LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania major
UniProt:
Q4QE46_LEIMA
TriTrypDb:
LmjF.17.1430 , LMJLV39_170022100 * , LMJSD75_170021800 *
Length:
500

Annotations

LeishMANIAdb annotations

An MFS-superfamily protein homologous to human FLVCR2 hem transporter. Only duplicated extensively in Strigomonas

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 8
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QE46
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE46

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 10
GO:0022857 transmembrane transporter activity 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 28 32 PF00656 0.701
CLV_C14_Caspase3-7 45 49 PF00656 0.678
CLV_MEL_PAP_1 126 132 PF00089 0.206
CLV_NRD_NRD_1 226 228 PF00675 0.511
CLV_NRD_NRD_1 475 477 PF00675 0.388
CLV_PCSK_KEX2_1 475 477 PF00082 0.377
CLV_PCSK_KEX2_1 496 498 PF00082 0.523
CLV_PCSK_PC1ET2_1 496 498 PF00082 0.523
CLV_PCSK_SKI1_1 274 278 PF00082 0.316
DEG_Nend_Nbox_1 1 3 PF02207 0.734
DOC_CDC14_PxL_1 176 184 PF14671 0.378
DOC_CDC14_PxL_1 384 392 PF14671 0.462
DOC_CYCLIN_yCln2_LP_2 110 116 PF00134 0.421
DOC_CYCLIN_yCln2_LP_2 309 315 PF00134 0.273
DOC_CYCLIN_yCln2_LP_2 393 399 PF00134 0.421
DOC_PP1_SILK_1 146 151 PF00149 0.236
DOC_PP2B_LxvP_1 110 113 PF13499 0.421
DOC_PP2B_LxvP_1 177 180 PF13499 0.346
DOC_PP2B_LxvP_1 393 396 PF13499 0.421
DOC_PP4_FxxP_1 213 216 PF00568 0.348
DOC_PP4_FxxP_1 495 498 PF00568 0.595
DOC_SPAK_OSR1_1 66 70 PF12202 0.568
DOC_USP7_MATH_1 144 148 PF00917 0.378
DOC_USP7_MATH_1 18 22 PF00917 0.752
DOC_USP7_MATH_1 198 202 PF00917 0.335
DOC_USP7_MATH_1 86 90 PF00917 0.421
DOC_USP7_UBL2_3 477 481 PF12436 0.632
DOC_WW_Pin1_4 212 217 PF00397 0.390
DOC_WW_Pin1_4 370 375 PF00397 0.286
DOC_WW_Pin1_4 60 65 PF00397 0.632
LIG_14-3-3_CanoR_1 193 203 PF00244 0.508
LIG_14-3-3_CanoR_1 259 268 PF00244 0.563
LIG_Actin_WH2_2 118 135 PF00022 0.411
LIG_BRCT_BRCA1_1 423 427 PF00533 0.421
LIG_BRCT_BRCA1_1 491 495 PF00533 0.580
LIG_CSL_BTD_1 186 189 PF09270 0.539
LIG_eIF4E_1 282 288 PF01652 0.406
LIG_FHA_1 240 246 PF00498 0.436
LIG_FHA_1 358 364 PF00498 0.376
LIG_FHA_1 371 377 PF00498 0.187
LIG_FHA_1 417 423 PF00498 0.570
LIG_FHA_1 454 460 PF00498 0.342
LIG_FHA_2 224 230 PF00498 0.327
LIG_FHA_2 261 267 PF00498 0.516
LIG_FHA_2 338 344 PF00498 0.400
LIG_GBD_Chelix_1 243 251 PF00786 0.462
LIG_GBD_Chelix_1 302 310 PF00786 0.421
LIG_GBD_Chelix_1 400 408 PF00786 0.367
LIG_LIR_Apic_2 265 271 PF02991 0.539
LIG_LIR_Apic_2 407 413 PF02991 0.563
LIG_LIR_Apic_2 492 498 PF02991 0.586
LIG_LIR_Gen_1 278 288 PF02991 0.489
LIG_LIR_Gen_1 296 307 PF02991 0.442
LIG_LIR_Gen_1 424 435 PF02991 0.422
LIG_LIR_Gen_1 448 459 PF02991 0.380
LIG_LIR_Nem_3 278 283 PF02991 0.505
LIG_LIR_Nem_3 284 288 PF02991 0.299
LIG_LIR_Nem_3 289 295 PF02991 0.284
LIG_LIR_Nem_3 296 302 PF02991 0.133
LIG_LIR_Nem_3 345 350 PF02991 0.498
LIG_LIR_Nem_3 380 386 PF02991 0.420
LIG_LIR_Nem_3 424 430 PF02991 0.419
LIG_LIR_Nem_3 447 453 PF02991 0.311
LIG_LIR_Nem_3 94 100 PF02991 0.287
LIG_LYPXL_yS_3 159 162 PF13949 0.331
LIG_NRBOX 106 112 PF00104 0.462
LIG_NRBOX 242 248 PF00104 0.459
LIG_NRBOX 305 311 PF00104 0.273
LIG_PAM2_1 372 384 PF00658 0.206
LIG_Pex14_1 155 159 PF04695 0.308
LIG_REV1ctd_RIR_1 466 475 PF16727 0.544
LIG_SH2_CRK 127 131 PF00017 0.525
LIG_SH2_CRK 134 138 PF00017 0.396
LIG_SH2_CRK 268 272 PF00017 0.524
LIG_SH2_CRK 350 354 PF00017 0.400
LIG_SH2_NCK_1 127 131 PF00017 0.530
LIG_SH2_NCK_1 350 354 PF00017 0.236
