF00069	0.499
MOD_NEK2_2	458	463	PF00069	0.548
MOD_PIKK_1	135	141	PF00454	0.438
MOD_PIKK_1	243	249	PF00454	0.579
MOD_PIKK_1	259	265	PF00454	0.568
MOD_PIKK_1	365	371	PF00454	0.499
MOD_PKA_2	32	38	PF00069	0.577
MOD_Plk_1	150	156	PF00069	0.555
MOD_Plk_1	259	265	PF00069	0.579
MOD_Plk_1	410	416	PF00069	0.524
MOD_Plk_4	200	206	PF00069	0.438
MOD_Plk_4	287	293	PF00069	0.438
MOD_Plk_4	32	38	PF00069	0.466
MOD_Plk_4	338	344	PF00069	0.499
MOD_Plk_4	391	397	PF00069	0.473
MOD_ProDKin_1	6	12	PF00069	0.666
MOD_SUMO_for_1	118	121	PF00179	0.463
MOD_SUMO_for_1	295	298	PF00179	0.487
MOD_SUMO_for_1	440	443	PF00179	0.558
MOD_SUMO_rev_2	244	253	PF00179	0.600
MOD_SUMO_rev_2	304	309	PF00179	0.438
MOD_SUMO_rev_2	436	442	PF00179	0.536
TRG_DiLeu_BaEn_1	401	406	PF01217	0.456
TRG_DiLeu_BaEn_2	409	415	PF01217	0.487
TRG_DiLeu_BaEn_3	410	416	PF01217	0.487
TRG_DiLeu_BaEn_4	455	461	PF01217	0.390
TRG_ENDOCYTIC_2	154	157	PF00928	0.543
TRG_ENDOCYTIC_2	172	175	PF00928	0.446
TRG_ENDOCYTIC_2	276	279	PF00928	0.507
TRG_ER_diArg_1	100	103	PF00400	0.515
TRG_ER_diArg_1	272	274	PF00400	0.487
TRG_NLS_MonoExtC_3	98	104	PF00514	0.524
TRG_NLS_MonoExtN_4	98	103	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6X5	Leptomonas seymouri	78%	93%
A0A0S4J2U4	Bodo saltans	57%	100%
A0A1X0NSX4	Trypanosomatidae	70%	100%
A0A3Q8IB01	Leishmania donovani	94%	100%
A0A3S5IQV9	Trypanosoma rangeli	67%	100%
A4H998	Leishmania braziliensis	83%	100%
A4HXL9	Leishmania infantum	94%	100%
A9CB27	Papio anubis	41%	100%
C9ZPB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ARB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O13724	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
O16999	Caenorhabditis elegans	42%	100%
O75312	Homo sapiens	40%	100%
P53303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q2TBX0	Bos taurus	41%	100%
Q55E13	Dictyostelium discoideum	41%	100%
Q62384	Mus musculus	41%	100%
Q9W379	Drosophila melanogaster	39%	100%
V5BJH3	Trypanosoma cruzi	66%	100%