LIG_SH2_PTP2 384 387 PF00017 0.378
LIG_SH2_PTP2 451 454 PF00017 0.400
LIG_SH2_STAT5 116 119 PF00017 0.349
LIG_SH2_STAT5 282 285 PF00017 0.473
LIG_SH2_STAT5 350 353 PF00017 0.378
LIG_SH2_STAT5 384 387 PF00017 0.333
LIG_SH2_STAT5 451 454 PF00017 0.410
LIG_SH2_STAT5 84 87 PF00017 0.400
LIG_SH2_STAT5 97 100 PF00017 0.244
LIG_SH3_3 151 157 PF00018 0.380
LIG_SH3_3 21 27 PF00018 0.725
LIG_SH3_3 382 388 PF00018 0.449
LIG_SH3_3 393 399 PF00018 0.405
LIG_SUMO_SIM_anti_2 241 248 PF11976 0.421
LIG_SUMO_SIM_anti_2 359 366 PF11976 0.440
LIG_SUMO_SIM_par_1 366 373 PF11976 0.248
LIG_SUMO_SIM_par_1 417 424 PF11976 0.530
LIG_SUMO_SIM_par_1 451 456 PF11976 0.413
LIG_TRFH_1 384 388 PF08558 0.410
LIG_TYR_ITIM 125 130 PF00017 0.400
LIG_TYR_ITIM 132 137 PF00017 0.531
LIG_UBA3_1 247 255 PF00899 0.462
LIG_UBA3_1 272 277 PF00899 0.568
LIG_UBA3_1 364 371 PF00899 0.236
LIG_WRC_WIRS_1 282 287 PF05994 0.468
LIG_WRC_WIRS_1 338 343 PF05994 0.439
LIG_WRC_WIRS_1 427 432 PF05994 0.419
MOD_CDK_SPxK_1 60 66 PF00069 0.624
MOD_CK1_1 233 239 PF00069 0.442
MOD_CK1_1 25 31 PF00069 0.715
MOD_CK1_1 261 267 PF00069 0.478
MOD_CK1_1 460 466 PF00069 0.382
MOD_CK2_1 223 229 PF00069 0.327
MOD_CK2_1 260 266 PF00069 0.539
MOD_CK2_1 98 104 PF00069 0.324
MOD_GlcNHglycan 100 103 PF01048 0.556
MOD_GlcNHglycan 319 322 PF01048 0.511
MOD_GlcNHglycan 325 328 PF01048 0.384
MOD_GlcNHglycan 331 334 PF01048 0.387
MOD_GlcNHglycan 4 7 PF01048 0.509
MOD_GlcNHglycan 459 462 PF01048 0.405
MOD_GSK3_1 18 25 PF00069 0.738
MOD_GSK3_1 194 201 PF00069 0.330
MOD_GSK3_1 258 265 PF00069 0.477
MOD_GSK3_1 293 300 PF00069 0.402
MOD_GSK3_1 313 320 PF00069 0.328
MOD_GSK3_1 412 419 PF00069 0.575
MOD_GSK3_1 442 449 PF00069 0.384
MOD_GSK3_1 453 460 PF00069 0.367
MOD_N-GLC_1 489 494 PF02516 0.427
MOD_NEK2_1 175 180 PF00069 0.317
MOD_NEK2_1 2 7 PF00069 0.758
MOD_NEK2_1 238 243 PF00069 0.434
MOD_NEK2_1 275 280 PF00069 0.552
MOD_NEK2_1 323 328 PF00069 0.375
MOD_NEK2_1 329 334 PF00069 0.372
MOD_NEK2_1 337 342 PF00069 0.376
MOD_NEK2_1 35 40 PF00069 0.706
MOD_NEK2_1 453 458 PF00069 0.360
MOD_NEK2_1 98 103 PF00069 0.319
MOD_PIKK_1 233 239 PF00454 0.442
MOD_PIKK_1 91 97 PF00454 0.324
MOD_PKA_2 258 264 PF00069 0.518
MOD_PKA_2 91 97 PF00069 0.368
MOD_Plk_1 191 197 PF00069 0.539
MOD_Plk_1 342 348 PF00069 0.568
MOD_Plk_1 406 412 PF00069 0.529
MOD_Plk_1 446 452 PF00069 0.315
MOD_Plk_2-3 42 48 PF00069 0.698
MOD_Plk_2-3 442 448 PF00069 0.420
MOD_Plk_4 144 150 PF00069 0.378
MOD_Plk_4 18 24 PF00069 0.741
MOD_Plk_4 198 204 PF00069 0.429
MOD_Plk_4 239 245 PF00069 0.335
MOD_Plk_4 281 287 PF00069 0.492
MOD_Plk_4 337 343 PF00069 0.373
MOD_Plk_4 416 422 PF00069 0.502
MOD_Plk_4 426 432 PF00069 0.242
MOD_Plk_4 446 452 PF00069 0.370
MOD_ProDKin_1 212 218 PF00069 0.390
MOD_ProDKin_1 370 376 PF00069 0.286
MOD_ProDKin_1 60 66 PF00069 0.624
MOD_SUMO_rev_2 311 320 PF00179 0.368
TRG_DiLeu_BaEn_1 104 109 PF01217 0.324
TRG_DiLeu_BaLyEn_6 157 162 PF01217 0.331
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.346
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.568
TRG_ENDOCYTIC_2 127 130 PF00928 0.515
TRG_ENDOCYTIC_2 134 137 PF00928 0.414
TRG_ENDOCYTIC_2 159 162 PF00928 0.315
TRG_ENDOCYTIC_2 282 285 PF00928 0.476
TRG_ENDOCYTIC_2 350 353 PF00928 0.400
TRG_ENDOCYTIC_2 384 387 PF00928 0.378
TRG_ENDOCYTIC_2 451 454 PF00928 0.410
TRG_ENDOCYTIC_2 84 87 PF00928 0.449
TRG_ENDOCYTIC_2 97 100 PF00928 0.285
TRG_ER_diArg_1 474 476 PF00400 0.573
TRG_PTS1 497 500 PF00515 0.591

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJH4 Leptomonas seymouri 22% 100%
A0A0N1ILZ7 Leptomonas seymouri 65% 93%
A0A0S4J692 Bodo saltans 33% 83%
A0A0S4J989 Bodo saltans 23% 100%
A0A0S4JN91 Bodo saltans 27% 100%
A0A1X0NWR8 Trypanosomatidae 28% 100%
A0A1X0NXK8 Trypanosomatidae 23% 100%
A0A3R7LY82 Trypanosoma rangeli 28% 91%
A0A3S7WUW1 Leishmania donovani 90% 97%
A0A3S7WW86 Leishmania donovani 23% 100%
A4H9A1 Leishmania braziliensis 74% 100%
A4HBK5 Leishmania braziliensis 23% 100%
A4HXM1 Leishmania infantum 90% 97%
B2RXV4 Mus musculus 25% 89%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 92%
E9AGU5 Leishmania infantum 23% 100%
E9ARB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AUX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
O01735 Caenorhabditis elegans 23% 85%
P60815 Rattus norvegicus 27% 92%
Q11073 Caenorhabditis elegans 24% 99%
Q28FF3 Xenopus tropicalis 26% 100%
Q4H425 Epichloe festucae (strain Fl1) 22% 100%
Q4QCK8 Leishmania major 24% 100%
Q501I9 Xenopus tropicalis 24% 100%
Q503P5 Danio rerio 23% 100%
Q66H95 Rattus norvegicus 23% 100%
Q6GNV7 Xenopus laevis 25% 100%
Q6UXD7 Homo sapiens 26% 89%
Q8BFQ6 Mus musculus 23% 100%
Q8CE47 Mus musculus 27% 97%
Q91X85 Mus musculus 27% 91%
Q96SL1 Homo sapiens 23% 100%
Q9ES43 Mus terricolor 25% 89%
Q9N1F2 Felis catus 27% 89%
Q9UPI3 Homo sapiens 28% 95%
Q9Y5Y0 Homo sapiens 26% 90%
V5BQV3 Trypanosoma cruzi 27% 91%
V5DGX2 Trypanosoma cruzi 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS